Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Voltage-dependent R-type calcium channel subunit alpha-1E

Gene

Cacna1e

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei260Calcium ion selectivity and permeabilityBy similarity1
Sitei608Calcium ion selectivity and permeabilityBy similarity1
Sitei1324Calcium ion selectivity and permeabilityBy similarity1
Sitei1615Calcium ion selectivity and permeabilityBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi377 – 388PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi1704 – 1715PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Voltage-dependent R-type calcium channel subunit alpha-1E
Alternative name(s):
BII
Brain calcium channel II
Calcium channel, L type, alpha-1 polypeptide, isoform 6
RBE-II
RBE2
Voltage-gated calcium channel subunit alpha Cav2.3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cacna1e
Synonyms:Cach6, Cacnl1a6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
2246 Cacna1e

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 40CytoplasmicSequence analysisAdd BLAST40
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei41 – 59Helical; Name=S1 of repeat ISequence analysisAdd BLAST19
Topological domaini60 – 78ExtracellularSequence analysisAdd BLAST19
Transmembranei79 – 97Helical; Name=S2 of repeat ISequence analysisAdd BLAST19
Topological domaini98 – 109CytoplasmicSequence analysisAdd BLAST12
Transmembranei110 – 124Helical; Name=S3 of repeat ISequence analysisAdd BLAST15
Topological domaini125 – 136ExtracellularSequence analysisAdd BLAST12
Transmembranei137 – 156Helical; Name=S4 of repeat ISequence analysisAdd BLAST20
Topological domaini157 – 174CytoplasmicSequence analysisAdd BLAST18
Transmembranei175 – 195Helical; Name=S5 of repeat ISequence analysisAdd BLAST21
Topological domaini196 – 277ExtracellularSequence analysisAdd BLAST82
Transmembranei278 – 301Helical; Name=S6 of repeat ISequence analysisAdd BLAST24
Topological domaini302 – 427CytoplasmicSequence analysisAdd BLAST126
Transmembranei428 – 447Helical; Name=S1 of repeat IISequence analysisAdd BLAST20
Topological domaini448 – 460ExtracellularSequence analysisAdd BLAST13
Transmembranei461 – 480Helical; Name=S2 of repeat IISequence analysisAdd BLAST20
Topological domaini481 – 489CytoplasmicSequence analysis9
Transmembranei490 – 508Helical; Name=S3 of repeat IISequence analysisAdd BLAST19
Topological domaini509 – 518ExtracellularSequence analysis10
Transmembranei519 – 537Helical; Name=S4 of repeat IISequence analysisAdd BLAST19
Topological domaini538 – 556CytoplasmicSequence analysisAdd BLAST19
Transmembranei557 – 576Helical; Name=S5 of repeat IISequence analysisAdd BLAST20
Topological domaini577 – 629ExtracellularSequence analysisAdd BLAST53
Transmembranei630 – 654Helical; Name=S6 of repeat IISequence analysisAdd BLAST25
Topological domaini655 – 1100CytoplasmicSequence analysisAdd BLAST446
Transmembranei1101 – 1117Helical; Name=S1 of repeat IIISequence analysisAdd BLAST17
Topological domaini1118 – 1141ExtracellularSequence analysisAdd BLAST24
Transmembranei1142 – 1161Helical; Name=S2 of repeat IIISequence analysisAdd BLAST20
Topological domaini1162 – 1169CytoplasmicSequence analysis8
Transmembranei1170 – 1192Helical; Name=S3 of repeat IIISequence analysisAdd BLAST23
Topological domaini1193 – 1206ExtracellularSequence analysisAdd BLAST14
Transmembranei1207 – 1224Helical; Name=S4 of repeat IIISequence analysisAdd BLAST18
Topological domaini1225 – 1243CytoplasmicSequence analysisAdd BLAST19
Transmembranei1244 – 1263Helical; Name=S5 of repeat IIISequence analysisAdd BLAST20
Topological domaini1264 – 1350ExtracellularSequence analysisAdd BLAST87
Transmembranei1351 – 1374Helical; Name=S6 of repeat IIISequence analysisAdd BLAST24
Topological domaini1375 – 1431CytoplasmicSequence analysisAdd BLAST57
Transmembranei1432 – 1450Helical; Name=S1 of repeat IVSequence analysisAdd BLAST19
Topological domaini1451 – 1467ExtracellularSequence analysisAdd BLAST17
Transmembranei1468 – 1485Helical; Name=S2 of repeat IVSequence analysisAdd BLAST18
Topological domaini1486 – 1493CytoplasmicSequence analysis8
Transmembranei1494 – 1512Helical; Name=S3 of repeat IVSequence analysisAdd BLAST19
Topological domaini1513 – 1523ExtracellularSequence analysisAdd BLAST11
Transmembranei1524 – 1542Helical; Name=S4 of repeat IVSequence analysisAdd BLAST19
Topological domaini1543 – 1561CytoplasmicSequence analysisAdd BLAST19
Transmembranei1562 – 1581Helical; Name=S5 of repeat IVSequence analysisAdd BLAST20
Topological domaini1582 – 1650ExtracellularSequence analysisAdd BLAST69
Transmembranei1651 – 1676Helical; Name=S6 of repeat IVSequence analysisAdd BLAST26
Topological domaini1677 – 2222CytoplasmicSequence analysisAdd BLAST546

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
534

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000539411 – 2222Voltage-dependent R-type calcium channel subunit alpha-1EAdd BLAST2222

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi205N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei378PhosphoserineBy similarity1
Modified residuei391PhosphothreonineBy similarity1
Modified residuei687PhosphoserineCombined sources1
Modified residuei696PhosphoserineBy similarity1
Modified residuei744PhosphoserineCombined sources1
Modified residuei766PhosphoserineBy similarity1
Modified residuei806PhosphoserineCombined sources1
Modified residuei898PhosphoserineCombined sources1
Modified residuei1049PhosphoserineCombined sources1
Glycosylationi1518N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1523N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1641N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1686Phosphoserine; by PKASequence analysis1
Modified residuei2003PhosphoserineBy similarity1
Modified residuei2022PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q07652

PRoteomics IDEntifications database

More...
PRIDEi
Q07652

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q07652

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q07652

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q07652

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in central nervous system and in insulinoma.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with EFHC1. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
CALM3P621582EBI-15734403,EBI-397435From a different organism.

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-46236N

Protein interaction database and analysis system

More...
IntActi
Q07652, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000003928

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12222
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q07652

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q07652

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q07652

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati27 – 305IAdd BLAST279
Repeati413 – 657IIAdd BLAST245
Repeati1092 – 1378IIIAdd BLAST287
Repeati1415 – 1678IVAdd BLAST264
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1691 – 1726EF-handPROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni325 – 342Binding to the beta subunitBy similarityAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi667 – 672Poly-Glu6
Compositional biasi699 – 704Poly-Arg6
Compositional biasi718 – 723Poly-Arg6
Compositional biasi1058 – 1064Poly-Glu7
Compositional biasi1180 – 1183Poly-Val4
Compositional biasi2193 – 2196Poly-Arg4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410INF5 Eukaryota
ENOG410YD06 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231530

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG050763

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q07652

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q07652

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002048 EF_hand_dom
IPR031649 GPHH_dom
IPR005821 Ion_trans_dom
IPR014873 VDCC_a1su_IQ
IPR005449 VDCC_R_a1su
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10037:SF57 PTHR10037:SF57, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08763 Ca_chan_IQ, 1 hit
PF16905 GPHH, 1 hit
PF00520 Ion_trans, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00167 CACHANNEL
PR01633 RVDCCALPHA1

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01062 Ca_chan_IQ, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50222 EF_HAND_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q07652-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALYNPIPVR QNCFTVNRSL FIFGEDNIVR KYAKKLIDWP PFEYMILATI
60 70 80 90 100
IANCIVLALE QHLPEDDKTP MSRRLEKTEP YFIGIFCFEA GIKIVALGFI
110 120 130 140 150
FHKGSYLRNG WNVMDFIVVL SGILATAGTH FNTHVDLRTL RAVRVLRPLK
160 170 180 190 200
LVSGIPSLQI VLKSIMKAMV PLLQIGLLLF FAILMFAIIG LEFYSGKLHR
210 220 230 240 250
ACFMNNSGIL EGFDPPHPCG VQGCPAGYEC KDWIGPNDGI TQFDNILFAV
260 270 280 290 300
LTVFQCITME GWTTVLYNTN DALGATWNWL YFIPLIIIGS FFVLNLVLGV
310 320 330 340 350
LSGEFAKERE RVENRRAFMK LRRQQQIERE LNGYRAWIDK AEEVMLAEEN
360 370 380 390 400
KNSGTSALEV LRRATIKRSR TEAMTRDSSD EHCVDISSVG TPLARASIKS
410 420 430 440 450
TKVDGASYFR HKERLLRISI RHMVKSQVFY WIVLSVVALN TACVAIVHHN
460 470 480 490 500
QPQWLTHLLY YAEFLFLGLF LLEMSLKMYG MGPRLYFHSS FNCFDFGVTV
510 520 530 540 550
GSIFEVVWAI FRPGTSFGIS VLRALRLLRI FKITKYWASL RNLVVSLMSS
560 570 580 590 600
MKSIISLLFL LFLFIVVFAL LGMQLFGGRF NFNDGTPSAN FDTFPAAIMT
610 620 630 640 650
VFQILTGEDW NEVMYNGIRS QGGVSSGMWS AIYFIVLTLF GNYTLLNVFL
660 670 680 690 700
AIAVDNLANA QELTKDEQEE EEAFNQKHAL QKAKEVSPMS APNMPSIERD
710 720 730 740 750
RRRRHHMSMW EPRSSHLRER RRRHHMSVWE QRTSQLRRHM QMSSQEALNK
760 770 780 790 800
EEAPPMNPLN PLNPLSPLNP LNAHPSLYRR PRPIEGLALG LGLEKCEEER
810 820 830 840 850
ISRGGSLKGD IGGLTSVLDN QRSPLSLGKR EPPWLPRSCH GNCDPTQQET
860 870 880 890 900
GGGETVVTFE DRARHRQSQR RSRHRRVRTE GKESASASRS RSASQERSLD
910 920 930 940 950
EGVSIDGEKE HEPQSSHRSK EPTIHEEERT QDLRRTNSLM VPRGSGLVGA
960 970 980 990 1000
LDEAETPLVQ PQPELEVGKD AALTEQEAEG SSEQALLADV QLDVGRGISQ
1010 1020 1030 1040 1050
SEPDLSCMTT NMDKATTEST SVTVAIPDVD PLVDSTVVNI SNKTDGEASP
1060 1070 1080 1090 1100
LKEAETKEEE EEVEKKKQKK EKRETGKAMV PHSSMFIFST TNPIRKACHY
1110 1120 1130 1140 1150
IVNLRYFEMC ILLVIAASSI ALAAEDPVLT NSERNKVLRY FDYVFTGVFT
1160 1170 1180 1190 1200
FEMVIKMIDQ GLILQDGSYF RDLWNILDFV VVVGALVAFA LANALGTNKG
1210 1220 1230 1240 1250
RDIKTIKSLR VLRVLRPLKT IKRLPKLKAV FDCVVTSLKN VFNILIVYKL
1260 1270 1280 1290 1300
FMFIFAVIAV QLFKGKFFYC TDSSKDTEKE CIGNYVDHEK NKMEVKGREW
1310 1320 1330 1340 1350
KRHEFHYDNI IWALLTLFTV STGEGWPQVL QHSVDVTEED RGPSRSNRME
1360 1370 1380 1390 1400
MSIFYVVYFV VFPFFFVNIF VALIIITFQE QGDKMMEECS LEKNERACID
1410 1420 1430 1440 1450
FAISAKPLTR YMPQNRHTFQ YRVWHFVVSP SFEYTIMAMI ALNTVVLMMK
1460 1470 1480 1490 1500
YYSAPWTYEL ALKYLNIAFT MVFSLECVLK VIAFGFLNYF RDTWNIFDFI
1510 1520 1530 1540 1550
TVIGSITEII LTDSKLVNTS GFNMSFLKLF RAARLIKLLR QGYTIRILLW
1560 1570 1580 1590 1600
TFVQSFKALP YVCLLIAMLF FIYAIIGMQV FGNIKLDEES HINRHNNFRS
1610 1620 1630 1640 1650
FFGSLMLLFR SATGEAWQEI MLSCLGEKGC EPDTTAPSGQ NESERCGTDL
1660 1670 1680 1690 1700
AYVYFVSFIF FCSFLMLNLF VAVIMDNFEY LTRDSSILGP HHLDEFVRVW
1710 1720 1730 1740 1750
AEYDRAACGR IHYTEMYEML TLMSPPLGLG KRCPSKVAYK RLVLMNMPVA
1760 1770 1780 1790 1800
EDMTVHFTST LMALIRTALD IKIAKGGADR QQLDSELQKE TLAIWPHLSQ
1810 1820 1830 1840 1850
KMLDLLVPMP KASDLTVGKI YAAMMIMDYY KQSKVKKQRQ QLEEQKNAPM
1860 1870 1880 1890 1900
FQRMEPSSLP QEIISNAKAL PYLQQDPVSG LSGRSGYPSM SPLSPQEIFQ
1910 1920 1930 1940 1950
LACMDPADDG QFQEQQSLVV TDPSSMRRSF STIRDKRSNS SWLEEFSMER
1960 1970 1980 1990 2000
SSENTYKSRR RSYHSSLRLS AHRLNSDSGH KSDTHRSGGR ERGRSKERKH
2010 2020 2030 2040 2050
LLSPDVSRCN SEERGTQADW ESPERRQSRS PSEGRSQTPN RQGTGSLSES
2060 2070 2080 2090 2100
SIPSISDTST PRRSRRQLPP VPPKPRPLLS YSSLMRHTGG ISPPPDGSEG
2110 2120 2130 2140 2150
GSPLASQALE SNSACLTESS NSLHPQQGQH PSPQHYISEP YLALHEDSHA
2160 2170 2180 2190 2200
SDCGEEETLT FEAAVATSLG RSNTIGSAPP LRHSWQMPNG HYRRRRLGGL
2210 2220
GLAMMCGAVS DLLSDTEEDD KC
Length:2,222
Mass (Da):252,116
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDF6452A2175CEB19
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1LMS1F1LMS1_RAT
Voltage-dependent R-type calcium ch...
Cacna1e
2,296Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1LNB9F1LNB9_RAT
Voltage-dependent R-type calcium ch...
Cacna1e
1,943Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JVW2A0A0G2JVW2_RAT
Voltage-dependent R-type calcium ch...
Cacna1e
1,960Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L15453 mRNA Translation: AAA40855.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A37490

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Rn.10742

Genome annotation databases

UCSC genome browser

More...
UCSCi
RGD:2246 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15453 mRNA Translation: AAA40855.1
PIRiA37490
UniGeneiRn.10742

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DVKX-ray2.30B1818-1837[»]
ProteinModelPortaliQ07652
SMRiQ07652
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46236N
IntActiQ07652, 2 interactors
STRINGi10116.ENSRNOP00000003928

Chemistry databases

GuidetoPHARMACOLOGYi534

PTM databases

CarbonylDBiQ07652
iPTMnetiQ07652
PhosphoSitePlusiQ07652

Proteomic databases

PaxDbiQ07652
PRIDEiQ07652

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:2246 rat

Organism-specific databases

RGDi2246 Cacna1e

Phylogenomic databases

eggNOGiENOG410INF5 Eukaryota
ENOG410YD06 LUCA
HOGENOMiHOG000231530
HOVERGENiHBG050763
InParanoidiQ07652
PhylomeDBiQ07652

Miscellaneous databases

EvolutionaryTraceiQ07652

Protein Ontology

More...
PROi
PR:Q07652

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR002048 EF_hand_dom
IPR031649 GPHH_dom
IPR005821 Ion_trans_dom
IPR014873 VDCC_a1su_IQ
IPR005449 VDCC_R_a1su
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10037:SF57 PTHR10037:SF57, 2 hits
PfamiView protein in Pfam
PF08763 Ca_chan_IQ, 1 hit
PF16905 GPHH, 1 hit
PF00520 Ion_trans, 4 hits
PRINTSiPR00167 CACHANNEL
PR01633 RVDCCALPHA1
SMARTiView protein in SMART
SM01062 Ca_chan_IQ, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAC1E_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q07652
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again