UniProtKB - Q07647 (GTR3_RAT)
Protein
Solute carrier family 2, facilitated glucose transporter member 3
Gene
Slc2a3
Organism
Rattus norvegicus (Rat)
Status
Functioni
Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.By similarity
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 315 | MonosaccharideBy similarity | 1 | |
Binding sitei | 378 | MonosaccharideBy similarity | 1 | |
Binding sitei | 386 | MonosaccharideBy similarity | 1 |
GO - Molecular functioni
- dehydroascorbic acid transmembrane transporter activity Source: UniProtKB
- D-glucose transmembrane transporter activity Source: UniProtKB
- galactoside binding Source: RGD
- glucose binding Source: RGD
- glucose transmembrane transporter activity Source: RGD
- kinase binding Source: RGD
- monosaccharide transmembrane transporter activity Source: RGD
- xylose binding Source: RGD
GO - Biological processi
- cerebral cortex development Source: RGD
- dehydroascorbic acid transport Source: UniProtKB
- glucose import Source: RGD
- glucose import across plasma membrane Source: RGD
- glucose transmembrane transport Source: UniProtKB
- monosaccharide transmembrane transport Source: RGD
- negative regulation of apoptotic process Source: RGD
- response to glucose Source: RGD
- response to Thyroglobulin triiodothyronine Source: RGD
- transport across blood-brain barrier Source: RGD
Keywordsi
Biological process | Sugar transport, Transport |
Enzyme and pathway databases
Reactomei | R-RNO-189200, Cellular hexose transport R-RNO-196836, Vitamin C (ascorbate) metabolism R-RNO-6798695, Neutrophil degranulation |
Protein family/group databases
TCDBi | 2.A.1.1.12, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 2, facilitated glucose transporter member 3CuratedAlternative name(s): Glucose transporter type 3, brain1 Publication Short name: GLUT-31 Publication |
Gene namesi | |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3706, Slc2a3 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Other locations
- Perikaryon 1 Publication
- Cell projection 1 Publication
Note: Localized to densely spaced patches along neuronal processes.1 Publication
Plasma Membrane
- caveola Source: RGD
- integral component of plasma membrane Source: UniProtKB
- integral component of synaptic membrane Source: SynGO
- plasma membrane Source: UniProtKB
Other locations
- acrosomal membrane Source: RGD
- cell projection Source: UniProtKB-SubCell
- cytoplasm Source: UniProtKB
- glutamatergic synapse Source: SynGO
- integral component of membrane Source: UniProtKB
- perikaryon Source: UniProtKB-SubCell
- synaptic vesicle membrane Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 10 | CytoplasmicBy similarity | 10 | |
Transmembranei | 11 – 32 | Helical; Name=1Sequence analysisBy similarityAdd BLAST | 22 | |
Topological domaini | 33 – 64 | ExtracellularBy similarityAdd BLAST | 32 | |
Transmembranei | 65 – 85 | Helical; Name=2Sequence analysisBy similarityAdd BLAST | 21 | |
Topological domaini | 86 – 90 | CytoplasmicBy similarity | 5 | |
Transmembranei | 91 – 111 | Helical; Name=3Sequence analysisBy similarityAdd BLAST | 21 | |
Topological domaini | 112 – 118 | ExtracellularBy similarity | 7 | |
Transmembranei | 119 – 142 | Helical; Name=4Sequence analysisBy similarityAdd BLAST | 24 | |
Topological domaini | 143 – 153 | CytoplasmicBy similarityAdd BLAST | 11 | |
Transmembranei | 154 – 174 | Helical; Name=5Sequence analysisBy similarityAdd BLAST | 21 | |
Topological domaini | 175 – 183 | ExtracellularBy similarity | 9 | |
Transmembranei | 184 – 204 | Helical; Name=6Sequence analysisBy similarityAdd BLAST | 21 | |
Topological domaini | 205 – 269 | CytoplasmicBy similarityAdd BLAST | 65 | |
Transmembranei | 270 – 290 | Helical; Name=7Sequence analysisBy similarityAdd BLAST | 21 | |
Topological domaini | 291 – 304 | ExtracellularBy similarityAdd BLAST | 14 | |
Transmembranei | 305 – 325 | Helical; Name=8Sequence analysisBy similarityAdd BLAST | 21 | |
Topological domaini | 326 – 331 | CytoplasmicBy similarity | 6 | |
Transmembranei | 332 – 352 | Helical; Name=9Sequence analysisBy similarityAdd BLAST | 21 | |
Topological domaini | 353 – 363 | ExtracellularBy similarityAdd BLAST | 11 | |
Transmembranei | 364 – 389 | Helical; Name=10Sequence analysisBy similarityAdd BLAST | 26 | |
Topological domaini | 390 – 399 | CytoplasmicBy similarity | 10 | |
Transmembranei | 400 – 420 | Helical; Name=11Sequence analysisBy similarityAdd BLAST | 21 | |
Topological domaini | 421 – 429 | ExtracellularBy similarity | 9 | |
Transmembranei | 430 – 450 | Helical; Name=12Sequence analysisBy similarityAdd BLAST | 21 | |
Topological domaini | 451 – 493 | CytoplasmicBy similarityAdd BLAST | 43 |
Keywords - Cellular componenti
Cell membrane, Cell projection, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050358 | 1 – 493 | Solute carrier family 2, facilitated glucose transporter member 3Add BLAST | 493 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 43 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 232 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 471 | PhosphoserineBy similarity | 1 | |
Modified residuei | 475 | PhosphoserineCombined sources | 1 | |
Modified residuei | 482 | PhosphoserineCombined sources | 1 | |
Modified residuei | 489 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | Q07647 |
PaxDbi | Q07647 |
PRIDEi | Q07647 |
PTM databases
GlyGeni | Q07647, 1 site |
iPTMneti | Q07647 |
PhosphoSitePlusi | Q07647 |
Expressioni
Tissue specificityi
Interactioni
GO - Molecular functioni
- kinase binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 247582, 1 interactor |
IntActi | Q07647, 1 interactor |
STRINGi | 10116.ENSRNOP00000066684 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 277 – 279 | Important for selectivity against fructoseBy similarity | 3 | |
Regioni | 280 – 286 | Monosaccharide bindingBy similarity | 7 |
Domaini
Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.By similarity
Sequence similaritiesi
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0569, Eukaryota |
InParanoidi | Q07647 |
OrthoDBi | 749998at2759 |
PhylomeDBi | Q07647 |
TreeFami | TF313762 |
Family and domain databases
InterProi | View protein in InterPro IPR002945, Glc_transpt_3 IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR01192, GLUCTRSPORT3 PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit PS00217, SUGAR_TRANSPORT_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q07647-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGTAKVTPSL VFAVTVATIG SFQFGYNTGV INAPETIIKD FLNYTLEERL
60 70 80 90 100
EDLPREGLLT TLWSLCVAIF SVGGMIGSFS VGLFVNRFGR RNSMLLVNLI
110 120 130 140 150
AILGGCLMGF AKIAESVEML ILGRLIIGIF CGLCTGFVPM YIGEVSPTAL
160 170 180 190 200
RGAFGTLNQL GIVVGILVAQ VFGLDFILGS EELWPGLLGL TIIPAILQSA
210 220 230 240 250
ALPFCPESPR FLLINRKEED QATEILQRLW GTPDVIQEIQ EMKDESIRMS
260 270 280 290 300
QEKQVTVLEL FKSPSYFQPL LISVVLQLSQ QFSGINAVFY YSTGIFQDAG
310 320 330 340 350
VQEPIYATIG AGVVNTIFTV VSLFLVERAG RRTLHMIGLG GMAVCSVFMT
360 370 380 390 400
ISLLLKDEYE AMSFVCIVAI LVYVAFFEIG PGPIPWFIVA ELFSQGPRPA
410 420 430 440 450
AMAVAGCSNW TSNFLVGMFF PSAAAYLGAY VFIIFAAFLV FFLIFTSFKV
460 470 480 490
PETKGRTFED ITRAFEGQAH SGKGSAGVEL NSMQPVKETP GNA
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JSJ3 | A0A0G2JSJ3_RAT | Solute carrier family 2 (Facilitate... | Slc2a3 LOC100909595, rCG_30128 | 493 | Annotation score: | ||
A0A0G2JVB0 | A0A0G2JVB0_RAT | Solute carrier family 2, facilitate... | Slc2a3 LOC100909595 | 495 | Annotation score: | ||
A0A0G2JX37 | A0A0G2JX37_RAT | Solute carrier family 2, facilitate... | Slc2a3 | 482 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 55 | R → S in AAA62503 (PubMed:7475896).Curated | 1 | |
Sequence conflicti | 447 | S → F in AAA62503 (PubMed:7475896).Curated | 1 | |
Sequence conflicti | 470 | H → Q in AAA62503 (PubMed:7475896).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D13962 mRNA Translation: BAA03065.1 U17978 mRNA Translation: AAA62503.1 |
PIRi | S38981 |
RefSeqi | NP_058798.2, NM_017102.2 XP_003749881.1, XM_003749833.4 XP_017458346.1, XM_017602857.1 |
Genome annotation databases
GeneIDi | 100909595 25551 |
KEGGi | rno:100909595 rno:25551 |
UCSCi | RGD:3706, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D13962 mRNA Translation: BAA03065.1 U17978 mRNA Translation: AAA62503.1 |
PIRi | S38981 |
RefSeqi | NP_058798.2, NM_017102.2 XP_003749881.1, XM_003749833.4 XP_017458346.1, XM_017602857.1 |
3D structure databases
SMRi | Q07647 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 247582, 1 interactor |
IntActi | Q07647, 1 interactor |
STRINGi | 10116.ENSRNOP00000066684 |
Protein family/group databases
TCDBi | 2.A.1.1.12, the major facilitator superfamily (mfs) |
PTM databases
GlyGeni | Q07647, 1 site |
iPTMneti | Q07647 |
PhosphoSitePlusi | Q07647 |
Proteomic databases
jPOSTi | Q07647 |
PaxDbi | Q07647 |
PRIDEi | Q07647 |
Genome annotation databases
GeneIDi | 100909595 25551 |
KEGGi | rno:100909595 rno:25551 |
UCSCi | RGD:3706, rat |
Organism-specific databases
CTDi | 6515 |
RGDi | 3706, Slc2a3 |
Phylogenomic databases
eggNOGi | KOG0569, Eukaryota |
InParanoidi | Q07647 |
OrthoDBi | 749998at2759 |
PhylomeDBi | Q07647 |
TreeFami | TF313762 |
Enzyme and pathway databases
Reactomei | R-RNO-189200, Cellular hexose transport R-RNO-196836, Vitamin C (ascorbate) metabolism R-RNO-6798695, Neutrophil degranulation |
Miscellaneous databases
PROi | PR:Q07647 |
Family and domain databases
InterProi | View protein in InterPro IPR002945, Glc_transpt_3 IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR01192, GLUCTRSPORT3 PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit PS00217, SUGAR_TRANSPORT_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GTR3_RAT | |
Accessioni | Q07647Primary (citable) accession number: Q07647 Secondary accession number(s): Q62729 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | October 1, 1994 | |
Last modified: | April 7, 2021 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families