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Entry version 133 (17 Jun 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Keratin-associated protein 1-1

Gene

KRTAP1-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-6805567 Keratinization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin-associated protein 1-1
Alternative name(s):
High sulfur keratin-associated protein 1.1
Keratin-associated protein 1.1
Keratin-associated protein 1.6
Keratin-associated protein 1.7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRTAP1-1
Synonyms:B2A, KAP1.1, KAP1.6, KAP1.7, KRTAP1.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000188581.8

Human Gene Nomenclature Database

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HGNCi
HGNC:16772 KRTAP1-1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
608819 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q07627

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000188581

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA38412

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q07627 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
KRTAP1-1

Domain mapping of disease mutations (DMDM)

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DMDMi
74722292

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002239011 – 177Keratin-associated protein 1-1Add BLAST177

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q07627

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q07627

PeptideAtlas

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PeptideAtlasi
Q07627

PRoteomics IDEntifications database

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PRIDEi
Q07627

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
58521

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000188581 Expressed in hair follicle and 36 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q07627 HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000188581 Tissue enriched (skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with hair keratins.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q07627
With#Exp.IntAct
ADAM12 - isoform 4 [O43184-4]3EBI-11959885,EBI-12006944
ADAMTSL3 [P82987]3EBI-11959885,EBI-10221726
ADAMTSL4 - isoform 3 [Q6UY14-3]3EBI-11959885,EBI-10173507
AGXT [P21549]3EBI-11959885,EBI-727098
AKR7A3 [O95154]3EBI-11959885,EBI-748869
ALDH3B1 [P43353]3EBI-11959885,EBI-2558314
ALPP [P05187]3EBI-11959885,EBI-1211484
AQP1 [P29972]3EBI-11959885,EBI-745213
ASPSCR1 [Q9BZE9]3EBI-11959885,EBI-1993677
ATG9A - isoform 3 [Q7Z3C6-3]3EBI-11959885,EBI-12006308
BCAM [P50895]3EBI-11959885,EBI-10212133
C10orf62 [Q5T681]3EBI-11959885,EBI-744052
C11orf87 [Q6NUJ2]3EBI-11959885,EBI-6660291
CAMK2B - isoform 2 [Q13554-3]3EBI-11959885,EBI-11523526
CATIP [Q7Z7H3]3EBI-11959885,EBI-10258233
CATSPER1 [Q8NEC5]3EBI-11959885,EBI-744545
CD300LG [Q6UXG3]3EBI-11959885,EBI-10254587
CERK [Q8TCT0]3EBI-11959885,EBI-10274247
CHIC2 [Q9UKJ5]3EBI-11959885,EBI-741528
CHRD [Q9H2X0]3EBI-11959885,EBI-947551
CHRNG - isoform 2 [P07510-2]3EBI-11959885,EBI-11979451
CLDN2 [P57739]3EBI-11959885,EBI-751440
CNNM3 [Q8NE01]3EBI-11959885,EBI-741032
CRY2 [Q49AN0]3EBI-11959885,EBI-2212355
CSF1 [P09603]3EBI-11959885,EBI-2872294
CST2 [P09228]3EBI-11959885,EBI-8832659
CTRC [Q99895]3EBI-11959885,EBI-10295404
CTSZ [Q9UBR2]3EBI-11959885,EBI-8636823
CYHR1 - isoform 3 [Q6ZMK1-3]3EBI-11959885,EBI-11997340
CYSLTR2 [Q9NS75]3EBI-11959885,EBI-3843579
CYSRT1 [A8MQ03]3EBI-11959885,EBI-3867333
DHRS1 [Q96LJ7]3EBI-11959885,EBI-746300
DMRT3 [Q9NQL9]3EBI-11959885,EBI-9679045
DOCK2 [Q92608]3EBI-11959885,EBI-448771
EFNA3 [P52797]3EBI-11959885,EBI-722730
EMC7 [Q9NPA0]3EBI-11959885,EBI-6309137
FAM221A [A4D161]3EBI-11959885,EBI-11960181
FAM71C [Q8NEG0]3EBI-11959885,EBI-752049
FAM76B - isoform 3 [Q5HYJ3-3]3EBI-11959885,EBI-11956087
FAM90A1 [Q86YD7]3EBI-11959885,EBI-6658203
FARS2 [O95363]3EBI-11959885,EBI-2513774
FEZF1 [A0PJY2]3EBI-11959885,EBI-11988727
FKBP1B - isoform 2 [P68106-2]3EBI-11959885,EBI-11998976
FOXD4L3 [Q6VB84]3EBI-11959885,EBI-11961494
FRS3 [O43559]3EBI-11959885,EBI-725515
FZD10 [Q9ULW2]3EBI-11959885,EBI-8803802
GLP1R [P43220]3EBI-11959885,EBI-7466542
GNE - isoform 2 [Q9Y223-2]3EBI-11959885,EBI-11975289
GRN [P28799]3EBI-11959885,EBI-747754
GSTP1 [P09211]3EBI-11959885,EBI-353467
GUCD1 - isoform 2 [Q96NT3-2]3EBI-11959885,EBI-11978177
HCK - isoform 2 [P08631-2]3EBI-11959885,EBI-9834454
HEY2 [Q9UBP5]3EBI-11959885,EBI-750630
HIDE1 [A8MVS5]3EBI-11959885,EBI-12168227
HOXA1 [P49639]3EBI-11959885,EBI-740785
HOXB5 [P09067]3EBI-11959885,EBI-3893317
HOXB9 [P17482]3EBI-11959885,EBI-745290
HOXC8 [P31273]3EBI-11959885,EBI-1752118
HPCAL1 [P37235]3EBI-11959885,EBI-749311
HSBP1 [O75506]3EBI-11959885,EBI-748664
HYAL2 [Q12891]3EBI-11959885,EBI-2806068
IFITM2 [Q6IBB0]3EBI-11959885,EBI-12167419
IGSF8 [Q969P0]3EBI-11959885,EBI-8293590
IL16 - isoform 2 [Q14005-2]4EBI-11959885,EBI-17178971
INS [P01308]3EBI-11959885,EBI-7090529
ITGB4 - isoform Beta-4A [P16144-2]3EBI-11959885,EBI-11051601
ITGB5 [P18084]3EBI-11959885,EBI-1223434
JOSD1 [Q15040]3EBI-11959885,EBI-2510602
KLHL38 [Q2WGJ6]3EBI-11959885,EBI-6426443
KLK8 [O60259]3EBI-11959885,EBI-3915857
KRT20 [P35900]3EBI-11959885,EBI-742094
KRTAP10-11 [P60412]3EBI-11959885,EBI-10217483
KRTAP10-8 [P60410]3EBI-11959885,EBI-10171774
KRTAP10-9 [P60411]3EBI-11959885,EBI-10172052
KRTAP12-1 [P59990]3EBI-11959885,EBI-10210845
KRTAP12-3 [P60328]3EBI-11959885,EBI-11953334
KRTAP13-2 [Q52LG2]3EBI-11959885,EBI-11953846
KRTAP2-4 [Q9BYR9]3EBI-11959885,EBI-14065470
KRTAP26-1 [Q6PEX3]3EBI-11959885,EBI-3957672
KRTAP4-12 [Q9BQ66]3EBI-11959885,EBI-739863
KRTAP4-5 [Q9BYR2]3EBI-11959885,EBI-11993254
KRTAP5-11 [Q6L8G4]3EBI-11959885,EBI-11993296
KRTAP5-4 [Q6L8H1]3EBI-11959885,EBI-11963072
KRTAP5-6 [Q6L8G9]3EBI-11959885,EBI-10250562
KRTAP9-2 [Q9BYQ4]3EBI-11959885,EBI-1044640
KRTAP9-3 [Q9BYQ3]3EBI-11959885,EBI-1043191
KRTAP9-8 [Q9BYQ0]3EBI-11959885,EBI-11958364
LCE1A [Q5T7P2]3EBI-11959885,EBI-11962058
LCE1E [Q5T753]3EBI-11959885,EBI-11955335
LCE1F [Q5T754]3EBI-11959885,EBI-11958008
LCE2B [O14633]3EBI-11959885,EBI-11478468
LCE2C [Q5TA81]3EBI-11959885,EBI-11973993
LCE2D [Q5TA82]3EBI-11959885,EBI-10246750
LCE3B [Q5TA77]3EBI-11959885,EBI-11974495
LCE3C [Q5T5A8]3EBI-11959885,EBI-10245291
LCE3D [Q9BYE3]3EBI-11959885,EBI-6658837
LCE3E [Q5T5B0]3EBI-11959885,EBI-10245456
LCE4A [Q5TA78]3EBI-11959885,EBI-10246358
LCE5A [Q5TCM9]3EBI-11959885,EBI-11955689
LNX1 [Q8TBB1]3EBI-11959885,EBI-739832
LRFN4 [Q6PJG9]3EBI-11959885,EBI-7910762
LRRN4 [Q8WUT4]3EBI-11959885,EBI-745046
MAGOHB [Q96A72]3EBI-11959885,EBI-746778
MAPKBP1 [O60336]3EBI-11959885,EBI-947402
MELTF - isoform 2 [P08582-2]3EBI-11959885,EBI-10195914
MRGBP [Q9NV56]3EBI-11959885,EBI-399076
MRPL23 [Q16540]3EBI-11959885,EBI-1046141
MT1B [P07438]3EBI-11959885,EBI-12015462
MXD3 [Q9BW11]3EBI-11959885,EBI-741574
MXI1 - isoform 3 [P50539-3]3EBI-11959885,EBI-10211940
MYOM1 - isoform 2 [P52179-2]3EBI-11959885,EBI-12010196
NECTIN2 - isoform Alpha [Q92692-2]3EBI-11959885,EBI-6979889
NECTIN3 - isoform 2 [Q9NQS3-2]3EBI-11959885,EBI-12106440
NMU [P48645]3EBI-11959885,EBI-10210351
NPDC1 [Q9NQX5]3EBI-11959885,EBI-748927
NR1D2 [Q6NSM0]3EBI-11959885,EBI-10250949
NTM - isoform 3 [Q9P121-3]3EBI-11959885,EBI-12027160
NUBP2 [Q9Y5Y2]3EBI-11959885,EBI-1048886
OLIG3 [Q7RTU3]3EBI-11959885,EBI-10225049
OR14I1 [A6ND48]3EBI-11959885,EBI-13413682
OTX1 [P32242]3EBI-11959885,EBI-740446
P2RX4 [Q99571]3EBI-11959885,EBI-2828248
P2RY6 [Q15077]3EBI-11959885,EBI-10235794
PCSK5 - isoform PC6A [Q92824-2]3EBI-11959885,EBI-11956269
PDE9A - isoform PDE9A2 [O76083-2]3EBI-11959885,EBI-11524542
PHLDA1 [A2BDE7]3EBI-11959885,EBI-14084211
PRKAB2 [O43741]3EBI-11959885,EBI-1053424
PRKAG1 [P54619]3EBI-11959885,EBI-1181439
PRPF31 [Q8WWY3]3EBI-11959885,EBI-1567797
PSMA1 [P25786]3EBI-11959885,EBI-359352
PVR [P15151]3EBI-11959885,EBI-3919694
QPRT [Q15274]3EBI-11959885,EBI-739851
R3HDM2 [Q9Y2K5]3EBI-11959885,EBI-948428
REM2 [Q8IYK8]3EBI-11959885,EBI-11304833
RPS19BP1 [Q86WX3]3EBI-11959885,EBI-4479407
RPS28 [P62857]3EBI-11959885,EBI-353027
RPUSD3 [Q6P087]3EBI-11959885,EBI-5458784
RTN4RL1 [Q86UN2]3EBI-11959885,EBI-10258951
SCARF1 [Q14162]3EBI-11959885,EBI-12056025
SCNM1 [Q9BWG6]3EBI-11959885,EBI-748391
SDC3 [A0A0S2Z4U3]3EBI-11959885,EBI-10204280
SEMA3B - isoform 2 [Q13214-2]3EBI-11959885,EBI-11017428
SHFL - isoform 4 [Q9NUL5-4]3EBI-11959885,EBI-11955083
SLC23A1 - isoform 3 [Q9UHI7-3]3EBI-11959885,EBI-11998660
SLC43A2 [Q8N370]3EBI-11959885,EBI-10265149
SLC6A20 [Q9NP91]3EBI-11959885,EBI-10311198
SLC7A11 [Q9UPY5]3EBI-11959885,EBI-3843348
SLIT1 [O75093]3EBI-11959885,EBI-947791
SMARCE1 [Q969G3]3EBI-11959885,EBI-455078
SMCP [P49901]3EBI-11959885,EBI-750494
SMOC1 - isoform 2 [Q9H4F8-2]3EBI-11959885,EBI-12162539
SNAI1 [O95863]3EBI-11959885,EBI-1045459
SNX18 [Q96RF0]3EBI-11959885,EBI-298169
SPACA9 [Q96E40]3EBI-11959885,EBI-722584
SPRY1 [O43609]3EBI-11959885,EBI-3866665
STK16 [O75716]3EBI-11959885,EBI-749295
TCEANC - isoform 2 [Q8N8B7-2]3EBI-11959885,EBI-11955057
TFAP2D [Q7Z6R9]3EBI-11959885,EBI-11952651
TGFB1 [P01137]3EBI-11959885,EBI-779636
TMEM8A [Q9HCN3]3EBI-11959885,EBI-10310808
TNP2 [Q05952]3EBI-11959885,EBI-12039775
TSFM [P43897]3EBI-11959885,EBI-1049298
VASN [Q6EMK4]3EBI-11959885,EBI-10249550
VGLL3 - isoform 2 [A8MV65-2]3EBI-11959885,EBI-11957216
VSTM4 [Q8IW00]3EBI-11959885,EBI-4311759
WNT11 [O96014]3EBI-11959885,EBI-8058160
ZBTB48 [P10074]3EBI-11959885,EBI-744864
ZBTB9 [Q96C00]3EBI-11959885,EBI-395708
ZDHHC1 [Q8WTX9]3EBI-11959885,EBI-2818796
ZNF124 [Q15973]3EBI-11959885,EBI-2555767
ZNF330 [Q9Y3S2]3EBI-11959885,EBI-373456
ZNF408 [Q9H9D4]3EBI-11959885,EBI-347633
ZNF439 [Q8NDP4]3EBI-11959885,EBI-747580
ZNF440 [Q8IYI8]3EBI-11959885,EBI-726439
ZNF446 - isoform 2 [Q9NWS9-2]3EBI-11959885,EBI-740232
ZNF491 [Q8N8L2]3EBI-11959885,EBI-12019860
ZNF497 [Q6ZNH5]3EBI-11959885,EBI-10486136
ZNF524 [Q96C55]3EBI-11959885,EBI-10283126
ZNF581 [Q9P0T4]3EBI-11959885,EBI-745520
ZNF587 [Q96SQ5]3EBI-11959885,EBI-6427977
ZNF648 [Q5T619]3EBI-11959885,EBI-11985915
ZNF669 [Q96BR6]3EBI-11959885,EBI-12006574
ZNF696 [Q9H7X3]3EBI-11959885,EBI-11090299
ZNF786 [Q8N393]3EBI-11959885,EBI-10265203
ZNF837 [Q96EG3]3EBI-11959885,EBI-11962574

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q07627, 185 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000305975

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q07627 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the KRTAP type 1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4726 Eukaryota
ENOG410XY8D LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160443

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_109417_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q07627

Identification of Orthologs from Complete Genome Data

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OMAi
ACCCEPT

Database for complete collections of gene phylogenies

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PhylomeDBi
Q07627

TreeFam database of animal gene trees

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TreeFami
TF351356

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002494 KAP

The PANTHER Classification System

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PANTHERi
PTHR23262 PTHR23262, 3 hits

Pfam protein domain database

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Pfami
View protein in Pfam
PF01500 Keratin_B2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q07627-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MACCQTSFCG FPSCSTSGTC GSSCCQPSCC ETSSCQPRCC ETSCCQPSCC
60 70 80 90 100
QTSFCGFPSF STGGTCDSSC CQPSCCETSC CQPSCYQTSS CGTGCGIGGG
110 120 130 140 150
IGYGQEGSSG AVSTRIRWCR PDCRVEGTCL PPCCVVSCTP PSCCQLHHAE
160 170
ASCCRPSYCG QSCCRPVCCC YCSEPTC
Length:177
Mass (Da):18,235
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8CD3613D3DFC3C79
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02534812 – 58PSCST…FCGFP → R in allele KAP1.6. Add BLAST47
Natural variantiVAR_02535319 – 110Missing in allele KAP1.7. 1 PublicationAdd BLAST92

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X63337 Genomic DNA Translation: CAA44937.1
AJ406926 mRNA Translation: CAC27565.1
AB052934 mRNA Translation: BAB61026.1
AB052868 mRNA Translation: BAB61024.1
AB055057 mRNA Translation: BAB61031.1
AC007455 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60699.1
BC105069 mRNA Translation: AAI05070.1
BC105071 mRNA Translation: AAI05072.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS42324.1

Protein sequence database of the Protein Information Resource

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PIRi
S37650

NCBI Reference Sequences

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RefSeqi
NP_112229.1, NM_030967.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000306271; ENSP00000305975; ENSG00000188581
ENST00000573871; ENSP00000460787; ENSG00000262808

Database of genes from NCBI RefSeq genomes

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GeneIDi
81851

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:81851

UCSC genome browser

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UCSCi
uc032fzn.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63337 Genomic DNA Translation: CAA44937.1
AJ406926 mRNA Translation: CAC27565.1
AB052934 mRNA Translation: BAB61026.1
AB052868 mRNA Translation: BAB61024.1
AB055057 mRNA Translation: BAB61031.1
AC007455 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60699.1
BC105069 mRNA Translation: AAI05070.1
BC105071 mRNA Translation: AAI05072.1
CCDSiCCDS42324.1
PIRiS37650
RefSeqiNP_112229.1, NM_030967.2

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ07627, 185 interactors
STRINGi9606.ENSP00000305975

Polymorphism and mutation databases

BioMutaiKRTAP1-1
DMDMi74722292

Proteomic databases

MassIVEiQ07627
PaxDbiQ07627
PeptideAtlasiQ07627
PRIDEiQ07627
ProteomicsDBi58521

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
55337 48 antibodies

Genome annotation databases

EnsembliENST00000306271; ENSP00000305975; ENSG00000188581
ENST00000573871; ENSP00000460787; ENSG00000262808
GeneIDi81851
KEGGihsa:81851
UCSCiuc032fzn.1 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
81851
EuPathDBiHostDB:ENSG00000188581.8

GeneCards: human genes, protein and diseases

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GeneCardsi
KRTAP1-1
HGNCiHGNC:16772 KRTAP1-1
HPAiENSG00000188581 Tissue enriched (skin)
MIMi608819 gene
neXtProtiNX_Q07627
OpenTargetsiENSG00000188581
PharmGKBiPA38412

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4726 Eukaryota
ENOG410XY8D LUCA
GeneTreeiENSGT00940000160443
HOGENOMiCLU_109417_0_0_1
InParanoidiQ07627
OMAiACCCEPT
PhylomeDBiQ07627
TreeFamiTF351356

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
81851 1 hit in 773 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
81851
PharosiQ07627 Tdark

Protein Ontology

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PROi
PR:Q07627
RNActiQ07627 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000188581 Expressed in hair follicle and 36 other tissues
GenevisibleiQ07627 HS

Family and domain databases

InterProiView protein in InterPro
IPR002494 KAP
PANTHERiPTHR23262 PTHR23262, 3 hits
PfamiView protein in Pfam
PF01500 Keratin_B2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKRA11_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q07627
Secondary accession number(s): A6NC32, Q96S60, Q96S67
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: November 1, 1996
Last modified: June 17, 2020
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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