We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback.
Take me to UniProt BETA
UniProtKB - Q07627 (KRA11_HUMAN)
Protein
Keratin-associated protein 1-1
Gene
KRTAP1-1
Organism
Homo sapiens (Human)
Status
Functioni
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Enzyme and pathway databases
PathwayCommonsi | Q07627 |
Reactomei | R-HSA-6805567, Keratinization |
SignaLinki | Q07627 |
Names & Taxonomyi
Protein namesi | Recommended name: Keratin-associated protein 1-1Alternative name(s): High sulfur keratin-associated protein 1.1 Keratin-associated protein 1.1 Keratin-associated protein 1.6 Keratin-associated protein 1.7 |
Gene namesi | Name:KRTAP1-1 Synonyms:B2A, KAP1.1, KAP1.6, KAP1.7, KRTAP1.1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16772, KRTAP1-1 |
MIMi | 608819, gene |
neXtProti | NX_Q07627 |
VEuPathDBi | HostDB:ENSG00000188581 |
Subcellular locationi
Cytoskeleton
- keratin filament Source: InterPro
Cytosol
- cytosol Source: Reactome
Keywords - Cellular componenti
KeratinPathology & Biotechi
Organism-specific databases
DisGeNETi | 81851 |
OpenTargetsi | ENSG00000188581 |
PharmGKBi | PA38412 |
Miscellaneous databases
Pharosi | Q07627, Tdark |
Genetic variation databases
BioMutai | KRTAP1-1 |
DMDMi | 74722292 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000223901 | 1 – 177 | Keratin-associated protein 1-1Add BLAST | 177 |
Proteomic databases
MassIVEi | Q07627 |
PaxDbi | Q07627 |
PeptideAtlasi | Q07627 |
PRIDEi | Q07627 |
ProteomicsDBi | 58521 |
Expressioni
Tissue specificityi
Expressed in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone.1 Publication
Gene expression databases
Bgeei | ENSG00000188581, Expressed in hair follicle and 66 other tissues |
Genevisiblei | Q07627, HS |
Organism-specific databases
HPAi | ENSG00000188581, Tissue enriched (skin) |
Interactioni
Subunit structurei
Interacts with hair keratins.
By similarityBinary interactionsi
Q07627
Protein-protein interaction databases
BioGRIDi | 123602, 189 interactors |
IntActi | Q07627, 185 interactors |
STRINGi | 9606.ENSP00000305975 |
Miscellaneous databases
RNActi | Q07627, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q07627 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Sequence similaritiesi
Belongs to the KRTAP type 1 family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG4726, Eukaryota |
GeneTreei | ENSGT00940000160443 |
HOGENOMi | CLU_109417_0_0_1 |
InParanoidi | Q07627 |
OMAi | MACCSTN |
PhylomeDBi | Q07627 |
TreeFami | TF351356 |
Family and domain databases
InterProi | View protein in InterPro IPR002494, KAP |
PANTHERi | PTHR23262, PTHR23262, 3 hits |
Pfami | View protein in Pfam PF01500, Keratin_B2, 2 hits |
i Sequence
Sequence statusi: Complete.
Q07627-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MACCQTSFCG FPSCSTSGTC GSSCCQPSCC ETSSCQPRCC ETSCCQPSCC
60 70 80 90 100
QTSFCGFPSF STGGTCDSSC CQPSCCETSC CQPSCYQTSS CGTGCGIGGG
110 120 130 140 150
IGYGQEGSSG AVSTRIRWCR PDCRVEGTCL PPCCVVSCTP PSCCQLHHAE
160 170
ASCCRPSYCG QSCCRPVCCC YCSEPTC
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_025348 | 12 – 58 | PSCST…FCGFP → R in allele KAP1.6. Add BLAST | 47 | |
Natural variantiVAR_025353 | 19 – 110 | Missing in allele KAP1.7. 1 PublicationAdd BLAST | 92 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X63337 Genomic DNA Translation: CAA44937.1 AJ406926 mRNA Translation: CAC27565.1 AB052934 mRNA Translation: BAB61026.1 AB052868 mRNA Translation: BAB61024.1 AB055057 mRNA Translation: BAB61031.1 AC007455 Genomic DNA No translation available. CH471152 Genomic DNA Translation: EAW60699.1 BC105069 mRNA Translation: AAI05070.1 BC105071 mRNA Translation: AAI05072.1 |
CCDSi | CCDS42324.1 |
PIRi | S37650 |
RefSeqi | NP_112229.1, NM_030967.2 |
Genome annotation databases
Ensembli | ENST00000306271.5; ENSP00000305975.4; ENSG00000188581.9 ENST00000573871.1; ENSP00000460787.1; ENSG00000262808.2 |
GeneIDi | 81851 |
KEGGi | hsa:81851 |
MANE-Selecti | ENST00000306271.5; ENSP00000305975.4; NM_030967.3; NP_112229.1 |
UCSCi | uc032fzn.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X63337 Genomic DNA Translation: CAA44937.1 AJ406926 mRNA Translation: CAC27565.1 AB052934 mRNA Translation: BAB61026.1 AB052868 mRNA Translation: BAB61024.1 AB055057 mRNA Translation: BAB61031.1 AC007455 Genomic DNA No translation available. CH471152 Genomic DNA Translation: EAW60699.1 BC105069 mRNA Translation: AAI05070.1 BC105071 mRNA Translation: AAI05072.1 |
CCDSi | CCDS42324.1 |
PIRi | S37650 |
RefSeqi | NP_112229.1, NM_030967.2 |
3D structure databases
AlphaFoldDBi | Q07627 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 123602, 189 interactors |
IntActi | Q07627, 185 interactors |
STRINGi | 9606.ENSP00000305975 |
Genetic variation databases
BioMutai | KRTAP1-1 |
DMDMi | 74722292 |
Proteomic databases
MassIVEi | Q07627 |
PaxDbi | Q07627 |
PeptideAtlasi | Q07627 |
PRIDEi | Q07627 |
ProteomicsDBi | 58521 |
Protocols and materials databases
Antibodypediai | 55337, 48 antibodies from 8 providers |
DNASUi | 81851 |
Genome annotation databases
Ensembli | ENST00000306271.5; ENSP00000305975.4; ENSG00000188581.9 ENST00000573871.1; ENSP00000460787.1; ENSG00000262808.2 |
GeneIDi | 81851 |
KEGGi | hsa:81851 |
MANE-Selecti | ENST00000306271.5; ENSP00000305975.4; NM_030967.3; NP_112229.1 |
UCSCi | uc032fzn.1, human |
Organism-specific databases
CTDi | 81851 |
DisGeNETi | 81851 |
GeneCardsi | KRTAP1-1 |
HGNCi | HGNC:16772, KRTAP1-1 |
HPAi | ENSG00000188581, Tissue enriched (skin) |
MIMi | 608819, gene |
neXtProti | NX_Q07627 |
OpenTargetsi | ENSG00000188581 |
PharmGKBi | PA38412 |
VEuPathDBi | HostDB:ENSG00000188581 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4726, Eukaryota |
GeneTreei | ENSGT00940000160443 |
HOGENOMi | CLU_109417_0_0_1 |
InParanoidi | Q07627 |
OMAi | MACCSTN |
PhylomeDBi | Q07627 |
TreeFami | TF351356 |
Enzyme and pathway databases
PathwayCommonsi | Q07627 |
Reactomei | R-HSA-6805567, Keratinization |
SignaLinki | Q07627 |
Miscellaneous databases
BioGRID-ORCSi | 81851, 10 hits in 994 CRISPR screens |
GenomeRNAii | 81851 |
Pharosi | Q07627, Tdark |
PROi | PR:Q07627 |
RNActi | Q07627, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000188581, Expressed in hair follicle and 66 other tissues |
Genevisiblei | Q07627, HS |
Family and domain databases
InterProi | View protein in InterPro IPR002494, KAP |
PANTHERi | PTHR23262, PTHR23262, 3 hits |
Pfami | View protein in Pfam PF01500, Keratin_B2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | KRA11_HUMAN | |
Accessioni | Q07627Primary (citable) accession number: Q07627 Secondary accession number(s): A6NC32, Q96S60, Q96S67 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2006 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families