Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q07617 (SPAG1_HUMAN)

Entry version 182 (10 Feb 2021)
Sequence version 3 (10 Feb 2009)
Previous versions | rss
Add a publicationFeedback
Protein

Sperm-associated antigen 1

Gene

SPAG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity). May play a role in fertilization. Binds GTP and has GTPase activity.By similarity2 Publications

Miscellaneous

Antibodies against SPAG1 interfere with fertilization.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi781 – 788GTPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

  • axonemal dynein complex assembly Source: UniProtKB
  • single fertilization Source: ProtInc
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processFertilization
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q07617

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q07617

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sperm-associated antigen 1
Alternative name(s):
HSD-3.8
Infertility-related sperm protein Spag-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPAG1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11212, SPAG1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603395, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q07617

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000104450.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ciliary dyskinesia, primary, 28 (CILD28)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. Patients may exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
Related information in OMIM

Keywords - Diseasei

Ciliopathy, Kartagener syndrome, Primary ciliary dyskinesia

Organism-specific databases

DisGeNET

More...DisGeNETi		6674

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		SPAG1

MalaCards human disease database

More...MalaCardsi		SPAG1
MIMi615505, phenotype

Open Targets

More...OpenTargetsi		ENSG00000104450

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		244, Primary ciliary dyskinesia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36049

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q07617, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SPAG1

Domain mapping of disease mutations (DMDM)

More...DMDMi		223634718

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001063241 – 926Sperm-associated antigen 1Add BLAST926

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei347PhosphoserineCombined sources1
Modified residuei354PhosphoserineBy similarity1
Modified residuei423PhosphoserineCombined sources1
Modified residuei791PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q07617

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q07617

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q07617

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q07617

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q07617

PeptideAtlas

More...PeptideAtlasi		Q07617

PRoteomics IDEntifications database

More...PRIDEi		Q07617

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		33786
58520 [Q07617-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q07617

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q07617

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present in most tissues, including lung, with the strongest expression in brain, colon, kidney, and testis. In sperm and testis, detected in particular in pachytene primary spermatocytes. Up-regulated in pancreatic tumor tissues and not in normal pancreatic tissue.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000104450, Expressed in bronchial epithelial cell and 200 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q07617, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000104450, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112556, 27 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-6150, R2SP co-chaperone complex
CPX-6152, R2SD co-chaperone complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q07617

Protein interaction database and analysis system

More...IntActi		Q07617, 9 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000373450

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q07617, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1926
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q07617

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati209 – 242TPR 1Add BLAST34
Repeati244 – 275TPR 2Add BLAST32
Repeati276 – 309TPR 3Add BLAST34
Repeati445 – 478TPR 4Add BLAST34
Repeati487 – 520TPR 5Add BLAST34
Repeati522 – 554TPR 6Add BLAST33
Repeati623 – 656TPR 7Add BLAST34
Repeati657 – 690TPR 8Add BLAST34
Repeati692 – 724TPR 9Add BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi422 – 428Poly-Ala7

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1124, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154697

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_044641_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q07617

Identification of Orthologs from Complete Genome Data

More...OMAi		QYRKAYV

Database of Orthologous Groups

More...OrthoDBi		1070087at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q07617

TreeFam database of animal gene trees

More...TreeFami		TF106251

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR025986, RPAP3-like_C
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR001440, TPR_1
IPR019734, TPR_repeat

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13877, RPAP3_C, 1 hit
PF00515, TPR_1, 1 hit
PF13181, TPR_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00028, TPR, 9 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48452, SSF48452, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50005, TPR, 8 hits
PS50293, TPR_REGION, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q07617-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTTKDYPSLW GFGTTKTFKI PIEHLDFKYI EKCSDVKHLE KILCVLRSGE 
        60         70         80         90        100
EGYYPELTEF CEKHLQALAP ESRALRKDKP AATAASFTAE EWEKIDGDIK 
       110        120        130        140        150
SWVSEIKKEE DKMHFHETET FPAMKDNLPP VRGSNSCLHV GKEKYSKRPT 
       160        170        180        190        200
KKKTPRDYAE WDKFDVEKEC LKIDEDYKEK TVIDKSHLSK IETRIDTAGL 
       210        220        230        240        250
TEKEKDFLAT REKEKGNEAF NSGDYEEAVM YYTRSISALP TVVAYNNRAQ 
       260        270        280        290        300
AEIKLQNWNS AFQDCEKVLE LEPGNVKALL RRATTYKHQN KLREATEDLS 
       310        320        330        340        350
KVLDVEPDND LAKKTLSEVE RDLKNSEAAS ETQTKGKRMV IQEIENSEDE 
       360        370        380        390        400
EGKSGRKHED GGGDKKPAEP AGAARAAQPC VMGNIQKKLT GKAEGGKRPA 
       410        420        430        440        450
RGAPQRGQTP EAGADKRSPR RASAAAAAGG GATGHPGGGQ GAENPAGLKS 
       460        470        480        490        500
QGNELFRSGQ FAEAAGKYSA AIALLEPAGS EIADDLSILY SNRAACYLKE 
       510        520        530        540        550
GNCSGCIQDC NRALELHPFS MKPLLRRAMA YETLEQYGKA YVDYKTVLQI 
       560        570        580        590        600
DCGLQLANDS VNRLSRILME LDGPNWREKL SPIPAVPASV PLQAWHPAKE 
       610        620        630        640        650
MISKQAGDSS SHRQQGITDE KTFKALKEEG NQCVNDKNYK DALSKYSECL 
       660        670        680        690        700
KINNKECAIY TNRALCYLKL CQFEEAKQDC DQALQLADGN VKAFYRRALA 
       710        720        730        740        750
HKGLKNYQKS LIDLNKVILL DPSIIEAKME LEEVTRLLNL KDKTAPFNKE 
       760        770        780        790        800
KERRKIEIQE VNEGKEEPGR PAGEVSMGCL ASEKGGKSSR SPEDPEKLPI 
       810        820        830        840        850
AKPNNAYEFG QIINALSTRK DKEACAHLLA ITAPKDLPMF LSNKLEGDTF 
       860        870        880        890        900
LLLIQSLKNN LIEKDPSLVY QHLLYLSKAE RFKMMLTLIS KGQKELIEQL 
       910        920 
FEDLSDTPNN HFTLEDIQAL KRQYEL
Length:926
Mass (Da):103,639
Last modified:February 10, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i947E460842AD9615
GO
Isoform 2 (identifier: Q07617-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     366-416: KPAEPAGAAR...GQTPEAGADK → SKIFFLFRLC...FTSQFRSSFS
     417-926: Missing.

Show »
Length:416
Mass (Da):48,031
Checksum:i369ECA250ED387EE
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH55091 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti187H → R in AAG23967 (PubMed:11517287).Curated1
Sequence conflicti195I → V in BAG51920 (PubMed:14702039).Curated1
Sequence conflicti655K → T in AAG23967 (PubMed:11517287).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054324331E → K. Corresponds to variant dbSNP:rs17335870EnsemblClinVar.1
Natural variantiVAR_054325777M → T1 PublicationCorresponds to variant dbSNP:rs6511EnsemblClinVar.1
Natural variantiVAR_054326827H → Y. Corresponds to variant dbSNP:rs6510EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054290366 – 416KPAEP…AGADK → SKIFFLFRLCKKLPFNMMSW LNFSIRTEIRNLSVFLALPC KFTSQFRSSFS in isoform 2. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_054291417 – 926Missing in isoform 2. 1 PublicationAdd BLAST510

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF311312 mRNA Translation: AAG23967.1
AK057482 mRNA Translation: BAG51920.1
AC025647 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW91800.1
BC055091 mRNA Translation: AAH55091.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34930.1 [Q07617-1]

NCBI Reference Sequences

More...RefSeqi		NP_003105.2, NM_003114.4 [Q07617-1]
NP_757367.1, NM_172218.2 [Q07617-1]
XP_011515544.1, XM_011517242.2
XP_011515545.1, XM_011517243.2 [Q07617-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000251809; ENSP00000251809; ENSG00000104450 [Q07617-1]
ENST00000388798; ENSP00000373450; ENSG00000104450 [Q07617-1]
ENST00000520508; ENSP00000428070; ENSG00000104450 [Q07617-2]
ENST00000520643; ENSP00000427716; ENSG00000104450 [Q07617-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6674

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6674

UCSC genome browser

More...UCSCi		uc003yjg.2, human [Q07617-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311312 mRNA Translation: AAG23967.1
AK057482 mRNA Translation: BAG51920.1
AC025647 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW91800.1
BC055091 mRNA Translation: AAH55091.1 Sequence problems.
CCDSiCCDS34930.1 [Q07617-1]
RefSeqiNP_003105.2, NM_003114.4 [Q07617-1]
NP_757367.1, NM_172218.2 [Q07617-1]
XP_011515544.1, XM_011517242.2
XP_011515545.1, XM_011517243.2 [Q07617-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6I57NMR-A622-742[»]
SMRiQ07617
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112556, 27 interactors
ComplexPortaliCPX-6150, R2SP co-chaperone complex
CPX-6152, R2SD co-chaperone complex
CORUMiQ07617
IntActiQ07617, 9 interactors
STRINGi9606.ENSP00000373450

PTM databases

iPTMnetiQ07617
PhosphoSitePlusiQ07617

Genetic variation databases

BioMutaiSPAG1
DMDMi223634718

Proteomic databases

EPDiQ07617
jPOSTiQ07617
MassIVEiQ07617
MaxQBiQ07617
PaxDbiQ07617
PeptideAtlasiQ07617
PRIDEiQ07617
ProteomicsDBi33786
58520 [Q07617-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26172, 165 antibodies

The DNASU plasmid repository

More...DNASUi		6674

Genome annotation databases

EnsembliENST00000251809; ENSP00000251809; ENSG00000104450 [Q07617-1]
ENST00000388798; ENSP00000373450; ENSG00000104450 [Q07617-1]
ENST00000520508; ENSP00000428070; ENSG00000104450 [Q07617-2]
ENST00000520643; ENSP00000427716; ENSG00000104450 [Q07617-2]
GeneIDi6674
KEGGihsa:6674
UCSCiuc003yjg.2, human [Q07617-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6674
DisGeNETi6674

GeneCards: human genes, protein and diseases

More...GeneCardsi		SPAG1
GeneReviewsiSPAG1
HGNCiHGNC:11212, SPAG1
HPAiENSG00000104450, Low tissue specificity
MalaCardsiSPAG1
MIMi603395, gene
615505, phenotype
neXtProtiNX_Q07617
OpenTargetsiENSG00000104450
Orphaneti244, Primary ciliary dyskinesia
PharmGKBiPA36049
VEuPathDBiHostDB:ENSG00000104450.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1124, Eukaryota
GeneTreeiENSGT00940000154697
HOGENOMiCLU_044641_0_0_1
InParanoidiQ07617
OMAiQYRKAYV
OrthoDBi1070087at2759
PhylomeDBiQ07617
TreeFamiTF106251

Enzyme and pathway databases

PathwayCommonsiQ07617
SIGNORiQ07617

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6674, 5 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SPAG1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SPAG1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6674
PharosiQ07617, Tbio

Protein Ontology

More...PROi		PR:Q07617
RNActiQ07617, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000104450, Expressed in bronchial epithelial cell and 200 other tissues
GenevisibleiQ07617, HS

Family and domain databases

Gene3Di1.25.40.10, 3 hits
InterProiView protein in InterPro
IPR025986, RPAP3-like_C
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR001440, TPR_1
IPR019734, TPR_repeat
PfamiView protein in Pfam
PF13877, RPAP3_C, 1 hit
PF00515, TPR_1, 1 hit
PF13181, TPR_8, 1 hit
SMARTiView protein in SMART
SM00028, TPR, 9 hits
SUPFAMiSSF48452, SSF48452, 3 hits
PROSITEiView protein in PROSITE
PS50005, TPR, 8 hits
PS50293, TPR_REGION, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPAG1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q07617
Secondary accession number(s): A6NP70
, B3KQ58, G3XAM3, Q7Z5G1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 10, 2009
Last modified: February 10, 2021
This is version 182 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human entries with genetic variants
    List of human entries with genetic variants
  2. Human variants curated from literature reports
    Index of human variants curated from literature reports
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again