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Entry version 104 (26 Feb 2020)
Sequence version 1 (01 Nov 1995)
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Protein

Inositol phosphate phosphatase IpgD

Gene

ipgD

Organism
Shigella flexneri
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Converts phosphatidylinositol 4,5-bisphosphate (PtdIns 4,5-P2) to PtdIns 5-P. IpgD is injected by Shigella into the host cell and is required for invasion. The accumulation of PtdIns 5-P causes membrane ruffling and actin cytoskeleton rearrangements at the entry site. Acts in concert with IpaA to coordinate and control the membrane and cytoskeletal rearrangements induced early after invasion of the host cell.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei439Sequence analysis1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processVirulence

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:MONOMER-14263

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.3.78 5712

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inositol phosphate phosphatase IpgD (EC:3.1.3.78)
Alternative name(s):
Effector protein IpgD
Phosphatidylinositol 4,5-bisphosphate 4-phosphatase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ipgD
Ordered Locus Names:CP0133
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniPlasmid pWR1003 Publications
Plasmid pCP3011 Publication
Plasmid pINV_F6_M13821 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiShigella flexneri
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri623 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001006 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Plasmid pCP301

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi439C → S: Loss of activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002204871 – 538Inositol phosphate phosphatase IpgDAdd BLAST538

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q07566

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By growth at 37 degrees Celsius.1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q07566

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi439 – 445CX5R motif7

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains the consensus sequence Cys-X(5)-Arg characteristic of Mg-independent phosphatases.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the phosphatase IpgD/SopB family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4108N4M Bacteria
ENOG410Y7WM LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_025781_1_0_6

KEGG Orthology (KO)

More...
KOi
K13085

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008108 IpgD/SopB

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05925 IpgD, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01734 TYPE3OMBPROT

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q07566-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHITNLGLHQ VSFQSGDSYK GAEETGKHKG VSVISYQRVK NGERNKGIEA
60 70 80 90 100
LNRLYLQNQT SLTGKSLLFA RDKAEVFCEA IKLAGGDTSK IKAMMERLDT
110 120 130 140 150
YKLGEVNKRH INELNKVISE EIRAQLGIKN KKELQTKIKQ IFTDYLNNKN
160 170 180 190 200
WGPVNKNISH HGKNYSFQLT PASHMKIGNK NIFVKEYNGK GICCASTRER
210 220 230 240 250
DHIANMWLSK VVDDEGKEIF SGIRHGVISA YGLKKNSSER AVAARNKAEE
260 270 280 290 300
LVSAALYSRP ELLSQALSGK TVDLKIVSTS LLTPTSLTGG EESMLKDQVS
310 320 330 340 350
ALKGLNSKRG GPTKLLIRNS DGLLKEVSVN LKVVTFNFGV NELALKMGLG
360 370 380 390 400
WRNVDKLNDE SICSLLGDNF LKNGVIGGWA AEAIEKNPPC KNDVIYLANQ
410 420 430 440 450
IKEIVNNKLQ KNDNGEPYKL SQRVTLLAYT IGAVPCWNCK SGKDRTGMQD
460 470 480 490 500
AEIKREIIRK HETGQFSQLN SKLSSEEKRL FSTILMNSGN MEIQEMNTGV
510 520 530
PGNKVMKKLP LSSLELSYSE RIGDPKIWNM VKGYSSFV
Length:538
Mass (Da):59,833
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i304D27839C64CF96
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti27 – 28KH → NQ in plasmid pINV_F6_M1382. 2
Natural varianti48I → V in plasmid pINV_F6_M1382. 1
Natural varianti66S → G in plasmid pINV_F6_M1382. 1
Natural varianti73 – 78KAEVFC → RAAVFY in plasmid pINV_F6_M1382. 6
Natural varianti73K → R in plasmid pCP301. 1
Natural varianti97R → Q in plasmid pINV_F6_M1382. 1
Natural varianti107N → D in plasmid pINV_F6_M1382. 1
Natural varianti110H → N in plasmid pINV_F6_M1382. 1
Natural varianti136 – 137TK → SE in plasmid pINV_F6_M1382. 2
Natural varianti144D → N in plasmid pINV_F6_M1382. 1
Natural varianti152 – 154GPV → EPI in plasmid pINV_F6_M1382. 3
Natural varianti155N → D in plasmid pCP301. 1
Natural varianti159 – 161SHH → NYN in plasmid pINV_F6_M1382. 3
Natural varianti166S → G in plasmid pCP301 and plasmid pINV_F6_M1382. 1
Natural varianti200 – 201RD → SK in plasmid pINV_F6_M1382. 2
Natural varianti200R → S in plasmid pCP301. 1
Natural varianti252V → A in plasmid pINV_F6_M1382. 1
Natural varianti260P → Q in plasmid pINV_F6_M1382. 1
Natural varianti300S → K in plasmid pINV_F6_M1382. 1
Natural varianti300S → N in plasmid pCP301. 1
Natural varianti304G → E in plasmid pINV_F6_M1382. 1
Natural varianti311G → E in plasmid pCP301 and plasmid pINV_F6_M1382. 1
Natural varianti325K → Q in plasmid pINV_F6_M1382. 1
Natural varianti328S → K in plasmid pINV_F6_M1382. 1
Natural varianti359D → G in plasmid pINV_F6_M1382. 1
Natural varianti405 – 407VNN → LNK in plasmid pINV_F6_M1382. 3
Natural varianti406 – 407NN → TK in plasmid pCP301. 2
Natural varianti424 – 425VT → MA in plasmid pINV_F6_M1382. 2
Natural varianti424V → M in plasmid pCP301. 1
Natural varianti519S → A in plasmid pINV_F6_M1382. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L04309 Genomic DNA Translation: AAA26517.1
AL391753 Genomic DNA Translation: CAC05808.1
AF348706 Genomic DNA Translation: AAK18452.1
AF386526 Genomic DNA Translation: AAL72339.1
AY206439 Genomic DNA Translation: AAP78996.1

NCBI Reference Sequences

More...
RefSeqi
NP_085296.1, NC_002698.1
NP_858266.1, NC_004851.1
WP_010921667.1, NZ_QWST01000007.1
YP_009062490.1, NC_024996.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAL72339; AAL72339; SF_p0133

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1238042
20467556
876495

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sfl:CP0133

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|198214.7.peg.5387

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04309 Genomic DNA Translation: AAA26517.1
AL391753 Genomic DNA Translation: CAC05808.1
AF348706 Genomic DNA Translation: AAK18452.1
AF386526 Genomic DNA Translation: AAL72339.1
AY206439 Genomic DNA Translation: AAP78996.1
RefSeqiNP_085296.1, NC_002698.1
NP_858266.1, NC_004851.1
WP_010921667.1, NZ_QWST01000007.1
YP_009062490.1, NC_024996.1

3D structure databases

SMRiQ07566
ModBaseiSearch...

Proteomic databases

PRIDEiQ07566

Genome annotation databases

EnsemblBacteriaiAAL72339; AAL72339; SF_p0133
GeneIDi1238042
20467556
876495
KEGGisfl:CP0133
PATRICifig|198214.7.peg.5387

Phylogenomic databases

eggNOGiENOG4108N4M Bacteria
ENOG410Y7WM LUCA
HOGENOMiCLU_025781_1_0_6
KOiK13085

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14263
BRENDAi3.1.3.78 5712

Family and domain databases

InterProiView protein in InterPro
IPR008108 IpgD/SopB
PfamiView protein in Pfam
PF05925 IpgD, 1 hit
PRINTSiPR01734 TYPE3OMBPROT

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIPGD_SHIFL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q07566
Secondary accession number(s): Q6XVY4, Q8VSH4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 26, 2020
This is version 104 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Plasmid, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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