UniProtKB - Q07563 (COHA1_MOUSE)
Collagen alpha-1(XVII) chain
Col17a1
Functioni
May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.
By similarityThe 120 kDa linear IgA disease antigen homolog is an anchoring filament component involved in dermal-epidermal cohesion.
By similarityGO - Molecular functioni
- extracellular matrix structural constituent Source: GO_Central
GO - Biological processi
- extracellular matrix organization Source: GO_Central
- hemidesmosome assembly Source: UniProtKB
Enzyme and pathway databases
Reactomei | R-MMU-1650814, Collagen biosynthesis and modifying enzymes R-MMU-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-MMU-2022090, Assembly of collagen fibrils and other multimeric structures R-MMU-446107, Type I hemidesmosome assembly R-MMU-8948216, Collagen chain trimerization |
Names & Taxonomyi
Protein namesi | Recommended name: Collagen alpha-1(XVII) chainAlternative name(s): 180 kDa bullous pemphigoid antigen 2 Bullous pemphigoid antigen 2 Cleaved into the following chain: |
Gene namesi | Name:Col17a1 Synonyms:Bp180, Bpag2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:88450, Col17a1 |
VEuPathDBi | HostDB:ENSMUSG00000025064 |
Subcellular locationi
Other locations
Note: Localized along the plasma membrane of the hemidesmosome.By similarity
Extracellular region or secreted
- basement membrane By similarity
Extracellular region or secreted
- extracellular space Source: GO_Central
Other locations
- basement membrane Source: UniProtKB-SubCell
- collagen trimer Source: UniProtKB-KW
- extracellular matrix Source: GO_Central
- hemidesmosome Source: MGI
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 476 | CytoplasmicSequence analysisAdd BLAST | 476 | |
Transmembranei | 477 – 497 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 498 – 1470 | ExtracellularSequence analysisAdd BLAST | 973 |
Keywords - Cellular componenti
Basement membrane, Cell junction, Extracellular matrix, Membrane, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000059408 | 1 – 1470 | Collagen alpha-1(XVII) chainAdd BLAST | 1470 | |
ChainiPRO_0000342558 | 531 – 1470 | 120 kDa linear IgA disease antigen homologBy similarityAdd BLAST | 940 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 551 | Phosphoserine; by CK2By similarity | 1 | |
Glycosylationi | 1273 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1395 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Hydroxylation, PhosphoproteinProteomic databases
jPOSTi | Q07563 |
PaxDbi | Q07563 |
PRIDEi | Q07563 |
ProteomicsDBi | 283423 [Q07563-1] 283424 [Q07563-2] |
PTM databases
GlyGeni | Q07563, 2 sites |
iPTMneti | Q07563 |
PhosphoSitePlusi | Q07563 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000025064, Expressed in substantia propria of cornea and 151 other tissues |
Genevisiblei | Q07563, MM |
Interactioni
Subunit structurei
Homotrimers of alpha 1(XVII)chains.
Interacts (via cytoplasmic region) with ITGB4 (via cytoplasmic region).
Interacts (via cytoplasmic region) with DST (via N-terminus).
Interacts (via N-terminus) with PLEC.
Interacts (via cytoplasmic region) with DSP (By similarity).
By similarityBinary interactionsi
Q07563
With | #Exp. | IntAct |
---|---|---|
ELANE [P08246] from Homo sapiens. | 2 | EBI-6251005,EBI-986345 |
Protein-protein interaction databases
ComplexPortali | CPX-2995, Collagen type XVII trimer |
IntActi | Q07563, 1 interactor |
STRINGi | 10090.ENSMUSP00000084141 |
Miscellaneous databases
RNActi | Q07563, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 573 | Nonhelical region (NC16)Add BLAST | 573 | |
Regioni | 1 – 155 | DisorderedSequence analysisAdd BLAST | 155 | |
Regioni | 146 – 231 | Necessary for interaction with DST and for the recruitment of DST to hemidesmosomeBy similarityAdd BLAST | 86 | |
Regioni | 167 – 193 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 422 – 452 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 568 – 873 | DisorderedSequence analysisAdd BLAST | 306 | |
Regioni | 574 – 1456 | Triple-helical regionAdd BLAST | 883 | |
Regioni | 885 – 999 | DisorderedSequence analysisAdd BLAST | 115 | |
Regioni | 1159 – 1181 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 1194 – 1220 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 1249 – 1298 | DisorderedSequence analysisAdd BLAST | 50 | |
Regioni | 1406 – 1470 | DisorderedSequence analysisAdd BLAST | 65 | |
Regioni | 1457 – 1470 | Nonhelical region (NC1)Add BLAST | 14 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 16 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 17 – 99 | Polar residuesSequence analysisAdd BLAST | 83 | |
Compositional biasi | 108 – 136 | Polar residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 170 – 193 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 826 – 849 | Pro residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 890 – 927 | Pro residuesSequence analysisAdd BLAST | 38 | |
Compositional biasi | 939 – 953 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1200 – 1216 | Pro residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1270 – 1297 | Polar residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 1430 – 1444 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1446 – 1462 | Basic and acidic residuesSequence analysisAdd BLAST | 17 |
Keywords - Domaini
Collagen, Repeat, Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3544, Eukaryota |
GeneTreei | ENSGT00940000161242 |
HOGENOMi | CLU_004285_0_0_1 |
InParanoidi | Q07563 |
OMAi | DYNELAL |
OrthoDBi | 718661at2759 |
PhylomeDBi | Q07563 |
TreeFami | TF332289 |
Family and domain databases
InterProi | View protein in InterPro IPR008160, Collagen |
Pfami | View protein in Pfam PF01391, Collagen, 4 hits |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDVTKKSKRD GTEVTERIVT ETVTTRLTSL PPKGSTSNGY AKTGSLGGGS
60 70 80 90 100
RLEKQSLTHG SSGYINSSGS IRGNASTSSY RRTHSPASTL PNSPGSTFER
110 120 130 140 150
KAHMTRHGTY EGSSSGNSSP EYPRKELASS STRGRSQTRE SEIRVRLQSA
160 170 180 190 200
SPSTRWTELD EVKRLLKGSR SASASPTRNT SNTLPIPKKG TVETKTVTAS
210 220 230 240 250
SHSVSGTYDS AILDTNFPPH MWSSTLPAGS SLGTYQNNIT AQSTSLLNTN
260 270 280 290 300
AYSTGSVFGV PNNMASCSPT LHPGLSSCSS VFGMQNNLAP SSSVLSHGTT
310 320 330 340 350
TASTAYGAKK NVPQPPTVTS TGVSTSATCT TSVQSDDLLH KDCKFLILEK
360 370 380 390 400
DNTPAKKEME LLIMTKDSGK VFTASPATIS STSFSEDTLK KEKQAAYAAD
410 420 430 440 450
TCLKADVNGD LNTVSTKSKM TSAENHGYDR GGGGGRGKGG GAGGGGGGGG
460 470 480 490 500
ASGGGGAWGA APAWCPCGSC CSWWKWLLGL LLTWLLLLGL LFGLIALAEE
510 520 530 540 550
VRKLKARVEE LEKTKVLYHD VQMDKSNRDR LQAEAPSLGP GLGKAELDGY
560 570 580 590 600
SQEAIWLFVR NKLMTEQENG NLRGSPGPKG DMGSQGPKGD RGLPGTPGIP
610 620 630 640 650
GPLGHPGPEG PKGQKGSIGD PGMEGPIGQR GLAGPMGPRG EPGPPGSGEK
660 670 680 690 700
GDRGIAGEQG PQGLPGVPGP PGLRGHSGSP GPQGPPGAVG PQGLRGDVGL
710 720 730 740 750
PGVKGDKGLM GPPGPKGDQG EKGPRGLTGE PGIRGLPGAV GEPGAKGAMG
760 770 780 790 800
PAGADGQQGS RGEQGLTGMP GTRGPPGPAG DPGKPGLTGP QGPQGLPGSP
810 820 830 840 850
GRPGTKGEPG APGRVMTSEG SSTITVPGPP GPPGAMGPPG PPGTPGPAGP
860 870 880 890 900
AGLPGQQGPR GEPGLAGDSF LSSGSSISEV LSAQGVDLRG PPGPPGPRGP
910 920 930 940 950
PGPSIPGPPG PRGPPGEGVP GPPGPPGSFL TDSETFFTGP PGPPGPPGPK
960 970 980 990 1000
GDQGDPGVPG TPGISGGLSH GASSSTLYMQ GPPGPPGPPG PPGSLSSSGQ
1010 1020 1030 1040 1050
DIQHYIAEYM QSDNIRTYLS GVQGPPGPPG PPGPVITITG ETFDYSQLAS
1060 1070 1080 1090 1100
QVVSYLRSSG YGAGLSSASS SEDILAMLRR NDVWQYLRQN LVGPPGPPGP
1110 1120 1130 1140 1150
PGVSGDGSLL SLDYGELSRH ILNYMSSSGI SFGHPGPPGP PGLPGTSYEE
1160 1170 1180 1190 1200
LLTMLRGSDY RNIIGPPGPP GPPGMPGNAW SSISVEDLSS YLHTAGLSSI
1210 1220 1230 1240 1250
PGPPGPPGPP GPRGPPGVSA ALSTYAAENS DNFRSELISY LTSPDVRSFI
1260 1270 1280 1290 1300
VGPPGPPGPQ GPPGDGHLRE NYNWSSNSSA RRGTSYSSST GTGGTNGGSL
1310 1320 1330 1340 1350
GEGGAYGAGD GGPYGTDIGP GGGYGAAAGG GIYGTNGDSF RDGFTGDLDY
1360 1370 1380 1390 1400
NKLAVRVSES MQRQGLLQGM AYTVQGPPGP QGPPGISRVF SAYSNVTQDL
1410 1420 1430 1440 1450
MDFFQTYGTI PGPPGQKGDV GTPGPKGDRG PAGPRGPPGP PGPRGNKGEK
1460 1470
GDKGDQVYTG RRKRSIAIKP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 164 | R → S in AAA37443 (PubMed:8473327).Curated | 1 | |
Sequence conflicti | 289 | A → G in AAA37443 (PubMed:8473327).Curated | 1 | |
Sequence conflicti | 324 | S → C in AAA37443 (PubMed:8473327).Curated | 1 | |
Sequence conflicti | 1275 | S → G in AAH03208 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1277 | N → S in AAA37443 (PubMed:8473327).Curated | 1 | |
Sequence conflicti | 1277 | N → S in AAH03208 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1277 | N → S in AAI25032 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1277 | N → S in AAI25033 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1292 | T → I in AAA37443 (PubMed:8473327).Curated | 1 | |
Sequence conflicti | 1292 | T → I in AAH03208 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1292 | T → I in AAI25032 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1292 | T → I in AAI25033 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1388 | R → W in AAA37443 (PubMed:8473327).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_009362 | 1157 – 1194 | GSDYR…SYLHT → A in isoform 2. 1 PublicationAdd BLAST | 38 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L08407 mRNA Translation: AAA37443.1 AC131719 Genomic DNA No translation available. BC003208 mRNA Translation: AAH03208.1 BC125031 mRNA Translation: AAI25032.1 BC125032 mRNA Translation: AAI25033.1 AK135150 mRNA Translation: BAE22442.1 |
CCDSi | CCDS38018.1 [Q07563-2] CCDS70959.1 [Q07563-1] |
PIRi | A46053 |
RefSeqi | NP_001277754.1, NM_001290825.1 [Q07563-1] NP_031758.2, NM_007732.2 [Q07563-2] |
Genome annotation databases
Ensembli | ENSMUST00000026045; ENSMUSP00000026045; ENSMUSG00000025064 [Q07563-1] ENSMUST00000086923; ENSMUSP00000084141; ENSMUSG00000025064 [Q07563-2] |
GeneIDi | 12821 |
KEGGi | mmu:12821 |
UCSCi | uc008hvi.2, mouse [Q07563-2] uc008hvj.2, mouse [Q07563-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L08407 mRNA Translation: AAA37443.1 AC131719 Genomic DNA No translation available. BC003208 mRNA Translation: AAH03208.1 BC125031 mRNA Translation: AAI25032.1 BC125032 mRNA Translation: AAI25033.1 AK135150 mRNA Translation: BAE22442.1 |
CCDSi | CCDS38018.1 [Q07563-2] CCDS70959.1 [Q07563-1] |
PIRi | A46053 |
RefSeqi | NP_001277754.1, NM_001290825.1 [Q07563-1] NP_031758.2, NM_007732.2 [Q07563-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
ComplexPortali | CPX-2995, Collagen type XVII trimer |
IntActi | Q07563, 1 interactor |
STRINGi | 10090.ENSMUSP00000084141 |
PTM databases
GlyGeni | Q07563, 2 sites |
iPTMneti | Q07563 |
PhosphoSitePlusi | Q07563 |
Proteomic databases
jPOSTi | Q07563 |
PaxDbi | Q07563 |
PRIDEi | Q07563 |
ProteomicsDBi | 283423 [Q07563-1] 283424 [Q07563-2] |
Protocols and materials databases
Antibodypediai | 18201, 244 antibodies from 29 providers |
DNASUi | 12821 |
Genome annotation databases
Ensembli | ENSMUST00000026045; ENSMUSP00000026045; ENSMUSG00000025064 [Q07563-1] ENSMUST00000086923; ENSMUSP00000084141; ENSMUSG00000025064 [Q07563-2] |
GeneIDi | 12821 |
KEGGi | mmu:12821 |
UCSCi | uc008hvi.2, mouse [Q07563-2] uc008hvj.2, mouse [Q07563-1] |
Organism-specific databases
CTDi | 1308 |
MGIi | MGI:88450, Col17a1 |
VEuPathDBi | HostDB:ENSMUSG00000025064 |
Phylogenomic databases
eggNOGi | KOG3544, Eukaryota |
GeneTreei | ENSGT00940000161242 |
HOGENOMi | CLU_004285_0_0_1 |
InParanoidi | Q07563 |
OMAi | DYNELAL |
OrthoDBi | 718661at2759 |
PhylomeDBi | Q07563 |
TreeFami | TF332289 |
Enzyme and pathway databases
Reactomei | R-MMU-1650814, Collagen biosynthesis and modifying enzymes R-MMU-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-MMU-2022090, Assembly of collagen fibrils and other multimeric structures R-MMU-446107, Type I hemidesmosome assembly R-MMU-8948216, Collagen chain trimerization |
Miscellaneous databases
BioGRID-ORCSi | 12821, 1 hit in 64 CRISPR screens |
ChiTaRSi | Col17a1, mouse |
PROi | PR:Q07563 |
RNActi | Q07563, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000025064, Expressed in substantia propria of cornea and 151 other tissues |
Genevisiblei | Q07563, MM |
Family and domain databases
InterProi | View protein in InterPro IPR008160, Collagen |
Pfami | View protein in Pfam PF01391, Collagen, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | COHA1_MOUSE | |
Accessioni | Q07563Primary (citable) accession number: Q07563 Secondary accession number(s): Q08AT3, Q3UXX1, Q99LK8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 2, 2004 |
Last sequence update: | May 1, 2007 | |
Last modified: | February 23, 2022 | |
This is version 165 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot