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UniProtKB - Q07563 (COHA1_MOUSE)

Entry version 165 (23 Feb 2022)
Sequence version 3 (01 May 2007)
Previous versions | rss
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Protein

Collagen alpha-1(XVII) chain

Gene

Col17a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.

By similarity

The 120 kDa linear IgA disease antigen homolog is an anchoring filament component involved in dermal-epidermal cohesion.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-1650814, Collagen biosynthesis and modifying enzymes
R-MMU-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-2022090, Assembly of collagen fibrils and other multimeric structures
R-MMU-446107, Type I hemidesmosome assembly
R-MMU-8948216, Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Collagen alpha-1(XVII) chain
Alternative name(s):
180 kDa bullous pemphigoid antigen 2
Bullous pemphigoid antigen 2
Cleaved into the following chain:
120 kDa linear IgA disease antigen homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Col17a1
Synonyms:Bp180, Bpag2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:88450, Col17a1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000025064

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 476CytoplasmicSequence analysisAdd BLAST476
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei477 – 497Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini498 – 1470ExtracellularSequence analysisAdd BLAST973

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Basement membrane, Cell junction, Extracellular matrix, Membrane, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000594081 – 1470Collagen alpha-1(XVII) chainAdd BLAST1470
ChainiPRO_0000342558531 – 1470120 kDa linear IgA disease antigen homologBy similarityAdd BLAST940

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei551Phosphoserine; by CK2By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi1273N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1395N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The intracellular/endo domain is disulfide-linked.By similarity
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
The ectodomain is shedded from the surface of keratinocytes resulting in a 120-kDa soluble form, also named as 120 kDa linear IgA disease antigen homolog. The shedding is mediated by membrane-bound metalloproteases. This cleavage is inhibited by phosphorylation at Ser-551 (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q07563

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q07563

PRoteomics IDEntifications database

More...PRIDEi		Q07563

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		283423 [Q07563-1]
283424 [Q07563-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q07563, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q07563

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q07563

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000025064, Expressed in substantia propria of cornea and 151 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q07563, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimers of alpha 1(XVII)chains.

Interacts (via cytoplasmic region) with ITGB4 (via cytoplasmic region).

Interacts (via cytoplasmic region) with DST (via N-terminus).

Interacts (via N-terminus) with PLEC.

Interacts (via cytoplasmic region) with DSP (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-2995, Collagen type XVII trimer

Protein interaction database and analysis system

More...IntActi		Q07563, 1 interactor

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000084141

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q07563, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 573Nonhelical region (NC16)Add BLAST573
Regioni1 – 155DisorderedSequence analysisAdd BLAST155
Regioni146 – 231Necessary for interaction with DST and for the recruitment of DST to hemidesmosomeBy similarityAdd BLAST86
Regioni167 – 193DisorderedSequence analysisAdd BLAST27
Regioni422 – 452DisorderedSequence analysisAdd BLAST31
Regioni568 – 873DisorderedSequence analysisAdd BLAST306
Regioni574 – 1456Triple-helical regionAdd BLAST883
Regioni885 – 999DisorderedSequence analysisAdd BLAST115
Regioni1159 – 1181DisorderedSequence analysisAdd BLAST23
Regioni1194 – 1220DisorderedSequence analysisAdd BLAST27
Regioni1249 – 1298DisorderedSequence analysisAdd BLAST50
Regioni1406 – 1470DisorderedSequence analysisAdd BLAST65
Regioni1457 – 1470Nonhelical region (NC1)Add BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 16Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi17 – 99Polar residuesSequence analysisAdd BLAST83
Compositional biasi108 – 136Polar residuesSequence analysisAdd BLAST29
Compositional biasi170 – 193Polar residuesSequence analysisAdd BLAST24
Compositional biasi826 – 849Pro residuesSequence analysisAdd BLAST24
Compositional biasi890 – 927Pro residuesSequence analysisAdd BLAST38
Compositional biasi939 – 953Pro residuesSequence analysisAdd BLAST15
Compositional biasi1200 – 1216Pro residuesSequence analysisAdd BLAST17
Compositional biasi1270 – 1297Polar residuesSequence analysisAdd BLAST28
Compositional biasi1430 – 1444Pro residuesSequence analysisAdd BLAST15
Compositional biasi1446 – 1462Basic and acidic residuesSequence analysisAdd BLAST17

Keywords - Domaini

Collagen, Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3544, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161242

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004285_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q07563

Identification of Orthologs from Complete Genome Data

More...OMAi		DYNELAL

Database of Orthologous Groups

More...OrthoDBi		718661at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q07563

TreeFam database of animal gene trees

More...TreeFami		TF332289

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008160, Collagen

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01391, Collagen, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q07563-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDVTKKSKRD GTEVTERIVT ETVTTRLTSL PPKGSTSNGY AKTGSLGGGS 
        60         70         80         90        100
RLEKQSLTHG SSGYINSSGS IRGNASTSSY RRTHSPASTL PNSPGSTFER 
       110        120        130        140        150
KAHMTRHGTY EGSSSGNSSP EYPRKELASS STRGRSQTRE SEIRVRLQSA 
       160        170        180        190        200
SPSTRWTELD EVKRLLKGSR SASASPTRNT SNTLPIPKKG TVETKTVTAS 
       210        220        230        240        250
SHSVSGTYDS AILDTNFPPH MWSSTLPAGS SLGTYQNNIT AQSTSLLNTN 
       260        270        280        290        300
AYSTGSVFGV PNNMASCSPT LHPGLSSCSS VFGMQNNLAP SSSVLSHGTT 
       310        320        330        340        350
TASTAYGAKK NVPQPPTVTS TGVSTSATCT TSVQSDDLLH KDCKFLILEK 
       360        370        380        390        400
DNTPAKKEME LLIMTKDSGK VFTASPATIS STSFSEDTLK KEKQAAYAAD 
       410        420        430        440        450
TCLKADVNGD LNTVSTKSKM TSAENHGYDR GGGGGRGKGG GAGGGGGGGG 
       460        470        480        490        500
ASGGGGAWGA APAWCPCGSC CSWWKWLLGL LLTWLLLLGL LFGLIALAEE 
       510        520        530        540        550
VRKLKARVEE LEKTKVLYHD VQMDKSNRDR LQAEAPSLGP GLGKAELDGY 
       560        570        580        590        600
SQEAIWLFVR NKLMTEQENG NLRGSPGPKG DMGSQGPKGD RGLPGTPGIP 
       610        620        630        640        650
GPLGHPGPEG PKGQKGSIGD PGMEGPIGQR GLAGPMGPRG EPGPPGSGEK 
       660        670        680        690        700
GDRGIAGEQG PQGLPGVPGP PGLRGHSGSP GPQGPPGAVG PQGLRGDVGL 
       710        720        730        740        750
PGVKGDKGLM GPPGPKGDQG EKGPRGLTGE PGIRGLPGAV GEPGAKGAMG 
       760        770        780        790        800
PAGADGQQGS RGEQGLTGMP GTRGPPGPAG DPGKPGLTGP QGPQGLPGSP 
       810        820        830        840        850
GRPGTKGEPG APGRVMTSEG SSTITVPGPP GPPGAMGPPG PPGTPGPAGP 
       860        870        880        890        900
AGLPGQQGPR GEPGLAGDSF LSSGSSISEV LSAQGVDLRG PPGPPGPRGP 
       910        920        930        940        950
PGPSIPGPPG PRGPPGEGVP GPPGPPGSFL TDSETFFTGP PGPPGPPGPK 
       960        970        980        990       1000
GDQGDPGVPG TPGISGGLSH GASSSTLYMQ GPPGPPGPPG PPGSLSSSGQ 
      1010       1020       1030       1040       1050
DIQHYIAEYM QSDNIRTYLS GVQGPPGPPG PPGPVITITG ETFDYSQLAS 
      1060       1070       1080       1090       1100
QVVSYLRSSG YGAGLSSASS SEDILAMLRR NDVWQYLRQN LVGPPGPPGP 
      1110       1120       1130       1140       1150
PGVSGDGSLL SLDYGELSRH ILNYMSSSGI SFGHPGPPGP PGLPGTSYEE 
      1160       1170       1180       1190       1200
LLTMLRGSDY RNIIGPPGPP GPPGMPGNAW SSISVEDLSS YLHTAGLSSI 
      1210       1220       1230       1240       1250
PGPPGPPGPP GPRGPPGVSA ALSTYAAENS DNFRSELISY LTSPDVRSFI 
      1260       1270       1280       1290       1300
VGPPGPPGPQ GPPGDGHLRE NYNWSSNSSA RRGTSYSSST GTGGTNGGSL 
      1310       1320       1330       1340       1350
GEGGAYGAGD GGPYGTDIGP GGGYGAAAGG GIYGTNGDSF RDGFTGDLDY 
      1360       1370       1380       1390       1400
NKLAVRVSES MQRQGLLQGM AYTVQGPPGP QGPPGISRVF SAYSNVTQDL 
      1410       1420       1430       1440       1450
MDFFQTYGTI PGPPGQKGDV GTPGPKGDRG PAGPRGPPGP PGPRGNKGEK 
      1460       1470
GDKGDQVYTG RRKRSIAIKP
Length:1,470
Mass (Da):147,975
Last modified:May 1, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7C38356D6ED68347
GO
Isoform 2 (identifier: Q07563-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1157-1194: GSDYRNIIGPPGPPGPPGMPGNAWSSISVEDLSSYLHT → A

Show »
Length:1,433
Mass (Da):144,140
Checksum:i0C8997CF58634BA1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti164R → S in AAA37443 (PubMed:8473327).Curated1
Sequence conflicti289A → G in AAA37443 (PubMed:8473327).Curated1
Sequence conflicti324S → C in AAA37443 (PubMed:8473327).Curated1
Sequence conflicti1275S → G in AAH03208 (PubMed:15489334).Curated1
Sequence conflicti1277N → S in AAA37443 (PubMed:8473327).Curated1
Sequence conflicti1277N → S in AAH03208 (PubMed:15489334).Curated1
Sequence conflicti1277N → S in AAI25032 (PubMed:15489334).Curated1
Sequence conflicti1277N → S in AAI25033 (PubMed:15489334).Curated1
Sequence conflicti1292T → I in AAA37443 (PubMed:8473327).Curated1
Sequence conflicti1292T → I in AAH03208 (PubMed:15489334).Curated1
Sequence conflicti1292T → I in AAI25032 (PubMed:15489334).Curated1
Sequence conflicti1292T → I in AAI25033 (PubMed:15489334).Curated1
Sequence conflicti1388R → W in AAA37443 (PubMed:8473327).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0093621157 – 1194GSDYR…SYLHT → A in isoform 2. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L08407 mRNA Translation: AAA37443.1
AC131719 Genomic DNA No translation available.
BC003208 mRNA Translation: AAH03208.1
BC125031 mRNA Translation: AAI25032.1
BC125032 mRNA Translation: AAI25033.1
AK135150 mRNA Translation: BAE22442.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS38018.1 [Q07563-2]
CCDS70959.1 [Q07563-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A46053

NCBI Reference Sequences

More...RefSeqi		NP_001277754.1, NM_001290825.1 [Q07563-1]
NP_031758.2, NM_007732.2 [Q07563-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000026045; ENSMUSP00000026045; ENSMUSG00000025064 [Q07563-1]
ENSMUST00000086923; ENSMUSP00000084141; ENSMUSG00000025064 [Q07563-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		12821

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:12821

UCSC genome browser

More...UCSCi		uc008hvi.2, mouse [Q07563-2]
uc008hvj.2, mouse [Q07563-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08407 mRNA Translation: AAA37443.1
AC131719 Genomic DNA No translation available.
BC003208 mRNA Translation: AAH03208.1
BC125031 mRNA Translation: AAI25032.1
BC125032 mRNA Translation: AAI25033.1
AK135150 mRNA Translation: BAE22442.1
CCDSiCCDS38018.1 [Q07563-2]
CCDS70959.1 [Q07563-1]
PIRiA46053
RefSeqiNP_001277754.1, NM_001290825.1 [Q07563-1]
NP_031758.2, NM_007732.2 [Q07563-2]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

ComplexPortaliCPX-2995, Collagen type XVII trimer
IntActiQ07563, 1 interactor
STRINGi10090.ENSMUSP00000084141

PTM databases

GlyGeniQ07563, 2 sites
iPTMnetiQ07563
PhosphoSitePlusiQ07563

Proteomic databases

jPOSTiQ07563
PaxDbiQ07563
PRIDEiQ07563
ProteomicsDBi283423 [Q07563-1]
283424 [Q07563-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		18201, 244 antibodies from 29 providers

The DNASU plasmid repository

More...DNASUi		12821

Genome annotation databases

EnsembliENSMUST00000026045; ENSMUSP00000026045; ENSMUSG00000025064 [Q07563-1]
ENSMUST00000086923; ENSMUSP00000084141; ENSMUSG00000025064 [Q07563-2]
GeneIDi12821
KEGGimmu:12821
UCSCiuc008hvi.2, mouse [Q07563-2]
uc008hvj.2, mouse [Q07563-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1308
MGIiMGI:88450, Col17a1
VEuPathDBiHostDB:ENSMUSG00000025064

Phylogenomic databases

eggNOGiKOG3544, Eukaryota
GeneTreeiENSGT00940000161242
HOGENOMiCLU_004285_0_0_1
InParanoidiQ07563
OMAiDYNELAL
OrthoDBi718661at2759
PhylomeDBiQ07563
TreeFamiTF332289

Enzyme and pathway databases

ReactomeiR-MMU-1650814, Collagen biosynthesis and modifying enzymes
R-MMU-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-2022090, Assembly of collagen fibrils and other multimeric structures
R-MMU-446107, Type I hemidesmosome assembly
R-MMU-8948216, Collagen chain trimerization

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		12821, 1 hit in 64 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Col17a1, mouse

Protein Ontology

More...PROi		PR:Q07563
RNActiQ07563, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000025064, Expressed in substantia propria of cornea and 151 other tissues
GenevisibleiQ07563, MM

Family and domain databases

InterProiView protein in InterPro
IPR008160, Collagen
PfamiView protein in Pfam
PF01391, Collagen, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOHA1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q07563
Secondary accession number(s): Q08AT3, Q3UXX1, Q99LK8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: May 1, 2007
Last modified: February 23, 2022
This is version 165 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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