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UniProtKB - Q07563 (COHA1_MOUSE)

Protein

Collagen alpha-1(XVII) chain

Gene

Col17a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.By similarity
The 120 kDa linear IgA disease antigen homolog is an anchoring filament component involved in dermal-epidermal cohesion.By similarity

GO - Molecular functioni

  • extracellular matrix structural constituent Source: GO_Central
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

ReactomeiR-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-2022090 Assembly of collagen fibrils and other multimeric structures
R-MMU-446107 Type I hemidesmosome assembly
R-MMU-8948216 Collagen chain trimerization

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(XVII) chain
Alternative name(s):
180 kDa bullous pemphigoid antigen 2
Bullous pemphigoid antigen 2
Cleaved into the following chain:
120 kDa linear IgA disease antigen homolog
Gene namesi
Name:Col17a1
Synonyms:Bp180, Bpag2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:88450 Col17a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 476CytoplasmicSequence analysisAdd BLAST476
Transmembranei477 – 497Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini498 – 1470ExtracellularSequence analysisAdd BLAST973

Keywords - Cellular componenti

Basement membrane, Cell junction, Extracellular matrix, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000594081 – 1470Collagen alpha-1(XVII) chainAdd BLAST1470
ChainiPRO_0000342558531 – 1470120 kDa linear IgA disease antigen homologBy similarityAdd BLAST940

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei551Phosphoserine; by CK2By similarity1
Glycosylationi1273N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1395N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

The intracellular/endo domain is disulfide-linked.By similarity
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
The ectodomain is shedded from the surface of keratinocytes resulting in a 120-kDa soluble form, also named as 120 kDa linear IgA disease antigen homolog. The shedding is mediated by membrane-bound metalloproteases. This cleavage is inhibited by phosphorylation at Ser-551 (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Phosphoprotein

Proteomic databases

PaxDbiQ07563
PRIDEiQ07563

PTM databases

iPTMnetiQ07563
PhosphoSitePlusiQ07563

Expressioni

Gene expression databases

BgeeiENSMUSG00000025064 Expressed in 113 organ(s), highest expression level in substantia propria of cornea
CleanExiMM_COL17A1
GenevisibleiQ07563 MM

Interactioni

Subunit structurei

Homotrimers of alpha 1(XVII)chains. Interacts (via cytoplasmic region) with ITGB4 (via cytoplasmic region). Interacts (via cytoplasmic region) with DST (via N-terminus). Interacts (via N-terminus) with PLEC. Interacts (via cytoplasmic region) with DSP (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ELANEP082462EBI-6251005,EBI-986345From Homo sapiens.

Protein-protein interaction databases

ComplexPortaliCPX-2995 Collagen type XVII trimer
IntActiQ07563, 1 interactor
STRINGi10090.ENSMUSP00000084141

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 573Nonhelical region (NC16)Add BLAST573
Regioni146 – 231Necessary for interaction with DST and for the recruitment of DST to hemidesmosomeBy similarityAdd BLAST86
Regioni574 – 1456Triple-helical regionAdd BLAST883
Regioni1457 – 1470Nonhelical region (NC1)Add BLAST14

Keywords - Domaini

Collagen, Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG41103C3 LUCA
GeneTreeiENSGT00820000126981
HOGENOMiHOG000111885
HOVERGENiHBG051065
InParanoidiQ07563
KOiK07603
OMAiWSSISME
OrthoDBiEOG091G025Z
PhylomeDBiQ07563
TreeFamiTF332289

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
PfamiView protein in Pfam
PF01391 Collagen, 4 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q07563-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDVTKKSKRD GTEVTERIVT ETVTTRLTSL PPKGSTSNGY AKTGSLGGGS 
        60         70         80         90        100
RLEKQSLTHG SSGYINSSGS IRGNASTSSY RRTHSPASTL PNSPGSTFER 
       110        120        130        140        150
KAHMTRHGTY EGSSSGNSSP EYPRKELASS STRGRSQTRE SEIRVRLQSA 
       160        170        180        190        200
SPSTRWTELD EVKRLLKGSR SASASPTRNT SNTLPIPKKG TVETKTVTAS 
       210        220        230        240        250
SHSVSGTYDS AILDTNFPPH MWSSTLPAGS SLGTYQNNIT AQSTSLLNTN 
       260        270        280        290        300
AYSTGSVFGV PNNMASCSPT LHPGLSSCSS VFGMQNNLAP SSSVLSHGTT 
       310        320        330        340        350
TASTAYGAKK NVPQPPTVTS TGVSTSATCT TSVQSDDLLH KDCKFLILEK 
       360        370        380        390        400
DNTPAKKEME LLIMTKDSGK VFTASPATIS STSFSEDTLK KEKQAAYAAD 
       410        420        430        440        450
TCLKADVNGD LNTVSTKSKM TSAENHGYDR GGGGGRGKGG GAGGGGGGGG 
       460        470        480        490        500
ASGGGGAWGA APAWCPCGSC CSWWKWLLGL LLTWLLLLGL LFGLIALAEE 
       510        520        530        540        550
VRKLKARVEE LEKTKVLYHD VQMDKSNRDR LQAEAPSLGP GLGKAELDGY 
       560        570        580        590        600
SQEAIWLFVR NKLMTEQENG NLRGSPGPKG DMGSQGPKGD RGLPGTPGIP 
       610        620        630        640        650
GPLGHPGPEG PKGQKGSIGD PGMEGPIGQR GLAGPMGPRG EPGPPGSGEK 
       660        670        680        690        700
GDRGIAGEQG PQGLPGVPGP PGLRGHSGSP GPQGPPGAVG PQGLRGDVGL 
       710        720        730        740        750
PGVKGDKGLM GPPGPKGDQG EKGPRGLTGE PGIRGLPGAV GEPGAKGAMG 
       760        770        780        790        800
PAGADGQQGS RGEQGLTGMP GTRGPPGPAG DPGKPGLTGP QGPQGLPGSP 
       810        820        830        840        850
GRPGTKGEPG APGRVMTSEG SSTITVPGPP GPPGAMGPPG PPGTPGPAGP 
       860        870        880        890        900
AGLPGQQGPR GEPGLAGDSF LSSGSSISEV LSAQGVDLRG PPGPPGPRGP 
       910        920        930        940        950
PGPSIPGPPG PRGPPGEGVP GPPGPPGSFL TDSETFFTGP PGPPGPPGPK 
       960        970        980        990       1000
GDQGDPGVPG TPGISGGLSH GASSSTLYMQ GPPGPPGPPG PPGSLSSSGQ 
      1010       1020       1030       1040       1050
DIQHYIAEYM QSDNIRTYLS GVQGPPGPPG PPGPVITITG ETFDYSQLAS 
      1060       1070       1080       1090       1100
QVVSYLRSSG YGAGLSSASS SEDILAMLRR NDVWQYLRQN LVGPPGPPGP 
      1110       1120       1130       1140       1150
PGVSGDGSLL SLDYGELSRH ILNYMSSSGI SFGHPGPPGP PGLPGTSYEE 
      1160       1170       1180       1190       1200
LLTMLRGSDY RNIIGPPGPP GPPGMPGNAW SSISVEDLSS YLHTAGLSSI 
      1210       1220       1230       1240       1250
PGPPGPPGPP GPRGPPGVSA ALSTYAAENS DNFRSELISY LTSPDVRSFI 
      1260       1270       1280       1290       1300
VGPPGPPGPQ GPPGDGHLRE NYNWSSNSSA RRGTSYSSST GTGGTNGGSL 
      1310       1320       1330       1340       1350
GEGGAYGAGD GGPYGTDIGP GGGYGAAAGG GIYGTNGDSF RDGFTGDLDY 
      1360       1370       1380       1390       1400
NKLAVRVSES MQRQGLLQGM AYTVQGPPGP QGPPGISRVF SAYSNVTQDL 
      1410       1420       1430       1440       1450
MDFFQTYGTI PGPPGQKGDV GTPGPKGDRG PAGPRGPPGP PGPRGNKGEK 
      1460       1470
GDKGDQVYTG RRKRSIAIKP
Length:1,470
Mass (Da):147,975
Last modified:May 1, 2007 - v3
Checksum:i7C38356D6ED68347
GO
Isoform 2 (identifier: Q07563-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1157-1194: GSDYRNIIGPPGPPGPPGMPGNAWSSISVEDLSSYLHT → A

Show »
Length:1,433
Mass (Da):144,140
Checksum:i0C8997CF58634BA1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti164R → S in AAA37443 (PubMed:8473327).Curated1
Sequence conflicti289A → G in AAA37443 (PubMed:8473327).Curated1
Sequence conflicti324S → C in AAA37443 (PubMed:8473327).Curated1
Sequence conflicti1275S → G in AAH03208 (PubMed:15489334).Curated1
Sequence conflicti1277N → S in AAA37443 (PubMed:8473327).Curated1
Sequence conflicti1277N → S in AAH03208 (PubMed:15489334).Curated1
Sequence conflicti1277N → S in AAI25032 (PubMed:15489334).Curated1
Sequence conflicti1277N → S in AAI25033 (PubMed:15489334).Curated1
Sequence conflicti1292T → I in AAA37443 (PubMed:8473327).Curated1
Sequence conflicti1292T → I in AAH03208 (PubMed:15489334).Curated1
Sequence conflicti1292T → I in AAI25032 (PubMed:15489334).Curated1
Sequence conflicti1292T → I in AAI25033 (PubMed:15489334).Curated1
Sequence conflicti1388R → W in AAA37443 (PubMed:8473327).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0093621157 – 1194GSDYR…SYLHT → A in isoform 2. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08407 mRNA Translation: AAA37443.1
AC131719 Genomic DNA No translation available.
BC003208 mRNA Translation: AAH03208.1
BC125031 mRNA Translation: AAI25032.1
BC125032 mRNA Translation: AAI25033.1
AK135150 mRNA Translation: BAE22442.1
CCDSiCCDS38018.1 [Q07563-2]
CCDS70959.1 [Q07563-1]
PIRiA46053
RefSeqiNP_001277754.1, NM_001290825.1 [Q07563-1]
NP_031758.2, NM_007732.2 [Q07563-2]
UniGeneiMm.1225

Genome annotation databases

EnsembliENSMUST00000026045; ENSMUSP00000026045; ENSMUSG00000025064 [Q07563-1]
ENSMUST00000086923; ENSMUSP00000084141; ENSMUSG00000025064 [Q07563-2]
GeneIDi12821
KEGGimmu:12821
UCSCiuc008hvi.2 mouse [Q07563-2]
uc008hvj.2 mouse [Q07563-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08407 mRNA Translation: AAA37443.1
AC131719 Genomic DNA No translation available.
BC003208 mRNA Translation: AAH03208.1
BC125031 mRNA Translation: AAI25032.1
BC125032 mRNA Translation: AAI25033.1
AK135150 mRNA Translation: BAE22442.1
CCDSiCCDS38018.1 [Q07563-2]
CCDS70959.1 [Q07563-1]
PIRiA46053
RefSeqiNP_001277754.1, NM_001290825.1 [Q07563-1]
NP_031758.2, NM_007732.2 [Q07563-2]
UniGeneiMm.1225

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-2995 Collagen type XVII trimer
IntActiQ07563, 1 interactor
STRINGi10090.ENSMUSP00000084141

PTM databases

iPTMnetiQ07563
PhosphoSitePlusiQ07563

Proteomic databases

PaxDbiQ07563
PRIDEiQ07563

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026045; ENSMUSP00000026045; ENSMUSG00000025064 [Q07563-1]
ENSMUST00000086923; ENSMUSP00000084141; ENSMUSG00000025064 [Q07563-2]
GeneIDi12821
KEGGimmu:12821
UCSCiuc008hvi.2 mouse [Q07563-2]
uc008hvj.2 mouse [Q07563-1]

Organism-specific databases

CTDi1308
MGIiMGI:88450 Col17a1

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG41103C3 LUCA
GeneTreeiENSGT00820000126981
HOGENOMiHOG000111885
HOVERGENiHBG051065
InParanoidiQ07563
KOiK07603
OMAiWSSISME
OrthoDBiEOG091G025Z
PhylomeDBiQ07563
TreeFamiTF332289

Enzyme and pathway databases

ReactomeiR-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-2022090 Assembly of collagen fibrils and other multimeric structures
R-MMU-446107 Type I hemidesmosome assembly
R-MMU-8948216 Collagen chain trimerization

Miscellaneous databases

PROiPR:Q07563
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025064 Expressed in 113 organ(s), highest expression level in substantia propria of cornea
CleanExiMM_COL17A1
GenevisibleiQ07563 MM

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
PfamiView protein in Pfam
PF01391 Collagen, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCOHA1_MOUSE
AccessioniPrimary (citable) accession number: Q07563
Secondary accession number(s): Q08AT3, Q3UXX1, Q99LK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: May 1, 2007
Last modified: November 7, 2018
This is version 148 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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