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Protein

tRNA (guanosine(18)-2'-O)-methyltransferase

Gene

TRM3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in various tRNAs.1 Publication

Miscellaneous

Present with 861 molecules/cell in log phase SD medium.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1389S-adenosyl-L-methionine; via amide nitrogenBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:YDL112W-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
tRNA (guanosine(18)-2'-O)-methyltransferase1 Publication (EC:2.1.1.341 Publication)
Alternative name(s):
tRNA [Gm18] ribose methylase1 Publication
tRNA methyltransferase 31 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRM31 Publication
Ordered Locus Names:YDL112WImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000002270 TRM3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002709211 – 1436tRNA (guanosine(18)-2'-O)-methyltransferaseAdd BLAST1436

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q07527

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q07527

PRoteomics IDEntifications database

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PRIDEi
Q07527

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q07527

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
31950, 100 interactors

Database of interacting proteins

More...
DIPi
DIP-2598N

Protein interaction database and analysis system

More...
IntActi
Q07527, 7 interactors

STRING: functional protein association networks

More...
STRINGi
4932.YDL112W

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q07527

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q07527

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1365 – 1367S-adenosyl-L-methionine bindingBy similarity3
Regioni1409 – 1418S-adenosyl-L-methionine bindingBy similarity10

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003939

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000141850

KEGG Orthology (KO)

More...
KOi
K15333

Identification of Orthologs from Complete Genome Data

More...
OMAi
AHGIPGH

Database of Orthologous Groups

More...
OrthoDBi
EOG092C057N

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1280.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029028 Alpha/beta_knot_MTases
IPR001537 SpoU_MeTrfase
IPR025759 Trm3
IPR029026 tRNA_m1G_MTases_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00588 SpoU_methylase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF75217 SSF75217, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51623 SAM_MT_TRMH_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q07527-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVGGALICKY LPREEQLKLI SDLIQNDSLE EVLELIETSP LDITTDSNIE
60 70 80 90 100
TPIFEKITEQ VIAYASIDGE AREMFRSSRA EMNKALRTSA QLLCCLPSVW
110 120 130 140 150
HKFQVWMSYR LNDIISENYK HLFNDNFGKK IVQPFFDSFA EEQNANIKHE
160 170 180 190 200
NLHLDILSLL HYLEVVYLFD ECKNGISSKC LDFIIVPLLG CNSEEIADSC
210 220 230 240 250
SKLMRWHIKY LSKCCNTDSN FDKLIWTFIK QLYAEGSQQA WKQKNSLSFL
260 270 280 290 300
LRFLLAAELS PELITYIKTD AYWRHIQTEL DNDVHEHRKL ALSILKLTIQ
310 320 330 340 350
KLSSHGITLQ TTFYKCNDLA NIEMLGSWKK FTTLYEMIAL DTSLNQIQAA
360 370 380 390 400
KQDIIKIFDN EHLHHSWGLI LLSTGLKSSM ESVRKYMMTL MFSITNMSAF
410 420 430 440 450
SSNLPLLTKT LLPAAMSAHY FDVKGVSCPH GEKLSLFVNN LLSQTTEGIS
460 470 480 490 500
DILFEILKLL VEKGTSFDPS RIYLSYGILV FFQNNKQKTI NSDHLSLIRK
510 520 530 540 550
LYDFAAEEEV LETTIQTIYL KFLLYIDPSV SASELLFTLV SHIKLKGGTY
560 570 580 590 600
KYVEPLFEDY RDLAVSHFDD LQAKENLTTN IGKDTIFDLL ASIIFDFKDI
610 620 630 640 650
DITPDFLIEV AKSKQDIPVY TSKAVTFLTQ LLSGEPSNGY TYENATALLS
660 670 680 690 700
YPNFTISTWK SINVNNLFKS VMEKFSLDKF KFFAEIYQKT YECRFDTIEL
710 720 730 740 750
NFNDLLSLYE MVKKSANQCS RESFKVKDSA YSSYFELLNT FLKTYALNRD
760 770 780 790 800
SSEGNDDELH ILLRLVDENI NKDNGNYLGN LAVCKLLYFI IDSYIHCSTS
810 820 830 840 850
VSDDDIFIVK FIFEKFSFIW ECINSERLVL KERDLHLMLI KGLFHPVILY
860 870 880 890 900
FGSNQYIDTL TSKLEEHAQT IISLSYSRRS LLPLLGSQLR VFMKFYGKLL
910 920 930 940 950
REDVNYWWLI NIIVGVFKQP QMDVNLYKLK PVISSLFDHK LNNYYIKGDE
960 970 980 990 1000
LYEKVYGPDE ILARVSIIDS ILYANDQLKI RLIEKVTEKT NALYAIKRTD
1010 1020 1030 1040 1050
GAEALQRLLQ WQLLLLSLLT TNEKKLSETS MIRILKSIED ESSPLVRVYK
1060 1070 1080 1090 1100
EWFISSKVVD YYKTGNPKFA EDYLFSLLED HSKPVFVVSA EKICFMVLKD
1110 1120 1130 1140 1150
LRNDEKKYGF TQLLDRFICT LVPNAASNKP LVRHFSNSLI ISLWPTFKAY
1160 1170 1180 1190 1200
LSDHTLRNII ENLYSNAKKT QIFGQYRAGD ANIWDLKGDR KLTNMFGGVL
1210 1220 1230 1240 1250
KKVTDHDCPY ISESVFEKYL QEKDIVPIGT DERSLWLDKR DTNTESVNNA
1260 1270 1280 1290 1300
NISCDTSPLQ TKSGAWETVL DLDNKKSNDV VTRSELIVVS SLVDKPPNLG
1310 1320 1330 1340 1350
GICRLCDVLG VGLLTVQDIK VKNHPQFKNV AVTADRWMPM EEVALDEIAS
1360 1370 1380 1390 1400
FMKEKKKEGY TLIGLEQTDK SVKLDNNFQF PKKSLILLGT EAFGIPGTLL
1410 1420 1430
SELDLCLEIQ QFGVIRSMNI QTATAVIVHS YTVQHM
Length:1,436
Mass (Da):165,048
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4B14823AF6E858F1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z74160 Genomic DNA Translation: CAA98680.1
X95644 Genomic DNA Translation: CAA64900.1
Z74159 Genomic DNA Translation: CAA98679.1
BK006938 Genomic DNA Translation: DAA11748.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S67655

NCBI Reference Sequences

More...
RefSeqi
NP_010171.1, NM_001180171.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YDL112W_mRNA; YDL112W_mRNA; YDL112W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
851446

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YDL112W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74160 Genomic DNA Translation: CAA98680.1
X95644 Genomic DNA Translation: CAA64900.1
Z74159 Genomic DNA Translation: CAA98679.1
BK006938 Genomic DNA Translation: DAA11748.1
PIRiS67655
RefSeqiNP_010171.1, NM_001180171.1

3D structure databases

ProteinModelPortaliQ07527
SMRiQ07527
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31950, 100 interactors
DIPiDIP-2598N
IntActiQ07527, 7 interactors
STRINGi4932.YDL112W

PTM databases

iPTMnetiQ07527

Proteomic databases

MaxQBiQ07527
PaxDbiQ07527
PRIDEiQ07527

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDL112W_mRNA; YDL112W_mRNA; YDL112W
GeneIDi851446
KEGGisce:YDL112W

Organism-specific databases

SGDiS000002270 TRM3

Phylogenomic databases

GeneTreeiENSGT00390000003939
HOGENOMiHOG000141850
KOiK15333
OMAiAHGIPGH
OrthoDBiEOG092C057N

Enzyme and pathway databases

BioCyciYEAST:YDL112W-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q07527

Family and domain databases

Gene3Di3.40.1280.10, 1 hit
InterProiView protein in InterPro
IPR029028 Alpha/beta_knot_MTases
IPR001537 SpoU_MeTrfase
IPR025759 Trm3
IPR029026 tRNA_m1G_MTases_N
PfamiView protein in Pfam
PF00588 SpoU_methylase, 1 hit
SUPFAMiSSF75217 SSF75217, 1 hit
PROSITEiView protein in PROSITE
PS51623 SAM_MT_TRMH_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRM3_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q07527
Secondary accession number(s): D6VRN8
, P89896, Q05336, Q7LGS3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 1, 1996
Last modified: December 5, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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