Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dermatopontin

Gene

DPT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Dermatopontin
Alternative name(s):
Tyrosine-rich acidic matrix protein
Short name:
TRAMP
Gene namesi
Name:DPT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143196.4
HGNCiHGNC:3011 DPT
MIMi125597 gene
neXtProtiNX_Q07507

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1805
OpenTargetsiENSG00000143196
PharmGKBiPA27471

Polymorphism and mutation databases

BioMutaiDPT

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000000736819 – 201DermatopontinAdd BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19Pyrrolidone carboxylic acidBy similarity1
Modified residuei23SulfotyrosineSequence analysis1
Disulfide bondi50 ↔ 77By similarity
Disulfide bondi90 ↔ 132Or C-90 with C-133By similarity
Disulfide bondi106 ↔ 133Or C-106 with C-132By similarity
Disulfide bondi139 ↔ 196By similarity
Disulfide bondi143 ↔ 189Sequence analysis
Modified residuei162SulfotyrosineSequence analysis1
Modified residuei164SulfotyrosineSequence analysis1
Modified residuei166SulfotyrosineSequence analysis1
Modified residuei167SulfotyrosineSequence analysis1
Modified residuei194SulfotyrosineSequence analysis1

Post-translational modificationi

Sulfated on tyrosine residue(s).By similarity

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid, Sulfation

Proteomic databases

PaxDbiQ07507
PeptideAtlasiQ07507
PRIDEiQ07507
ProteomicsDBi58518

PTM databases

iPTMnetiQ07507
PhosphoSitePlusiQ07507

Expressioni

Tissue specificityi

Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta. Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts.2 Publications

Inductioni

Induced by TGFB1, repressed by IL4/interleukin-4.1 Publication

Gene expression databases

BgeeiENSG00000143196 Expressed in 191 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_DPT
GenevisibleiQ07507 HS

Organism-specific databases

HPAiHPA065548

Interactioni

Subunit structurei

Interacts with TGFB1, DCN and collagen.By similarity

Protein-protein interaction databases

BioGridi108139, 1 interactor
IntActiQ07507, 3 interactors
STRINGi9606.ENSP00000356791

Structurei

3D structure databases

ProteinModelPortaliQ07507
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati26 – 791-1Add BLAST54
Repeati70 – 752-16
Repeati80 – 1351-2Add BLAST56
Repeati125 – 1302-26
Repeati181 – 1863-36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni26 – 1862 X 53-55 AA tandem repeatsAdd BLAST161
Regioni70 – 1863 X 6 AA repeats of D-R-[EQ]-W-[NQK]-[FY]Add BLAST117

Sequence similaritiesi

Belongs to the dermatopontin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IGCN Eukaryota
ENOG4111HSK LUCA
GeneTreeiENSGT00390000010760
HOGENOMiHOG000013186
HOVERGENiHBG005473
InParanoidiQ07507
OMAiGFNFQCP
OrthoDBiEOG091G0L6V
PhylomeDBiQ07507
TreeFamiTF328602

Family and domain databases

InterProiView protein in InterPro
IPR026645 Dermatopontin_fam
PANTHERiPTHR15040 PTHR15040, 1 hit
PfamiView protein in Pfam
PF14704 DERM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07507-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLSLLWVLL PLVTMAWGQY GDYGYPYQQY HDYSDDGWVN LNRQGFSYQC
60 70 80 90 100
PQGQVIVAVR SIFSKKEGSD RQWNYACMPT PQSLGEPTEC WWEEINRAGM
110 120 130 140 150
EWYQTCSNNG LVAGFQSRYF ESVLDREWQF YCCRYSKRCP YSCWLTTEYP
160 170 180 190 200
GHYGEEMDMI SYNYDYYIRG ATTTFSAVER DRQWKFIMCR MTEYDCEFAN

V
Length:201
Mass (Da):24,005
Last modified:December 13, 2002 - v2
Checksum:iC886D2FB624DDB49
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10L → M in CAA80487 (PubMed:8104875).Curated1
Sequence conflicti147T → I in AAH33736 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048888201V → I. Corresponds to variant dbSNP:rs6698023Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22865 mRNA Translation: CAA80487.1
AK292596 mRNA Translation: BAF85285.1
AL049798 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90830.1
BC033736 mRNA Translation: AAH33736.1
CCDSiCCDS1275.1
PIRiA47220
RefSeqiNP_001928.2, NM_001937.4
UniGeneiHs.80552

Genome annotation databases

EnsembliENST00000367817; ENSP00000356791; ENSG00000143196
GeneIDi1805
KEGGihsa:1805
UCSCiuc001gfp.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDERM_HUMAN
AccessioniPrimary (citable) accession number: Q07507
Secondary accession number(s): A8K981, Q8N4R2, Q9UIX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 13, 2002
Last modified: September 12, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again