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Protein

Dermatopontin

Gene

DPT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • collagen fibril organization Source: GO_Central
  • negative regulation of cell proliferation Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dermatopontin
Alternative name(s):
Tyrosine-rich acidic matrix protein
Short name:
TRAMP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DPT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000143196.4

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3011 DPT

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
125597 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q07507

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1805

Open Targets

More...
OpenTargetsi
ENSG00000143196

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27471

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DPT

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18By similarityAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000736819 – 201DermatopontinAdd BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei19Pyrrolidone carboxylic acidBy similarity1
Modified residuei23SulfotyrosineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi50 ↔ 77By similarity
Disulfide bondi90 ↔ 132Or C-90 with C-133By similarity
Disulfide bondi106 ↔ 133Or C-106 with C-132By similarity
Disulfide bondi139 ↔ 196By similarity
Disulfide bondi143 ↔ 189Sequence analysis
Modified residuei162SulfotyrosineSequence analysis1
Modified residuei164SulfotyrosineSequence analysis1
Modified residuei166SulfotyrosineSequence analysis1
Modified residuei167SulfotyrosineSequence analysis1
Modified residuei194SulfotyrosineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sulfated on tyrosine residue(s).By similarity

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid, Sulfation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q07507

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q07507

PeptideAtlas

More...
PeptideAtlasi
Q07507

PRoteomics IDEntifications database

More...
PRIDEi
Q07507

ProteomicsDB human proteome resource

More...
ProteomicsDBi
58518

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q07507

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q07507

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta. Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced by TGFB1, repressed by IL4/interleukin-4.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000143196 Expressed in 191 organ(s), highest expression level in tendon of biceps brachii

CleanEx database of gene expression profiles

More...
CleanExi
HS_DPT

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q07507 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA065548

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TGFB1, DCN and collagen.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108139, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q07507, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000356791

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q07507

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q07507

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati26 – 791-1Add BLAST54
Repeati70 – 752-16
Repeati80 – 1351-2Add BLAST56
Repeati125 – 1302-26
Repeati181 – 1863-36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni26 – 1862 X 53-55 AA tandem repeatsAdd BLAST161
Regioni70 – 1863 X 6 AA repeats of D-R-[EQ]-W-[NQK]-[FY]Add BLAST117

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dermatopontin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGCN Eukaryota
ENOG4111HSK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000010760

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000013186

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG005473

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q07507

Identification of Orthologs from Complete Genome Data

More...
OMAi
GFNFQCP

Database of Orthologous Groups

More...
OrthoDBi
1271391at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q07507

TreeFam database of animal gene trees

More...
TreeFami
TF328602

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026645 Dermatopontin_fam

The PANTHER Classification System

More...
PANTHERi
PTHR15040 PTHR15040, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14704 DERM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q07507-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLSLLWVLL PLVTMAWGQY GDYGYPYQQY HDYSDDGWVN LNRQGFSYQC
60 70 80 90 100
PQGQVIVAVR SIFSKKEGSD RQWNYACMPT PQSLGEPTEC WWEEINRAGM
110 120 130 140 150
EWYQTCSNNG LVAGFQSRYF ESVLDREWQF YCCRYSKRCP YSCWLTTEYP
160 170 180 190 200
GHYGEEMDMI SYNYDYYIRG ATTTFSAVER DRQWKFIMCR MTEYDCEFAN

V
Length:201
Mass (Da):24,005
Last modified:December 13, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC886D2FB624DDB49
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti10L → M in CAA80487 (PubMed:8104875).Curated1
Sequence conflicti147T → I in AAH33736 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048888201V → I. Corresponds to variant dbSNP:rs6698023Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z22865 mRNA Translation: CAA80487.1
AK292596 mRNA Translation: BAF85285.1
AL049798 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90830.1
BC033736 mRNA Translation: AAH33736.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1275.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A47220

NCBI Reference Sequences

More...
RefSeqi
NP_001928.2, NM_001937.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.80552

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000367817; ENSP00000356791; ENSG00000143196

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1805

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1805

UCSC genome browser

More...
UCSCi
uc001gfp.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22865 mRNA Translation: CAA80487.1
AK292596 mRNA Translation: BAF85285.1
AL049798 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90830.1
BC033736 mRNA Translation: AAH33736.1
CCDSiCCDS1275.1
PIRiA47220
RefSeqiNP_001928.2, NM_001937.4
UniGeneiHs.80552

3D structure databases

ProteinModelPortaliQ07507
SMRiQ07507
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108139, 1 interactor
IntActiQ07507, 3 interactors
STRINGi9606.ENSP00000356791

PTM databases

iPTMnetiQ07507
PhosphoSitePlusiQ07507

Polymorphism and mutation databases

BioMutaiDPT

Proteomic databases

jPOSTiQ07507
PaxDbiQ07507
PeptideAtlasiQ07507
PRIDEiQ07507
ProteomicsDBi58518

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1805
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367817; ENSP00000356791; ENSG00000143196
GeneIDi1805
KEGGihsa:1805
UCSCiuc001gfp.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1805
DisGeNETi1805
EuPathDBiHostDB:ENSG00000143196.4

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DPT
HGNCiHGNC:3011 DPT
HPAiHPA065548
MIMi125597 gene
neXtProtiNX_Q07507
OpenTargetsiENSG00000143196
PharmGKBiPA27471

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGCN Eukaryota
ENOG4111HSK LUCA
GeneTreeiENSGT00390000010760
HOGENOMiHOG000013186
HOVERGENiHBG005473
InParanoidiQ07507
OMAiGFNFQCP
OrthoDBi1271391at2759
PhylomeDBiQ07507
TreeFamiTF328602

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Dermatopontin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1805

Protein Ontology

More...
PROi
PR:Q07507

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000143196 Expressed in 191 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_DPT
GenevisibleiQ07507 HS

Family and domain databases

InterProiView protein in InterPro
IPR026645 Dermatopontin_fam
PANTHERiPTHR15040 PTHR15040, 1 hit
PfamiView protein in Pfam
PF14704 DERM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDERM_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q07507
Secondary accession number(s): A8K981, Q8N4R2, Q9UIX8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 13, 2002
Last modified: January 16, 2019
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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