DPT

Functionⁱ

Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity).By similarity

GO - Biological processⁱ

cell adhesion Source: UniProtKB-KW
collagen fibril organization Source: GO_Central
negative regulation of cell proliferation Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell adhesion

Biological process

Cell adhesion

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Dermatopontin Alternative name(s): Tyrosine-rich acidic matrix protein Short name: TRAMP
Gene namesⁱ	Name:DPT
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000143196.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3011 DPT
MIMⁱ	125597 gene
neXtProtⁱ	NX_Q07507

Keywords - Cellular componentⁱ

Extracellular matrix, Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1805
Open Targets More...OpenTargetsⁱ	ENSG00000143196
PharmGKBⁱ	PA27471

Polymorphism and mutation databases

BioMutaⁱ	DPT

BioMutaⁱ

DPT

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 18	By similarityAdd BLAST		18
ChainⁱPRO_0000007368	19 – 201	DermatopontinAdd BLAST		183

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	19	Pyrrolidone carboxylic acidBy similarity	1
Modified residueⁱ	23	SulfotyrosineSequence analysis	1
Disulfide bondⁱ	50 ↔ 77	By similarity
Disulfide bondⁱ	90 ↔ 132	Or C-90 with C-133By similarity
Disulfide bondⁱ	106 ↔ 133	Or C-106 with C-132By similarity
Disulfide bondⁱ	139 ↔ 196	By similarity
Disulfide bondⁱ	143 ↔ 189	Sequence analysis
Modified residueⁱ	162	SulfotyrosineSequence analysis	1
Modified residueⁱ	164	SulfotyrosineSequence analysis	1
Modified residueⁱ	166	SulfotyrosineSequence analysis	1
Modified residueⁱ	167	SulfotyrosineSequence analysis	1
Modified residueⁱ	194	SulfotyrosineSequence analysis	1

Post-translational modificationⁱ

Sulfated on tyrosine residue(s).By similarity

Keywords - PTMⁱ

Disulfide bond, Pyrrolidone carboxylic acid, Sulfation

Proteomic databases

PaxDbⁱ	Q07507
PeptideAtlas More...PeptideAtlasⁱ	Q07507
PRIDEⁱ	Q07507
ProteomicsDBⁱ	58518

PTM databases

iPTMnetⁱ	Q07507
PhosphoSitePlusⁱ	Q07507

Expressionⁱ

Tissue specificityⁱ

Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta. Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts.2 Publications

Inductionⁱ

Induced by TGFB1, repressed by IL4/interleukin-4.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000143196
CleanExⁱ	HS_DPT
Genevisibleⁱ	Q07507 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA065548

HPAⁱ

HPA065548

Interactionⁱ

Subunit structureⁱ

Interacts with TGFB1, DCN and collagen.By similarity

Protein-protein interaction databases

BioGridⁱ	108139, 1 interactor
IntActⁱ	Q07507, 3 interactors
STRINGⁱ	9606.ENSP00000356791

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q07507
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	26 – 79	1-1Add BLAST	54
Repeatⁱ	70 – 75	2-1	6
Repeatⁱ	80 – 135	1-2Add BLAST	56
Repeatⁱ	125 – 130	2-2	6
Repeatⁱ	181 – 186	3-3	6

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	26 – 186	2 X 53-55 AA tandem repeatsAdd BLAST		161
Regionⁱ	70 – 186	3 X 6 AA repeats of D-R-[EQ]-W-[NQK]-[FY]Add BLAST		117

Sequence similaritiesⁱ

Belongs to the dermatopontin family.Curated

Keywords - Domainⁱ

Repeat, Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IGCN Eukaryota ENOG4111HSK LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000010760
HOGENOMⁱ	HOG000013186
HOVERGENⁱ	HBG005473
InParanoidⁱ	Q07507
OMAⁱ	GFNFQCP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0L6V
PhylomeDBⁱ	Q07507
TreeFamⁱ	TF328602

Family and domain databases

InterProⁱ	View protein in InterPro IPR026645 Dermatopontin_fam
PANTHERⁱ	PTHR15040 PTHR15040, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q07507-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDLSLLWVLL PLVTMAWGQY GDYGYPYQQY HDYSDDGWVN LNRQGFSYQC 
        60         70         80         90        100
PQGQVIVAVR SIFSKKEGSD RQWNYACMPT PQSLGEPTEC WWEEINRAGM 
       110        120        130        140        150
EWYQTCSNNG LVAGFQSRYF ESVLDREWQF YCCRYSKRCP YSCWLTTEYP 
       160        170        180        190        200
GHYGEEMDMI SYNYDYYIRG ATTTFSAVER DRQWKFIMCR MTEYDCEFAN 

V

Length:201

Mass (Da):24,005

Last modified:December 13, 2002 - v2

Checksum:ⁱC886D2FB624DDB49

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	10	L → M in CAA80487 (PubMed:8104875).Curated		1
Sequence conflictⁱ	147	T → I in AAH33736 (PubMed:15489334).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_048888	201	V → I. Corresponds to variant dbSNP:rs6698023Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z22865 mRNA Translation: CAA80487.1 AK292596 mRNA Translation: BAF85285.1 AL049798 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW90830.1 BC033736 mRNA Translation: AAH33736.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1275.1
PIRⁱ	A47220
NCBI Reference Sequences More...RefSeqⁱ	NP_001928.2, NM_001937.4
UniGeneⁱ	Hs.80552

Genome annotation databases

Ensemblⁱ	ENST00000367817; ENSP00000356791; ENSG00000143196
GeneIDⁱ	1805
KEGGⁱ	hsa:1805
UCSC genome browser More...UCSCⁱ	uc001gfp.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q07507	DPT isoform 1		PANTR		201
DPT isoform 1		PONAB		201
Dermatopontin		PANPA		201
Dermatopontin		NOMLE		201
Dermatopontin		GORGO		201

Protein	Similar proteins		Species	Score	Length
Q07507	Dermatopontin		BOVIN		201
UPI000812C601		MANJA		226
UPI0004549710		CRIGR		211
UPI0004BD5465		EQUPR		210
Dermatopontin		FELCA		210
+98

Protein	Similar proteins		Species	Score	Length
Q07507	Dermatopontin		BOVIN		201
UPI000812C601		MANJA		226
UPI0004549710		CRIGR		211
Dermatopontin		FELCA		210
Dermatopontin (Fragment)		CANLF		148
+149

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z22865 mRNA Translation: CAA80487.1 AK292596 mRNA Translation: BAF85285.1 AL049798 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW90830.1 BC033736 mRNA Translation: AAH33736.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1275.1
PIRⁱ	A47220
NCBI Reference Sequences More...RefSeqⁱ	NP_001928.2, NM_001937.4
UniGeneⁱ	Hs.80552

3D structure databases

ProteinModelPortalⁱ	Q07507
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108139, 1 interactor
IntActⁱ	Q07507, 3 interactors
STRINGⁱ	9606.ENSP00000356791

PTM databases

iPTMnetⁱ	Q07507
PhosphoSitePlusⁱ	Q07507

Polymorphism and mutation databases

BioMutaⁱ	DPT

BioMutaⁱ

DPT

Proteomic databases

PaxDbⁱ	Q07507
PeptideAtlas More...PeptideAtlasⁱ	Q07507
PRIDEⁱ	Q07507
ProteomicsDBⁱ	58518

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1805
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000367817; ENSP00000356791; ENSG00000143196
GeneIDⁱ	1805
KEGGⁱ	hsa:1805
UCSC genome browser More...UCSCⁱ	uc001gfp.4 human

Organism-specific databases

CTDⁱ	1805
DisGeNET More...DisGeNETⁱ	1805
EuPathDBⁱ	HostDB:ENSG00000143196.4
GeneCardsⁱ	DPT
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3011 DPT
Human Protein Atlas More...HPAⁱ	HPA065548
MIMⁱ	125597 gene
neXtProtⁱ	NX_Q07507
Open Targets More...OpenTargetsⁱ	ENSG00000143196
PharmGKBⁱ	PA27471
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IGCN Eukaryota ENOG4111HSK LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000010760
HOGENOMⁱ	HOG000013186
HOVERGENⁱ	HBG005473
InParanoidⁱ	Q07507
OMAⁱ	GFNFQCP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0L6V
PhylomeDBⁱ	Q07507
TreeFamⁱ	TF328602

Miscellaneous databases

GeneWikiⁱ	Dermatopontin
GenomeRNAiⁱ	1805
Protein Ontology More...PROⁱ	PR:Q07507
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000143196
CleanExⁱ	HS_DPT
Genevisibleⁱ	Q07507 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR026645 Dermatopontin_fam
PANTHERⁱ	PTHR15040 PTHR15040, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DERM_HUMAN
Accessionⁱ	Q07507Primary (citable) accession number: Q07507 Secondary accession number(s): A8K981, Q8N4R2, Q9UIX8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	December 13, 2002
	Last modified:	June 20, 2018
	This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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UniRef

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UniProtKB - Q07507 (DERM_HUMAN)

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Dermatopontin

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

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Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ