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UniProtKB - Q07507 (DERM_HUMAN)
Protein
Dermatopontin
Gene
DPT
Organism
Homo sapiens (Human)
Status
Functioni
Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity).
By similarityGO - Molecular functioni
- extracellular matrix structural constituent Source: BHF-UCL
GO - Biological processi
- cell adhesion Source: UniProtKB-KW
- collagen fibril organization Source: GO_Central
- negative regulation of cell population proliferation Source: Ensembl
Keywordsi
Biological process | Cell adhesion |
Enzyme and pathway databases
PathwayCommonsi | Q07507 |
SignaLinki | Q07507 |
Names & Taxonomyi
Protein namesi | Recommended name: DermatopontinAlternative name(s): Tyrosine-rich acidic matrix protein Short name: TRAMP |
Gene namesi | Name:DPT |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3011, DPT |
MIMi | 125597, gene |
neXtProti | NX_Q07507 |
VEuPathDBi | HostDB:ENSG00000143196 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix By similarity
Extracellular region or secreted
- extracellular space Source: BHF-UCL
Other locations
- collagen-containing extracellular matrix Source: BHF-UCL
Keywords - Cellular componenti
Extracellular matrix, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 1805 |
OpenTargetsi | ENSG00000143196 |
PharmGKBi | PA27471 |
Miscellaneous databases
Pharosi | Q07507, Tbio |
Genetic variation databases
BioMutai | DPT |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | By similarityAdd BLAST | 18 | |
ChainiPRO_0000007368 | 19 – 201 | DermatopontinAdd BLAST | 183 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 19 | Pyrrolidone carboxylic acidBy similarity | 1 | |
Modified residuei | 23 | SulfotyrosineSequence analysis | 1 | |
Disulfide bondi | 50 ↔ 77 | By similarity | ||
Disulfide bondi | 90 ↔ 132 | Or C-90 with C-133By similarity | ||
Disulfide bondi | 106 ↔ 133 | Or C-106 with C-132By similarity | ||
Disulfide bondi | 139 ↔ 196 | By similarity | ||
Disulfide bondi | 143 ↔ 189 | Sequence analysis | ||
Modified residuei | 162 | SulfotyrosineSequence analysis | 1 | |
Modified residuei | 164 | SulfotyrosineSequence analysis | 1 | |
Modified residuei | 166 | SulfotyrosineSequence analysis | 1 | |
Modified residuei | 167 | SulfotyrosineSequence analysis | 1 | |
Modified residuei | 194 | SulfotyrosineSequence analysis | 1 |
Post-translational modificationi
Sulfated on tyrosine residue(s).By similarity
Keywords - PTMi
Disulfide bond, Pyrrolidone carboxylic acid, SulfationProteomic databases
jPOSTi | Q07507 |
MassIVEi | Q07507 |
PaxDbi | Q07507 |
PeptideAtlasi | Q07507 |
PRIDEi | Q07507 |
ProteomicsDBi | 58518 |
PTM databases
GlyGeni | Q07507, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q07507 |
PhosphoSitePlusi | Q07507 |
Expressioni
Tissue specificityi
Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta. Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts.2 Publications
Inductioni
Induced by TGFB1, repressed by IL4/interleukin-4.1 Publication
Gene expression databases
Bgeei | ENSG00000143196, Expressed in tendon of biceps brachii and 205 other tissues |
Genevisiblei | Q07507, HS |
Organism-specific databases
HPAi | ENSG00000143196, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with TGFB1, DCN and collagen.
By similarityBinary interactionsi
Q07507
With | #Exp. | IntAct |
---|---|---|
P28300 (PRO_0000018520) | 2 | EBI-719535,EBI-20724846 |
Protein-protein interaction databases
BioGRIDi | 108139, 1 interactor |
IntActi | Q07507, 4 interactors |
STRINGi | 9606.ENSP00000356791 |
Miscellaneous databases
RNActi | Q07507, protein |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 26 – 79 | 1-1Add BLAST | 54 | |
Repeati | 70 – 75 | 2-1 | 6 | |
Repeati | 80 – 135 | 1-2Add BLAST | 56 | |
Repeati | 125 – 130 | 2-2 | 6 | |
Repeati | 181 – 186 | 3-3 | 6 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 26 – 186 | 2 X 53-55 AA tandem repeatsAdd BLAST | 161 | |
Regioni | 70 – 186 | 3 X 6 AA repeats of D-R-[EQ]-W-[NQK]-[FY]Add BLAST | 117 |
Sequence similaritiesi
Belongs to the dermatopontin family.Curated
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502RTKC, Eukaryota |
GeneTreei | ENSGT00390000010760 |
HOGENOMi | CLU_122082_1_0_1 |
InParanoidi | Q07507 |
OMAi | QGFSFQC |
OrthoDBi | 1271391at2759 |
PhylomeDBi | Q07507 |
TreeFami | TF328602 |
Family and domain databases
InterProi | View protein in InterPro IPR026645, Dermatopontin_fam |
PANTHERi | PTHR15040, PTHR15040, 1 hit |
Pfami | View protein in Pfam PF14704, DERM, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q07507-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDLSLLWVLL PLVTMAWGQY GDYGYPYQQY HDYSDDGWVN LNRQGFSYQC
60 70 80 90 100
PQGQVIVAVR SIFSKKEGSD RQWNYACMPT PQSLGEPTEC WWEEINRAGM
110 120 130 140 150
EWYQTCSNNG LVAGFQSRYF ESVLDREWQF YCCRYSKRCP YSCWLTTEYP
160 170 180 190 200
GHYGEEMDMI SYNYDYYIRG ATTTFSAVER DRQWKFIMCR MTEYDCEFAN
V
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 10 | L → M in CAA80487 (PubMed:8104875).Curated | 1 | |
Sequence conflicti | 147 | T → I in AAH33736 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048888 | 201 | V → I. Corresponds to variant dbSNP:rs6698023EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z22865 mRNA Translation: CAA80487.1 AK292596 mRNA Translation: BAF85285.1 AL049798 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW90830.1 BC033736 mRNA Translation: AAH33736.1 |
CCDSi | CCDS1275.1 |
PIRi | A47220 |
RefSeqi | NP_001928.2, NM_001937.4 |
Genome annotation databases
Ensembli | ENST00000367817; ENSP00000356791; ENSG00000143196 |
GeneIDi | 1805 |
KEGGi | hsa:1805 |
MANE-Selecti | ENST00000367817.4; ENSP00000356791.3; NM_001937.5; NP_001928.2 |
UCSCi | uc001gfp.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z22865 mRNA Translation: CAA80487.1 AK292596 mRNA Translation: BAF85285.1 AL049798 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW90830.1 BC033736 mRNA Translation: AAH33736.1 |
CCDSi | CCDS1275.1 |
PIRi | A47220 |
RefSeqi | NP_001928.2, NM_001937.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 108139, 1 interactor |
IntActi | Q07507, 4 interactors |
STRINGi | 9606.ENSP00000356791 |
PTM databases
GlyGeni | Q07507, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q07507 |
PhosphoSitePlusi | Q07507 |
Genetic variation databases
BioMutai | DPT |
Proteomic databases
jPOSTi | Q07507 |
MassIVEi | Q07507 |
PaxDbi | Q07507 |
PeptideAtlasi | Q07507 |
PRIDEi | Q07507 |
ProteomicsDBi | 58518 |
Protocols and materials databases
Antibodypediai | 34354, 164 antibodies from 30 providers |
DNASUi | 1805 |
Genome annotation databases
Ensembli | ENST00000367817; ENSP00000356791; ENSG00000143196 |
GeneIDi | 1805 |
KEGGi | hsa:1805 |
MANE-Selecti | ENST00000367817.4; ENSP00000356791.3; NM_001937.5; NP_001928.2 |
UCSCi | uc001gfp.4, human |
Organism-specific databases
CTDi | 1805 |
DisGeNETi | 1805 |
GeneCardsi | DPT |
HGNCi | HGNC:3011, DPT |
HPAi | ENSG00000143196, Low tissue specificity |
MIMi | 125597, gene |
neXtProti | NX_Q07507 |
OpenTargetsi | ENSG00000143196 |
PharmGKBi | PA27471 |
VEuPathDBi | HostDB:ENSG00000143196 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RTKC, Eukaryota |
GeneTreei | ENSGT00390000010760 |
HOGENOMi | CLU_122082_1_0_1 |
InParanoidi | Q07507 |
OMAi | QGFSFQC |
OrthoDBi | 1271391at2759 |
PhylomeDBi | Q07507 |
TreeFami | TF328602 |
Enzyme and pathway databases
PathwayCommonsi | Q07507 |
SignaLinki | Q07507 |
Miscellaneous databases
BioGRID-ORCSi | 1805, 7 hits in 1034 CRISPR screens |
ChiTaRSi | DPT, human |
GeneWikii | Dermatopontin |
GenomeRNAii | 1805 |
Pharosi | Q07507, Tbio |
PROi | PR:Q07507 |
RNActi | Q07507, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000143196, Expressed in tendon of biceps brachii and 205 other tissues |
Genevisiblei | Q07507, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026645, Dermatopontin_fam |
PANTHERi | PTHR15040, PTHR15040, 1 hit |
Pfami | View protein in Pfam PF14704, DERM, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DERM_HUMAN | |
Accessioni | Q07507Primary (citable) accession number: Q07507 Secondary accession number(s): A8K981, Q8N4R2, Q9UIX8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | December 13, 2002 | |
Last modified: | February 23, 2022 | |
This is version 161 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families