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Protein

Ephrin type-B receptor 5

Gene

EPHB5

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for members of the ephrin-B family.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei669ATPPROSITE-ProRule annotation1
Active sitei762Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi643 – 651ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Receptor, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1 1306

Names & Taxonomyi

Protein namesi
Recommended name:
Ephrin type-B receptor 5 (EC:2.7.10.1)
Alternative name(s):
EPH-like kinase 9
Short name:
EK9
Short name:
cEK9
Gene namesi
Name:EPHB5
Synonyms:CEK9
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 564ExtracellularSequence analysisAdd BLAST535
Transmembranei565 – 585HelicalSequence analysisAdd BLAST21
Topological domaini586 – 1002CytoplasmicSequence analysisAdd BLAST417

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000001683630 – 1002Ephrin type-B receptor 5Add BLAST973

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi446N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ07497

PTM databases

iPTMnetiQ07497

Expressioni

Tissue specificityi

Most abundant in thymus and detectable in brain, retina, kidney, lung and heart. Not detected in skeletal muscle and liver.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000023737

Structurei

3D structure databases

ProteinModelPortaliQ07497
SMRiQ07497
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 213Eph LBDPROSITE-ProRule annotationAdd BLAST183
Domaini344 – 452Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST109
Domaini453 – 548Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini637 – 900Protein kinasePROSITE-ProRule annotationAdd BLAST264
Domaini929 – 993SAMPROSITE-ProRule annotationAdd BLAST65

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1000 – 1002PDZ-bindingSequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi195 – 338Cys-richAdd BLAST144
Compositional biasi862 – 865Poly-Pro4

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0196 Eukaryota
COG0515 LUCA
HOGENOMiHOG000233856
HOVERGENiHBG062180
InParanoidiQ07497
KOiK05114
PhylomeDBiQ07497

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.120.260, 1 hit
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR027936 Eph_TM
IPR001090 Ephrin_rcpt_lig-bd_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR008979 Galactose-bd-like_sf
IPR009030 Growth_fac_rcpt_cys_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016257 Tyr_kinase_ephrin_rcpt
IPR001426 Tyr_kinase_rcpt_V_CS
PfamiView protein in Pfam
PF14575 EphA2_TM, 1 hit
PF01404 Ephrin_lbd, 1 hit
PF07699 Ephrin_rec_like, 1 hit
PF00041 fn3, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PF07647 SAM_2, 1 hit
PIRSFiPIRSF000666 TyrPK_ephrin_receptor, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00615 EPH_lbd, 1 hit
SM01411 Ephrin_rec_like, 1 hit
SM00060 FN3, 2 hits
SM00454 SAM, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF49265 SSF49265, 1 hit
SSF49785 SSF49785, 1 hit
SSF56112 SSF56112, 1 hit
SSF57184 SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS01186 EGF_2, 1 hit
PS51550 EPH_LBD, 1 hit
PS50853 FN3, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00790 RECEPTOR_TYR_KIN_V_1, 1 hit
PS00791 RECEPTOR_TYR_KIN_V_2, 1 hit
PS50105 SAM_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07497-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSNADISAR RVSGMDWLWL VCFFHLVTSL EEILLDTTGE TSEIGWTSHP
60 70 80 90 100
PDGWEEVSVR DDKERQIRTF QVCNMDEPGQ NNWLRTHFIE RRGAHRVHVR
110 120 130 140 150
LHFSVRDCAS MRTVASTCKE TFTLYYHQSD VDIASQELPE WHEGPWTKVD
160 170 180 190 200
TIAADESFSQ VDRTGKVVRM NVKVRSFGPL TKHGFYLAFQ DSGACMSLVA
210 220 230 240 250
VQVFFYKCPA VVKGFASFPE TFAGGERTSL VESLGTCVAN AEEASTTGSS
260 270 280 290 300
GVRLHCNGEG EWMVATGRCS CKAGYQSVDN EQACQACPIG SFKASVGDDP
310 320 330 340 350
CLLCPAHSHA PLPLPGSIEC VCQSHYYRSA SDNSDAPCTG IPSAPRDLSY
360 370 380 390 400
EIVGSNVLLT WRLPKDLGGR KDVFFNVICK ECPTRSAGTC VRCGDNVQFE
410 420 430 440 450
PRQVGLTESR VQVSNLLARV QYTFEIQAVN LVTELSSEAP QYATINVSTS
460 470 480 490 500
QSVPSAIPMM HQVSRATSSI TLSWPQPDQP NGVILDYQLR YFDKAEDEDN
510 520 530 540 550
SFTLTSETNM ATILNLSPGK IYVFQVRART AVGYGPYSGK MYFQTLMAGE
560 570 580 590 600
HSEMAQDRLP LIVGSALGGL AFLVIAAIAI LAIIFKSKRR ETPYTDRLQQ
610 620 630 640 650
YISTRGLGVK YYIDPSTYED PNEAIREFAK EIDVSFIKIE EVIGSGEFGE
660 670 680 690 700
VCFGRLKHPG KREYTVAIKT LKSGYTDEQR REFLSEASIM GQFEHPNVIH
710 720 730 740 750
LEGVVTKSRP VMIVTEFMEN GSLDSFLRQK EGQFSVLQLV GMLRGIAAGM
760 770 780 790 800
RYLSDMNYVH RDLAARNILV NSNLVCKVSD FGLSRFLEDD ASNPTYTGAL
810 820 830 840 850
GCKIPIRWTA PEAVQYRKFT SSSDVWSYGI VMWEVMSYGE RPYWDMSNQD
860 870 880 890 900
VINAIDQDYR LPPPPDCPTV LHLLMLDCWQ KDRVQRPKFE QIVSALDKMI
910 920 930 940 950
RKPSALKATG TGSSRPSQPL LSNSPPDFPS LSNAHEWLDA IKMGRYKENF
960 970 980 990 1000
DQAGLITFDV ISRMTLEDLQ RIGITLVGHQ KKILNSIQLM KVHLNQLEPV

EV
Length:1,002
Mass (Da):111,947
Last modified:November 1, 1996 - v1
Checksum:i6D9635B500D8B0DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23783 mRNA Translation: AAB41054.1
PIRiS33506
RefSeqiNP_001004387.1, NM_001004387.1
UniGeneiGga.633

Genome annotation databases

GeneIDi418308
KEGGigga:418308

Similar proteinsi

Entry informationi

Entry nameiEPHB5_CHICK
AccessioniPrimary (citable) accession number: Q07497
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: February 28, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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