Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 163 (29 Sep 2021)
Sequence version 3 (21 Jun 2005)
Previous versions | rss
Add a publicationFeedback
Protein

Protein expanded

Gene

ex

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Activates the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:8269855, PubMed:20159598, PubMed:27462444, PubMed:26954546).

The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Ex acts synergistically along with Mer and Kibra to regulate the Hippo signaling pathway (PubMed:20159598).

Involved in the control of cell proliferation in imaginal disks (PubMed:8269855, PubMed:27462444).

May bind to certain proteins of signal transduction pathways by interaction with their SH3 domains (PubMed:20159598).

Required for apical localization of Schip1 (PubMed:26954546).

4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-451806, Phosphorylation-independent inhibition of YKI

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein expanded
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ex
ORF Names:CG4114
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0004583, ex

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0004583

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Hyperplasia of the imaginal disk resulting in wing overgrowth (PubMed:8269855). This overgrowth is limited to specific regions along the 2 wing axes (PubMed:8269855). Defects also in eyes, head, thorax and limbs where duplication and bulging often occur (PubMed:8269855). RNAi-mediated knockdown reduces the amount of Schip1 in the apical region of the cell.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi227Y → A: Inhibits wing growth. Reduces phosphorylation by Ack; when associated with A-423, A-679, A-766 and A-1103. 1 Publication1
Mutagenesisi423Y → A: Inhibits wing growth. Reduces phosphorylation by Ack; when associated with A-227, A-679, A-766 and A-1103. 1 Publication1
Mutagenesisi679Y → A: Inhibits wing growth. Reduces phosphorylation by Ack; when associated with A-227, A-423, A-766 and A-1103. 1 Publication1
Mutagenesisi766Y → A: Inhibits wing growth. Reduces phosphorylation by Ack; when associated with A-227, A-423, A-679, and A-1103. 1 Publication1
Mutagenesisi1103Y → A: Inhibits wing growth. Reduces phosphorylation by Ack; when associated with A-227, A-423, A-679 and A-766. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002194431 – 1427Protein expandedAdd BLAST1427

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei227Phosphotyrosine1 Publication1
Modified residuei423Phosphotyrosine1 Publication1
Modified residuei679Phosphotyrosine1 Publication1
Modified residuei766Phosphotyrosine1 Publication1
Modified residuei1103Phosphotyrosine1 Publication1
Modified residuei1181Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by Ack at several tyrosines including Tyr-227, Tyr-423, Tyr-679, Tyr-766 and Tyr-1103.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q07436

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q07436

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected in wing disks (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0004583, Expressed in imaginal disc and 23 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q07436, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q07436, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a complex with Kibra and Mer (PubMed:20159598).

Interacts (via RXPPXY motif) with Kibra (via domain WW 1) (PubMed:20159598).

Interacts with Mer and Hpo (via SARAH domain) (PubMed:20159598).

Interacts with Schip1; the interaction results in recruitment of Schip1 to the apical cell membrane (PubMed:26954546).

Interacts with ack and yki (PubMed:27462444).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
59474, 44 interactors

Database of interacting proteins

More...
DIPi
DIP-59337N

Protein interaction database and analysis system

More...
IntActi
Q07436, 1 interactor

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0077719

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q07436

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 399FERMPROSITE-ProRule annotationAdd BLAST374

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni176 – 212DisorderedSequence analysisAdd BLAST37
Regioni520 – 566DisorderedSequence analysisAdd BLAST47
Regioni611 – 656DisorderedSequence analysisAdd BLAST46
Regioni688 – 732DisorderedSequence analysisAdd BLAST45
Regioni766 – 792DisorderedSequence analysisAdd BLAST27
Regioni815 – 880DisorderedSequence analysisAdd BLAST66
Regioni939 – 963DisorderedSequence analysisAdd BLAST25
Regioni1000 – 1022DisorderedSequence analysisAdd BLAST23
Regioni1190 – 1267DisorderedSequence analysisAdd BLAST78
Regioni1345 – 1398DisorderedSequence analysisAdd BLAST54

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi842 – 847RXPPXY motif6
Motifi1008 – 1020SH3-bindingSequence analysisAdd BLAST13
Motifi1149 – 1157SH3-bindingSequence analysis9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi178 – 212Polar residuesSequence analysisAdd BLAST35
Compositional biasi611 – 638Polar residuesSequence analysisAdd BLAST28
Compositional biasi689 – 710Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi711 – 732Polar residuesSequence analysisAdd BLAST22
Compositional biasi815 – 851Pro residuesSequence analysisAdd BLAST37
Compositional biasi852 – 880Polar residuesSequence analysisAdd BLAST29
Compositional biasi1000 – 1021Pro residuesSequence analysisAdd BLAST22
Compositional biasi1195 – 1247Pro residuesSequence analysisAdd BLAST53
Compositional biasi1249 – 1263Polar residuesSequence analysisAdd BLAST15
Compositional biasi1345 – 1379Polar residuesSequence analysisAdd BLAST35

Keywords - Domaini

SH3-binding

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4371, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162787

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003533_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q07436

Identification of Orthologs from Complete Genome Data

More...
OMAi
LIDGEYM

Database of Orthologous Groups

More...
OrthoDBi
339620at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q07436

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14473, FERM_B-lobe, 1 hit
cd13185, FERM_C_FRMD1_FRMD6, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019749, Band_41_domain
IPR035963, FERM_2
IPR019748, FERM_central
IPR000299, FERM_domain
IPR018980, FERM_PH-like_C
IPR041781, FRMD6-FERM_C
IPR011993, PH-like_dom_sf
IPR029071, Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09380, FERM_C, 1 hit
PF00373, FERM_M, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00295, B41, 1 hit
SM01196, FERM_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47031, SSF47031, 1 hit
SSF54236, SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50057, FERM_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q07436-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRAFCTVSAP LEVCASSAEQ LSPGSRFLAL RLLGQQQPKT LYFLVDAKSR
60 70 80 90 100
VREVYTQTCL HFATQGMLDT ELFGLAVLID GEYMFADPES KLSKYGPKSW
110 120 130 140 150
RSSHTHGLDA NGRPLLELHF RVQFYIESPF MLKDETSRHN YYLQLRHNIL
160 170 180 190 200
QRDLPREQAE QALVFLAGLA LQADLGDAPP GTSNSKDDSG EETSASPSNG
210 220 230 240 250
GRGLSATTTL PKISKRANER MLRLSTYVAS TSKRETIPLP PSLPPNGADY
260 270 280 290 300
YRIEDYLPSG LHTPWARSAM RACHREHLGM ATAEAELLYI QQACSLHETI
310 320 330 340 350
NAHTYRMRLA KSEQGSGSAW FVVYAKGIKI LGGESTNSSS NPETTTFLWP
360 370 380 390 400
NITKLSFERK KFEIRSGESR ITLYAASDEK NKLLLTLCKD THQWSMKLAA
410 420 430 440 450
RLKEVSKREE EEAAESQRLH ASYACSRSLL LPYKSKNEQR ISVISSTSSN
460 470 480 490 500
TTSGIVSDRV HSEDELEIMI NTPPAPLAAP STESLALAHL LDRPSVSRQT
510 520 530 540 550
SSVGQMSLKD LEEQLAALSV RPQDASSNGA TIVTNSSVQR NSMGTTANDS
560 570 580 590 600
STATDSPSSQ HNIGSQCSST CSTVVVTSPV NGAGASSSGA PIPVHSTSSS
610 620 630 640 650
LELGFSHTAQ NSALSETSPD DFLSTSAREE TESVSGASGV YTLAHGAPPT
660 670 680 690 700
ETSGVYTMHS SELTGQSSEI AESEKSSHYG MFQPQKLEET HVQHSDSVDG
710 720 730 740 750
KKKEDFRPRS DSNVSTGSSF RGDGSDPTDN KHSLLSAEEL TNLIVGRGTY
760 770 780 790 800
PSRKTVSSSL HSDCDYVTLP LGDQGEEEVD QPPAPPPPYS ARHEKTGLCG
810 820 830 840 850
PPIAKPIPKP IAVVAPKPDS PPCSPPVPPA PIPAPPPAIR RRDPPPYSIS
860 870 880 890 900
SKPRPTSLIS VSSSAHPAPS AAGSMSSLKS EEVTARFITT RPQISILKAH
910 920 930 940 950
TSLIPDGAKP SYAAPHHCSS VASSNGSVCS HQLSQQSLHN SNYAGGSQAS
960 970 980 990 1000
LHHHHVPSHH RHSGSAAIGI VPYGLHKSTA SLHHQQSCVL LPVIKPRQFL
1010 1020 1030 1040 1050
APPPPSLPRQ PPPPPPPNHP HLASHLYERE MARKQLELYQ QQLYSDVDYV
1060 1070 1080 1090 1100
IYPIQDPAVS QQEYLDAKQG SLLAAMAQAA PPPPHHPYLA MQVSPAIYRS
1110 1120 1130 1140 1150
TPYLPLTLST HSRYASTQNL SDTYVQLPGP GYSPLYSPSM ASLCSSYEPP
1160 1170 1180 1190 1200
PPPPLHPAAL AAAAAAGAGS SSSSMFARSR SDDNILNSLD LLPKGKRLPP
1210 1220 1230 1240 1250
PPPPPYVNRR LKKPPMPAPS EKPPPIPSKP IPSRMSPIPP RKPPTLNPHH
1260 1270 1280 1290 1300
ANSPLTKTSS GAQWAGERPR PDLGLGLGLN RGNNSILAQL QASMVAQSHA
1310 1320 1330 1340 1350
QAQAQALDIA LLREKSKHLD LPLISALCND RSLLKQTKVV INPKTGQEMP
1360 1370 1380 1390 1400
TSSAQPSGAT TNGVANSSAG AGTLSKARKG STVSHRHPQD KLPPLPVQQL
1410 1420
AEANNYVIDP AVMMKQQQQQ QQHNKTS
Length:1,427
Mass (Da):153,644
Last modified:June 21, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3CC1AD0B4D900EB2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PC08M9PC08_DROME
Expanded, isoform B
ex 1270, brl, Dmel\CG4114, EX, Ex
1,427Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti160 – 161EQ → DE in AAB39774 (PubMed:8269855).Curated2
Sequence conflicti194S → L in AAB39774 (PubMed:8269855).Curated1
Sequence conflicti347F → S in AAB39774 (PubMed:8269855).Curated1
Sequence conflicti563I → T in AAB39774 (PubMed:8269855).Curated1
Sequence conflicti671A → D in AAB39774 (PubMed:8269855).Curated1
Sequence conflicti693Q → S in AAB39774 (PubMed:8269855).Curated1
Sequence conflicti1293 – 1294SM → FN in AAB39774 (PubMed:8269855).Curated2
Sequence conflicti1422Q → QQQ in AAB39774 (PubMed:8269855).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L14768 mRNA Translation: AAB39774.1
AE014134 Genomic DNA Translation: AAF51495.1
AY069068 mRNA Translation: AAL39213.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T13720

NCBI Reference Sequences

More...
RefSeqi
NP_001259823.1, NM_001272894.1
NP_476840.2, NM_057492.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0078059; FBpp0077719; FBgn0004583
FBtr0329832; FBpp0302878; FBgn0004583

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
33218

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG4114

UCSC genome browser

More...
UCSCi
CG4114-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14768 mRNA Translation: AAB39774.1
AE014134 Genomic DNA Translation: AAF51495.1
AY069068 mRNA Translation: AAL39213.1
PIRiT13720
RefSeqiNP_001259823.1, NM_001272894.1
NP_476840.2, NM_057492.4

3D structure databases

SMRiQ07436
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi59474, 44 interactors
DIPiDIP-59337N
IntActiQ07436, 1 interactor
STRINGi7227.FBpp0077719

PTM databases

iPTMnetiQ07436

Proteomic databases

PaxDbiQ07436

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
33218

Genome annotation databases

EnsemblMetazoaiFBtr0078059; FBpp0077719; FBgn0004583
FBtr0329832; FBpp0302878; FBgn0004583
GeneIDi33218
KEGGidme:Dmel_CG4114
UCSCiCG4114-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
110023
FlyBaseiFBgn0004583, ex
VEuPathDBiVectorBase:FBgn0004583

Phylogenomic databases

eggNOGiKOG4371, Eukaryota
GeneTreeiENSGT00940000162787
HOGENOMiCLU_003533_0_0_1
InParanoidiQ07436
OMAiLIDGEYM
OrthoDBi339620at2759
PhylomeDBiQ07436

Enzyme and pathway databases

ReactomeiR-DME-451806, Phosphorylation-independent inhibition of YKI

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
33218, 0 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ex, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
33218

Protein Ontology

More...
PROi
PR:Q07436

Gene expression databases

BgeeiFBgn0004583, Expressed in imaginal disc and 23 other tissues
ExpressionAtlasiQ07436, baseline and differential
GenevisibleiQ07436, DM

Family and domain databases

CDDicd14473, FERM_B-lobe, 1 hit
cd13185, FERM_C_FRMD1_FRMD6, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR019749, Band_41_domain
IPR035963, FERM_2
IPR019748, FERM_central
IPR000299, FERM_domain
IPR018980, FERM_PH-like_C
IPR041781, FRMD6-FERM_C
IPR011993, PH-like_dom_sf
IPR029071, Ubiquitin-like_domsf
PfamiView protein in Pfam
PF09380, FERM_C, 1 hit
PF00373, FERM_M, 1 hit
SMARTiView protein in SMART
SM00295, B41, 1 hit
SM01196, FERM_C, 1 hit
SUPFAMiSSF47031, SSF47031, 1 hit
SSF54236, SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50057, FERM_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEXPA_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q07436
Secondary accession number(s): Q9VPQ0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 21, 2005
Last modified: September 29, 2021
This is version 163 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again