Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Triosephosphate isomerase

Gene

TPI

Organism
Plasmodium falciparum
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glyceraldehyde 3-phosphate = glycerone phosphate.

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Triosephosphate isomerase (TPI), Triosephosphate isomerase (PocGH01_08029700), Triosephosphate isomerase (TIM)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei10Substrate1
Binding sitei12Substrate1
Active sitei95Electrophile1
Active sitei165Proton acceptor1

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • triose-phosphate isomerase activity Source: CACAO

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

BRENDAi5.3.1.1 4889
SABIO-RKiQ07412
UniPathwayi
UPA00109;UER00189

UPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Triosephosphate isomerase (EC:5.3.1.1)
Short name:
TIM
Alternative name(s):
Triose-phosphate isomerase
Gene namesi
Name:TPI
OrganismiPlasmodium falciparum
Taxonomic identifieri5833 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)

Pathology & Biotechi

Chemistry databases

DrugBankiDB01709 2-Phosphoglyceric Acid
DB02726 2-Phosphoglycolic Acid
DB02951 3-Hydroxypyruvic Acid
DB04510 3-Phosphoglyceric Acid
DB02515 3-Phosphoglycerol
DB01779 Glycerol-2-Phosphate

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000901381 – 248Triosephosphate isomeraseAdd BLAST248

Interactioni

Subunit structurei

Homodimer.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself5EBI-7086711,EBI-7086711

GO - Molecular functioni

Protein-protein interaction databases

MINTiQ07412

Structurei

Secondary structure

1248
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00614
ProteinModelPortaliQ07412
SMRiQ07412
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ07412

Family & Domainsi

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.Curated

Phylogenomic databases

eggNOGiKOG1643 Eukaryota
COG0149 LUCA

Family and domain databases

CDDicd00311 TIM, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00147_B TIM_B, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR035990 TIM_sf
IPR022896 TrioseP_Isoase_bac/euk
IPR000652 Triosephosphate_isomerase
IPR020861 Triosephosphate_isomerase_AS
PANTHERiPTHR21139 PTHR21139, 1 hit
PfamiView protein in Pfam
PF00121 TIM, 1 hit
SUPFAMiSSF51351 SSF51351, 1 hit
TIGRFAMsiTIGR00419 tim, 1 hit
PROSITEiView protein in PROSITE
PS00171 TIM_1, 1 hit
PS51440 TIM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q07412-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARKYFVAAN WKCNGTLESI KSLTNSFNNL DFDPSKLDVV VFPVSVHYDH
60 70 80 90 100
TRKLLQSKFS TGIQNVSKFG NGSYTGEVSA EIAKDLNIEY VIIGHFERRK
110 120 130 140 150
YFHETDEDVR EKLQASLKNN LKAVVCFGES LEQREQNKTI EVITKQVKAF
160 170 180 190 200
VDLIDNFDNV ILAYEPLWAI GTGKTATPEQ AQLVHKEIRK IVKDTCGEKQ
210 220 230 240
ANQIRILYGG SVNTENCSSL IQQEDIDGFL VGNASLKESF VDIIKSAM
Length:248
Mass (Da):27,935
Last modified:October 1, 1994 - v1
Checksum:iEFC8A4373EA9BED1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01654 mRNA Translation: AAA18799.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01654 mRNA Translation: AAA18799.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LYXX-ray1.90A1-248[»]
1LZOX-ray2.80A/B/C/D1-248[»]
1M7OX-ray2.40A/B1-248[»]
1M7PX-ray2.40A/B1-248[»]
1O5XX-ray1.10A/B1-248[»]
1VGAX-ray1.80A/B/C/D1-248[»]
1WOAX-ray2.80A/B/C/D1-248[»]
1WOBX-ray2.80A/B/C/D1-248[»]
1YDVX-ray2.20A/B1-248[»]
2FI6model-A1-248[»]
2VFDX-ray1.40A/B1-248[»]
2VFEX-ray2.20A/B1-248[»]
2VFFX-ray1.70A/B1-248[»]
2VFGX-ray1.95A/B/C/D1-248[»]
2VFHX-ray2.00A/B1-248[»]
2VFIX-ray2.25A/B1-248[»]
3PSVX-ray2.00A/B1-248[»]
3PSWX-ray1.99A/B1-248[»]
3PVFX-ray1.73A1-248[»]
3PWAX-ray2.04A/B1-248[»]
3PY2X-ray1.93A/B1-248[»]
4YWIX-ray1.85A/B1-248[»]
4YXGX-ray1.90A/B1-248[»]
4Z0JX-ray2.07A/B1-248[»]
4Z0SX-ray2.39A/B1-248[»]
4ZZ9X-ray1.81A/B1-248[»]
5BMWX-ray1.86A/B1-248[»]
5BMXX-ray1.80A/B/C/D1-248[»]
5BNKX-ray1.80A/B1-248[»]
5BRBX-ray2.53A/B1-248[»]
5GV4X-ray2.09A1-248[»]
5GZPX-ray2.03A/B1-248[»]
DisProtiDP00614
ProteinModelPortaliQ07412
SMRiQ07412
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiQ07412

Chemistry databases

DrugBankiDB01709 2-Phosphoglyceric Acid
DB02726 2-Phosphoglycolic Acid
DB02951 3-Hydroxypyruvic Acid
DB04510 3-Phosphoglyceric Acid
DB02515 3-Phosphoglycerol
DB01779 Glycerol-2-Phosphate

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1643 Eukaryota
COG0149 LUCA

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00189

UPA00138

BRENDAi5.3.1.1 4889
SABIO-RKiQ07412

Miscellaneous databases

EvolutionaryTraceiQ07412

Family and domain databases

CDDicd00311 TIM, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00147_B TIM_B, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR035990 TIM_sf
IPR022896 TrioseP_Isoase_bac/euk
IPR000652 Triosephosphate_isomerase
IPR020861 Triosephosphate_isomerase_AS
PANTHERiPTHR21139 PTHR21139, 1 hit
PfamiView protein in Pfam
PF00121 TIM, 1 hit
SUPFAMiSSF51351 SSF51351, 1 hit
TIGRFAMsiTIGR00419 tim, 1 hit
PROSITEiView protein in PROSITE
PS00171 TIM_1, 1 hit
PS51440 TIM_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTPIS_PLAFA
AccessioniPrimary (citable) accession number: Q07412
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: April 25, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again