UniProtKB - Q07409 (CNTN3_MOUSE)
Protein
Contactin-3
Gene
Cntn3
Organism
Mus musculus (Mouse)
Status
Functioni
Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity (By similarity).By similarity
GO - Biological processi
- cell adhesion Source: UniProtKB-KW
- nervous system development Source: MGI
Keywordsi
Biological process | Cell adhesion |
Enzyme and pathway databases
Reactomei | R-MMU-163125, Post-translational modification: synthesis of GPI-anchored proteins |
Names & Taxonomyi
Protein namesi | Recommended name: Contactin-3Alternative name(s): Brain-derived immunoglobulin superfamily protein 1 Short name: BIG-1 Plasmacytoma-associated neuronal glycoprotein |
Gene namesi | Name:Cntn3 Synonyms:Pang, Pcs |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:99534, Cntn3 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; GPI-anchor By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- anchored component of membrane Source: UniProtKB-KW
- neuron projection Source: GO_Central
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000014707 | 20 – 1002 | Contactin-3Add BLAST | 983 | |
PropeptideiPRO_0000014708 | 1003 – 1028 | Removed in mature formSequence analysisAdd BLAST | 26 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 50 ↔ 100 | PROSITE-ProRule annotation | ||
Glycosylationi | 65 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 144 ↔ 196 | PROSITE-ProRule annotation | ||
Glycosylationi | 193 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 249 ↔ 297 | PROSITE-ProRule annotation | ||
Disulfide bondi | 339 ↔ 386 | PROSITE-ProRule annotation | ||
Glycosylationi | 377 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 431 ↔ 479 | PROSITE-ProRule annotation | ||
Glycosylationi | 468 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 489 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 521 ↔ 577 | PROSITE-ProRule annotation | ||
Glycosylationi | 765 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 860 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 895 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 913 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 931 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 956 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 1002 | GPI-anchor amidated serineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, GPI-anchor, LipoproteinProteomic databases
PaxDbi | Q07409 |
PeptideAtlasi | Q07409 |
PRIDEi | Q07409 |
PTM databases
GlyConnecti | 2226, 4 N-Linked glycans (3 sites) |
GlyGeni | Q07409, 11 sites |
PhosphoSitePlusi | Q07409 |
Expressioni
Tissue specificityi
Specifically expressed in brain. Ectopically expressed in tumors expressing endogenous intracisternal A-type particles (IAPs).1 Publication
Gene expression databases
Bgeei | ENSMUSG00000030075, Expressed in epithelium of cochlear duct and 175 other tissues |
Genevisiblei | Q07409, MM |
Interactioni
Subunit structurei
Interacts with PTPRG.
1 PublicationProtein-protein interaction databases
BioGRIDi | 202024, 1 interactor |
STRINGi | 10090.ENSMUSP00000032159 |
Miscellaneous databases
RNActi | Q07409, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q07409 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 117 | Ig-like C2-type 1Add BLAST | 86 | |
Domaini | 122 – 209 | Ig-like C2-type 2Add BLAST | 88 | |
Domaini | 227 – 313 | Ig-like C2-type 3Add BLAST | 87 | |
Domaini | 318 – 402 | Ig-like C2-type 4Add BLAST | 85 | |
Domaini | 408 – 497 | Ig-like C2-type 5Add BLAST | 90 | |
Domaini | 499 – 593 | Ig-like C2-type 6Add BLAST | 95 | |
Domaini | 600 – 698 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 99 | |
Domaini | 703 – 800 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 98 | |
Domaini | 805 – 901 | Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST | 97 | |
Domaini | 902 – 998 | Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST | 97 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, SignalPhylogenomic databases
eggNOGi | KOG3513, Eukaryota |
GeneTreei | ENSGT00940000160282 |
HOGENOMi | CLU_005756_0_0_1 |
InParanoidi | Q07409 |
OMAi | DISFTWY |
OrthoDBi | 655902at2759 |
TreeFami | TF351103 |
Family and domain databases
CDDi | cd00063, FN3, 4 hits |
Gene3Di | 2.60.40.10, 10 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 |
Pfami | View protein in Pfam PF00041, fn3, 3 hits PF07679, I-set, 2 hits |
SMARTi | View protein in SMART SM00060, FN3, 4 hits SM00409, IG, 6 hits SM00408, IGc2, 6 hits |
SUPFAMi | SSF48726, SSF48726, 6 hits SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 4 hits PS50835, IG_LIKE, 6 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q07409-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMLSWKQLIL LSFIGCLAGE LLLQGPVFIK EPSNSIFPVD SEDKKITLNC
60 70 80 90 100
EARGNPSPHY RWQLNGSDID TSLDHRYKLN GGNLIVINPN RNWDTGSYQC
110 120 130 140 150
FATNSLGTIV SREAKLQFAY LENFKTRMRS TVSVREGQGV VLLCGPPPHS
160 170 180 190 200
GELSYAWVFN EYPSFVEEDS RRFVSQETGH LYIAKVEPSD VGNYTCVVTS
210 220 230 240 250
TVTNTRVLGS PTPLVLRSDG VMGEYEPKIE VQFPETLPAA KGSTVRLECF
260 270 280 290 300
ALGNPVPQIN WRRSDGMPFP NKIKLRKFNG MLEIQNFQQE DTGSYECIAE
310 320 330 340 350
NSRGKNVARG RLTYYAKPYW LQLLRDVEIA VEDSLYWECR ASGKPKPSYR
360 370 380 390 400
WLKNGDALVL EERIQIENGA LTITNLNVTD SGMFQCIAEN KHGLIYSSAE
410 420 430 440 450
LKVVASAPDF SRNPMKKMVQ VQVGSLVILD CKPRASPRAL SFWKKGDMMV
460 470 480 490 500
REQARVSFLN DGGLKIMNVT KADAGTYTCT AENQFGKANG TTHLVVTEPT
510 520 530 540 550
RIILAPSNMD VAVGESVILP CQVQHDPLLD IMFAWYFNGA LTDFKKDGSH
560 570 580 590 600
FEKVGGSSSG DLMIRNIQLK HSGKYVCMVQ TGVDSVSSAA ELIVRGSPGP
610 620 630 640 650
PENVKVDEIT DTTAQLSWTE GTDSHSPVIS YAVQARTPFS VGWQSVRTVP
660 670 680 690 700
EVIDGKTHTA TVVELNPWVE YEFRIVASNK IGGGEPSLPS EKVRTEEAAP
710 720 730 740 750
EIAPSEVSGG GGSRSELVIT WDPVPEELQN GGGFGYVVAF RPLGVTTWIQ
760 770 780 790 800
TVVTSPDNPR YVFRNESIVP FSPYEVKVGV YNNKGEGPFS PVTTVFSAEE
810 820 830 840 850
EPTVAPSHIS AHSLSSSEIE VSWNTIPWKL SNGHLLGYEV RYWNNGGEEE
860 870 880 890 900
SSRKVKVAGN QTSAVLRGLK SNLAYYTAVR AYNSAGAGPF SATVNATTKK
910 920 930 940 950
TPPSQPPGNV VWNATDTKVL LNWEQVKAME NESEVTGYKV FYRTSSQNNV
960 970 980 990 1000
HVLNTNKTSA ELLLPIKEDY IIEVKATTDG GDGTSSEQIR IPRITSMDAR
1010 1020
GSTSAISNIH PLSGYMSVLL FFIVNALW
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 173 | F → L in AAA17403 (PubMed:8108413).Curated | 1 | |
Sequence conflicti | 297 | C → G in AAA17403 (PubMed:8108413).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L01991 mRNA Translation: AAA17403.1 AC114423 Genomic DNA No translation available. AC153597 Genomic DNA No translation available. AC153600 Genomic DNA No translation available. AC155328 Genomic DNA No translation available. CH466523 Genomic DNA Translation: EDK99385.1 |
CCDSi | CCDS39581.1 |
PIRi | A53449 |
RefSeqi | NP_032805.2, NM_008779.2 XP_006505788.1, XM_006505725.3 XP_006505790.1, XM_006505727.3 XP_006505791.1, XM_006505728.3 XP_017176937.1, XM_017321448.1 |
Genome annotation databases
Ensembli | ENSMUST00000032159; ENSMUSP00000032159; ENSMUSG00000030075 ENSMUST00000203619; ENSMUSP00000145176; ENSMUSG00000030075 |
GeneIDi | 18488 |
KEGGi | mmu:18488 |
UCSCi | uc009dch.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L01991 mRNA Translation: AAA17403.1 AC114423 Genomic DNA No translation available. AC153597 Genomic DNA No translation available. AC153600 Genomic DNA No translation available. AC155328 Genomic DNA No translation available. CH466523 Genomic DNA Translation: EDK99385.1 |
CCDSi | CCDS39581.1 |
PIRi | A53449 |
RefSeqi | NP_032805.2, NM_008779.2 XP_006505788.1, XM_006505725.3 XP_006505790.1, XM_006505727.3 XP_006505791.1, XM_006505728.3 XP_017176937.1, XM_017321448.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5E4Q | X-ray | 2.82 | A | 604-900 | [»] | |
5E5R | X-ray | 2.60 | B/D | 124-316 | [»] | |
5I99 | X-ray | 2.40 | A | 406-801 | [»] | |
SMRi | Q07409 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 202024, 1 interactor |
STRINGi | 10090.ENSMUSP00000032159 |
PTM databases
GlyConnecti | 2226, 4 N-Linked glycans (3 sites) |
GlyGeni | Q07409, 11 sites |
PhosphoSitePlusi | Q07409 |
Proteomic databases
PaxDbi | Q07409 |
PeptideAtlasi | Q07409 |
PRIDEi | Q07409 |
Protocols and materials databases
Antibodypediai | 1216, 161 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000032159; ENSMUSP00000032159; ENSMUSG00000030075 ENSMUST00000203619; ENSMUSP00000145176; ENSMUSG00000030075 |
GeneIDi | 18488 |
KEGGi | mmu:18488 |
UCSCi | uc009dch.1, mouse |
Organism-specific databases
CTDi | 5067 |
MGIi | MGI:99534, Cntn3 |
Phylogenomic databases
eggNOGi | KOG3513, Eukaryota |
GeneTreei | ENSGT00940000160282 |
HOGENOMi | CLU_005756_0_0_1 |
InParanoidi | Q07409 |
OMAi | DISFTWY |
OrthoDBi | 655902at2759 |
TreeFami | TF351103 |
Enzyme and pathway databases
Reactomei | R-MMU-163125, Post-translational modification: synthesis of GPI-anchored proteins |
Miscellaneous databases
BioGRID-ORCSi | 18488, 1 hit in 17 CRISPR screens |
ChiTaRSi | Cntn3, mouse |
PROi | PR:Q07409 |
RNActi | Q07409, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030075, Expressed in epithelium of cochlear duct and 175 other tissues |
Genevisiblei | Q07409, MM |
Family and domain databases
CDDi | cd00063, FN3, 4 hits |
Gene3Di | 2.60.40.10, 10 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 |
Pfami | View protein in Pfam PF00041, fn3, 3 hits PF07679, I-set, 2 hits |
SMARTi | View protein in SMART SM00060, FN3, 4 hits SM00409, IG, 6 hits SM00408, IGc2, 6 hits |
SUPFAMi | SSF48726, SSF48726, 6 hits SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 4 hits PS50835, IG_LIKE, 6 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CNTN3_MOUSE | |
Accessioni | Q07409Primary (citable) accession number: Q07409 Secondary accession number(s): G5E878 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 23, 2004 |
Last sequence update: | October 3, 2012 | |
Last modified: | December 2, 2020 | |
This is version 144 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families