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Entry version 199 (07 Oct 2020)
Sequence version 3 (14 Apr 2009)
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Protein

Fibroblast growth factor receptor homolog 1

Gene

htl

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be required for patterning of muscle precursor cells. May be essential for generation of mesodermal and endodermal layers, invaginations of various types of cells and CNS formation.1 Publication

Caution

It is uncertain whether Met-1 or Met-16 is the initiator.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei443ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei556Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi422 – 430ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.10.1, 1994

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-109704, PI3K Cascade
R-DME-1257604, PIP3 activates AKT signaling
R-DME-1307965, betaKlotho-mediated ligand binding
R-DME-190322, FGFR4 ligand binding and activation
R-DME-190371, FGFR3b ligand binding and activation
R-DME-190372, FGFR3c ligand binding and activation
R-DME-190375, FGFR2c ligand binding and activation
R-DME-190377, FGFR2b ligand binding and activation
R-DME-5654221, Phospholipase C-mediated cascade, FGFR2
R-DME-5654227, Phospholipase C-mediated cascade, FGFR3
R-DME-5654228, Phospholipase C-mediated cascade, FGFR4
R-DME-5654695, PI-3K cascade:FGFR2
R-DME-5654699, SHC-mediated cascade:FGFR2
R-DME-5654700, FRS-mediated FGFR2 signaling
R-DME-5654704, SHC-mediated cascade:FGFR3
R-DME-5654706, FRS-mediated FGFR3 signaling
R-DME-5654710, PI-3K cascade:FGFR3
R-DME-5654712, FRS-mediated FGFR4 signaling
R-DME-5654719, SHC-mediated cascade:FGFR4
R-DME-5654720, PI-3K cascade:FGFR4
R-DME-5654727, Negative regulation of FGFR2 signaling
R-DME-5654732, Negative regulation of FGFR3 signaling
R-DME-5654733, Negative regulation of FGFR4 signaling
R-DME-5673001, RAF/MAP kinase cascade
R-DME-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fibroblast growth factor receptor homolog 1 (EC:2.7.10.1)
Alternative name(s):
DmHD-38
Protein heartless
Tyrosine kinase 1
Short name:
dTk1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:htl
Synonyms:FR1, Tk1
ORF Names:CG7223
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0010389, htl

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini37 – 309ExtracellularSequence analysisAdd BLAST273
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Topological domaini331 – 729CytoplasmicSequence analysisAdd BLAST399

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 36Sequence analysisAdd BLAST36
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001679437 – 729Fibroblast growth factor receptor homolog 1Add BLAST693

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi125 ↔ 174PROSITE-ProRule annotation
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi140N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi171N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi207N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi213N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi220 ↔ 272PROSITE-ProRule annotation
Glycosylationi242N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi246N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi282N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei587Phosphotyrosine; by autocatalysisBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q07407

PRoteomics IDEntifications database

More...
PRIDEi
Q07407

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In early embryos, expression is specific to mesodermal primordium and invaginated mesodermal cells. At later stages, expression is seen in putative muscle precursor cells and in the CNS.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Embryogenesis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0010389, Expressed in crop (Drosophila) and 59 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q07407, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
67184, 15 interactors

Protein interaction database and analysis system

More...
IntActi
Q07407, 3 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0082970

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q07407

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini106 – 192Ig-like C2-type 1Add BLAST87
Domaini203 – 279Ig-like C2-type 2Add BLAST77
Domaini416 – 692Protein kinasePROSITE-ProRule annotationAdd BLAST277

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0200, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000167157

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000288_74_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q07407

KEGG Orthology (KO)

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KOi
K05094

Identification of Orthologs from Complete Genome Data

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OMAi
RHDTQVI

Database of Orthologous Groups

More...
OrthoDBi
220433at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q07407

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016248, FGF_rcpt_fam
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR008266, Tyr_kinase_AS
IPR020635, Tyr_kinase_cat_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13895, Ig_2, 1 hit
PF07714, PK_Tyr_Ser-Thr, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000628, FGFR, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00109, TYRKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409, IG, 2 hits
SM00408, IGc2, 1 hit
SM00219, TyrKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 2 hits
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835, IG_LIKE, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q07407-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAWSWRAS HSTITMTSGS LVVLFLLLSI WQPAVQVEGR RQMANSQEMI
60 70 80 90 100
KDHLGARSQN KTPAITNNAN QSSTSSADLD DGAADDDDNK ADLPVNVSSK
110 120 130 140 150
PYWRNPKKMS FLQTRPSGSL LTLNCHALGN PEPNITWYRN GTVDWTRGYG
160 170 180 190 200
SLKRNRWTLT MEDLVPGDCG NYTCKVCNSL GCIRHDTQVI VSDRVNHKPI
210 220 230 240 250
LMTGPLNLTL VVNSTGSMHC KYLSDLTSKK AWIFVPCHGM TNCSNNRSII
260 270 280 290 300
AEDKDQLDFV NVRMEQEGWY TCVESNSLGQ SNSTAYLRVV RSLHVLEAGV
310 320 330 340 350
ASGSLHSTSF VYIFVFGGLI FIFMTTLFVF YAIRKMKHEK VLKQRIETVH
360 370 380 390 400
QWTKKVIIFK PEGGGDSSGS MDTMIMPVVR IQKQRTTVLQ NGNEPAPFNE
410 420 430 440 450
YEFPLDSNWE LPRSHLVLGA TLGEGAFGRV VMAEVNNAIV AVKMVKEGHT
460 470 480 490 500
DDDIASLVRE MEVMKIIGRH INIINLLGCC SQNGPLYVIV EYAPHGNLKD
510 520 530 540 550
FLYKNRPFGR DQDRDSSQPP PSPPAHVITE KDLIKFAHQI ARGMDYLASR
560 570 580 590 600
RCIHRDLAAR NVLVSDDYVL KIADFGLARD IQSTDYYRKN TNGRLPIKWM
610 620 630 640 650
APESLQEKFY DSKSDVWSYG ILLWEIMTYG QQPYPTIMSA EELYTYLMSG
660 670 680 690 700
QRMEKPAKCS MNIYILMRQC WHFNADDRPP FTEIVEYMDK LLQTKEDYLD
710 720
VDIANLDTPP STSDEEEDET DNLQKWCNY
Length:729
Mass (Da):82,586
Last modified:April 14, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i199166043EC87386
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti21L → V in CAA52189 (PubMed:8330538).Curated1
Sequence conflicti21L → V in BAA03616 (PubMed:8112607).Curated1
Sequence conflicti21L → V in BAA03617 (PubMed:8112607).Curated1
Sequence conflicti29S → T in CAA52189 (PubMed:8330538).Curated1
Sequence conflicti29S → T in BAA03616 (PubMed:8112607).Curated1
Sequence conflicti29S → T in BAA03617 (PubMed:8112607).Curated1
Sequence conflicti77A → V in CAA52189 (PubMed:8330538).Curated1
Sequence conflicti167G → A in CAA52189 (PubMed:8330538).Curated1
Sequence conflicti218M → S in BAA03616 (PubMed:8112607).Curated1
Sequence conflicti218M → S in BAA03617 (PubMed:8112607).Curated1
Sequence conflicti237C → V in BAA03616 (PubMed:8112607).Curated1
Sequence conflicti237C → V in BAA03617 (PubMed:8112607).Curated1
Sequence conflicti358I → II in BAA03616 (PubMed:8112607).Curated1
Sequence conflicti358I → II in BAA03617 (PubMed:8112607).Curated1
Sequence conflicti430V → M in CAA52189 (PubMed:8330538).Curated1
Sequence conflicti504K → R in CAA52189 (PubMed:8330538).Curated1
Sequence conflicti507 – 508PF → RS in CAA52189 (PubMed:8330538).Curated2
Sequence conflicti562V → L in CAA52189 (PubMed:8330538).Curated1
Sequence conflicti568Missing in CAA05748 (PubMed:9731193).Curated1
Sequence conflicti570L → Q in BAA03616 (PubMed:8112607).Curated1
Sequence conflicti570L → Q in BAA03617 (PubMed:8112607).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X74030 mRNA Translation: CAA52189.1
D14976 mRNA Translation: BAA03616.1
D14977 mRNA Translation: BAA03617.1
AE014297 Genomic DNA Translation: AAF55489.1
AE014297 Genomic DNA Translation: AAF55490.1
AE014297 Genomic DNA Translation: AAN13755.1
AY051812 mRNA Translation: AAK93236.1
S55969 Genomic DNA Translation: AAB19903.1
AJ002913 Genomic DNA Translation: CAA05748.1

Protein sequence database of the Protein Information Resource

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PIRi
A49120

NCBI Reference Sequences

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RefSeqi
NP_524394.2, NM_079670.3
NP_732286.1, NM_169784.2
NP_732287.1, NM_169785.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0083548; FBpp0082970; FBgn0010389
FBtr0083549; FBpp0082971; FBgn0010389
FBtr0083550; FBpp0082972; FBgn0010389

Database of genes from NCBI RefSeq genomes

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GeneIDi
42160

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG7223

UCSC genome browser

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UCSCi
CG7223-RB, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74030 mRNA Translation: CAA52189.1
D14976 mRNA Translation: BAA03616.1
D14977 mRNA Translation: BAA03617.1
AE014297 Genomic DNA Translation: AAF55489.1
AE014297 Genomic DNA Translation: AAF55490.1
AE014297 Genomic DNA Translation: AAN13755.1
AY051812 mRNA Translation: AAK93236.1
S55969 Genomic DNA Translation: AAB19903.1
AJ002913 Genomic DNA Translation: CAA05748.1
PIRiA49120
RefSeqiNP_524394.2, NM_079670.3
NP_732286.1, NM_169784.2
NP_732287.1, NM_169785.2

3D structure databases

SMRiQ07407
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi67184, 15 interactors
IntActiQ07407, 3 interactors
STRINGi7227.FBpp0082970

Proteomic databases

PaxDbiQ07407
PRIDEiQ07407

Genome annotation databases

EnsemblMetazoaiFBtr0083548; FBpp0082970; FBgn0010389
FBtr0083549; FBpp0082971; FBgn0010389
FBtr0083550; FBpp0082972; FBgn0010389
GeneIDi42160
KEGGidme:Dmel_CG7223
UCSCiCG7223-RB, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3343
FlyBaseiFBgn0010389, htl

Phylogenomic databases

eggNOGiKOG0200, Eukaryota
GeneTreeiENSGT00940000167157
HOGENOMiCLU_000288_74_1_1
InParanoidiQ07407
KOiK05094
OMAiRHDTQVI
OrthoDBi220433at2759
PhylomeDBiQ07407

Enzyme and pathway databases

BRENDAi2.7.10.1, 1994
ReactomeiR-DME-109704, PI3K Cascade
R-DME-1257604, PIP3 activates AKT signaling
R-DME-1307965, betaKlotho-mediated ligand binding
R-DME-190322, FGFR4 ligand binding and activation
R-DME-190371, FGFR3b ligand binding and activation
R-DME-190372, FGFR3c ligand binding and activation
R-DME-190375, FGFR2c ligand binding and activation
R-DME-190377, FGFR2b ligand binding and activation
R-DME-5654221, Phospholipase C-mediated cascade, FGFR2
R-DME-5654227, Phospholipase C-mediated cascade, FGFR3
R-DME-5654228, Phospholipase C-mediated cascade, FGFR4
R-DME-5654695, PI-3K cascade:FGFR2
R-DME-5654699, SHC-mediated cascade:FGFR2
R-DME-5654700, FRS-mediated FGFR2 signaling
R-DME-5654704, SHC-mediated cascade:FGFR3
R-DME-5654706, FRS-mediated FGFR3 signaling
R-DME-5654710, PI-3K cascade:FGFR3
R-DME-5654712, FRS-mediated FGFR4 signaling
R-DME-5654719, SHC-mediated cascade:FGFR4
R-DME-5654720, PI-3K cascade:FGFR4
R-DME-5654727, Negative regulation of FGFR2 signaling
R-DME-5654732, Negative regulation of FGFR3 signaling
R-DME-5654733, Negative regulation of FGFR4 signaling
R-DME-5673001, RAF/MAP kinase cascade
R-DME-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
42160, 0 hits in 5 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
42160

Protein Ontology

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PROi
PR:Q07407

Gene expression databases

BgeeiFBgn0010389, Expressed in crop (Drosophila) and 59 other tissues
GenevisibleiQ07407, DM

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR016248, FGF_rcpt_fam
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR008266, Tyr_kinase_AS
IPR020635, Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF13895, Ig_2, 1 hit
PF07714, PK_Tyr_Ser-Thr, 1 hit
PIRSFiPIRSF000628, FGFR, 1 hit
PRINTSiPR00109, TYRKINASE
SMARTiView protein in SMART
SM00409, IG, 2 hits
SM00408, IGc2, 1 hit
SM00219, TyrKc, 1 hit
SUPFAMiSSF48726, SSF48726, 2 hits
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFGFR1_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q07407
Secondary accession number(s): A4V320
, O18371, Q26294, Q9VED5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 14, 2009
Last modified: October 7, 2020
This is version 199 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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