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Entry version 155 (02 Jun 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Ribosome biogenesis protein TSR1

Gene

TSR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for 40S ribosomal subunit synthesis. Required for normal export of the pre-40S particles from the nucleus to the cytoplasm. Its subcellular location and association with pre-40S subunitshifts from mixed cytoplasm/nucleus to all nuclear in RPS19 disruptions, suggesting it acts after the ribosomal protein.

4 Publications

Miscellaneous

Present with 1390 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRibosome biogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ribosome biogenesis protein TSR1
Alternative name(s):
20S rRNA accumulation protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TSR1
Ordered Locus Names:YDL060W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000002218, TSR1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YDL060W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000656711 – 788Ribosome biogenesis protein TSR1Add BLAST788

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q07381

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q07381

PRoteomics IDEntifications database

More...
PRIDEi
Q07381

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q07381

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RIO2.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
31998, 167 interactors

Database of interacting proteins

More...
DIPi
DIP-6294N

Protein interaction database and analysis system

More...
IntActi
Q07381, 40 interactors

Molecular INTeraction database

More...
MINTi
Q07381

STRING: functional protein association networks

More...
STRINGi
4932.YDL060W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q07381, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1788
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q07381

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini82 – 248Bms1-type GPROSITE-ProRule annotationAdd BLAST167

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 57DisorderedSequence analysisAdd BLAST57

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 28Basic residuesSequence analysisAdd BLAST28
Compositional biasi29 – 53Basic and acidic residuesSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1980, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153195

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009858_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q07381

Identification of Orthologs from Complete Genome Data

More...
OMAi
KTPHQQV

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012948, AARP2CN
IPR039761, Bms1/Tsr1
IPR007034, BMS1_TSR1_C
IPR030387, G_Bms1/Tsr1_dom

The PANTHER Classification System

More...
PANTHERi
PTHR12858, PTHR12858, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08142, AARP2CN, 1 hit
PF04950, RIBIOP_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00785, AARP2CN, 1 hit
SM01362, DUF663, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51714, G_BMS1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q07381-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGHSHRSSL KNGHKSYKSK HASKGALKRL YKGKVEKEPV GTGKPDKQVS
60 70 80 90 100
KLQRKNKAKQ LRAQRILDSI ENRKLFEGKN GAAKIITIVP LVNDLDPLDI
110 120 130 140 150
LYKLLKCADD EGIMVQEVDS KRIFNVHIKK FKSNLKIIIP DMTNFLNILD
160 170 180 190 200
CAKVADFVVF GLSGVQEVDE EFGEQIIRAL ELQGIASYIG VISNLSAVHE
210 220 230 240 250
KEKFQLDVKQ SLESYFKHFF PSEERVYNLE KNSDALNVLR TLCQRLPRSI
260 270 280 290 300
NWRDNRGYVV ADFVDFVETS PDSGDLVIEG TVRGIGFNAN RLVHIPDFGD
310 320 330 340 350
FQLNKIEKIS ESSQKRKIIK EKATDSLSLE LDLQTVFESN MNRDTLDEYA
360 370 380 390 400
PEGTEDWSDY DEDFEYDGLT TARYDDHGFL PGREQTSKKA AVPKGTSDYQ
410 420 430 440 450
AKWYLDDVID ANEEEEAEQT NGKDETMMEI DDEMMVEQDN EEVAGDEEYD
460 470 480 490 500
IEDNEGFEEL SPEEEERQLR EFRDMEKEDR EFPDEIELEP SESAIERLKR
510 520 530 540 550
YRGLKNLYNC DWQVDEKDPS SPAEWKRLLR IGNYKNTKNR IIKETKNEAQ
560 570 580 590 600
AIAGDRIRMF IRFPKFLLEK IQDPKQLLFA VYGLLLHEHK NAVVNFSLQR
610 620 630 640 650
WEQYDKPVPS QEPIVVQYGV RRYTIQPLFS QGSNSPNNVH KYERFLHPDT
660 670 680 690 700
VSVATCIAPV DFTQSPAIFF KPSPTDAKNI ELIGHGTFLN ADHSRILAKR
710 720 730 740 750
AILTGHPFRF HKTVVTVRYM FFRPEDVEWF KSIPLFTKSG RSGFIKESLG
760 770 780
THGYFKATFD GKLSAQDVVA MSLYKRMWPM PSLPWNGM
Length:788
Mass (Da):90,748
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i71BA5461E8A858C7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z74108 Genomic DNA Translation: CAA98623.1
U53668 Genomic DNA Translation: AAB66661.1
BK006938 Genomic DNA Translation: DAA11796.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S67595

NCBI Reference Sequences

More...
RefSeqi
NP_010223.1, NM_001180119.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YDL060W_mRNA; YDL060W; YDL060W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
851499

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YDL060W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74108 Genomic DNA Translation: CAA98623.1
U53668 Genomic DNA Translation: AAB66661.1
BK006938 Genomic DNA Translation: DAA11796.1
PIRiS67595
RefSeqiNP_010223.1, NM_001180119.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IW7X-ray3.60A/B/C/D46-409[»]
A/B/C/D477-788[»]
5WWNX-ray2.81A80-788[»]
6EMLelectron microscopy3.60t1-788[»]
6FAIelectron microscopy3.40k1-788[»]
6RBDelectron microscopy3.47k1-788[»]
6WDRelectron microscopy3.70k1-788[»]
6Y7Celectron microscopy3.80t1-788[»]
SMRiQ07381
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi31998, 167 interactors
DIPiDIP-6294N
IntActiQ07381, 40 interactors
MINTiQ07381
STRINGi4932.YDL060W

PTM databases

iPTMnetiQ07381

Proteomic databases

MaxQBiQ07381
PaxDbiQ07381
PRIDEiQ07381

Genome annotation databases

EnsemblFungiiYDL060W_mRNA; YDL060W; YDL060W
GeneIDi851499
KEGGisce:YDL060W

Organism-specific databases

SGDiS000002218, TSR1
VEuPathDBiFungiDB:YDL060W

Phylogenomic databases

eggNOGiKOG1980, Eukaryota
GeneTreeiENSGT00940000153195
HOGENOMiCLU_009858_1_0_1
InParanoidiQ07381
OMAiKTPHQQV

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q07381
RNActiQ07381, protein

Family and domain databases

InterProiView protein in InterPro
IPR012948, AARP2CN
IPR039761, Bms1/Tsr1
IPR007034, BMS1_TSR1_C
IPR030387, G_Bms1/Tsr1_dom
PANTHERiPTHR12858, PTHR12858, 1 hit
PfamiView protein in Pfam
PF08142, AARP2CN, 1 hit
PF04950, RIBIOP_C, 1 hit
SMARTiView protein in SMART
SM00785, AARP2CN, 1 hit
SM01362, DUF663, 1 hit
PROSITEiView protein in PROSITE
PS51714, G_BMS1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTSR1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q07381
Secondary accession number(s): D6VRT6, Q03128
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: November 1, 1996
Last modified: June 2, 2021
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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