PDE4B

Functionⁱ

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.2 Publications

Catalytic activityⁱ

3',5'-cyclic AMP
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H₂O
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See the description of this molecule in ChEBI.
=
AMP
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H⁺
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See the description of this molecule in ChEBI.
EC:3.1.4.53
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
3',5'-cyclic AMP
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H₂O
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AMP
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H⁺
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Cofactorⁱ

a divalent metal cation2 PublicationsNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.2 Publications

Activity regulationⁱ

Inhibited by rolipram.

Pathwayⁱ: 3',5'-cyclic AMP degradation

This protein is involved in step 1 of the subpathway that synthesizes AMP from 3',5'-cyclic AMP.
Proteins known to be involved in this subpathway in this organism are:

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (PDE8A), High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (PDE7A), cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A), cAMP-specific 3',5'-cyclic phosphodiesterase 4D (PDE4D), cAMP-specific 3',5'-cyclic phosphodiesterase 4C (PDE4C), High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (PDE8B), cAMP-specific 3',5'-cyclic phosphodiesterase 4A (PDE4A), cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B), cAMP-specific 3',5'-cyclic phosphodiesterase 7B (PDE7B)

This subpathway is part of the pathway 3',5'-cyclic AMP degradation, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from 3',5'-cyclic AMP, the pathway 3',5'-cyclic AMP degradation and in Purine metabolism.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	406	Proton donor	1
Metal bindingⁱ	410	Divalent metal cation 1	1
Metal bindingⁱ	446	Divalent metal cation 1	1
Metal bindingⁱ	447	Divalent metal cation 1	1
Metal bindingⁱ	447	Divalent metal cation 2	1
Binding siteⁱ	447	cAMP	1
Metal bindingⁱ	564	Divalent metal cation 1	1
Binding siteⁱ	564	cAMP	1
Siteⁱ	567	Binds AMP, but not cAMPBy similarity	1
Binding siteⁱ	615	cAMP	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	406 – 410	cAMP		5

GO - Molecular functionⁱ

3',5'-cyclic-AMP phosphodiesterase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 17404263
cAMP binding
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 8413254
gamma-tubulin binding Source: Ensembl
ion channel binding Source: BHF-UCL
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cAMP catabolic process Source: UniProtKB-UniPathway
cellular response to drug Source: BHF-UCL
cellular response to epinephrine stimulus Source: BHF-UCL
cellular response to lipopolysaccharide Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: Reactome
leukocyte migration Source: BHF-UCL
negative regulation of relaxation of cardiac muscle Source: BHF-UCL
neutrophil chemotaxis Source: BHF-UCL
neutrophil homeostasis Source: BHF-UCL
positive regulation of interferon-gamma production
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17404263
positive regulation of interleukin-2 production
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17404263
regulation of cardiac muscle cell contraction Source: BHF-UCL
regulation of high voltage-gated calcium channel activity Source: BHF-UCL
T cell receptor signaling pathway
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17404263

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Ligand	cAMP, Metal-binding

Enzyme and pathway databases

BRENDAⁱ	3.1.4.53 2681
Reactomeⁱ	R-HSA-180024 DARPP-32 events R-HSA-418555 G alpha (s) signalling events
SIGNORⁱ	Q07343
UniPathwayⁱ	UPA00762;UER00747

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC:3.1.4.53) Alternative name(s): DPDE4 PDE32
Gene namesⁱ	Name:PDE4B Synonyms:DPDE4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000184588.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8781 PDE4B
MIMⁱ	600127 gene
neXtProtⁱ	NX_Q07343

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5142
Open Targets More...OpenTargetsⁱ	ENSG00000184588
PharmGKBⁱ	PA33129

Chemistry databases

ChEMBLⁱ	CHEMBL275
Drug and drug target database More...DrugBankⁱ	DB01647 (R)-Mesopram DB04149 (R)-Rolipram DB03606 (S)-Rolipram DB03349 8-Bromo-Adenosine-5'-Monophosphate DB00131 Adenosine monophosphate DB01427 Amrinone DB05676 Apremilast DB00201 Caffeine DB03849 Cilomilast DB05219 Crisaborole DB00651 Dyphylline DB00824 Enprofylline DB02660 Filaminast DB05266 Ibudilast DB01088 Iloprost DB01113 Papaverine DB00806 Pentoxifylline DB01791 Piclamilast DB01656 Roflumilast DB01954 Rolipram DB01412 Theobromine DB00277 Theophylline
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1301

Polymorphism and mutation databases

BioMutaⁱ	PDE4B
DMDMⁱ	729163

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000198809	1 – 736	cAMP-specific 3',5'-cyclic phosphodiesterase 4BAdd BLAST		736

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	290	PhosphoserineBy similarity	1
Modified residueⁱ	659	PhosphoserineBy similarity	1
Modified residueⁱ	661	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q07343
PeptideAtlas More...PeptideAtlasⁱ	Q07343
PRIDEⁱ	Q07343
ProteomicsDBⁱ	58512 58513 [Q07343-2] 58514 [Q07343-3]

PTM databases

iPTMnetⁱ	Q07343
PhosphoSitePlusⁱ	Q07343

Expressionⁱ

Tissue specificityⁱ

Expressed in brain, heart, lung and skeletal muscle.

Gene expression databases

Bgeeⁱ	ENSG00000184588 Expressed in 231 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_PDE4B
ExpressionAtlasⁱ	Q07343 baseline and differential
Genevisibleⁱ	Q07343 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA003005

HPAⁱ

HPA003005

Interactionⁱ

GO - Molecular functionⁱ

gamma-tubulin binding Source: Ensembl
ion channel binding Source: BHF-UCL

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111168, 11 interactors
CORUMⁱ	Q07343
ELMⁱ	Q07343
IntActⁱ	Q07343, 4 interactors
STRINGⁱ	9606.ENSP00000332116

Chemistry databases

BindingDBⁱ

Q07343

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	168 – 183	Combined sources	16
Helixⁱ	217 – 235	Combined sources	19
Helixⁱ	239 – 264	Combined sources	26
Helixⁱ	266 – 279	Combined sources	14
Helixⁱ	324 – 327	Combined sources	4
Beta strandⁱ	328 – 330	Combined sources	3
Turnⁱ	332 – 334	Combined sources	3
Helixⁱ	335 – 342	Combined sources	8
Turnⁱ	343 – 346	Combined sources	4
Helixⁱ	352 – 358	Combined sources	7
Turnⁱ	359 – 361	Combined sources	3
Helixⁱ	363 – 374	Combined sources	12
Helixⁱ	377 – 380	Combined sources	4
Helixⁱ	385 – 397	Combined sources	13
Beta strandⁱ	403 – 407	Combined sources	5
Helixⁱ	408 – 422	Combined sources	15
Helixⁱ	425 – 427	Combined sources	3
Turnⁱ	428 – 430	Combined sources	3
Helixⁱ	433 – 445	Combined sources	13
Turnⁱ	446 – 449	Combined sources	4
Helixⁱ	455 – 460	Combined sources	6
Helixⁱ	464 – 468	Combined sources	5
Turnⁱ	469 – 471	Combined sources	3
Helixⁱ	474 – 486	Combined sources	13
Helixⁱ	490 – 492	Combined sources	3
Turnⁱ	494 – 497	Combined sources	4
Helixⁱ	500 – 515	Combined sources	16
Helixⁱ	519 – 521	Combined sources	3
Helixⁱ	522 – 534	Combined sources	13
Beta strandⁱ	540 – 542	Combined sources	3
Helixⁱ	549 – 564	Combined sources	16
Helixⁱ	567 – 569	Combined sources	3
Helixⁱ	572 – 595	Combined sources	24
Helixⁱ	602 – 604	Combined sources	3
Turnⁱ	606 – 608	Combined sources	3
Helixⁱ	611 – 621	Combined sources	11
Helixⁱ	623 – 633	Combined sources	11
Turnⁱ	634 – 638	Combined sources	5
Helixⁱ	639 – 654	Combined sources	16
Beta strandⁱ	656 – 658	Combined sources	3
Beta strandⁱ	659 – 662	Combined sources	4
Helixⁱ	664 – 666	Combined sources	3
Helixⁱ	671 – 677	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	Q07343
SMRⁱ	Q07343
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q07343

EvolutionaryTraceⁱ

Q07343

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	330 – 659	PDEasePROSITE-ProRule annotationAdd BLAST		330

Sequence similaritiesⁱ

Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG3689 Eukaryota ENOG410XRI7 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000155190
HOGENOMⁱ	HOG000236297
HOVERGENⁱ	HBG108239
KEGG Orthology (KO) More...KOⁱ	K13293
OMAⁱ	EGHNYFS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06CD
PhylomeDBⁱ	Q07343
TreeFamⁱ	TF314638

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00077 HDc, 1 hit
Gene3Dⁱ	1.10.1300.10, 1 hit
InterProⁱ	View protein in InterPro IPR003607 HD/PDEase_dom IPR023088 PDEase IPR002073 PDEase_catalytic_dom IPR036971 PDEase_catalytic_dom_sf IPR023174 PDEase_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00233 PDEase_I, 1 hit
PRINTSⁱ	PR00387 PDIESTERASE1
SMARTⁱ	View protein in SMART SM00471 HDc, 1 hit
PROSITEⁱ	View protein in PROSITE PS00126 PDEASE_I_1, 1 hit PS51845 PDEASE_I_2, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform PDE4B1 (identifier: Q07343-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MKKSRSVMTV MADDNVKDYF ECSLSKSYSS SSNTLGIDLW RGRRCCSGNL 
        60         70         80         90        100
QLPPLSQRQS ERARTPEGDG ISRPTTLPLT TLPSIAITTV SQECFDVENG 
       110        120        130        140        150
PSPGRSPLDP QASSSAGLVL HATFPGHSQR RESFLYRSDS DYDLSPKAMS 
       160        170        180        190        200
RNSSLPSEQH GDDLIVTPFA QVLASLRSVR NNFTILTNLH GTSNKRSPAA 
       210        220        230        240        250
SQPPVSRVNP QEESYQKLAM ETLEELDWCL DQLETIQTYR SVSEMASNKF 
       260        270        280        290        300
KRMLNRELTH LSEMSRSGNQ VSEYISNTFL DKQNDVEIPS PTQKDREKKK 
       310        320        330        340        350
KQQLMTQISG VKKLMHSSSL NNTSISRFGV NTENEDHLAK ELEDLNKWGL 
       360        370        380        390        400
NIFNVAGYSH NRPLTCIMYA IFQERDLLKT FRISSDTFIT YMMTLEDHYH 
       410        420        430        440        450
SDVAYHNSLH AADVAQSTHV LLSTPALDAV FTDLEILAAI FAAAIHDVDH 
       460        470        480        490        500
PGVSNQFLIN TNSELALMYN DESVLENHHL AVGFKLLQEE HCDIFMNLTK 
       510        520        530        540        550
KQRQTLRKMV IDMVLATDMS KHMSLLADLK TMVETKKVTS SGVLLLDNYT 
       560        570        580        590        600
DRIQVLRNMV HCADLSNPTK SLELYRQWTD RIMEEFFQQG DKERERGMEI 
       610        620        630        640        650
SPMCDKHTAS VEKSQVGFID YIVHPLWETW ADLVQPDAQD ILDTLEDNRN 
       660        670        680        690        700
WYQSMIPQSP SPPLDEQNRD CQGLMEKFQF ELTLDEEDSE GPEKEGEGHS 
       710        720        730 
YFSSTKTLCV IDPENRDSLG ETDIDIATED KSPVDT

Length:736

Mass (Da):83,343

Last modified:February 1, 1995 - v1

Checksum:ⁱ208FCE9CD40EF5EB

GO

Isoform PDE4B2 (identifier: Q07343-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-211: MKKSRSVMTV...QPPVSRVNPQ → MKEHGGTFSS...PNYMPVCLFA

« Hide

        10         20         30         40         50
MKEHGGTFSS TGISGGSGDS AMDSLQPLQP NYMPVCLFAE ESYQKLAMET 
        60         70         80         90        100
LEELDWCLDQ LETIQTYRSV SEMASNKFKR MLNRELTHLS EMSRSGNQVS 
       110        120        130        140        150
EYISNTFLDK QNDVEIPSPT QKDREKKKKQ QLMTQISGVK KLMHSSSLNN 
       160        170        180        190        200
TSISRFGVNT ENEDHLAKEL EDLNKWGLNI FNVAGYSHNR PLTCIMYAIF 
       210        220        230        240        250
QERDLLKTFR ISSDTFITYM MTLEDHYHSD VAYHNSLHAA DVAQSTHVLL 
       260        270        280        290        300
STPALDAVFT DLEILAAIFA AAIHDVDHPG VSNQFLINTN SELALMYNDE 
       310        320        330        340        350
SVLENHHLAV GFKLLQEEHC DIFMNLTKKQ RQTLRKMVID MVLATDMSKH 
       360        370        380        390        400
MSLLADLKTM VETKKVTSSG VLLLDNYTDR IQVLRNMVHC ADLSNPTKSL 
       410        420        430        440        450
ELYRQWTDRI MEEFFQQGDK ERERGMEISP MCDKHTASVE KSQVGFIDYI 
       460        470        480        490        500
VHPLWETWAD LVQPDAQDIL DTLEDNRNWY QSMIPQSPSP PLDEQNRDCQ 
       510        520        530        540        550
GLMEKFQFEL TLDEEDSEGP EKEGEGHSYF SSTKTLCVID PENRDSLGET 
       560 
DIDIATEDKS PVDT

Show »

Length:564

Mass (Da):64,352

Checksum:ⁱA4F9FA0C5DB43380

GO

Isoform PDE4B3 (identifier: Q07343-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-93: MKKSRSVMTV...SIAITTVSQE → MTAKDSSKEL...QRRRFTVAHT

« Hide

        10         20         30         40         50
MTAKDSSKEL TASEPEVCIK TFKEQMHLEL ELPRLPGNRP TSPKISPRSS 
        60         70         80         90        100
PRNSPCFFRK LLVNKSIRQR RRFTVAHTCF DVENGPSPGR SPLDPQASSS 
       110        120        130        140        150
AGLVLHATFP GHSQRRESFL YRSDSDYDLS PKAMSRNSSL PSEQHGDDLI 
       160        170        180        190        200
VTPFAQVLAS LRSVRNNFTI LTNLHGTSNK RSPAASQPPV SRVNPQEESY 
       210        220        230        240        250
QKLAMETLEE LDWCLDQLET IQTYRSVSEM ASNKFKRMLN RELTHLSEMS 
       260        270        280        290        300
RSGNQVSEYI SNTFLDKQND VEIPSPTQKD REKKKKQQLM TQISGVKKLM 
       310        320        330        340        350
HSSSLNNTSI SRFGVNTENE DHLAKELEDL NKWGLNIFNV AGYSHNRPLT 
       360        370        380        390        400
CIMYAIFQER DLLKTFRISS DTFITYMMTL EDHYHSDVAY HNSLHAADVA 
       410        420        430        440        450
QSTHVLLSTP ALDAVFTDLE ILAAIFAAAI HDVDHPGVSN QFLINTNSEL 
       460        470        480        490        500
ALMYNDESVL ENHHLAVGFK LLQEEHCDIF MNLTKKQRQT LRKMVIDMVL 
       510        520        530        540        550
ATDMSKHMSL LADLKTMVET KKVTSSGVLL LDNYTDRIQV LRNMVHCADL 
       560        570        580        590        600
SNPTKSLELY RQWTDRIMEE FFQQGDKERE RGMEISPMCD KHTASVEKSQ 
       610        620        630        640        650
VGFIDYIVHP LWETWADLVQ PDAQDILDTL EDNRNWYQSM IPQSPSPPLD 
       660        670        680        690        700
EQNRDCQGLM EKFQFELTLD EEDSEGPEKE GEGHSYFSST KTLCVIDPEN 
       710        720 
RDSLGETDID IATEDKSPVD T

Show »

Length:721

Mass (Da):82,096

Checksum:ⁱ49618FFEAFF33D30

GO

Isoform PDE4B5 (identifier: Q07343-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-15: MKKSRSVMTVMADDN → MPEANYLLSVSWGYI
16-248: Missing.

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        10         20         30         40         50
MPEANYLLSV SWGYIKFKRM LNRELTHLSE MSRSGNQVSE YISNTFLDKQ 
        60         70         80         90        100
NDVEIPSPTQ KDREKKKKQQ LMTQISGVKK LMHSSSLNNT SISRFGVNTE 
       110        120        130        140        150
NEDHLAKELE DLNKWGLNIF NVAGYSHNRP LTCIMYAIFQ ERDLLKTFRI 
       160        170        180        190        200
SSDTFITYMM TLEDHYHSDV AYHNSLHAAD VAQSTHVLLS TPALDAVFTD 
       210        220        230        240        250
LEILAAIFAA AIHDVDHPGV SNQFLINTNS ELALMYNDES VLENHHLAVG 
       260        270        280        290        300
FKLLQEEHCD IFMNLTKKQR QTLRKMVIDM VLATDMSKHM SLLADLKTMV 
       310        320        330        340        350
ETKKVTSSGV LLLDNYTDRI QVLRNMVHCA DLSNPTKSLE LYRQWTDRIM 
       360        370        380        390        400
EEFFQQGDKE RERGMEISPM CDKHTASVEK SQVGFIDYIV HPLWETWADL 
       410        420        430        440        450
VQPDAQDILD TLEDNRNWYQ SMIPQSPSPP LDEQNRDCQG LMEKFQFELT 
       460        470        480        490        500
LDEEDSEGPE KEGEGHSYFS STKTLCVIDP ENRDSLGETD IDIATEDKSP 

VDT

Note: Brain-specific isoform.

Show »

Length:503

Mass (Da):57,709

Checksum:ⁱ23AF122BAF338C42

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PR34	E9PR34_HUMAN	cAMP-specific 3',5'-cyclic phosphod... cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	152	Annotation score:
E9PNB0	E9PNB0_HUMAN	cAMP-specific 3',5'-cyclic phosphod... cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	143	Annotation score:
E9PJ03	E9PJ03_HUMAN	cAMP-specific 3',5'-cyclic phosphod... cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	137	Annotation score:
E9PMG3	E9PMG3_HUMAN	cAMP-specific 3',5'-cyclic phosphod... cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	147	Annotation score:
H0YCV7	H0YCV7_HUMAN	cAMP-specific 3',5'-cyclic phosphod... cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	66	Annotation score:

Sequence cautionⁱ

The sequence AAA35643 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_034373	703	S → C. Corresponds to variant dbSNP:rs2227297Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_004572	1 – 211	MKKSR…RVNPQ → MKEHGGTFSSTGISGGSGDS AMDSLQPLQPNYMPVCLFA in isoform PDE4B2. 3 PublicationsAdd BLAST	211
Alternative sequenceⁱVSP_004571	1 – 93	MKKSR…TVSQE → MTAKDSSKELTASEPEVCIK TFKEQMHLELELPRLPGNRP TSPKISPRSSPRNSPCFFRK LLVNKSIRQRRRFTVAHT in isoform PDE4B3. 2 PublicationsAdd BLAST	93
Alternative sequenceⁱVSP_047723	1 – 15	MKKSR…MADDN → MPEANYLLSVSWGYI in isoform PDE4B5. 2 PublicationsAdd BLAST	15
Alternative sequenceⁱVSP_047724	16 – 248	Missing in isoform PDE4B5. 2 PublicationsAdd BLAST	233

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L12686 mRNA Translation: AAA35643.1 Different initiation. L20966 mRNA Translation: AAA03589.1 L20971 mRNA Translation: AAA03593.1 U85048 mRNA Translation: AAB96381.1 M97515 mRNA Translation: AAA36426.1 EF595686 mRNA Translation: ABQ85407.1 AK289969 mRNA Translation: BAF82658.1 AK290006 mRNA Translation: BAF82695.1 AK290206 mRNA Translation: BAF82895.1 AL592285 Genomic DNA No translation available. AL357273 Genomic DNA No translation available. AL109926 Genomic DNA No translation available. AL359701 Genomic DNA No translation available. AL513493 Genomic DNA No translation available. AL590783 Genomic DNA No translation available. AL591487 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06524.1 BC101480 mRNA Translation: AAI01481.1 BC105040 mRNA Translation: AAI05041.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30742.1 [Q07343-3] CCDS30743.1 [Q07343-2] CCDS632.1 [Q07343-1] CCDS72802.1 [Q07343-4]
PIRⁱ	I61354
NCBI Reference Sequences More...RefSeqⁱ	NP_001032416.1, NM_001037339.2 [Q07343-2] NP_001032417.1, NM_001037340.2 [Q07343-3] NP_001032418.1, NM_001037341.1 [Q07343-1] NP_001284369.1, NM_001297440.1 NP_001284370.1, NM_001297441.1 NP_001284371.1, NM_001297442.1 [Q07343-4] NP_002591.2, NM_002600.3 [Q07343-1]
UniGeneⁱ	Hs.198072

Genome annotation databases

Ensemblⁱ	ENST00000329654; ENSP00000332116; ENSG00000184588 [Q07343-1] ENST00000341517; ENSP00000342637; ENSG00000184588 [Q07343-1] ENST00000371045; ENSP00000360084; ENSG00000184588 [Q07343-2] ENST00000423207; ENSP00000392947; ENSG00000184588 [Q07343-3] ENST00000480109; ENSP00000432592; ENSG00000184588 [Q07343-4]
GeneIDⁱ	5142
KEGGⁱ	hsa:5142
UCSC genome browser More...UCSCⁱ	uc001dcp.4 human [Q07343-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q07343	Phosphodiesterase (Fragment)		HUMAN		736	UniRef100_Q07343
Phosphodiesterase		PANPA		642
Uncharacterized protein DKFZp686F2182 (Fragment)		HUMAN		14
Q07343-2	Phosphodiesterase		PANTR		564	UniRef100_Q07343-2
Q07343-3	Phosphodiesterase (Fragment)		HUMAN		726	UniRef100_Q07343-3
Q07343-4	Phosphodiesterase		PANTR		503	UniRef100_Q07343-4
Phosphodiesterase		MACMU		503
Phosphodiesterase		RHIRO		503
Phosphodiesterase		PAPAN		503
Phosphodiesterase		PANPA		503
+3

Protein	Similar proteins		Species	Score	Length	Source
Q07343	cAMP-specific 3',5'-cyclic phosphodiesterase 4B		RAT		736	UniRef90_Q07343
Phosphodiesterase (Fragment)		HUMAN		736
Phosphodiesterase		PANPA		642
Phosphodiesterase		LIPVE		739
Phosphodiesterase		MESAU		738
+171
Q07343-2	Phosphodiesterase		PANTR		564	UniRef90_Q07343-2
Phosphodiesterase		DELLE		584
Phosphodiesterase		PROCO		567
Phosphodiesterase		PONAB		564
Phosphodiesterase		SAIBB		564
+45
Q07343-3	Phosphodiesterase (Fragment)		HUMAN		726	UniRef90_Q07343-3
Phosphodiesterase		MESAU		723
Phosphodiesterase		ODORO		722
Phosphodiesterase		Enhydra lutris kenyoni		722
Phosphodiesterase		NEOSC		722
+111
Q07343-4	Phosphodiesterase		PANTR		503	UniRef90_Q07343-4
Phosphodiesterase		MACMU		503
Phosphodiesterase		RHIRO		503
Phosphodiesterase		PAPAN		503
Phosphodiesterase		PANPA		503
+173

Protein	Similar proteins		Species	Score	Length	Source
Q07343	cAMP-specific 3',5'-cyclic phosphodiesterase 4B		RAT		736	UniRef50_Q07343
Phosphodiesterase (Fragment)		HUMAN		736
Phosphodiesterase		PANPA		642
Phosphodiesterase		LIPVE		739
Phosphodiesterase		MESAU		738
+323
Q07343-2	Isoform 6 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D		RAT		517	UniRef50_P14270-7
Phosphodiesterase		ODORO		518
Phosphodiesterase		PIG		518
Phosphodiesterase		PANTR		518
Phosphodiesterase		MACMU		518
+429
Q07343-3	Isoform 5 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D		RAT		745	UniRef50_P14270-8
Phosphodiesterase (Fragment)		MOUSE		754
Phosphodiesterase		Florida manatee		747
Phosphodiesterase		PHYCD		747
Phosphodiesterase		BALAS		747
+1032
Q07343-4	Isoform 6 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D		RAT		517	UniRef50_P14270-7
Phosphodiesterase		ODORO		518
Phosphodiesterase		PIG		518
Phosphodiesterase		PANTR		518
Phosphodiesterase		MACMU		518
+429

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L12686 mRNA Translation: AAA35643.1 Different initiation. L20966 mRNA Translation: AAA03589.1 L20971 mRNA Translation: AAA03593.1 U85048 mRNA Translation: AAB96381.1 M97515 mRNA Translation: AAA36426.1 EF595686 mRNA Translation: ABQ85407.1 AK289969 mRNA Translation: BAF82658.1 AK290006 mRNA Translation: BAF82695.1 AK290206 mRNA Translation: BAF82895.1 AL592285 Genomic DNA No translation available. AL357273 Genomic DNA No translation available. AL109926 Genomic DNA No translation available. AL359701 Genomic DNA No translation available. AL513493 Genomic DNA No translation available. AL590783 Genomic DNA No translation available. AL591487 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06524.1 BC101480 mRNA Translation: AAI01481.1 BC105040 mRNA Translation: AAI05041.1
CCDSⁱ	CCDS30742.1 [Q07343-3] CCDS30743.1 [Q07343-2] CCDS632.1 [Q07343-1] CCDS72802.1 [Q07343-4]
PIRⁱ	I61354
RefSeqⁱ	NP_001032416.1, NM_001037339.2 [Q07343-2] NP_001032417.1, NM_001037340.2 [Q07343-3] NP_001032418.1, NM_001037341.1 [Q07343-1] NP_001284369.1, NM_001297440.1 NP_001284370.1, NM_001297441.1 NP_001284371.1, NM_001297442.1 [Q07343-4] NP_002591.2, NM_002600.3 [Q07343-1]
UniGeneⁱ	Hs.198072

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1F0J	X-ray	1.77	A/B	324-700	[»]
	1JP1	model	-	A	324-700	[»]
	1JP2	model	-	A	324-700	[»]
	1RO6	X-ray	2.00	A/B	324-700	[»]
	1RO9	X-ray	2.13	A/B	324-700	[»]
	1ROR	X-ray	2.00	A/B	324-700	[»]
	1TB5	X-ray	2.15	A/B	324-700	[»]
	1XLX	X-ray	2.19	A/B	324-700	[»]
	1XLZ	X-ray	2.06	A/B	324-700	[»]
	1XM4	X-ray	2.31	A/B	324-700	[»]
	1XM6	X-ray	1.92	A/B	324-700	[»]
	1XMU	X-ray	2.30	A/B	324-700	[»]
	1XMY	X-ray	2.40	A/B	324-700	[»]
	1XN0	X-ray	2.31	A/B	324-700	[»]
	1XOS	X-ray	2.28	A	324-700	[»]
	1XOT	X-ray	2.34	A/B	324-700	[»]
	1Y2H	X-ray	2.40	A/B	324-700	[»]
	1Y2J	X-ray	2.55	A/B	324-700	[»]
	2CHM	X-ray	1.60	A	450-475	[»]
	2QYL	X-ray	1.95	A	324-659	[»]
	3D3P	X-ray	1.75	A	324-675	[»]
	3FRG	X-ray	1.70	A	324-675	[»]
	3G45	X-ray	2.63	A/B	241-289	[»]
				A/B	305-659	[»]
	3GWT	X-ray	1.75	A	324-675	[»]
	3HC8	X-ray	1.79	A	451-474	[»]
	3HDZ	X-ray	1.80	A	451-474	[»]
	3HMV	X-ray	2.23	A/B	324-700	[»]
	3KKT	X-ray	2.48	A/B	324-700	[»]
	3LY2	X-ray	2.60	A/B/C/D/E/F/G/H	324-659	[»]
	3O0J	X-ray	1.95	A	334-656	[»]
	3O56	X-ray	2.42	A	324-675	[»]
	3O57	X-ray	2.00	A	324-675	[»]
	3W5E	X-ray	2.30	A/B	324-700	[»]
	3WD9	X-ray	2.50	A/B	324-700	[»]
	4KP6	X-ray	1.50	A	324-659	[»]
	4MYQ	X-ray	1.90	A	324-691	[»]
	4NW7	X-ray	2.15	A	324-691	[»]
	4WZI	X-ray	2.58	A/B	122-736	[»]
	4X0F	X-ray	3.22	A/B	122-736	[»]
	5K6J	X-ray	1.86	A	334-656	[»]
	5LAQ	X-ray	2.40	A	241-289	[»]
				A	305-659	[»]
	5OHJ	X-ray	1.60	A/B	241-659	[»]
	6BOJ	X-ray	1.70	A/B/C/D	663-673	[»]
ProteinModelPortalⁱ	Q07343
SMRⁱ	Q07343
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111168, 11 interactors
CORUMⁱ	Q07343
ELMⁱ	Q07343
IntActⁱ	Q07343, 4 interactors
STRINGⁱ	9606.ENSP00000332116

Chemistry databases

BindingDBⁱ	Q07343
ChEMBLⁱ	CHEMBL275
DrugBankⁱ	DB01647 (R)-Mesopram DB04149 (R)-Rolipram DB03606 (S)-Rolipram DB03349 8-Bromo-Adenosine-5'-Monophosphate DB00131 Adenosine monophosphate DB01427 Amrinone DB05676 Apremilast DB00201 Caffeine DB03849 Cilomilast DB05219 Crisaborole DB00651 Dyphylline DB00824 Enprofylline DB02660 Filaminast DB05266 Ibudilast DB01088 Iloprost DB01113 Papaverine DB00806 Pentoxifylline DB01791 Piclamilast DB01656 Roflumilast DB01954 Rolipram DB01412 Theobromine DB00277 Theophylline
GuidetoPHARMACOLOGYⁱ	1301

PTM databases

iPTMnetⁱ	Q07343
PhosphoSitePlusⁱ	Q07343

Polymorphism and mutation databases

BioMutaⁱ	PDE4B
DMDMⁱ	729163

Proteomic databases

PaxDbⁱ	Q07343
PeptideAtlasⁱ	Q07343
PRIDEⁱ	Q07343
ProteomicsDBⁱ	58512 58513 [Q07343-2] 58514 [Q07343-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000329654; ENSP00000332116; ENSG00000184588 [Q07343-1] ENST00000341517; ENSP00000342637; ENSG00000184588 [Q07343-1] ENST00000371045; ENSP00000360084; ENSG00000184588 [Q07343-2] ENST00000423207; ENSP00000392947; ENSG00000184588 [Q07343-3] ENST00000480109; ENSP00000432592; ENSG00000184588 [Q07343-4]
GeneIDⁱ	5142
KEGGⁱ	hsa:5142
UCSCⁱ	uc001dcp.4 human [Q07343-1]

Organism-specific databases

CTDⁱ	5142
DisGeNETⁱ	5142
EuPathDBⁱ	HostDB:ENSG00000184588.17
GeneCardsⁱ	PDE4B
HGNCⁱ	HGNC:8781 PDE4B
HPAⁱ	HPA003005
MIMⁱ	600127 gene
neXtProtⁱ	NX_Q07343
OpenTargetsⁱ	ENSG00000184588
PharmGKBⁱ	PA33129
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3689 Eukaryota ENOG410XRI7 LUCA
GeneTreeⁱ	ENSGT00940000155190
HOGENOMⁱ	HOG000236297
HOVERGENⁱ	HBG108239
KOⁱ	K13293
OMAⁱ	EGHNYFS
OrthoDBⁱ	EOG091G06CD
PhylomeDBⁱ	Q07343
TreeFamⁱ	TF314638

Enzyme and pathway databases

UniPathwayⁱ	UPA00762;UER00747
BRENDAⁱ	3.1.4.53 2681
Reactomeⁱ	R-HSA-180024 DARPP-32 events R-HSA-418555 G alpha (s) signalling events
SIGNORⁱ	Q07343

Miscellaneous databases

ChiTaRSⁱ	PDE4B human
EvolutionaryTraceⁱ	Q07343
GeneWikiⁱ	PDE4B
GenomeRNAiⁱ	5142
Protein Ontology More...PROⁱ	PR:Q07343
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000184588 Expressed in 231 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_PDE4B
ExpressionAtlasⁱ	Q07343 baseline and differential
Genevisibleⁱ	Q07343 HS

Family and domain databases

CDDⁱ	cd00077 HDc, 1 hit
Gene3Dⁱ	1.10.1300.10, 1 hit
InterProⁱ	View protein in InterPro IPR003607 HD/PDEase_dom IPR023088 PDEase IPR002073 PDEase_catalytic_dom IPR036971 PDEase_catalytic_dom_sf IPR023174 PDEase_CS
Pfamⁱ	View protein in Pfam PF00233 PDEase_I, 1 hit
PRINTSⁱ	PR00387 PDIESTERASE1
SMARTⁱ	View protein in SMART SM00471 HDc, 1 hit
PROSITEⁱ	View protein in PROSITE PS00126 PDEASE_I_1, 1 hit PS51845 PDEASE_I_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PDE4B_HUMAN
Accessionⁱ	Q07343Primary (citable) accession number: Q07343 Secondary accession number(s): A5YW33 , O15443, Q13945, Q5TEK4, Q5TEK5, Q5TEK6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
	Last sequence update:	February 1, 1995
	Last modified:	December 5, 2018
	This is version 185 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
PATHWAY comments
Index of metabolic and biosynthesis pathways
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

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Supporting data

UniProtKB - Q07343 (PDE4B_HUMAN)

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cAMP-specific 3',5'-cyclic phosphodiesterase 4B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: 3',5'-cyclic AMP degradation

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Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytosol

Plasma Membrane

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Catalytic activityⁱ

Pathwayⁱ: 3',5'-cyclic AMP degradation

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ