UniProtKB - Q07343 (PDE4B_HUMAN)
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
PDE4B
Functioni
Catalytic activityi
- EC:3.1.4.53
Cofactori
Activity regulationi
: 3',5'-cyclic AMP degradation Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes AMP from 3',5'-cyclic AMP.Proteins known to be involved in this subpathway in this organism are:
- Phosphodiesterase, Phosphodiesterase (PDE4C), Phosphodiesterase (PDE4C), Phosphodiesterase (PDE4D), 3',5'-cyclic-AMP phosphodiesterase (PDE4B), Phosphodiesterase (PDE8A), Phosphodiesterase, Phosphodiesterase (PDE4B), Phosphodiesterase, Phosphodiesterase (PDE4C), Phosphodiesterase, 3',5'-cyclic-AMP phosphodiesterase (PDE4B), 3',5'-cyclic-AMP phosphodiesterase (PDE4D), Phosphodiesterase (PDE8B), 3',5'-cyclic-AMP phosphodiesterase (PDE4B), Phosphodiesterase (PDE4D), 3',5'-cyclic-AMP phosphodiesterase (PDE4DN2), Phosphodiesterase, cAMP-specific 3',5'-cyclic phosphodiesterase 4C (PDE4C), Phosphodiesterase, 3',5'-cyclic-AMP phosphodiesterase (HSPDE4D), cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A), Phosphodiesterase (PDE4D), Phosphodiesterase (PDE4C), Phosphodiesterase (PDE4C), High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (PDE7A), cAMP-specific 3',5'-cyclic phosphodiesterase 7B (PDE7B), Phosphodiesterase (PDE4C), cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B), cAMP-specific 3',5'-cyclic phosphodiesterase 4D (PDE4D), Phosphodiesterase (PDE4D), High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (PDE8B), 3',5'-cyclic-AMP phosphodiesterase (PDE4A), High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (PDE8A), 3',5'-cyclic-AMP phosphodiesterase (PDE4B), Phosphodiesterase (PDE4B), 3',5'-cyclic-AMP phosphodiesterase (PDE4C), 3',5'-cyclic-AMP phosphodiesterase (PDE4A), Phosphodiesterase (PDE4C), cAMP-specific 3',5'-cyclic phosphodiesterase 4A (PDE4A), 3',5'-cyclic-AMP phosphodiesterase (PDE4B), Phosphodiesterase, 3',5'-cyclic-AMP phosphodiesterase (PDE4C)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from 3',5'-cyclic AMP, the pathway 3',5'-cyclic AMP degradation and in Purine metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 406 | Proton donor | 1 | |
Metal bindingi | 410 | Divalent metal cation 1 | 1 | |
Metal bindingi | 446 | Divalent metal cation 1 | 1 | |
Metal bindingi | 447 | Divalent metal cation 1 | 1 | |
Metal bindingi | 447 | Divalent metal cation 2 | 1 | |
Binding sitei | 447 | cAMP | 1 | |
Metal bindingi | 564 | Divalent metal cation 1 | 1 | |
Binding sitei | 564 | cAMP | 1 | |
Sitei | 567 | Binds AMP, but not cAMPBy similarity | 1 | |
Binding sitei | 615 | cAMP | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 406 – 410 | cAMP | 5 |
GO - Molecular functioni
- 3',5'-cyclic-AMP phosphodiesterase activity Source: BHF-UCL
- 3',5'-cyclic-nucleotide phosphodiesterase activity Source: GO_Central
- cAMP binding Source: BHF-UCL
- gamma-tubulin binding Source: Ensembl
- ion channel binding Source: BHF-UCL
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- cAMP catabolic process Source: UniProtKB-UniPathway
- cellular response to drug Source: BHF-UCL
- cellular response to epinephrine stimulus Source: BHF-UCL
- cellular response to lipopolysaccharide Source: BHF-UCL
- G protein-coupled receptor signaling pathway Source: Reactome
- leukocyte migration Source: BHF-UCL
- negative regulation of relaxation of cardiac muscle Source: BHF-UCL
- neutrophil chemotaxis Source: BHF-UCL
- neutrophil homeostasis Source: BHF-UCL
- positive regulation of interferon-gamma production Source: BHF-UCL
- positive regulation of interleukin-2 production Source: BHF-UCL
- regulation of cardiac muscle cell contraction Source: BHF-UCL
- regulation of high voltage-gated calcium channel activity Source: BHF-UCL
- signal transduction Source: GO_Central
- T cell receptor signaling pathway Source: BHF-UCL
Keywordsi
Molecular function | Hydrolase |
Ligand | cAMP, Metal-binding |
Enzyme and pathway databases
BRENDAi | 3.1.4.53, 2681 |
PathwayCommonsi | Q07343 |
Reactomei | R-HSA-180024, DARPP-32 events |
SIGNORi | Q07343 |
UniPathwayi | UPA00762;UER00747 |
Names & Taxonomyi
Protein namesi | Recommended name: cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC:3.1.4.53)Alternative name(s): DPDE4 PDE32 |
Gene namesi | Name:PDE4B Synonyms:DPDE4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8781, PDE4B |
MIMi | 600127, gene |
neXtProti | NX_Q07343 |
VEuPathDBi | HostDB:ENSG00000184588.17 |
Subcellular locationi
Cytoskeleton
- centrosome Source: Ensembl
- gamma-tubulin complex Source: Ensembl
Cytosol
- cytosol Source: GO_Central
Nucleus
- nucleus Source: GO_Central
Plasma Membrane
- voltage-gated calcium channel complex Source: BHF-UCL
Other locations
- dendritic spine Source: Ensembl
- excitatory synapse Source: Ensembl
- perinuclear region of cytoplasm Source: GO_Central
- postsynaptic density Source: Ensembl
- synaptic vesicle Source: Ensembl
- Z disc Source: BHF-UCL
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 5142 |
OpenTargetsi | ENSG00000184588 |
PharmGKBi | PA33129 |
Miscellaneous databases
Pharosi | Q07343, Tclin |
Chemistry databases
ChEMBLi | CHEMBL275 |
DrugBanki | DB04149, (R)-Rolipram DB03606, (S)-Rolipram DB03807, 1-(2-Chlorophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester DB06909, 1-ethyl-N-(phenylmethyl)-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide DB01959, 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester DB08299, 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid DB03349, 8-Bromo-Adenosine-5'-Monophosphate DB00131, Adenosine phosphate DB01427, Amrinone DB00201, Caffeine DB03849, Cilomilast DB05219, Crisaborole DB01647, Daxalipram DB00651, Dyphylline DB00824, Enprofylline DB02660, Filaminast DB05266, Ibudilast DB01088, Iloprost DB01113, Papaverine DB01791, Piclamilast DB01656, Roflumilast DB01954, Rolipram DB04530, S,S-(2-Hydroxyethyl)Thiocysteine DB01412, Theobromine DB00277, Theophylline DB09283, Trapidil |
DrugCentrali | Q07343 |
GuidetoPHARMACOLOGYi | 1301 |
Genetic variation databases
BioMutai | PDE4B |
DMDMi | 729163 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000198809 | 1 – 736 | cAMP-specific 3',5'-cyclic phosphodiesterase 4BAdd BLAST | 736 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 290 | PhosphoserineBy similarity | 1 | |
Modified residuei | 659 | PhosphoserineBy similarity | 1 | |
Modified residuei | 661 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q07343 |
MassIVEi | Q07343 |
PaxDbi | Q07343 |
PeptideAtlasi | Q07343 |
PRIDEi | Q07343 |
ProteomicsDBi | 58512 [Q07343-1] 58513 [Q07343-2] 58514 [Q07343-3] 65061 768 |
PTM databases
iPTMneti | Q07343 |
PhosphoSitePlusi | Q07343 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000184588, Expressed in corpus callosum and 241 other tissues |
ExpressionAtlasi | Q07343, baseline and differential |
Genevisiblei | Q07343, HS |
Organism-specific databases
HPAi | ENSG00000184588, Tissue enhanced (bone) |
Interactioni
GO - Molecular functioni
- gamma-tubulin binding Source: Ensembl
- ion channel binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 111168, 12 interactors |
CORUMi | Q07343 |
ELMi | Q07343 |
IntActi | Q07343, 7 interactors |
STRINGi | 9606.ENSP00000332116 |
Chemistry databases
BindingDBi | Q07343 |
Miscellaneous databases
RNActi | Q07343, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q07343 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q07343 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 330 – 659 | PDEasePROSITE-ProRule annotationAdd BLAST | 330 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3689, Eukaryota |
GeneTreei | ENSGT00940000155190 |
HOGENOMi | CLU_005940_5_3_1 |
OMAi | XFDVENG |
OrthoDBi | 199083at2759 |
PhylomeDBi | Q07343 |
TreeFami | TF314638 |
Family and domain databases
CDDi | cd00077, HDc, 1 hit |
Gene3Di | 1.10.1300.10, 1 hit |
InterProi | View protein in InterPro IPR003607, HD/PDEase_dom IPR043371, PDE4 IPR040844, PDE4_UCR IPR023088, PDEase IPR002073, PDEase_catalytic_dom IPR036971, PDEase_catalytic_dom_sf IPR023174, PDEase_CS |
PANTHERi | PTHR11347:SF108, PTHR11347:SF108, 1 hit |
Pfami | View protein in Pfam PF18100, PDE4_UCR, 1 hit PF00233, PDEase_I, 1 hit |
PRINTSi | PR00387, PDIESTERASE1 |
SMARTi | View protein in SMART SM00471, HDc, 1 hit |
PROSITEi | View protein in PROSITE PS00126, PDEASE_I_1, 1 hit PS51845, PDEASE_I_2, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKKSRSVMTV MADDNVKDYF ECSLSKSYSS SSNTLGIDLW RGRRCCSGNL
60 70 80 90 100
QLPPLSQRQS ERARTPEGDG ISRPTTLPLT TLPSIAITTV SQECFDVENG
110 120 130 140 150
PSPGRSPLDP QASSSAGLVL HATFPGHSQR RESFLYRSDS DYDLSPKAMS
160 170 180 190 200
RNSSLPSEQH GDDLIVTPFA QVLASLRSVR NNFTILTNLH GTSNKRSPAA
210 220 230 240 250
SQPPVSRVNP QEESYQKLAM ETLEELDWCL DQLETIQTYR SVSEMASNKF
260 270 280 290 300
KRMLNRELTH LSEMSRSGNQ VSEYISNTFL DKQNDVEIPS PTQKDREKKK
310 320 330 340 350
KQQLMTQISG VKKLMHSSSL NNTSISRFGV NTENEDHLAK ELEDLNKWGL
360 370 380 390 400
NIFNVAGYSH NRPLTCIMYA IFQERDLLKT FRISSDTFIT YMMTLEDHYH
410 420 430 440 450
SDVAYHNSLH AADVAQSTHV LLSTPALDAV FTDLEILAAI FAAAIHDVDH
460 470 480 490 500
PGVSNQFLIN TNSELALMYN DESVLENHHL AVGFKLLQEE HCDIFMNLTK
510 520 530 540 550
KQRQTLRKMV IDMVLATDMS KHMSLLADLK TMVETKKVTS SGVLLLDNYT
560 570 580 590 600
DRIQVLRNMV HCADLSNPTK SLELYRQWTD RIMEEFFQQG DKERERGMEI
610 620 630 640 650
SPMCDKHTAS VEKSQVGFID YIVHPLWETW ADLVQPDAQD ILDTLEDNRN
660 670 680 690 700
WYQSMIPQSP SPPLDEQNRD CQGLMEKFQF ELTLDEEDSE GPEKEGEGHS
710 720 730
YFSSTKTLCV IDPENRDSLG ETDIDIATED KSPVDT
The sequence of this isoform differs from the canonical sequence as follows:
1-211: MKKSRSVMTV...QPPVSRVNPQ → MKEHGGTFSS...PNYMPVCLFA
The sequence of this isoform differs from the canonical sequence as follows:
1-93: MKKSRSVMTV...SIAITTVSQE → MTAKDSSKEL...QRRRFTVAHT
The sequence of this isoform differs from the canonical sequence as follows:
1-15: MKKSRSVMTVMADDN → MPEANYLLSVSWGYI
16-248: Missing.
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PNB0 | E9PNB0_HUMAN | 3',5'-cyclic-AMP phosphodiesterase | PDE4B | 143 | Annotation score: | ||
E9PR34 | E9PR34_HUMAN | 3',5'-cyclic-AMP phosphodiesterase | PDE4B | 152 | Annotation score: | ||
E9PJ03 | E9PJ03_HUMAN | 3',5'-cyclic-AMP phosphodiesterase | PDE4B | 137 | Annotation score: | ||
E9PMG3 | E9PMG3_HUMAN | 3',5'-cyclic-AMP phosphodiesterase | PDE4B | 147 | Annotation score: | ||
H0YCV7 | H0YCV7_HUMAN | 3',5'-cyclic-AMP phosphodiesterase | PDE4B | 66 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034373 | 703 | S → C. Corresponds to variant dbSNP:rs2227297EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_004572 | 1 – 211 | MKKSR…RVNPQ → MKEHGGTFSSTGISGGSGDS AMDSLQPLQPNYMPVCLFA in isoform PDE4B2. 3 PublicationsAdd BLAST | 211 | |
Alternative sequenceiVSP_004571 | 1 – 93 | MKKSR…TVSQE → MTAKDSSKELTASEPEVCIK TFKEQMHLELELPRLPGNRP TSPKISPRSSPRNSPCFFRK LLVNKSIRQRRRFTVAHT in isoform PDE4B3. 2 PublicationsAdd BLAST | 93 | |
Alternative sequenceiVSP_047723 | 1 – 15 | MKKSR…MADDN → MPEANYLLSVSWGYI in isoform PDE4B5. 2 PublicationsAdd BLAST | 15 | |
Alternative sequenceiVSP_047724 | 16 – 248 | Missing in isoform PDE4B5. 2 PublicationsAdd BLAST | 233 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L12686 mRNA Translation: AAA35643.1 Different initiation. L20966 mRNA Translation: AAA03589.1 L20971 mRNA Translation: AAA03593.1 U85048 mRNA Translation: AAB96381.1 M97515 mRNA Translation: AAA36426.1 EF595686 mRNA Translation: ABQ85407.1 AK289969 mRNA Translation: BAF82658.1 AK290006 mRNA Translation: BAF82695.1 AK290206 mRNA Translation: BAF82895.1 AL592285 Genomic DNA No translation available. AL357273 Genomic DNA No translation available. AL109926 Genomic DNA No translation available. AL359701 Genomic DNA No translation available. AL513493 Genomic DNA No translation available. AL590783 Genomic DNA No translation available. AL591487 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06524.1 BC101480 mRNA Translation: AAI01481.1 BC105040 mRNA Translation: AAI05041.1 |
CCDSi | CCDS30742.1 [Q07343-3] CCDS30743.1 [Q07343-2] CCDS632.1 [Q07343-1] CCDS72802.1 [Q07343-4] |
PIRi | I61354 |
RefSeqi | NP_001032416.1, NM_001037339.2 [Q07343-2] NP_001032417.1, NM_001037340.2 [Q07343-3] NP_001032418.1, NM_001037341.1 [Q07343-1] NP_001284369.1, NM_001297440.1 NP_001284370.1, NM_001297441.1 NP_001284371.1, NM_001297442.1 [Q07343-4] NP_002591.2, NM_002600.3 [Q07343-1] |
Genome annotation databases
Ensembli | ENST00000329654; ENSP00000332116; ENSG00000184588 [Q07343-1] ENST00000341517; ENSP00000342637; ENSG00000184588 [Q07343-1] ENST00000371045; ENSP00000360084; ENSG00000184588 [Q07343-2] ENST00000423207; ENSP00000392947; ENSG00000184588 [Q07343-3] ENST00000480109; ENSP00000432592; ENSG00000184588 [Q07343-4] |
GeneIDi | 5142 |
KEGGi | hsa:5142 |
UCSCi | uc001dcp.4, human [Q07343-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L12686 mRNA Translation: AAA35643.1 Different initiation. L20966 mRNA Translation: AAA03589.1 L20971 mRNA Translation: AAA03593.1 U85048 mRNA Translation: AAB96381.1 M97515 mRNA Translation: AAA36426.1 EF595686 mRNA Translation: ABQ85407.1 AK289969 mRNA Translation: BAF82658.1 AK290006 mRNA Translation: BAF82695.1 AK290206 mRNA Translation: BAF82895.1 AL592285 Genomic DNA No translation available. AL357273 Genomic DNA No translation available. AL109926 Genomic DNA No translation available. AL359701 Genomic DNA No translation available. AL513493 Genomic DNA No translation available. AL590783 Genomic DNA No translation available. AL591487 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06524.1 BC101480 mRNA Translation: AAI01481.1 BC105040 mRNA Translation: AAI05041.1 |
CCDSi | CCDS30742.1 [Q07343-3] CCDS30743.1 [Q07343-2] CCDS632.1 [Q07343-1] CCDS72802.1 [Q07343-4] |
PIRi | I61354 |
RefSeqi | NP_001032416.1, NM_001037339.2 [Q07343-2] NP_001032417.1, NM_001037340.2 [Q07343-3] NP_001032418.1, NM_001037341.1 [Q07343-1] NP_001284369.1, NM_001297440.1 NP_001284370.1, NM_001297441.1 NP_001284371.1, NM_001297442.1 [Q07343-4] NP_002591.2, NM_002600.3 [Q07343-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1F0J | X-ray | 1.77 | A/B | 324-700 | [»] | |
1JP1 | model | - | A | 324-700 | [»] | |
1JP2 | model | - | A | 324-700 | [»] | |
1RO6 | X-ray | 2.00 | A/B | 324-700 | [»] | |
1RO9 | X-ray | 2.13 | A/B | 324-700 | [»] | |
1ROR | X-ray | 2.00 | A/B | 324-700 | [»] | |
1TB5 | X-ray | 2.15 | A/B | 324-700 | [»] | |
1XLX | X-ray | 2.19 | A/B | 324-700 | [»] | |
1XLZ | X-ray | 2.06 | A/B | 324-700 | [»] | |
1XM4 | X-ray | 2.31 | A/B | 324-700 | [»] | |
1XM6 | X-ray | 1.92 | A/B | 324-700 | [»] | |
1XMU | X-ray | 2.30 | A/B | 324-700 | [»] | |
1XMY | X-ray | 2.40 | A/B | 324-700 | [»] | |
1XN0 | X-ray | 2.31 | A/B | 324-700 | [»] | |
1XOS | X-ray | 2.28 | A | 324-700 | [»] | |
1XOT | X-ray | 2.34 | A/B | 324-700 | [»] | |
1Y2H | X-ray | 2.40 | A/B | 324-700 | [»] | |
1Y2J | X-ray | 2.55 | A/B | 324-700 | [»] | |
2CHM | X-ray | 1.60 | A | 450-475 | [»] | |
2QYL | X-ray | 1.95 | A | 324-659 | [»] | |
3D3P | X-ray | 1.75 | A | 324-675 | [»] | |
3FRG | X-ray | 1.70 | A | 324-675 | [»] | |
3G45 | X-ray | 2.63 | A/B | 241-289 | [»] | |
A/B | 305-659 | [»] | ||||
3GWT | X-ray | 1.75 | A | 324-675 | [»] | |
3HC8 | X-ray | 1.79 | A | 451-474 | [»] | |
3HDZ | X-ray | 1.80 | A | 451-474 | [»] | |
3HMV | X-ray | 2.23 | A/B | 324-700 | [»] | |
3KKT | X-ray | 2.48 | A/B | 324-700 | [»] | |
3LY2 | X-ray | 2.60 | A/B/C/D/E/F/G/H | 324-659 | [»] | |
3O0J | X-ray | 1.95 | A | 334-656 | [»] | |
3O56 | X-ray | 2.42 | A | 324-675 | [»] | |
3O57 | X-ray | 2.00 | A | 324-675 | [»] | |
3W5E | X-ray | 2.30 | A/B | 324-700 | [»] | |
3WD9 | X-ray | 2.50 | A/B | 324-700 | [»] | |
4KP6 | X-ray | 1.50 | A | 324-659 | [»] | |
4MYQ | X-ray | 1.90 | A | 324-691 | [»] | |
4NW7 | X-ray | 2.15 | A | 324-691 | [»] | |
4WZI | X-ray | 2.58 | A/B | 122-736 | [»] | |
4X0F | X-ray | 3.22 | A/B | 122-736 | [»] | |
5K6J | X-ray | 1.86 | A | 334-656 | [»] | |
5LAQ | X-ray | 2.40 | A | 241-289 | [»] | |
A | 305-659 | [»] | ||||
5OHJ | X-ray | 1.60 | A/B | 241-659 | [»] | |
6BOJ | X-ray | 1.70 | A/B/C/D | 663-673 | [»] | |
SMRi | Q07343 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111168, 12 interactors |
CORUMi | Q07343 |
ELMi | Q07343 |
IntActi | Q07343, 7 interactors |
STRINGi | 9606.ENSP00000332116 |
Chemistry databases
BindingDBi | Q07343 |
ChEMBLi | CHEMBL275 |
DrugBanki | DB04149, (R)-Rolipram DB03606, (S)-Rolipram DB03807, 1-(2-Chlorophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester DB06909, 1-ethyl-N-(phenylmethyl)-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide DB01959, 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester DB08299, 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid DB03349, 8-Bromo-Adenosine-5'-Monophosphate DB00131, Adenosine phosphate DB01427, Amrinone DB00201, Caffeine DB03849, Cilomilast DB05219, Crisaborole DB01647, Daxalipram DB00651, Dyphylline DB00824, Enprofylline DB02660, Filaminast DB05266, Ibudilast DB01088, Iloprost DB01113, Papaverine DB01791, Piclamilast DB01656, Roflumilast DB01954, Rolipram DB04530, S,S-(2-Hydroxyethyl)Thiocysteine DB01412, Theobromine DB00277, Theophylline DB09283, Trapidil |
DrugCentrali | Q07343 |
GuidetoPHARMACOLOGYi | 1301 |
PTM databases
iPTMneti | Q07343 |
PhosphoSitePlusi | Q07343 |
Genetic variation databases
BioMutai | PDE4B |
DMDMi | 729163 |
Proteomic databases
jPOSTi | Q07343 |
MassIVEi | Q07343 |
PaxDbi | Q07343 |
PeptideAtlasi | Q07343 |
PRIDEi | Q07343 |
ProteomicsDBi | 58512 [Q07343-1] 58513 [Q07343-2] 58514 [Q07343-3] 65061 768 |
Protocols and materials databases
Antibodypediai | 1172, 470 antibodies |
Genome annotation databases
Ensembli | ENST00000329654; ENSP00000332116; ENSG00000184588 [Q07343-1] ENST00000341517; ENSP00000342637; ENSG00000184588 [Q07343-1] ENST00000371045; ENSP00000360084; ENSG00000184588 [Q07343-2] ENST00000423207; ENSP00000392947; ENSG00000184588 [Q07343-3] ENST00000480109; ENSP00000432592; ENSG00000184588 [Q07343-4] |
GeneIDi | 5142 |
KEGGi | hsa:5142 |
UCSCi | uc001dcp.4, human [Q07343-1] |
Organism-specific databases
CTDi | 5142 |
DisGeNETi | 5142 |
GeneCardsi | PDE4B |
HGNCi | HGNC:8781, PDE4B |
HPAi | ENSG00000184588, Tissue enhanced (bone) |
MIMi | 600127, gene |
neXtProti | NX_Q07343 |
OpenTargetsi | ENSG00000184588 |
PharmGKBi | PA33129 |
VEuPathDBi | HostDB:ENSG00000184588.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3689, Eukaryota |
GeneTreei | ENSGT00940000155190 |
HOGENOMi | CLU_005940_5_3_1 |
OMAi | XFDVENG |
OrthoDBi | 199083at2759 |
PhylomeDBi | Q07343 |
TreeFami | TF314638 |
Enzyme and pathway databases
UniPathwayi | UPA00762;UER00747 |
BRENDAi | 3.1.4.53, 2681 |
PathwayCommonsi | Q07343 |
Reactomei | R-HSA-180024, DARPP-32 events |
SIGNORi | Q07343 |
Miscellaneous databases
BioGRID-ORCSi | 5142, 1 hit in 878 CRISPR screens |
ChiTaRSi | PDE4B, human |
EvolutionaryTracei | Q07343 |
GeneWikii | PDE4B |
GenomeRNAii | 5142 |
Pharosi | Q07343, Tclin |
PROi | PR:Q07343 |
RNActi | Q07343, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000184588, Expressed in corpus callosum and 241 other tissues |
ExpressionAtlasi | Q07343, baseline and differential |
Genevisiblei | Q07343, HS |
Family and domain databases
CDDi | cd00077, HDc, 1 hit |
Gene3Di | 1.10.1300.10, 1 hit |
InterProi | View protein in InterPro IPR003607, HD/PDEase_dom IPR043371, PDE4 IPR040844, PDE4_UCR IPR023088, PDEase IPR002073, PDEase_catalytic_dom IPR036971, PDEase_catalytic_dom_sf IPR023174, PDEase_CS |
PANTHERi | PTHR11347:SF108, PTHR11347:SF108, 1 hit |
Pfami | View protein in Pfam PF18100, PDE4_UCR, 1 hit PF00233, PDEase_I, 1 hit |
PRINTSi | PR00387, PDIESTERASE1 |
SMARTi | View protein in SMART SM00471, HDc, 1 hit |
PROSITEi | View protein in PROSITE PS00126, PDEASE_I_1, 1 hit PS51845, PDEASE_I_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PDE4B_HUMAN | |
Accessioni | Q07343Primary (citable) accession number: Q07343 Secondary accession number(s): A5YW33 Q5TEK6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | February 10, 2021 | |
This is version 199 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families