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UniProtKB - Q07343 (PDE4B_HUMAN)

Entry version 187 (13 Feb 2019)
Sequence version 1 (01 Feb 1995)
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Protein

cAMP-specific 3',5'-cyclic phosphodiesterase 4B

Gene

PDE4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

a divalent metal cation2 PublicationsNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.2 Publications

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by rolipram.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: 3',5'-cyclic AMP degradation

This protein is involved in step 1 of the subpathway that synthesizes AMP from 3',5'-cyclic AMP.
Proteins known to be involved in this subpathway in this organism are:
  1. cAMP-specific 3',5'-cyclic phosphodiesterase 7B (PDE7B), High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (PDE7A), cAMP-specific 3',5'-cyclic phosphodiesterase 4A (PDE4A), cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A), cAMP-specific 3',5'-cyclic phosphodiesterase 4C (PDE4C), High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (PDE8B), cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B), cAMP-specific 3',5'-cyclic phosphodiesterase 4D (PDE4D), High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (PDE8A)
This subpathway is part of the pathway 3',5'-cyclic AMP degradation, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from 3',5'-cyclic AMP, the pathway 3',5'-cyclic AMP degradation and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei406Proton donor1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi410Divalent metal cation 11
Metal bindingi446Divalent metal cation 11
Metal bindingi447Divalent metal cation 11
Metal bindingi447Divalent metal cation 21
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei447cAMP1
Metal bindingi564Divalent metal cation 11
Binding sitei564cAMP1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei567Binds AMP, but not cAMPBy similarity1
Binding sitei615cAMP1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi406 – 410cAMP5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 3',5'-cyclic-AMP phosphodiesterase activity Source: BHF-UCL
  • cAMP binding Source: BHF-UCL
  • gamma-tubulin binding Source: Ensembl
  • ion channel binding Source: BHF-UCL
  • metal ion binding Source: UniProtKB-KW
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandcAMP, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.1.4.53 2681

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-180024 DARPP-32 events
R-HSA-418555 G alpha (s) signalling events

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q07343

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi
UPA00762;UER00747

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC:3.1.4.53)
Alternative name(s):
DPDE4
PDE32
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PDE4B
Synonyms:DPDE4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000184588.17

Human Gene Nomenclature Database

More...HGNCi		HGNC:8781 PDE4B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600127 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q07343

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		5142

Open Targets

More...OpenTargetsi		ENSG00000184588

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33129

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL275

Drug and drug target database

More...DrugBanki		DB01647 (R)-Mesopram
DB04149 (R)-Rolipram
DB03606 (S)-Rolipram
DB03349 8-Bromo-Adenosine-5'-Monophosphate
DB00131 Adenosine monophosphate
DB01427 Amrinone
DB05676 Apremilast
DB00201 Caffeine
DB03849 Cilomilast
DB05219 Crisaborole
DB00651 Dyphylline
DB00824 Enprofylline
DB02660 Filaminast
DB05266 Ibudilast
DB01088 Iloprost
DB01113 Papaverine
DB00806 Pentoxifylline
DB01791 Piclamilast
DB01656 Roflumilast
DB01954 Rolipram
DB01412 Theobromine
DB00277 Theophylline

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1301

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PDE4B

Domain mapping of disease mutations (DMDM)

More...DMDMi		729163

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001988091 – 736cAMP-specific 3',5'-cyclic phosphodiesterase 4BAdd BLAST736

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei290PhosphoserineBy similarity1
Modified residuei659PhosphoserineBy similarity1
Modified residuei661PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q07343

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q07343

PeptideAtlas

More...PeptideAtlasi		Q07343

PRoteomics IDEntifications database

More...PRIDEi		Q07343

ProteomicsDB human proteome resource

More...ProteomicsDBi		58512
58513 [Q07343-2]
58514 [Q07343-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q07343

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q07343

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, heart, lung and skeletal muscle.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000184588 Expressed in 231 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q07343 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q07343 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA003005

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		111168, 12 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q07343

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q07343

Protein interaction database and analysis system

More...IntActi		Q07343, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000332116

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q07343

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1736
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F0JX-ray1.77A/B324-700[»]
1JP1model-A324-700[»]
1JP2model-A324-700[»]
1RO6X-ray2.00A/B324-700[»]
1RO9X-ray2.13A/B324-700[»]
1RORX-ray2.00A/B324-700[»]
1TB5X-ray2.15A/B324-700[»]
1XLXX-ray2.19A/B324-700[»]
1XLZX-ray2.06A/B324-700[»]
1XM4X-ray2.31A/B324-700[»]
1XM6X-ray1.92A/B324-700[»]
1XMUX-ray2.30A/B324-700[»]
1XMYX-ray2.40A/B324-700[»]
1XN0X-ray2.31A/B324-700[»]
1XOSX-ray2.28A324-700[»]
1XOTX-ray2.34A/B324-700[»]
1Y2HX-ray2.40A/B324-700[»]
1Y2JX-ray2.55A/B324-700[»]
2CHMX-ray1.60A450-475[»]
2QYLX-ray1.95A324-659[»]
3D3PX-ray1.75A324-675[»]
3FRGX-ray1.70A324-675[»]
3G45X-ray2.63A/B241-289[»]
A/B305-659[»]
3GWTX-ray1.75A324-675[»]
3HC8X-ray1.79A451-474[»]
3HDZX-ray1.80A451-474[»]
3HMVX-ray2.23A/B324-700[»]
3KKTX-ray2.48A/B324-700[»]
3LY2X-ray2.60A/B/C/D/E/F/G/H324-659[»]
3O0JX-ray1.95A334-656[»]
3O56X-ray2.42A324-675[»]
3O57X-ray2.00A324-675[»]
3W5EX-ray2.30A/B324-700[»]
3WD9X-ray2.50A/B324-700[»]
4KP6X-ray1.50A324-659[»]
4MYQX-ray1.90A324-691[»]
4NW7X-ray2.15A324-691[»]
4WZIX-ray2.58A/B122-736[»]
4X0FX-ray3.22A/B122-736[»]
5K6JX-ray1.86A334-656[»]
5LAQX-ray2.40A241-289[»]
A305-659[»]
5OHJX-ray1.60A/B241-659[»]
6BOJX-ray1.70A/B/C/D663-673[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q07343

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q07343

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q07343

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini330 – 659PDEasePROSITE-ProRule annotationAdd BLAST330

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3689 Eukaryota
ENOG410XRI7 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155190

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000236297

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG108239

KEGG Orthology (KO)

More...KOi		K13293

Identification of Orthologs from Complete Genome Data

More...OMAi		EGHNYFS

Database of Orthologous Groups

More...OrthoDBi		904682at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q07343

TreeFam database of animal gene trees

More...TreeFami		TF314638

Family and domain databases

Conserved Domains Database

More...CDDi		cd00077 HDc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1300.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003607 HD/PDEase_dom
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00233 PDEase_I, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00387 PDIESTERASE1

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00471 HDc, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform PDE4B1 (identifier: Q07343-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKKSRSVMTV MADDNVKDYF ECSLSKSYSS SSNTLGIDLW RGRRCCSGNL 
        60         70         80         90        100
QLPPLSQRQS ERARTPEGDG ISRPTTLPLT TLPSIAITTV SQECFDVENG 
       110        120        130        140        150
PSPGRSPLDP QASSSAGLVL HATFPGHSQR RESFLYRSDS DYDLSPKAMS 
       160        170        180        190        200
RNSSLPSEQH GDDLIVTPFA QVLASLRSVR NNFTILTNLH GTSNKRSPAA 
       210        220        230        240        250
SQPPVSRVNP QEESYQKLAM ETLEELDWCL DQLETIQTYR SVSEMASNKF 
       260        270        280        290        300
KRMLNRELTH LSEMSRSGNQ VSEYISNTFL DKQNDVEIPS PTQKDREKKK 
       310        320        330        340        350
KQQLMTQISG VKKLMHSSSL NNTSISRFGV NTENEDHLAK ELEDLNKWGL 
       360        370        380        390        400
NIFNVAGYSH NRPLTCIMYA IFQERDLLKT FRISSDTFIT YMMTLEDHYH 
       410        420        430        440        450
SDVAYHNSLH AADVAQSTHV LLSTPALDAV FTDLEILAAI FAAAIHDVDH 
       460        470        480        490        500
PGVSNQFLIN TNSELALMYN DESVLENHHL AVGFKLLQEE HCDIFMNLTK 
       510        520        530        540        550
KQRQTLRKMV IDMVLATDMS KHMSLLADLK TMVETKKVTS SGVLLLDNYT 
       560        570        580        590        600
DRIQVLRNMV HCADLSNPTK SLELYRQWTD RIMEEFFQQG DKERERGMEI 
       610        620        630        640        650
SPMCDKHTAS VEKSQVGFID YIVHPLWETW ADLVQPDAQD ILDTLEDNRN 
       660        670        680        690        700
WYQSMIPQSP SPPLDEQNRD CQGLMEKFQF ELTLDEEDSE GPEKEGEGHS 
       710        720        730 
YFSSTKTLCV IDPENRDSLG ETDIDIATED KSPVDT
Length:736
Mass (Da):83,343
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i208FCE9CD40EF5EB
GO
Isoform PDE4B2 (identifier: Q07343-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-211: MKKSRSVMTV...QPPVSRVNPQ → MKEHGGTFSS...PNYMPVCLFA

Show »
Length:564
Mass (Da):64,352
Checksum:iA4F9FA0C5DB43380
GO
Isoform PDE4B3 (identifier: Q07343-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-93: MKKSRSVMTV...SIAITTVSQE → MTAKDSSKEL...QRRRFTVAHT

Show »
Length:721
Mass (Da):82,096
Checksum:i49618FFEAFF33D30
GO
Isoform PDE4B5 (identifier: Q07343-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MKKSRSVMTVMADDN → MPEANYLLSVSWGYI
     16-248: Missing.

Note: Brain-specific isoform.
Show »
Length:503
Mass (Da):57,709
Checksum:i23AF122BAF338C42
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PR34E9PR34_HUMAN
cAMP-specific 3',5'-cyclic phosphod...
PDE4B
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJ03E9PJ03_HUMAN
cAMP-specific 3',5'-cyclic phosphod...
PDE4B
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNB0E9PNB0_HUMAN
cAMP-specific 3',5'-cyclic phosphod...
PDE4B
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMG3E9PMG3_HUMAN
cAMP-specific 3',5'-cyclic phosphod...
PDE4B
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCV7H0YCV7_HUMAN
cAMP-specific 3',5'-cyclic phosphod...
PDE4B
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA35643 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034373703S → C. Corresponds to variant dbSNP:rs2227297Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0045721 – 211MKKSR…RVNPQ → MKEHGGTFSSTGISGGSGDS AMDSLQPLQPNYMPVCLFA in isoform PDE4B2. 3 PublicationsAdd BLAST211
Alternative sequenceiVSP_0045711 – 93MKKSR…TVSQE → MTAKDSSKELTASEPEVCIK TFKEQMHLELELPRLPGNRP TSPKISPRSSPRNSPCFFRK LLVNKSIRQRRRFTVAHT in isoform PDE4B3. 2 PublicationsAdd BLAST93
Alternative sequenceiVSP_0477231 – 15MKKSR…MADDN → MPEANYLLSVSWGYI in isoform PDE4B5. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_04772416 – 248Missing in isoform PDE4B5. 2 PublicationsAdd BLAST233

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L12686 mRNA Translation: AAA35643.1 Different initiation.
L20966 mRNA Translation: AAA03589.1
L20971 mRNA Translation: AAA03593.1
U85048 mRNA Translation: AAB96381.1
M97515 mRNA Translation: AAA36426.1
EF595686 mRNA Translation: ABQ85407.1
AK289969 mRNA Translation: BAF82658.1
AK290006 mRNA Translation: BAF82695.1
AK290206 mRNA Translation: BAF82895.1
AL592285 Genomic DNA No translation available.
AL357273 Genomic DNA No translation available.
AL109926 Genomic DNA No translation available.
AL359701 Genomic DNA No translation available.
AL513493 Genomic DNA No translation available.
AL590783 Genomic DNA No translation available.
AL591487 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06524.1
BC101480 mRNA Translation: AAI01481.1
BC105040 mRNA Translation: AAI05041.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS30742.1 [Q07343-3]
CCDS30743.1 [Q07343-2]
CCDS632.1 [Q07343-1]
CCDS72802.1 [Q07343-4]

Protein sequence database of the Protein Information Resource

More...PIRi		I61354

NCBI Reference Sequences

More...RefSeqi		NP_001032416.1, NM_001037339.2 [Q07343-2]
NP_001032417.1, NM_001037340.2 [Q07343-3]
NP_001032418.1, NM_001037341.1 [Q07343-1]
NP_001284369.1, NM_001297440.1
NP_001284370.1, NM_001297441.1
NP_001284371.1, NM_001297442.1 [Q07343-4]
NP_002591.2, NM_002600.3 [Q07343-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.198072

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000329654; ENSP00000332116; ENSG00000184588 [Q07343-1]
ENST00000341517; ENSP00000342637; ENSG00000184588 [Q07343-1]
ENST00000371045; ENSP00000360084; ENSG00000184588 [Q07343-2]
ENST00000423207; ENSP00000392947; ENSG00000184588 [Q07343-3]
ENST00000480109; ENSP00000432592; ENSG00000184588 [Q07343-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5142

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5142

UCSC genome browser

More...UCSCi		uc001dcp.4 human [Q07343-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12686 mRNA Translation: AAA35643.1 Different initiation.
L20966 mRNA Translation: AAA03589.1
L20971 mRNA Translation: AAA03593.1
U85048 mRNA Translation: AAB96381.1
M97515 mRNA Translation: AAA36426.1
EF595686 mRNA Translation: ABQ85407.1
AK289969 mRNA Translation: BAF82658.1
AK290006 mRNA Translation: BAF82695.1
AK290206 mRNA Translation: BAF82895.1
AL592285 Genomic DNA No translation available.
AL357273 Genomic DNA No translation available.
AL109926 Genomic DNA No translation available.
AL359701 Genomic DNA No translation available.
AL513493 Genomic DNA No translation available.
AL590783 Genomic DNA No translation available.
AL591487 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06524.1
BC101480 mRNA Translation: AAI01481.1
BC105040 mRNA Translation: AAI05041.1
CCDSiCCDS30742.1 [Q07343-3]
CCDS30743.1 [Q07343-2]
CCDS632.1 [Q07343-1]
CCDS72802.1 [Q07343-4]
PIRiI61354
RefSeqiNP_001032416.1, NM_001037339.2 [Q07343-2]
NP_001032417.1, NM_001037340.2 [Q07343-3]
NP_001032418.1, NM_001037341.1 [Q07343-1]
NP_001284369.1, NM_001297440.1
NP_001284370.1, NM_001297441.1
NP_001284371.1, NM_001297442.1 [Q07343-4]
NP_002591.2, NM_002600.3 [Q07343-1]
UniGeneiHs.198072

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F0JX-ray1.77A/B324-700[»]
1JP1model-A324-700[»]
1JP2model-A324-700[»]
1RO6X-ray2.00A/B324-700[»]
1RO9X-ray2.13A/B324-700[»]
1RORX-ray2.00A/B324-700[»]
1TB5X-ray2.15A/B324-700[»]
1XLXX-ray2.19A/B324-700[»]
1XLZX-ray2.06A/B324-700[»]
1XM4X-ray2.31A/B324-700[»]
1XM6X-ray1.92A/B324-700[»]
1XMUX-ray2.30A/B324-700[»]
1XMYX-ray2.40A/B324-700[»]
1XN0X-ray2.31A/B324-700[»]
1XOSX-ray2.28A324-700[»]
1XOTX-ray2.34A/B324-700[»]
1Y2HX-ray2.40A/B324-700[»]
1Y2JX-ray2.55A/B324-700[»]
2CHMX-ray1.60A450-475[»]
2QYLX-ray1.95A324-659[»]
3D3PX-ray1.75A324-675[»]
3FRGX-ray1.70A324-675[»]
3G45X-ray2.63A/B241-289[»]
A/B305-659[»]
3GWTX-ray1.75A324-675[»]
3HC8X-ray1.79A451-474[»]
3HDZX-ray1.80A451-474[»]
3HMVX-ray2.23A/B324-700[»]
3KKTX-ray2.48A/B324-700[»]
3LY2X-ray2.60A/B/C/D/E/F/G/H324-659[»]
3O0JX-ray1.95A334-656[»]
3O56X-ray2.42A324-675[»]
3O57X-ray2.00A324-675[»]
3W5EX-ray2.30A/B324-700[»]
3WD9X-ray2.50A/B324-700[»]
4KP6X-ray1.50A324-659[»]
4MYQX-ray1.90A324-691[»]
4NW7X-ray2.15A324-691[»]
4WZIX-ray2.58A/B122-736[»]
4X0FX-ray3.22A/B122-736[»]
5K6JX-ray1.86A334-656[»]
5LAQX-ray2.40A241-289[»]
A305-659[»]
5OHJX-ray1.60A/B241-659[»]
6BOJX-ray1.70A/B/C/D663-673[»]
ProteinModelPortaliQ07343
SMRiQ07343
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111168, 12 interactors
CORUMiQ07343
ELMiQ07343
IntActiQ07343, 4 interactors
STRINGi9606.ENSP00000332116

Chemistry databases

BindingDBiQ07343
ChEMBLiCHEMBL275
DrugBankiDB01647 (R)-Mesopram
DB04149 (R)-Rolipram
DB03606 (S)-Rolipram
DB03349 8-Bromo-Adenosine-5'-Monophosphate
DB00131 Adenosine monophosphate
DB01427 Amrinone
DB05676 Apremilast
DB00201 Caffeine
DB03849 Cilomilast
DB05219 Crisaborole
DB00651 Dyphylline
DB00824 Enprofylline
DB02660 Filaminast
DB05266 Ibudilast
DB01088 Iloprost
DB01113 Papaverine
DB00806 Pentoxifylline
DB01791 Piclamilast
DB01656 Roflumilast
DB01954 Rolipram
DB01412 Theobromine
DB00277 Theophylline
GuidetoPHARMACOLOGYi1301

PTM databases

iPTMnetiQ07343
PhosphoSitePlusiQ07343

Polymorphism and mutation databases

BioMutaiPDE4B
DMDMi729163

Proteomic databases

jPOSTiQ07343
PaxDbiQ07343
PeptideAtlasiQ07343
PRIDEiQ07343
ProteomicsDBi58512
58513 [Q07343-2]
58514 [Q07343-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329654; ENSP00000332116; ENSG00000184588 [Q07343-1]
ENST00000341517; ENSP00000342637; ENSG00000184588 [Q07343-1]
ENST00000371045; ENSP00000360084; ENSG00000184588 [Q07343-2]
ENST00000423207; ENSP00000392947; ENSG00000184588 [Q07343-3]
ENST00000480109; ENSP00000432592; ENSG00000184588 [Q07343-4]
GeneIDi5142
KEGGihsa:5142
UCSCiuc001dcp.4 human [Q07343-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5142
DisGeNETi5142
EuPathDBiHostDB:ENSG00000184588.17

GeneCards: human genes, protein and diseases

More...GeneCardsi		PDE4B
HGNCiHGNC:8781 PDE4B
HPAiHPA003005
MIMi600127 gene
neXtProtiNX_Q07343
OpenTargetsiENSG00000184588
PharmGKBiPA33129

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3689 Eukaryota
ENOG410XRI7 LUCA
GeneTreeiENSGT00940000155190
HOGENOMiHOG000236297
HOVERGENiHBG108239
KOiK13293
OMAiEGHNYFS
OrthoDBi904682at2759
PhylomeDBiQ07343
TreeFamiTF314638

Enzyme and pathway databases

UniPathwayi
UPA00762;UER00747

BRENDAi3.1.4.53 2681
ReactomeiR-HSA-180024 DARPP-32 events
R-HSA-418555 G alpha (s) signalling events
SIGNORiQ07343

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PDE4B human
EvolutionaryTraceiQ07343

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PDE4B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5142

Protein Ontology

More...PROi		PR:Q07343

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000184588 Expressed in 231 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ07343 baseline and differential
GenevisibleiQ07343 HS

Family and domain databases

CDDicd00077 HDc, 1 hit
Gene3Di1.10.1300.10, 1 hit
InterProiView protein in InterPro
IPR003607 HD/PDEase_dom
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS
PfamiView protein in Pfam
PF00233 PDEase_I, 1 hit
PRINTSiPR00387 PDIESTERASE1
SMARTiView protein in SMART
SM00471 HDc, 1 hit
PROSITEiView protein in PROSITE
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPDE4B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q07343
Secondary accession number(s): A5YW33
, O15443, Q13945, Q5TEK4, Q5TEK5, Q5TEK6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 13, 2019
This is version 187 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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