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Protein

Neurexin-3

Gene

Nrxn3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi308CalciumBy similarity1
Metal bindingi325Calcium; via carbonyl oxygenBy similarity1
Metal bindingi378Calcium; via carbonyl oxygenBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neurexin-3
Alternative name(s):
Neurexin III-alpha
Neurexin-3-alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nrxn3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
620212 Nrxn3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini28 – 1503ExtracellularSequence analysisAdd BLAST1476
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1504 – 1524HelicalSequence analysisAdd BLAST21
Topological domaini1525 – 1578CytoplasmicSequence analysisAdd BLAST54

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 271 PublicationAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001950028 – 1578Neurexin-3Add BLAST1551

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi202 ↔ 213By similarity
Disulfide bondi207 ↔ 222By similarity
Disulfide bondi224 ↔ 234By similarity
Disulfide bondi408 ↔ 444By similarity
Disulfide bondi614 ↔ 643By similarity
Disulfide bondi651 ↔ 662By similarity
Disulfide bondi656 ↔ 671By similarity
Disulfide bondi673 ↔ 683By similarity
Glycosylationi761N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1022 ↔ 1050By similarity
Disulfide bondi1057 ↔ 1068By similarity
Disulfide bondi1062 ↔ 1077By similarity
Disulfide bondi1079 ↔ 1089By similarity
Glycosylationi1193N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1291N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1335N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1500N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q07310

PRoteomics IDEntifications database

More...
PRIDEi
Q07310

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q07310

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q07310

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The laminin G-like domain 2 binds to NXPH1. Isoforms alpha 4B bind to alpha-dystroglycan. The cytoplasmic C-terminal region binds to CASK.3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
250475, 2 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q07310

Protein interaction database and analysis system

More...
IntActi
Q07310, 1 interactor

Molecular INTeraction database

More...
MINTi
Q07310

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000060600

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q07310

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q07310

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 202Laminin G-like 1PROSITE-ProRule annotationAdd BLAST175
Domaini198 – 235EGF-like 1PROSITE-ProRule annotationAdd BLAST38
Domaini260 – 444Laminin G-like 2PROSITE-ProRule annotationAdd BLAST185
Domaini451 – 643Laminin G-like 3PROSITE-ProRule annotationAdd BLAST193
Domaini647 – 684EGF-like 2PROSITE-ProRule annotationAdd BLAST38
Domaini689 – 861Laminin G-like 4PROSITE-ProRule annotationAdd BLAST173
Domaini875 – 1050Laminin G-like 5PROSITE-ProRule annotationAdd BLAST176
Domaini1053 – 1090EGF-like 3PROSITE-ProRule annotationAdd BLAST38
Domaini1094 – 1294Laminin G-like 6PROSITE-ProRule annotationAdd BLAST201

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi282 – 285Poly-Ser4
Compositional biasi1323 – 1326Poly-Thr4
Compositional biasi1329 – 1332Poly-Thr4
Compositional biasi1407 – 1410Poly-Thr4
Compositional biasi1422 – 1425Poly-Ser4
Compositional biasi1511 – 1514Poly-Ala4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the neurexin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230481

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG052670

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q07310

KEGG Orthology (KO)

More...
KOi
K07377

Database of Orthologous Groups

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OrthoDBi
35129at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q07310

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR001791 Laminin_G
IPR037440 Neurexin
IPR003585 Neurexin-like
IPR027789 Syndecan/Neurexin_dom

The PANTHER Classification System

More...
PANTHERi
PTHR44287 PTHR44287, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008 EGF, 1 hit
PF02210 Laminin_G_2, 6 hits
PF01034 Syndecan, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00294 4.1m, 1 hit
SM00181 EGF, 3 hits
SM00282 LamG, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS50026 EGF_3, 3 hits
PS50025 LAM_G_DOMAIN, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (19+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 19 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: There are five major alternatively spliced sites, each of which may be spliced in up to twelve different ways. Combinatorial splicing at each of these five sites may lead to the generation of at least 288 isoforms but for simplicity only individual splice events are explicitly described below. Isoforms Alpha 5A to isoform Alpha 5H lack the transmembrane domain. Experimental confirmation may be lacking for some isoforms.

This entry has 19 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q07310-1) [UniParc]FASTAAdd to basket
Also known as: Alpha-5I

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSFTLHSVFF TLKVSSFLGS LVGLCLGLEF MGLPNQWARY LRWDASTRSD
60 70 80 90 100
LSFQFKTNVS TGLLLYLDDG GVCDFLCLSL VDGRVQLRFS MDCAETTVLS
110 120 130 140 150
NKQVNDSSWH FLMVSRDRVR TGLVIDGEGQ SGELRAQRPY MDVVSDLFLG
160 170 180 190 200
GGPADIRPSA LTLDGVQNMP GFKGLMLDLK YGNSEPRLLG SQSVQLEAEG
210 220 230 240 250
PCGERPCENG GICFLLDGHP TCDCSTTGYG GTLCSEDVSQ GPGLSHLMMS
260 270 280 290 300
EQGRSKAREE NVATFRGSEY LSYDLSQNPI QSSSSEITLS FKTWQRNGLI
310 320 330 340 350
LHTGKSADYV NLALKDGAVS LVINLGSGAF EAIVEPVNGK FNDNAWHDVK
360 370 380 390 400
VTRNLRQVTI SVDGILTTTG YTQEDYTMLG SDDSSYVGPS PSTADLPGSP
410 420 430 440 450
VSNNFMGCLK EVVYKNNDIR LELSRLARIG ATKMKIYGEV VFKCENVATL
460 470 480 490 500
DPINFETPEA YISLPKWNTK RMGSISFDFR TTEPNGLILL THGKPQERKD
510 520 530 540 550
VRSQKNTKVD FFAVELLDGN LYLLLDMGSG TIKVKATQKK ANDGEWYHVD
560 570 580 590 600
IQRDGRSGTI SVNSRRTPFT ASGQSEILDL EGDMYLGGLP ENRAGLILPT
610 620 630 640 650
ELWTAMLNYG YVGCIRDLFI DGRSKNIRQL AEMQNAAGVK SSCSRMSAKQ
660 670 680 690 700
CDSYPCKNNA VCKDGWNRFI CDCTGTGYWG RTCEREASIL SYDGSMYMKV
710 720 730 740 750
IMPMVMHTEA EDVSFRFMSQ RAYGLLVATT SRDSADTLRL ELDGGRVKLM
760 770 780 790 800
VNLDCIRINC NSSKGPETLY AGQKLNDNEW HTVRVVRRGK SLKLTVDDDV
810 820 830 840 850
AEGTMVGDHT RLEFHNIETG IMTEKRYISV VPSSFIGHLQ SLMFNGLLYI
860 870 880 890 900
DLCKNGDIDY CELKARFGLR NIIADPVTFK TKSSYLTLAT LQAYTSMHLF
910 920 930 940 950
FQFKTTSADG FILFNSGDGN NFIAVELVKG YIHYVFDLGN GPNVIKGNSD
960 970 980 990 1000
RPLNDNQWHN VVITRDNSNT HSLKVDTKVV TQVINGAKNL DLKGDLYMAG
1010 1020 1030 1040 1050
LAQGMYSNLP KLVASRDGFQ GCLASVDLNG RLPDLINDAL HRSGQIDRGC
1060 1070 1080 1090 1100
EGPSTTCQED SCANQGVCMQ QWEGFTCDCS MTSYSGNQCN DPGATYIFGK
1110 1120 1130 1140 1150
SGGLILYTWP ANDRPSTRSD RLAVGFSTTV KDGVLVRIDS APGLGDFLQL
1160 1170 1180 1190 1200
HIEQGKIGVV FNIGTVDISI KEERTPVNDG KYHVVRFTRN GANATLQVDN
1210 1220 1230 1240 1250
WPVNEHYPTG NTDNERRQMV KQKIPFKYNR PVEEWLQEKG RQLTIFNTQA
1260 1270 1280 1290 1300
QIAIGGKDKG RLFQGQLSGL YYDGLKVLNM AAENNPNIKI NGSVRLVGEV
1310 1320 1330 1340 1350
PSVSGTTHTT SMPPEMSTTV METTTTMATT TTRKNRSTAS IQPTSDDLVS
1360 1370 1380 1390 1400
SAECSSDDED FVECEPSTGR SDKSLSTSIF EGGYKAHAPK WESKDFRPNK
1410 1420 1430 1440 1450
VSETSRTTTT SLSPELIRFT ASSSSGMVPK LPAGKMNNRD LKPQPDIVLL
1460 1470 1480 1490 1500
PLPTAYELDS TKLKSPLITC PMFRNVPTAN PTEPGIRRVP GASEVIRESN
1510 1520 1530 1540 1550
STTGMVVGIV AAAALCILIL LYAMYKYRNR DEGSYQVDET RNYISNSAQS
1560 1570
NGTLMKEKQA SSKSGHKKQK NKDKEYYV
Length:1,578
Mass (Da):173,994
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i936CF8529143D0C7
GO
Isoform 2 (identifier: Q07310-2) [UniParc]FASTAAdd to basket
Also known as: Alpha-1B

The sequence of this isoform differs from the canonical sequence as follows:
     253-256: Missing.

Show »
Length:1,574
Mass (Da):173,565
Checksum:iA565F06AC79EBC8C
GO
Isoform 3 (identifier: Q07310-3) [UniParc]FASTAAdd to basket
Also known as: Alpha-1C

The sequence of this isoform differs from the canonical sequence as follows:
     237-242: Missing.

Show »
Length:1,572
Mass (Da):173,410
Checksum:i35F97FD2C2C71884
GO
Isoform 4 (identifier: Q07310-4) [UniParc]FASTAAdd to basket
Also known as: Alpha-1D

The sequence of this isoform differs from the canonical sequence as follows:
     237-242: Missing.
     253-256: Missing.

Show »
Length:1,568
Mass (Da):172,982
Checksum:i86E13829189881D9
GO
Isoform 5 (identifier: Q07310-5) [UniParc]FASTAAdd to basket
Also known as: Alpha-1E

The sequence of this isoform differs from the canonical sequence as follows:
     243-256: Missing.

Show »
Length:1,564
Mass (Da):172,451
Checksum:iD34F1E83B6B42035
GO
Isoform 6 (identifier: Q07310-6) [UniParc]FASTAAdd to basket
Also known as: Alpha-1F

The sequence of this isoform differs from the canonical sequence as follows:
     237-256: Missing.

Show »
Length:1,558
Mass (Da):171,867
Checksum:iA7AE5CCE2C75CE76
GO
Isoform 7 (identifier: Q07310-7) [UniParc]FASTAAdd to basket
Also known as: Alpha-3B

The sequence of this isoform differs from the canonical sequence as follows:
     754-763: DCIRINCNSS → G

Show »
Length:1,569
Mass (Da):172,945
Checksum:iB993492919356CC5
GO
Isoform 8 (identifier: Q07310-8) [UniParc]FASTAAdd to basket
Also known as: Alpha-4B

The sequence of this isoform differs from the canonical sequence as follows:
     1210-1239: Missing.

Show »
Length:1,548
Mass (Da):170,250
Checksum:i44A42D2AA6053D62
GO
Isoform 9 (identifier: Q07310-9) [UniParc]FASTAAdd to basket
Also known as: Alpha-5A

The sequence of this isoform differs from the canonical sequence as follows:
     1372-1478: Missing.
     1479-1578: ANPTEPGIRR...QKNKDKEYYV → ARSSNAARIT...LKFMCCHPPP

Show »
Length:1,438
Mass (Da):158,689
Checksum:i5DA4C69346C7FFF6
GO
Isoform 10 (identifier: Q07310-10) [UniParc]FASTAAdd to basket
Also known as: Alpha-5B

The sequence of this isoform differs from the canonical sequence as follows:
     1369-1371: Missing.
     1372-1478: Missing.
     1479-1578: ANPTEPGIRR...QKNKDKEYYV → ARSSNAARIT...LKFMCCHPPP

Show »
Length:1,435
Mass (Da):158,388
Checksum:i4DA00E05678DB01F
GO
Isoform 11 (identifier: Q07310-11) [UniParc]FASTAAdd to basket
Also known as: Alpha-5C

The sequence of this isoform differs from the canonical sequence as follows:
     1372-1478: Missing.
     1479-1578: ANPTEPGIRR...QKNKDKEYYV → VLERRIILNLKTNAHPKSLQSKTC

Show »
Length:1,395
Mass (Da):153,889
Checksum:iF51D7F30DADE9E49
GO
Isoform 12 (identifier: Q07310-12) [UniParc]FASTAAdd to basket
Also known as: Alpha-5D

The sequence of this isoform differs from the canonical sequence as follows:
     1369-1371: Missing.
     1372-1478: Missing.
     1479-1578: ANPTEPGIRR...QKNKDKEYYV → VLERRIILNLKTNAHPKSLQSKTC

Show »
Length:1,392
Mass (Da):153,589
Checksum:iF8D7669F3A237005
GO
Isoform 13 (identifier: Q07310-13) [UniParc]FASTAAdd to basket
Also known as: Alpha-5E

The sequence of this isoform differs from the canonical sequence as follows:
     1372-1478: Missing.
     1479-1578: ANPTEPGIRR...QKNKDKEYYV → DILLKSF

Show »
Length:1,378
Mass (Da):151,961
Checksum:iFB88CCC4F7199BCB
GO
Isoform 14 (identifier: Q07310-14) [UniParc]FASTAAdd to basket
Also known as: Alpha-5F

The sequence of this isoform differs from the canonical sequence as follows:
     1369-1371: Missing.
     1372-1478: Missing.
     1479-1578: ANPTEPGIRR...QKNKDKEYYV → DILLKSF

Show »
Length:1,375
Mass (Da):151,660
Checksum:iDA058AF65978461C
GO
Isoform 15 (identifier: Q07310-15) [UniParc]FASTAAdd to basket
Also known as: Alpha-5G

The sequence of this isoform differs from the canonical sequence as follows:
     1372-1478: Missing.
     1479-1578: ANPTEPGIRR...QKNKDKEYYV → ATTTTKKSNFQECGNSICPRAFLHNFLL

Show »
Length:1,399
Mass (Da):154,268
Checksum:iEAEE734DFC9B091A
GO
Isoform 16 (identifier: Q07310-16) [UniParc]FASTAAdd to basket
Also known as: Alpha-5H

The sequence of this isoform differs from the canonical sequence as follows:
     1369-1371: Missing.
     1372-1478: Missing.
     1479-1578: ANPTEPGIRR...QKNKDKEYYV → ATTTTKKSNFQECGNSICPRAFLHNFLL

Show »
Length:1,396
Mass (Da):153,968
Checksum:i687D090AB15110B5
GO
Isoform 17 (identifier: Q07310-17) [UniParc]FASTAAdd to basket
Also known as: Alpha-5J

The sequence of this isoform differs from the canonical sequence as follows:
     1369-1371: Missing.

Show »
Length:1,575
Mass (Da):173,693
Checksum:iBBAF52E01BDA3562
GO
Isoform 18 (identifier: Q07310-18) [UniParc]FASTAAdd to basket
Also known as: Alpha-5K

The sequence of this isoform differs from the canonical sequence as follows:
     1372-1478: Missing.

Show »
Length:1,471
Mass (Da):162,216
Checksum:iCB2D693F873094A1
GO
Isoform 19 (identifier: Q07310-19) [UniParc]FASTAAdd to basket
Also known as: Alpha-5L

The sequence of this isoform differs from the canonical sequence as follows:
     1369-1371: Missing.
     1372-1478: Missing.

Show »
Length:1,468
Mass (Da):161,916
Checksum:i5E3B919BD0323E7F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3ZKS5D3ZKS5_RAT
Neurexin-3
Nrxn3
430Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3ZSD9D3ZSD9_RAT
Neurexin-3
Nrxn3
236Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003522237 – 256Missing in isoform 6. CuratedAdd BLAST20
Alternative sequenceiVSP_003521237 – 242Missing in isoform 3 and isoform 4. Curated6
Alternative sequenceiVSP_003523243 – 256Missing in isoform 5. CuratedAdd BLAST14
Alternative sequenceiVSP_003524253 – 256Missing in isoform 2 and isoform 4. Curated4
Alternative sequenceiVSP_003525754 – 763DCIRINCNSS → G in isoform 7. Curated10
Alternative sequenceiVSP_0035261210 – 1239Missing in isoform 8. CuratedAdd BLAST30
Alternative sequenceiVSP_0035271369 – 1371Missing in isoform 10, isoform 12, isoform 14, isoform 16, isoform 17 and isoform 19. Curated3
Alternative sequenceiVSP_0035281372 – 1478Missing in isoform 9, isoform 10, isoform 11, isoform 12, isoform 13, isoform 14, isoform 15, isoform 16, isoform 18 and isoform 19. CuratedAdd BLAST107
Alternative sequenceiVSP_0035301479 – 1578ANPTE…KEYYV → VLERRIILNLKTNAHPKSLQ SKTC in isoform 11 and isoform 12. CuratedAdd BLAST100
Alternative sequenceiVSP_0035311479 – 1578ANPTE…KEYYV → DILLKSF in isoform 13 and isoform 14. CuratedAdd BLAST100
Alternative sequenceiVSP_0035321479 – 1578ANPTE…KEYYV → ATTTTKKSNFQECGNSICPR AFLHNFLL in isoform 15 and isoform 16. CuratedAdd BLAST100
Alternative sequenceiVSP_0035291479 – 1578ANPTE…KEYYV → ARSSNAARITPCRPYMDMAT HLHIYPSHLHLLCSTLIDTP LPFPHPFFPMLPPSLALLKF MCCHPPP in isoform 9 and isoform 10. CuratedAdd BLAST100

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L14851 mRNA Translation: AAA02853.1
L14851 mRNA Translation: AAA02854.1
L14851 mRNA Translation: AAA02855.1
L14851 mRNA Translation: AAA02856.1
L14851 mRNA Translation: AAA02857.1
L14851 mRNA Translation: AAA02858.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I48216

NCBI Reference Sequences

More...
RefSeqi
NP_446269.2, NM_053817.2 [Q07310-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Rn.10926

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
116508

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:116508

UCSC genome browser

More...
UCSCi
RGD:620212 rat [Q07310-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14851 mRNA Translation: AAA02853.1
L14851 mRNA Translation: AAA02854.1
L14851 mRNA Translation: AAA02855.1
L14851 mRNA Translation: AAA02856.1
L14851 mRNA Translation: AAA02857.1
L14851 mRNA Translation: AAA02858.1
PIRiI48216
RefSeqiNP_446269.2, NM_053817.2 [Q07310-1]
UniGeneiRn.10926

3D structure databases

ProteinModelPortaliQ07310
SMRiQ07310
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250475, 2 interactors
ELMiQ07310
IntActiQ07310, 1 interactor
MINTiQ07310
STRINGi10116.ENSRNOP00000060600

PTM databases

iPTMnetiQ07310
PhosphoSitePlusiQ07310

Proteomic databases

PaxDbiQ07310
PRIDEiQ07310

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi116508
KEGGirno:116508
UCSCiRGD:620212 rat [Q07310-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9369
RGDi620212 Nrxn3

Phylogenomic databases

HOGENOMiHOG000230481
HOVERGENiHBG052670
InParanoidiQ07310
KOiK07377
OrthoDBi35129at2759
PhylomeDBiQ07310

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR001791 Laminin_G
IPR037440 Neurexin
IPR003585 Neurexin-like
IPR027789 Syndecan/Neurexin_dom
PANTHERiPTHR44287 PTHR44287, 2 hits
PfamiView protein in Pfam
PF00008 EGF, 1 hit
PF02210 Laminin_G_2, 6 hits
PF01034 Syndecan, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
SM00181 EGF, 3 hits
SM00282 LamG, 6 hits
SUPFAMiSSF49899 SSF49899, 6 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS50026 EGF_3, 3 hits
PS50025 LAM_G_DOMAIN, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNRX3A_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q07310
Secondary accession number(s): Q07280
, Q07311, Q07312, Q07313, Q07314
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 1, 1996
Last modified: January 16, 2019
This is version 158 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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