Transforming growth factor beta-3 proprotein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cytokine activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• growth factor activity Source: UniProtKB-KW
• identical protein binding Source: AgBase
• protein-containing complex binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Transforming growth factor-beta induces cellular injury in experimental diabetic neuropathy."
    Anjaneyulu M., Berent-Spillson A., Inoue T., Choi J., Cherian K., Russell J.W.
    Exp Neurol 211:469-479(2008) [PubMed] [Europe PMC] [Abstract]
• transforming growth factor beta binding Source: AgBase
• transforming growth factor beta receptor binding Source: RGD <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • Ref.1

    "Cloning and expression of glucocorticoid-induced genes in fetal rat lung fibroblasts. Transforming growth factor-beta 3."
    Wang J., Kuliszewski M., Yee W., Sedlackova L., Xu J., Tseu I., Post M.
    J. Biol. Chem. 270:2722-2728(1995) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• type III transforming growth factor beta receptor binding Source: AgBase
• type II transforming growth factor beta receptor binding Source: AgBase
• type I transforming growth factor beta receptor binding Source: AgBase

GO - Biological processⁱ

• activation of MAPK activity Source: RGDInferred from direct assayⁱ
  • "Involvement of protein kinase C-dependent mitogen-activated protein kinase p44/42 signaling pathway for cross-talk between estradiol and transforming growth factor-beta3 in increasing basic fibroblast growth factor in folliculostellate cells."
    Chaturvedi K., Sarkar D.K.
    Endocrinology 145:706-715(2004) [PubMed] [Europe PMC] [Abstract]
• aging Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Transforming growth factor-beta(s) and their receptors in aging rat prostate."
    Zhao H., Patra A., Tanaka Y., Li L.C., Dahiya R.
    Biochem Biophys Res Commun 294:464-469(2002) [PubMed] [Europe PMC] [Abstract]
• animal organ morphogenesis Source: RGD
• BMP signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cell-cell junction organization Source: AgBase
• cellular response to growth factor stimulus Source: RGD
• detection of hypoxia Source: AgBase
• digestive tract development Source: RGDInferred from expression patternⁱ
  • "Ontogenic expression of TGFbeta 1, 2, and 3 and its receptors in the rat gastric mucosa."
    de Andrade Sa E.R., Jordao L.R., Takahashi C.A., Alvares E.P., Gama P.
    Dev Dyn 227:450-457(2003) [PubMed] [Europe PMC] [Abstract]
• embryonic neurocranium morphogenesis Source: RGDInferred from direct assayⁱ
  • "Transforming growth factor-beta 2 and TGF-beta 3 regulate fetal rat cranial suture morphogenesis by regulating rates of cell proliferation and apoptosis."
    Opperman L.A., Adab K., Gakunga P.T.
    Dev Dyn 219:237-247(2000) [PubMed] [Europe PMC] [Abstract]
• face morphogenesis Source: AgBase
• female pregnancy Source: RGDInferred from expression patternⁱ
  • "TGF-beta expression during rat pregnancy and activity on decidual cell survival."
    Shooner C., Caron P.L., Frechette-Frigon G., Leblanc V., Dery M.C., Asselin E.
    Reprod Biol Endocrinol 3:20-20(2005) [PubMed] [Europe PMC] [Abstract]
• frontal suture morphogenesis Source: RGDInferred from expression patternⁱ
  • "Tgf-beta1, Tgf-beta2, Tgf-beta3 and Msx2 expression is elevated during frontonasal suture morphogenesis and during active postnatal facial growth."
    Adab K., Sayne J.R., Carlson D.S., Opperman L.A.
    Orthod Craniofac Res 5:227-237(2002) [PubMed] [Europe PMC] [Abstract]
• gene expression Source: RGD
• inner ear development Source: RGDInferred from expression patternⁱ
  • "Expression of TGFbeta family in the developing internal ear of rat embryos."
    Kim H.J., Kang K.Y., Baek J.G., Jo H.C., Kim H.
    J Korean Med Sci 21:136-142(2006) [PubMed] [Europe PMC] [Abstract]
• in utero embryonic development Source: RGD
• lung alveolus development Source: RGD
• lung development Source: RGD <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • Ref.1

    "Cloning and expression of glucocorticoid-induced genes in fetal rat lung fibroblasts. Transforming growth factor-beta 3."
    Wang J., Kuliszewski M., Yee W., Sedlackova L., Xu J., Tseu I., Post M.
    J. Biol. Chem. 270:2722-2728(1995) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• mammary gland development Source: RGD
• negative regulation of cell population proliferation Source: RGDInferred from direct assayⁱ
  • "Transforming growth factor-beta 2 and TGF-beta 3 regulate fetal rat cranial suture morphogenesis by regulating rates of cell proliferation and apoptosis."
    Opperman L.A., Adab K., Gakunga P.T.
    Dev Dyn 219:237-247(2000) [PubMed] [Europe PMC] [Abstract]
• negative regulation of macrophage cytokine production Source: AgBase
• negative regulation of neuron apoptotic process Source: RGD
• negative regulation of transforming growth factor beta receptor signaling pathway Source: RGDInferred from direct assayⁱ
  • "Transforming growth factor-beta3 (Tgf-beta3) down-regulates Tgf-beta3 receptor type I (Tbetar-I) during rescue of cranial sutures from osseous obliteration."
    Opperman L.A., Galanis V., Williams A.R., Adab K.
    Orthod Craniofac Res 5:5-16(2002) [PubMed] [Europe PMC] [Abstract]
• negative regulation of vascular associated smooth muscle cell proliferation Source: RGD
• ossification involved in bone remodeling Source: AgBase
• positive regulation of apoptotic process Source: RGDInferred from direct assayⁱ
  • "Transforming growth factor-beta 2 and TGF-beta 3 regulate fetal rat cranial suture morphogenesis by regulating rates of cell proliferation and apoptosis."
    Opperman L.A., Adab K., Gakunga P.T.
    Dev Dyn 219:237-247(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of bone mineralization Source: AgBase
• positive regulation of cell division Source: UniProtKB-KW
• positive regulation of cell population proliferation Source: BHF-UCL
• positive regulation of collagen biosynthetic process Source: AgBase
• positive regulation of epithelial to mesenchymal transition Source: AgBase
• positive regulation of filopodium assembly Source: RGD
• positive regulation of gene expression Source: RGD
• positive regulation of pathway-restricted SMAD protein phosphorylation Source: RGD
• positive regulation of protein secretion Source: RGD
• positive regulation of SMAD protein signal transduction Source: RGD
• positive regulation of stress fiber assembly Source: RGD
• positive regulation of tight junction disassembly Source: RGD
• positive regulation of transcription, DNA-templated Source: AgBase
• positive regulation of transcription by RNA polymerase II Source: RGD
• regulation of cell population proliferation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of endothelial cell differentiation Source: RGDTraceable author statementⁱ
  • "Regulation of TGF-beta ligand and receptor expression in neonatal rat lungs exposed to chronic hypoxia."
    Vicencio A.G., Eickelberg O., Stankewich M.C., Kashgarian M., Haddad G.G.
    J Appl Physiol (1985) 93:1123-1130(2002) [PubMed] [Europe PMC] [Abstract]
• regulation of epithelial cell differentiation Source: RGDTraceable author statementⁱ
  • "Regulation of TGF-beta ligand and receptor expression in neonatal rat lungs exposed to chronic hypoxia."
    Vicencio A.G., Eickelberg O., Stankewich M.C., Kashgarian M., Haddad G.G.
    J Appl Physiol (1985) 93:1123-1130(2002) [PubMed] [Europe PMC] [Abstract]
• regulation of epithelial cell proliferation Source: RGDTraceable author statementⁱ
  • "Regulation of TGF-beta ligand and receptor expression in neonatal rat lungs exposed to chronic hypoxia."
    Vicencio A.G., Eickelberg O., Stankewich M.C., Kashgarian M., Haddad G.G.
    J Appl Physiol (1985) 93:1123-1130(2002) [PubMed] [Europe PMC] [Abstract]
• response to estrogen Source: RGDInferred from direct assayⁱ
  • "Involvement of protein kinase C-dependent mitogen-activated protein kinase p44/42 signaling pathway for cross-talk between estradiol and transforming growth factor-beta3 in increasing basic fibroblast growth factor in folliculostellate cells."
    Chaturvedi K., Sarkar D.K.
    Endocrinology 145:706-715(2004) [PubMed] [Europe PMC] [Abstract]
• response to hypoxia Source: RGDInferred from expression patternⁱ
  • "Effects of endogenous carbon monoxide on collagen synthesis in pulmonary artery in rats under hypoxia."
    Gong L.M., Du J.B., Shi L., Shi Y., Tang C.S.
    Life Sci 74:1225-1241(2004) [PubMed] [Europe PMC] [Abstract]
• response to laminar fluid shear stress Source: RGDInferred from expression patternⁱ
  • "Microarray analysis of mechanical shear effects on flexor tendon cells."
    Fong K.D., Trindade M.C., Wang Z., Nacamuli R.P., Pham H., Fang T.D., Song H.M., Smith R.L., Longaker M.T., Chang J.
    Plast Reconstr Surg 116:1393-1404(2005) [PubMed] [Europe PMC] [Abstract]
• response to progesterone Source: AgBase
• roof of mouth development Source: RGD
• salivary gland morphogenesis Source: AgBase
• secondary palate development Source: UniProtKB
• SMAD protein signal transduction Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• transforming growth factor beta receptor signaling pathway Source: AgBase
• wound healing Source: RGDInferred from expression patternⁱ
  • "Differential cytokine activity and morphology during wound healing in the neonatal and adult rat skin."
    Wagner W., Wehrmann M.
    J Cell Mol Med 11:1342-1351(2007) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• cytokine activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• growth factor activity Source: UniProtKB-KW
• identical protein binding Source: AgBase
• transforming growth factor beta binding Source: AgBase
• transforming growth factor beta receptor binding Source: RGDTraceable author statementⁱ
  • Ref.1

    "Cloning and expression of glucocorticoid-induced genes in fetal rat lung fibroblasts. Transforming growth factor-beta 3."
    Wang J., Kuliszewski M., Yee W., Sedlackova L., Xu J., Tseu I., Post M.
    J. Biol. Chem. 270:2722-2728(1995) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• type III transforming growth factor beta receptor binding Source: AgBase
• type II transforming growth factor beta receptor binding Source: AgBase
• type I transforming growth factor beta receptor binding Source: AgBase

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Motif

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MKMHLQRALV VLALLNLATV SLSLSTCTTL DFGHIKKKRV EAIRGQILSK 
        60         70         80         90        100
LRLTSPPEPS VMTHVPYQVL ALYNSTRELL EEMHGEREEG CTQETSESEY 
       110        120        130        140        150
YAKEIHKFDM IQGLAEHNEL AVCPKGITSK VFRFNVSSVE KNGTNLFRAE 
       160        170        180        190        200
FRVLRVPNPS SKRTEQRIEL FQILRPDEHI AKQRYIGGKN LPTRGTAEWL 
       210        220        230        240        250
SFDVTDTVRE WLLRRESNLG LEISIHCPCH TFQPNGDILE NVHEVMEIKF 
       260        270        280        290        300
KGVDNEDDHG RGDLGRLKKQ KDHHNPHLIL MMIPPHRLDS PGQGGQRKKR 
       310        320        330        340        350
ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY 
       360        370        380        390        400
LRSSDTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ 
       410 
LSNMVVKSCK CS                                          

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families