UniProtKB - Q07257 (TGFB2_RAT)
Transforming growth factor beta-2 proprotein
Tgfb2
Functioni
GO - Molecular functioni
- amyloid-beta binding Source: AgBase
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- identical protein binding Source: RGD
- protein-containing complex binding Source: RGD
- protein homodimerization activity Source: AgBase
- protein N-terminus binding Source: RGD
- signaling receptor binding Source: AgBase
- transforming growth factor beta receptor binding Source: AgBase
- type III transforming growth factor beta receptor binding Source: AgBase
- type II transforming growth factor beta receptor binding Source: AgBase
GO - Biological processi
- activation of protein kinase activity Source: AgBase
- aging Source: RGD
- ascending aorta morphogenesis Source: RGD
- atrial septum morphogenesis Source: RGD
- atrial septum primum morphogenesis Source: RGD
- atrioventricular valve morphogenesis Source: RGD
- axon guidance Source: RGD
- blood vessel development Source: RGD
- blood vessel remodeling Source: RGD
- BMP signaling pathway Source: GO_Central
- cardiac epithelial to mesenchymal transition Source: AgBase
- cardiac muscle cell proliferation Source: AgBase
- cardiac right ventricle morphogenesis Source: RGD
- cardioblast differentiation Source: AgBase
- cartilage condensation Source: RGD
- cell-cell junction organization Source: AgBase
- cell cycle arrest Source: AgBase
- cell death Source: AgBase
- cell migration Source: AgBase
- cell morphogenesis Source: AgBase
- collagen fibril organization Source: AgBase
- cranial skeletal system development Source: RGD
- digestive tract development Source: RGD
- dopamine biosynthetic process Source: UniProtKB
- embryonic digestive tract development Source: AgBase
- embryonic limb morphogenesis Source: RGD
- embryonic neurocranium morphogenesis Source: RGD
- endocardial cushion fusion Source: RGD
- endocardial cushion morphogenesis Source: RGD
- epithelial to mesenchymal transition Source: AgBase
- extracellular matrix organization Source: RGD
- extrinsic apoptotic signaling pathway Source: AgBase
- eye development Source: AgBase
- face morphogenesis Source: RGD
- female pregnancy Source: RGD
- frontal suture morphogenesis Source: RGD
- glial cell migration Source: AgBase
- hair follicle development Source: AgBase
- hair follicle morphogenesis Source: UniProtKB
- heart development Source: AgBase
- heart morphogenesis Source: AgBase
- heart valve morphogenesis Source: RGD
- hemopoiesis Source: UniProtKB
- hindbrain development Source: RGD
- inner ear development Source: RGD
- kidney development Source: RGD
- lung development Source: RGD
- male gonad development Source: RGD
- membranous septum morphogenesis Source: RGD
- negative regulation of alkaline phosphatase activity Source: AgBase
- negative regulation of angiogenesis Source: RGD
- negative regulation of apoptotic process Source: RGD
- negative regulation of cartilage development Source: RGD
- negative regulation of cell growth Source: AgBase
- negative regulation of cell population proliferation Source: RGD
- negative regulation of epithelial cell proliferation Source: AgBase
- negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation Source: RGD
- negative regulation of gene expression Source: RGD
- negative regulation of immune response Source: RGD
- negative regulation of macrophage cytokine production Source: AgBase
- negative regulation of Ras protein signal transduction Source: RGD
- negative regulation of release of sequestered calcium ion into cytosol Source: RGD
- neural retina development Source: RGD
- neural tube closure Source: RGD
- neuron development Source: UniProtKB
- neuron fate commitment Source: RGD
- neutrophil chemotaxis Source: UniProtKB
- outflow tract septum morphogenesis Source: RGD
- pancreas development Source: RGD
- pathway-restricted SMAD protein phosphorylation Source: AgBase
- pharyngeal arch artery morphogenesis Source: RGD
- positive regulation of activation-induced cell death of T cells Source: RGD
- positive regulation of apoptotic process Source: RGD
- positive regulation of cardioblast differentiation Source: AgBase
- positive regulation of cell adhesion mediated by integrin Source: AgBase
- positive regulation of cell cycle Source: UniProtKB
- positive regulation of cell division Source: UniProtKB-KW
- positive regulation of cell growth Source: AgBase
- positive regulation of cell migration Source: RGD
- positive regulation of cell population proliferation Source: RGD
- positive regulation of epithelial cell migration Source: AgBase
- positive regulation of epithelial to mesenchymal transition Source: AgBase
- positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation Source: RGD
- positive regulation of extracellular matrix disassembly Source: RGD
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: RGD
- positive regulation of gene expression Source: RGD
- positive regulation of GTP binding Source: RGD
- positive regulation of heart contraction Source: AgBase
- positive regulation of immune response Source: UniProtKB
- positive regulation of integrin biosynthetic process Source: AgBase
- positive regulation of neuron apoptotic process Source: AgBase
- positive regulation of Notch signaling pathway Source: RGD
- positive regulation of ossification Source: AgBase
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
- positive regulation of phosphatidylinositol 3-kinase signaling Source: AgBase
- positive regulation of pri-miRNA transcription by RNA polymerase II Source: RGD
- positive regulation of protein localization to nucleus Source: RGD
- positive regulation of protein secretion Source: AgBase
- positive regulation of stress-activated MAPK cascade Source: AgBase
- positive regulation of timing of catagen Source: AgBase
- protein phosphorylation Source: AgBase
- pulmonary valve morphogenesis Source: RGD
- regulation of actin cytoskeleton organization Source: RGD
- regulation of apoptotic process Source: RGD
- regulation of apoptotic process involved in outflow tract morphogenesis Source: RGD
- regulation of cell growth Source: RGD
- regulation of cell population proliferation Source: GO_Central
- regulation of extracellular matrix organization Source: RGD
- regulation of timing of catagen Source: UniProtKB
- regulation of transforming growth factor beta2 production Source: AgBase
- response to cold Source: RGD
- response to cytokine Source: RGD
- response to drug Source: RGD
- response to estradiol Source: RGD
- response to estrogen Source: RGD
- response to hypoxia Source: UniProtKB
- response to laminar fluid shear stress Source: RGD
- response to organonitrogen compound Source: RGD
- response to progesterone Source: AgBase
- response to radiation Source: RGD
- response to retinoic acid Source: RGD
- response to vitamin D Source: RGD
- response to wounding Source: AgBase
- salivary gland morphogenesis Source: AgBase
- secondary palate development Source: RGD
- signal transduction by protein phosphorylation Source: AgBase
- skeletal muscle tissue development Source: RGD
- skeletal system development Source: RGD
- SMAD protein signal transduction Source: BHF-UCL
- somatic stem cell division Source: UniProtKB
- substantia propria of cornea development Source: RGD
- thyroid gland development Source: RGD
- transforming growth factor beta receptor signaling pathway Source: AgBase
- uterus development Source: RGD
- ventricular septum morphogenesis Source: RGD
- ventricular trabecula myocardium morphogenesis Source: RGD
- wound healing Source: RGD
Keywordsi
Molecular function | Growth factor, Mitogen |
Enzyme and pathway databases
Reactomei | R-RNO-114608, Platelet degranulation R-RNO-2129379, Molecules associated with elastic fibres |
Names & Taxonomyi
Protein namesi | Recommended name: Transforming growth factor beta-2 proproteinCleaved into the following 2 chains: |
Gene namesi | Name:Tgfb2 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 70491, Tgfb2 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix By similarity
Extracellular region or secreted
- Secreted By similarity
Endosome
- endosome Source: RGD
Extracellular region or secreted
- basement membrane Source: RGD
- collagen-containing extracellular matrix Source: RGD
- extracellular matrix Source: AgBase
- extracellular region Source: AgBase
- extracellular space Source: RGD
Golgi apparatus
- trans-Golgi network Source: RGD
Other locations
- axon Source: UniProtKB
- cell surface Source: RGD
- cytoplasm Source: RGD
- neuronal cell body Source: UniProtKB
- secretory granule Source: RGD
Keywords - Cellular componenti
Extracellular matrix, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000033790 | 21 – 330 | Latency-associated peptideBy similarityAdd BLAST | 310 | |
ChainiPRO_0000033791 | 331 – 442 | Transforming growth factor beta-2By similarityAdd BLAST | 112 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 72 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 168 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 269 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 337 ↔ 346 | By similarity | ||
Disulfide bondi | 345 ↔ 408 | By similarity | ||
Disulfide bondi | 374 ↔ 439 | By similarity | ||
Disulfide bondi | 378 ↔ 441 | By similarity | ||
Disulfide bondi | 407 | InterchainBy similarity |
Post-translational modificationi
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q07257 |
PRIDEi | Q07257 |
PTM databases
GlyGeni | Q07257, 3 sites |
PhosphoSitePlusi | Q07257 |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSRNOG00000002418, Expressed in lung and 22 other tissues |
ExpressionAtlasi | Q07257, baseline and differential |
Interactioni
Subunit structurei
Interacts with the serine proteases, HTRA1 and HTRA3 (By similarity).
Interacts with ASPN (By similarity).
Interacts with MFAP5 (By similarity). Latency-associated peptide:
Interacts with Transforming growth factor beta-2 (TGF-beta-2) chain; interaction is non-covalent and maintains (TGF-beta-2) in a latent state (By similarity). Latency-associated peptide:
Interacts with LRRC32/GARP; leading to regulate activation of TGF-beta-2 (By similarity). Latency-associated peptide:
Interacts with NREP; the interaction results in a decrease in TGFB2 autoinduction (By similarity). Transforming growth factor beta-2: Homodimer; disulfide-linked (By similarity). Transforming growth factor beta-2:
Interacts with TGF-beta receptors (TGFBR1 and TGFBR2), leading to signal transduction (By similarity).
By similarityGO - Molecular functioni
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- identical protein binding Source: RGD
- protein homodimerization activity Source: AgBase
- protein N-terminus binding Source: RGD
- signaling receptor binding Source: AgBase
- transforming growth factor beta receptor binding Source: AgBase
- type III transforming growth factor beta receptor binding Source: AgBase
- type II transforming growth factor beta receptor binding Source: AgBase
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000003313 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00940000157390 |
InParanoidi | Q07257 |
OrthoDBi | 643840at2759 |
PhylomeDBi | Q07257 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR016319, TGF-beta IPR015615, TGF-beta-rel IPR003940, TGFb2 IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PIRSFi | PIRSF001787, TGF-beta, 1 hit |
PRINTSi | PR01423, TGFBETA PR01425, TGFBETA2 |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MHYCVLRTFL LLHLVPVALS LSTCSTLDMD QFMRKRIEAI RGQILSKLKL
60 70 80 90 100
TSPPEDYPEP DEVPPEVISI YNSTRDLLQE KASRRAAACE RERSDEEYYA
110 120 130 140 150
KEVYKIDMPS HFPSETVCPV VTTSSGSVGS FCSIQSQVLC GYLDAIPPTF
160 170 180 190 200
YRPYFRIVRF DVSTMEKNAS NLVKAEFRVF RLQNPKARVA EQRIELYQIL
210 220 230 240 250
KSKDLTSPTQ RYIDSKVVKT RAEGEWLSFD VTDAVHEWLH HKDRNLGFKI
260 270 280 290 300
SLHCPCCTFI PSNNYIIPNK SQELEARFAG IDGTSTYASG DQKTIKSTRK
310 320 330 340 350
KSSGKTPHLL LMLLPSYRLE SQQSSRRRKR ALDAAYCFRN VQDNCCLRPL
360 370 380 390 400
YIDFKRDLGW KWIHEPKGYN ANFCAGACPY LWSSDTQHTK VLSLYNTINP
410 420 430 440
EASASPCCVS QDLEPLTILY YIGNTPKIEQ LSNMIVKSCK CS
The sequence of this isoform differs from the canonical sequence as follows:
116-143: Missing.
144-144: D → N
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V6B1 | G3V6B1_RAT | Transforming growth factor beta | Tgfb2 rCG_20076 | 442 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 99 | Y → C in CAB42003 (PubMed:11014222).Curated | 1 | |
Sequence conflicti | 310 | L → P in AAD24484 (Ref. 3) Curated | 1 | |
Sequence conflicti | 343 | D → H in CAB42003 (PubMed:11014222).Curated | 1 | |
Sequence conflicti | 343 | D → H in CAA50723 (PubMed:8509457).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006418 | 116 – 143 | Missing in isoform TGF-beta2A. 3 PublicationsAdd BLAST | 28 | |
Alternative sequenceiVSP_006419 | 144 | D → N in isoform TGF-beta2A. 3 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF153012 mRNA Translation: AAD34159.1 AF153013 mRNA Translation: AAD34160.1 AJ132718 mRNA Translation: CAB42003.1 AF135598 mRNA Translation: AAD24484.1 X71904 mRNA Translation: CAA50723.1 M96643 mRNA Translation: AAA88514.1 Sequence problems. |
PIRi | A40699 |
RefSeqi | NP_112393.1, NM_031131.1 [Q07257-1] XP_006250510.1, XM_006250448.3 [Q07257-2] |
Genome annotation databases
Ensembli | ENSRNOT00000087023; ENSRNOP00000074059; ENSRNOG00000002418 [Q07257-2] |
GeneIDi | 81809 |
KEGGi | rno:81809 |
UCSCi | RGD:70491, rat [Q07257-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF153012 mRNA Translation: AAD34159.1 AF153013 mRNA Translation: AAD34160.1 AJ132718 mRNA Translation: CAB42003.1 AF135598 mRNA Translation: AAD24484.1 X71904 mRNA Translation: CAA50723.1 M96643 mRNA Translation: AAA88514.1 Sequence problems. |
PIRi | A40699 |
RefSeqi | NP_112393.1, NM_031131.1 [Q07257-1] XP_006250510.1, XM_006250448.3 [Q07257-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000003313 |
PTM databases
GlyGeni | Q07257, 3 sites |
PhosphoSitePlusi | Q07257 |
Proteomic databases
PaxDbi | Q07257 |
PRIDEi | Q07257 |
Genome annotation databases
Ensembli | ENSRNOT00000087023; ENSRNOP00000074059; ENSRNOG00000002418 [Q07257-2] |
GeneIDi | 81809 |
KEGGi | rno:81809 |
UCSCi | RGD:70491, rat [Q07257-1] |
Organism-specific databases
CTDi | 7042 |
RGDi | 70491, Tgfb2 |
Phylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00940000157390 |
InParanoidi | Q07257 |
OrthoDBi | 643840at2759 |
PhylomeDBi | Q07257 |
Enzyme and pathway databases
Reactomei | R-RNO-114608, Platelet degranulation R-RNO-2129379, Molecules associated with elastic fibres |
Miscellaneous databases
PROi | PR:Q07257 |
Gene expression databases
Bgeei | ENSRNOG00000002418, Expressed in lung and 22 other tissues |
ExpressionAtlasi | Q07257, baseline and differential |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR016319, TGF-beta IPR015615, TGF-beta-rel IPR003940, TGFb2 IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PIRSFi | PIRSF001787, TGF-beta, 1 hit |
PRINTSi | PR01423, TGFBETA PR01425, TGFBETA2 |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TGFB2_RAT | |
Accessioni | Q07257Primary (citable) accession number: Q07257 Secondary accession number(s): Q63574 Q9WUQ8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | May 15, 2002 | |
Last modified: | December 2, 2020 | |
This is version 165 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families