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Protein

Metal regulatory transcription factor 1

Gene

Mtf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activates the metallothionein I promoter. Binds to the metal responsive element (MRE).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri139 – 163C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri169 – 193C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri199 – 223C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri228 – 252C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri258 – 282C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri288 – 312C2H2-type 6PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metal regulatory transcription factor 1
Alternative name(s):
MRE-binding transcription factor
Transcription factor MTF-1
Gene namesi
Name:Mtf1
Synonyms:Mtf-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:101786 Mtf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000472212 – 675Metal regulatory transcription factor 1Add BLAST674

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycineCombined sources1
Modified residuei5PhosphoserineCombined sources1
Modified residuei304PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ07243
PaxDbiQ07243
PRIDEiQ07243

PTM databases

iPTMnetiQ07243
PhosphoSitePlusiQ07243

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000028890 Expressed in 281 organ(s), highest expression level in primary oocyte
ExpressionAtlasiQ07243 baseline and differential
GenevisibleiQ07243 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201591, 4 interactors
STRINGi10090.ENSMUSP00000030723

Structurei

3D structure databases

ProteinModelPortaliQ07243
SMRiQ07243
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi132 – 137Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi329 – 405Asp-rich (acidic)Add BLAST77
Compositional biasi406 – 506Pro-richAdd BLAST101

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri139 – 163C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri169 – 193C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri199 – 223C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri228 – 252C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri258 – 282C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri288 – 312C2H2-type 6PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144040
HOGENOMiHOG000059609
HOVERGENiHBG006412
InParanoidiQ07243
OMAiQEESCQC
OrthoDBiEOG091G06R4
TreeFamiTF106493

Family and domain databases

InterProiView protein in InterPro
IPR029796 Metal_TF1
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR44900 PTHR44900, 1 hit
PfamiView protein in Pfam
PF00096 zf-C2H2, 6 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q07243-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGEHSPDDNI IFFKGEEDDL TPHDKMLRFV DDNGLVPSSS GTVYDRTTVL
60 70 80 90 100
IEQDPGTLED DEDDGQCGEP LPFLVEGEEG FLIDQEAMSQ GYVQHIISPD
110 120 130 140 150
QIHLTINPGS TPMPRNIEGA TLTLQSECPE TKRKEVKRYQ CTFEGCPRTY
160 170 180 190 200
STAGNLRTHQ KTHRGEYTFV CNQEGCGKAF LTSYSLRIHV RVHTKEKPFE
210 220 230 240 250
CDVQGCEKAF NTLYRLKAHQ RLHTGKTFNC ESQGCSKYFT TLSDLRKHIR
260 270 280 290 300
THTGEKPFRC DHDGCGKAFA ASHHLKTHVR THTGERPFFC PSNGCEKTFS
310 320 330 340 350
TQYSLKSHMK GHDNKGTAYS ALPQHNGSED TNHSLYLSEL GLLSTDSELQ
360 370 380 390 400
ENSSSTQDQD LSTISPAIIF ESMFQNSDDP GIQDDPLQTA ALIDSFNGDA
410 420 430 440 450
ESVIDVPPPA GNSASLSLPL VLQSGISEPP QPLLPATAPS APPPAPSLGP
460 470 480 490 500
GSQPAAFGSP PALLQPPEVP VPHSTQFAAN HQEFLPHPQA PPQTIVPGLS
510 520 530 540 550
VVAGAPASAA TVASAVAAPA PPQSTTEPLP AMVQTLPLGA NSVLTNNPTI
560 570 580 590 600
TITPTPNTAI LQSSLVMGEQ NLQWILNGAT SSPQNQEQIQ QASKVEQVYF
610 620 630 640 650
ATAVPVASGT GSSVQQIGLS VPVIIIKQEE ACQCQCACRD SAKERAAGRR
660 670
KGCSSPPPPE PNPQPPDGPS LQLPP
Length:675
Mass (Da):72,603
Last modified:July 27, 2011 - v2
Checksum:i3FD37F1736D07FC6
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1ARW6B1ARW6_MOUSE
Metal regulatory transcription fact...
Mtf1
142Annotation score:
A0A0G2JDC6A0A0G2JDC6_MOUSE
Metal regulatory transcription fact...
Mtf1
10Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti603A → T in CAA50470 (PubMed:8467794).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71327 mRNA Translation: CAA50470.1
AJ251880 Genomic DNA Translation: CAB71344.1
AL606933 Genomic DNA Translation: CAM16099.1
CH466552 Genomic DNA Translation: EDL30350.1
BC017679 mRNA Translation: AAH17679.1
CCDSiCCDS18627.1
PIRiS35335
RefSeqiNP_032662.3, NM_008636.4
UniGeneiMm.272397

Genome annotation databases

EnsembliENSMUST00000030723; ENSMUSP00000030723; ENSMUSG00000028890
ENSMUST00000106193; ENSMUSP00000101799; ENSMUSG00000028890
GeneIDi17764
KEGGimmu:17764
UCSCiuc008urb.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71327 mRNA Translation: CAA50470.1
AJ251880 Genomic DNA Translation: CAB71344.1
AL606933 Genomic DNA Translation: CAM16099.1
CH466552 Genomic DNA Translation: EDL30350.1
BC017679 mRNA Translation: AAH17679.1
CCDSiCCDS18627.1
PIRiS35335
RefSeqiNP_032662.3, NM_008636.4
UniGeneiMm.272397

3D structure databases

ProteinModelPortaliQ07243
SMRiQ07243
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201591, 4 interactors
STRINGi10090.ENSMUSP00000030723

PTM databases

iPTMnetiQ07243
PhosphoSitePlusiQ07243

Proteomic databases

MaxQBiQ07243
PaxDbiQ07243
PRIDEiQ07243

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030723; ENSMUSP00000030723; ENSMUSG00000028890
ENSMUST00000106193; ENSMUSP00000101799; ENSMUSG00000028890
GeneIDi17764
KEGGimmu:17764
UCSCiuc008urb.2 mouse

Organism-specific databases

CTDi4520
MGIiMGI:101786 Mtf1

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144040
HOGENOMiHOG000059609
HOVERGENiHBG006412
InParanoidiQ07243
OMAiQEESCQC
OrthoDBiEOG091G06R4
TreeFamiTF106493

Miscellaneous databases

ChiTaRSiMtf1 mouse
PROiPR:Q07243
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028890 Expressed in 281 organ(s), highest expression level in primary oocyte
ExpressionAtlasiQ07243 baseline and differential
GenevisibleiQ07243 MM

Family and domain databases

InterProiView protein in InterPro
IPR029796 Metal_TF1
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR44900 PTHR44900, 1 hit
PfamiView protein in Pfam
PF00096 zf-C2H2, 6 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMTF1_MOUSE
AccessioniPrimary (citable) accession number: Q07243
Secondary accession number(s): Q9JJW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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