UniProtKB - Q07243 (MTF1_MOUSE)
Metal regulatory transcription factor 1
Mtf1
Functioni
Zinc-dependent transcriptional regulator of cellular adaption to conditions of exposure to heavy metals (PubMed:24529376).
Binds to metal responsive elements (MRE) in promoters and activates the transcription of metallothionein genes like metallothionein-2/MT2A (By similarity).
Also regulates the expression of metalloproteases in response to intracellular zinc and functions as a catabolic regulator of cartilages (PubMed:24529376).
By similarity1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 139 – 163 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 169 – 193 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 199 – 223 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 228 – 252 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 258 – 282 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 288 – 312 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- cis-regulatory region sequence-specific DNA binding Source: MGI
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- histone acetyltransferase binding Source: MGI
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- cartilage homeostasis Source: UniProtKB
- cellular response to zinc ion Source: UniProtKB
- central nervous system development Source: GO_Central
- positive regulation of transcription, DNA-templated Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to cadmium ion Source: MGI
- response to oxidative stress Source: MGI
- transcription, DNA-templated Source: UniProtKB
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Metal regulatory transcription factor 1Alternative name(s): MRE-binding transcription factor Transcription factor MTF-1 |
Gene namesi | Name:Mtf1 Synonyms:Mtf-1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:101786, Mtf1 |
VEuPathDBi | HostDB:ENSMUSG00000028890 |
Subcellular locationi
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000047221 | 2 – 675 | Metal regulatory transcription factor 1Add BLAST | 674 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylglycineCombined sources | 1 | |
Modified residuei | 5 | PhosphoserineCombined sources | 1 | |
Modified residuei | 304 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
MaxQBi | Q07243 |
PaxDbi | Q07243 |
PRIDEi | Q07243 |
ProteomicsDBi | 287632 |
PTM databases
iPTMneti | Q07243 |
PhosphoSitePlusi | Q07243 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000028890, Expressed in spermatid and 302 other tissues |
ExpressionAtlasi | Q07243, baseline and differential |
Genevisiblei | Q07243, MM |
Interactioni
GO - Molecular functioni
- histone acetyltransferase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 201591, 4 interactors |
IntActi | Q07243, 3 interactors |
STRINGi | 10090.ENSMUSP00000030723 |
Miscellaneous databases
RNActi | Q07243, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 427 – 464 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 645 – 675 | DisorderedSequence analysisAdd BLAST | 31 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 132 – 137 | Nuclear localization signalSequence analysis | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 432 – 450 | Pro residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 654 – 675 | Pro residuesSequence analysisAdd BLAST | 22 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 139 – 163 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 169 – 193 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 199 – 223 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 228 – 252 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 258 – 282 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 288 – 312 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000157291 |
HOGENOMi | CLU_026685_0_0_1 |
InParanoidi | Q07243 |
OMAi | SMFQSPD |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q07243 |
TreeFami | TF106493 |
Family and domain databases
InterProi | View protein in InterPro IPR029796, Metal_TF1 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR19818:SF131, PTHR19818:SF131, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 6 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 6 hits |
SUPFAMi | SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MGEHSPDDNI IFFKGEEDDL TPHDKMLRFV DDNGLVPSSS GTVYDRTTVL
60 70 80 90 100
IEQDPGTLED DEDDGQCGEP LPFLVEGEEG FLIDQEAMSQ GYVQHIISPD
110 120 130 140 150
QIHLTINPGS TPMPRNIEGA TLTLQSECPE TKRKEVKRYQ CTFEGCPRTY
160 170 180 190 200
STAGNLRTHQ KTHRGEYTFV CNQEGCGKAF LTSYSLRIHV RVHTKEKPFE
210 220 230 240 250
CDVQGCEKAF NTLYRLKAHQ RLHTGKTFNC ESQGCSKYFT TLSDLRKHIR
260 270 280 290 300
THTGEKPFRC DHDGCGKAFA ASHHLKTHVR THTGERPFFC PSNGCEKTFS
310 320 330 340 350
TQYSLKSHMK GHDNKGTAYS ALPQHNGSED TNHSLYLSEL GLLSTDSELQ
360 370 380 390 400
ENSSSTQDQD LSTISPAIIF ESMFQNSDDP GIQDDPLQTA ALIDSFNGDA
410 420 430 440 450
ESVIDVPPPA GNSASLSLPL VLQSGISEPP QPLLPATAPS APPPAPSLGP
460 470 480 490 500
GSQPAAFGSP PALLQPPEVP VPHSTQFAAN HQEFLPHPQA PPQTIVPGLS
510 520 530 540 550
VVAGAPASAA TVASAVAAPA PPQSTTEPLP AMVQTLPLGA NSVLTNNPTI
560 570 580 590 600
TITPTPNTAI LQSSLVMGEQ NLQWILNGAT SSPQNQEQIQ QASKVEQVYF
610 620 630 640 650
ATAVPVASGT GSSVQQIGLS VPVIIIKQEE ACQCQCACRD SAKERAAGRR
660 670
KGCSSPPPPE PNPQPPDGPS LQLPP
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB1ARW6 | B1ARW6_MOUSE | Metal regulatory transcription fact... | Mtf1 | 142 | Annotation score: | ||
A0A0G2JDC6 | A0A0G2JDC6_MOUSE | Metal regulatory transcription fact... | Mtf1 | 10 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 603 | A → T in CAA50470 (PubMed:8467794).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X71327 mRNA Translation: CAA50470.1 AJ251880 Genomic DNA Translation: CAB71344.1 AL606933 Genomic DNA No translation available. CH466552 Genomic DNA Translation: EDL30350.1 BC017679 mRNA Translation: AAH17679.1 |
CCDSi | CCDS18627.1 |
PIRi | S35335 |
RefSeqi | NP_032662.3, NM_008636.4 |
Genome annotation databases
Ensembli | ENSMUST00000030723; ENSMUSP00000030723; ENSMUSG00000028890 ENSMUST00000106193; ENSMUSP00000101799; ENSMUSG00000028890 |
GeneIDi | 17764 |
KEGGi | mmu:17764 |
UCSCi | uc008urb.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X71327 mRNA Translation: CAA50470.1 AJ251880 Genomic DNA Translation: CAB71344.1 AL606933 Genomic DNA No translation available. CH466552 Genomic DNA Translation: EDL30350.1 BC017679 mRNA Translation: AAH17679.1 |
CCDSi | CCDS18627.1 |
PIRi | S35335 |
RefSeqi | NP_032662.3, NM_008636.4 |
3D structure databases
AlphaFoldDBi | Q07243 |
SMRi | Q07243 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 201591, 4 interactors |
IntActi | Q07243, 3 interactors |
STRINGi | 10090.ENSMUSP00000030723 |
PTM databases
iPTMneti | Q07243 |
PhosphoSitePlusi | Q07243 |
Proteomic databases
MaxQBi | Q07243 |
PaxDbi | Q07243 |
PRIDEi | Q07243 |
ProteomicsDBi | 287632 |
Protocols and materials databases
Antibodypediai | 17617, 217 antibodies from 29 providers |
DNASUi | 17764 |
Genome annotation databases
Ensembli | ENSMUST00000030723; ENSMUSP00000030723; ENSMUSG00000028890 ENSMUST00000106193; ENSMUSP00000101799; ENSMUSG00000028890 |
GeneIDi | 17764 |
KEGGi | mmu:17764 |
UCSCi | uc008urb.2, mouse |
Organism-specific databases
CTDi | 4520 |
MGIi | MGI:101786, Mtf1 |
VEuPathDBi | HostDB:ENSMUSG00000028890 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000157291 |
HOGENOMi | CLU_026685_0_0_1 |
InParanoidi | Q07243 |
OMAi | SMFQSPD |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q07243 |
TreeFami | TF106493 |
Miscellaneous databases
BioGRID-ORCSi | 17764, 11 hits in 72 CRISPR screens |
ChiTaRSi | Mtf1, mouse |
PROi | PR:Q07243 |
RNActi | Q07243, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000028890, Expressed in spermatid and 302 other tissues |
ExpressionAtlasi | Q07243, baseline and differential |
Genevisiblei | Q07243, MM |
Family and domain databases
InterProi | View protein in InterPro IPR029796, Metal_TF1 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR19818:SF131, PTHR19818:SF131, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 6 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 6 hits |
SUPFAMi | SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | MTF1_MOUSE | |
Accessioni | Q07243Primary (citable) accession number: Q07243 Secondary accession number(s): Q9JJW8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | July 27, 2011 | |
Last modified: | May 25, 2022 | |
This is version 163 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot