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Protein

Glia-derived nexin

Gene

Serpine2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei364 – 365Reactive bondBy similarity2

GO - Molecular functioni

  • glycosaminoglycan binding Source: MGI
  • heparin binding Source: MGI
  • serine-type endopeptidase inhibitor activity Source: BHF-UCL
  • signaling receptor binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Heparin-binding, Protease inhibitor, Serine protease inhibitor
Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiR-MMU-140837 Intrinsic Pathway of Fibrin Clot Formation
R-MMU-140875 Common Pathway of Fibrin Clot Formation
R-MMU-75205 Dissolution of Fibrin Clot

Protein family/group databases

MEROPSiI04.021

Names & Taxonomyi

Protein namesi
Recommended name:
Glia-derived nexin
Short name:
GDN
Alternative name(s):
Peptidase inhibitor 7
Short name:
PI-7
Protease nexin 1
Short name:
PN-1
Protease nexin I
Serine protease-inhibitor 4
Serpin E2
Gene namesi
Name:Serpine2
Synonyms:Pi7, Pn1, Spi4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:101780 Serpine2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000003250520 – 397Glia-derived nexinAdd BLAST378

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ07235
PaxDbiQ07235
PeptideAtlasiQ07235
PRIDEiQ07235

PTM databases

PhosphoSitePlusiQ07235

Expressioni

Tissue specificityi

Most abundant in seminal vesicles.

Gene expression databases

BgeeiENSMUSG00000026249 Expressed in 340 organ(s), highest expression level in seminal vesicle
ExpressionAtlasiQ07235 baseline and differential
GenevisibleiQ07235 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203445, 1 interactor
STRINGi10090.ENSMUSP00000027467

Structurei

3D structure databases

ProteinModelPortaliQ07235
SMRiQ07235
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00930000150820
HOGENOMiHOG000238519
HOVERGENiHBG106493
InParanoidiQ07235
KOiK16643
OMAiKANFQCE
OrthoDBiEOG091G0ION
PhylomeDBiQ07235
TreeFamiTF352620

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q07235-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNWHFPFFIL TTVTLYSVHS QFNSLSLEEL GSNTGIQVFN QIIKSRPHEN
60 70 80 90 100
VVVSPHGIAS ILGMLQLGAD GKTKKQLSTV MRYNVNGVGK VLKKINKAIV
110 120 130 140 150
SKKNKDIVTV ANAVFLRNGF KMEVPFAVRN KDVFQCEVQN VNFQDPASAS
160 170 180 190 200
ESINFWVKNE TRGMIDNLLS PNLIDGALTR LVLVNAVYFK GLWKSRFQPE
210 220 230 240 250
STKKRTFVAG DGKSYQVPML AQLSVFRSGS TRTPNGLWYN FIELPYHGES
260 270 280 290 300
ISMLIALPTE SSTPLSAIIP HITTKTIDSW MNTMVPKRMQ LVLPKFTAVA
310 320 330 340 350
QTDLKEPLKA LGITEMFEPS KANFTKITRS ESLHVSHILQ KAKIEVSEDG
360 370 380 390
TKASAATTAI LIARSSPPWF IVDRPFLFSI RHNPTGAILF LGQVNKP
Length:397
Mass (Da):44,207
Last modified:February 1, 1996 - v2
Checksum:iB8EBAE3CA899D4A5
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WQM1A0A087WQM1_MOUSE
Glia-derived nexin
Serpine2
232Annotation score:
A0A087WQ70A0A087WQ70_MOUSE
Glia-derived nexin
Serpine2
232Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti313I → V in AAH10675 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70296 mRNA Translation: CAA49777.1
BC010675 mRNA Translation: AAH10675.1
X70946 Genomic DNA Translation: CAA50285.1
CCDSiCCDS15092.1
PIRiI48717
RefSeqiNP_033281.1, NM_009255.4
XP_006496522.1, XM_006496459.3
UniGeneiMm.3093

Genome annotation databases

EnsembliENSMUST00000027467; ENSMUSP00000027467; ENSMUSG00000026249
GeneIDi20720
KEGGimmu:20720
UCSCiuc007bqz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70296 mRNA Translation: CAA49777.1
BC010675 mRNA Translation: AAH10675.1
X70946 Genomic DNA Translation: CAA50285.1
CCDSiCCDS15092.1
PIRiI48717
RefSeqiNP_033281.1, NM_009255.4
XP_006496522.1, XM_006496459.3
UniGeneiMm.3093

3D structure databases

ProteinModelPortaliQ07235
SMRiQ07235
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203445, 1 interactor
STRINGi10090.ENSMUSP00000027467

Protein family/group databases

MEROPSiI04.021

PTM databases

PhosphoSitePlusiQ07235

Proteomic databases

EPDiQ07235
PaxDbiQ07235
PeptideAtlasiQ07235
PRIDEiQ07235

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027467; ENSMUSP00000027467; ENSMUSG00000026249
GeneIDi20720
KEGGimmu:20720
UCSCiuc007bqz.2 mouse

Organism-specific databases

CTDi5270
MGIiMGI:101780 Serpine2

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00930000150820
HOGENOMiHOG000238519
HOVERGENiHBG106493
InParanoidiQ07235
KOiK16643
OMAiKANFQCE
OrthoDBiEOG091G0ION
PhylomeDBiQ07235
TreeFamiTF352620

Enzyme and pathway databases

ReactomeiR-MMU-140837 Intrinsic Pathway of Fibrin Clot Formation
R-MMU-140875 Common Pathway of Fibrin Clot Formation
R-MMU-75205 Dissolution of Fibrin Clot

Miscellaneous databases

ChiTaRSiSerpine2 mouse
PROiPR:Q07235
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026249 Expressed in 340 organ(s), highest expression level in seminal vesicle
ExpressionAtlasiQ07235 baseline and differential
GenevisibleiQ07235 MM

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGDN_MOUSE
AccessioniPrimary (citable) accession number: Q07235
Secondary accession number(s): Q921T7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: February 1, 1996
Last modified: November 7, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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