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UniProtKB - Q07230 (ZSCA2_MOUSE)
Protein
Zinc finger and SCAN domain-containing protein 2
Gene
Zscan2
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 222 – 244 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 250 – 272 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 278 – 300 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 306 – 328 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 334 – 356 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 362 – 384 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 390 – 412 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 418 – 440 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 446 – 468 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 474 – 496 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 502 – 524 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 530 – 552 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 558 – 580 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 586 – 608 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- regulation of transcription by RNA polymerase II Source: GO_Central
- spermatogenesis Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Differentiation, Spermatogenesis, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger and SCAN domain-containing protein 2Alternative name(s): Zinc finger protein 29 Short name: Zfp-29 |
Gene namesi | Name:Zscan2 Synonyms:Zfp-29, Zfp29 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:99176, Zscan2 |
VEuPathDBi | HostDB:ENSMUSG00000038797 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation1 Publication
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047750 | 1 – 614 | Zinc finger and SCAN domain-containing protein 2Add BLAST | 614 |
Proteomic databases
PaxDbi | Q07230 |
PRIDEi | Q07230 |
ProteomicsDBi | 275107 |
PTM databases
iPTMneti | Q07230 |
PhosphoSitePlusi | Q07230 |
Expressioni
Tissue specificityi
In the adult, predominantly found in spermatids. Also present in the embryo.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000038797, Expressed in testis and 96 other tissues |
Genevisiblei | Q07230, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 204655, 4 interactors |
IntActi | Q07230, 4 interactors |
STRINGi | 10090.ENSMUSP00000042321 |
Miscellaneous databases
RNActi | Q07230, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q07230 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q07230 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 69 – 127 | SCAN boxPROSITE-ProRule annotationAdd BLAST | 59 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 25 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 42 – 73 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 162 – 200 | DisorderedSequence analysisAdd BLAST | 39 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 222 – 244 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 250 – 272 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 278 – 300 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 306 – 328 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 334 – 356 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 362 – 384 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 390 – 412 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 418 – 440 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 446 – 468 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 474 – 496 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 502 – 524 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 530 – 552 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 558 – 580 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 586 – 608 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161710 |
HOGENOMi | CLU_002678_57_1_1 |
InParanoidi | Q07230 |
OMAi | ILLMHQR |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q07230 |
TreeFami | TF337913 |
Family and domain databases
CDDi | cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF02023, SCAN, 1 hit PF00096, zf-C2H2, 14 hits |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 14 hits |
SUPFAMi | SSF57667, SSF57667, 9 hits |
PROSITEi | View protein in PROSITE PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 14 hits PS50157, ZINC_FINGER_C2H2_2, 14 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q07230-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAEVPAVST PLSPLVQVPQ EEDEQAEVTT MILEDDAWVQ EAVLQEDGPE
60 70 80 90 100
SEPFPQSAGK GSPQEEDAAE GPQGALVRFR ELCRRWLRPE VHTKEQMLTV
110 120 130 140 150
LPREIQAWLQ EHRPESSEEA VALVEDLTQT FRHSDFEIQS ENGENSNEDM
160 170 180 190 200
FEGVESHGMF LNISGGEGGQ QSDGDSDFER DCGSGGAQGH APGEDPRVVP
210 220 230 240 250
SEGREVGQLI GLQGTYLGEK PYECPQCGKT FSRKSHLITH ERTHTGEKYY
260 270 280 290 300
KCDECGKSFS DGSNFSRHQT THTGEKPYKC RDCGKSFSRS ANLITHQRIH
310 320 330 340 350
TGEKPFQCAE CGKSFSRSPN LIAHQRTHTG EKPYSCPECG KSFGNRSSLN
360 370 380 390 400
THQGIHTGEK PYACKECGES FSYNSNLIRH QRIHTGEKPY KCTECGQKFS
410 420 430 440 450
QSSALITHRR THTGEKPYQC GECGKNFSRS SNLATHRRTH LVEKPYKCGL
460 470 480 490 500
CGKSFSQSSS LIAHQGTHTG EKPYECLTCG ESFSWSSNLI KHQRTHTGEK
510 520 530 540 550
PYRCGDCGKG FSQRSQLVVH QRTHTGEKPY KCLMCGKSFS RGSILVMHQR
560 570 580 590 600
AHLGDKPYRC PECGKGFSWN SVLIIHQRIH TGEKPYRCPE CGKGFSNSSN
610
FITHQRTHLK EKLY
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3YTK9 | D3YTK9_MOUSE | Zinc finger and SCAN domain-contain... | Zscan2 | 452 | Annotation score: | ||
D3YYN4 | D3YYN4_MOUSE | Zinc finger and SCAN domain-contain... | Zscan2 | 145 | Annotation score: | ||
D3YW76 | D3YW76_MOUSE | Zinc finger and SCAN domain-contain... | Zscan2 | 188 | Annotation score: | ||
A0A0U1RQ38 | A0A0U1RQ38_MOUSE | Zinc finger and SCAN domain-contain... | Zscan2 | 69 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X55126 mRNA Translation: CAA38920.1 BC046961 mRNA Translation: AAH46961.1 |
CCDSi | CCDS21399.1 |
PIRi | JH0500 |
RefSeqi | NP_033579.1, NM_009553.2 XP_006540868.1, XM_006540805.3 XP_006540869.1, XM_006540806.3 XP_006540870.1, XM_006540807.3 XP_006540871.1, XM_006540808.3 XP_006540872.1, XM_006540809.3 XP_006540873.1, XM_006540810.3 XP_006540874.1, XM_006540811.3 XP_006540875.1, XM_006540812.3 |
Genome annotation databases
Ensembli | ENSMUST00000044115; ENSMUSP00000042321; ENSMUSG00000038797 |
GeneIDi | 22691 |
KEGGi | mmu:22691 |
UCSCi | uc009ibh.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X55126 mRNA Translation: CAA38920.1 BC046961 mRNA Translation: AAH46961.1 |
CCDSi | CCDS21399.1 |
PIRi | JH0500 |
RefSeqi | NP_033579.1, NM_009553.2 XP_006540868.1, XM_006540805.3 XP_006540869.1, XM_006540806.3 XP_006540870.1, XM_006540807.3 XP_006540871.1, XM_006540808.3 XP_006540872.1, XM_006540809.3 XP_006540873.1, XM_006540810.3 XP_006540874.1, XM_006540811.3 XP_006540875.1, XM_006540812.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2I13 | X-ray | 1.96 | A/B | 218-388 | [»] | |
SMRi | Q07230 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 204655, 4 interactors |
IntActi | Q07230, 4 interactors |
STRINGi | 10090.ENSMUSP00000042321 |
PTM databases
iPTMneti | Q07230 |
PhosphoSitePlusi | Q07230 |
Proteomic databases
PaxDbi | Q07230 |
PRIDEi | Q07230 |
ProteomicsDBi | 275107 |
Protocols and materials databases
Antibodypediai | 1841, 135 antibodies from 23 providers |
DNASUi | 22691 |
Genome annotation databases
Ensembli | ENSMUST00000044115; ENSMUSP00000042321; ENSMUSG00000038797 |
GeneIDi | 22691 |
KEGGi | mmu:22691 |
UCSCi | uc009ibh.1, mouse |
Organism-specific databases
CTDi | 54993 |
MGIi | MGI:99176, Zscan2 |
VEuPathDBi | HostDB:ENSMUSG00000038797 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161710 |
HOGENOMi | CLU_002678_57_1_1 |
InParanoidi | Q07230 |
OMAi | ILLMHQR |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q07230 |
TreeFami | TF337913 |
Miscellaneous databases
BioGRID-ORCSi | 22691, 2 hits in 65 CRISPR screens |
EvolutionaryTracei | Q07230 |
PROi | PR:Q07230 |
RNActi | Q07230, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000038797, Expressed in testis and 96 other tissues |
Genevisiblei | Q07230, MM |
Family and domain databases
CDDi | cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF02023, SCAN, 1 hit PF00096, zf-C2H2, 14 hits |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 14 hits |
SUPFAMi | SSF57667, SSF57667, 9 hits |
PROSITEi | View protein in PROSITE PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 14 hits PS50157, ZINC_FINGER_C2H2_2, 14 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZSCA2_MOUSE | |
Accessioni | Q07230Primary (citable) accession number: Q07230 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 179 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families