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Protein

Zinc finger and SCAN domain-containing protein 2

Gene

Zscan2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 244C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 552C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri558 – 580C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri586 – 608C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA-binding transcription factor activity Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
  • sequence-specific DNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Spermatogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 2
Alternative name(s):
Zinc finger protein 29
Short name:
Zfp-29
Gene namesi
Name:Zscan2
Synonyms:Zfp-29, Zfp29
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:99176 Zscan2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477501 – 614Zinc finger and SCAN domain-containing protein 2Add BLAST614

Proteomic databases

PaxDbiQ07230
PRIDEiQ07230

PTM databases

iPTMnetiQ07230
PhosphoSitePlusiQ07230

Expressioni

Tissue specificityi

In the adult, predominantly found in spermatids. Also present in the embryo.1 Publication

Gene expression databases

BgeeiENSMUSG00000038797 Expressed in 47 organ(s), highest expression level in testis
CleanExiMM_ZSCAN2
ExpressionAtlasiQ07230 baseline and differential
GenevisibleiQ07230 MM

Interactioni

Protein-protein interaction databases

BioGridi204655, 4 interactors
STRINGi10090.ENSMUSP00000042321

Structurei

Secondary structure

1614
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ07230
SMRiQ07230
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ07230

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 127SCAN boxPROSITE-ProRule annotationAdd BLAST59

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 244C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 552C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri558 – 580C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri586 – 608C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150882
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiQ07230
KOiK09230
OMAiIAHQGTH
OrthoDBiEOG091G02KC
PhylomeDBiQ07230
TreeFamiTF337913

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 14 hits
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 14 hits
SUPFAMiSSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 14 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q07230-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAEVPAVST PLSPLVQVPQ EEDEQAEVTT MILEDDAWVQ EAVLQEDGPE
60 70 80 90 100
SEPFPQSAGK GSPQEEDAAE GPQGALVRFR ELCRRWLRPE VHTKEQMLTV
110 120 130 140 150
LPREIQAWLQ EHRPESSEEA VALVEDLTQT FRHSDFEIQS ENGENSNEDM
160 170 180 190 200
FEGVESHGMF LNISGGEGGQ QSDGDSDFER DCGSGGAQGH APGEDPRVVP
210 220 230 240 250
SEGREVGQLI GLQGTYLGEK PYECPQCGKT FSRKSHLITH ERTHTGEKYY
260 270 280 290 300
KCDECGKSFS DGSNFSRHQT THTGEKPYKC RDCGKSFSRS ANLITHQRIH
310 320 330 340 350
TGEKPFQCAE CGKSFSRSPN LIAHQRTHTG EKPYSCPECG KSFGNRSSLN
360 370 380 390 400
THQGIHTGEK PYACKECGES FSYNSNLIRH QRIHTGEKPY KCTECGQKFS
410 420 430 440 450
QSSALITHRR THTGEKPYQC GECGKNFSRS SNLATHRRTH LVEKPYKCGL
460 470 480 490 500
CGKSFSQSSS LIAHQGTHTG EKPYECLTCG ESFSWSSNLI KHQRTHTGEK
510 520 530 540 550
PYRCGDCGKG FSQRSQLVVH QRTHTGEKPY KCLMCGKSFS RGSILVMHQR
560 570 580 590 600
AHLGDKPYRC PECGKGFSWN SVLIIHQRIH TGEKPYRCPE CGKGFSNSSN
610
FITHQRTHLK EKLY
Length:614
Mass (Da):68,714
Last modified:November 1, 1996 - v1
Checksum:i738156A0A9413DF7
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YTK9D3YTK9_MOUSE
Zinc finger and SCAN domain-contain...
Zscan2
452Annotation score:
D3YW76D3YW76_MOUSE
Zinc finger and SCAN domain-contain...
Zscan2
188Annotation score:
D3YYN4D3YYN4_MOUSE
Zinc finger and SCAN domain-contain...
Zscan2
145Annotation score:
A0A0U1RQ38A0A0U1RQ38_MOUSE
Zinc finger and SCAN domain-contain...
Zscan2
69Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55126 mRNA Translation: CAA38920.1
BC046961 mRNA Translation: AAH46961.1
CCDSiCCDS21399.1
PIRiJH0500
RefSeqiNP_033579.1, NM_009553.2
XP_006540868.1, XM_006540805.3
XP_006540869.1, XM_006540806.3
XP_006540870.1, XM_006540807.3
XP_006540871.1, XM_006540808.3
XP_006540872.1, XM_006540809.3
XP_006540873.1, XM_006540810.3
XP_006540874.1, XM_006540811.3
XP_006540875.1, XM_006540812.3
UniGeneiMm.358645

Genome annotation databases

EnsembliENSMUST00000044115; ENSMUSP00000042321; ENSMUSG00000038797
GeneIDi22691
KEGGimmu:22691
UCSCiuc009ibh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55126 mRNA Translation: CAA38920.1
BC046961 mRNA Translation: AAH46961.1
CCDSiCCDS21399.1
PIRiJH0500
RefSeqiNP_033579.1, NM_009553.2
XP_006540868.1, XM_006540805.3
XP_006540869.1, XM_006540806.3
XP_006540870.1, XM_006540807.3
XP_006540871.1, XM_006540808.3
XP_006540872.1, XM_006540809.3
XP_006540873.1, XM_006540810.3
XP_006540874.1, XM_006540811.3
XP_006540875.1, XM_006540812.3
UniGeneiMm.358645

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2I13X-ray1.96A/B218-388[»]
ProteinModelPortaliQ07230
SMRiQ07230
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204655, 4 interactors
STRINGi10090.ENSMUSP00000042321

PTM databases

iPTMnetiQ07230
PhosphoSitePlusiQ07230

Proteomic databases

PaxDbiQ07230
PRIDEiQ07230

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044115; ENSMUSP00000042321; ENSMUSG00000038797
GeneIDi22691
KEGGimmu:22691
UCSCiuc009ibh.1 mouse

Organism-specific databases

CTDi54993
MGIiMGI:99176 Zscan2

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150882
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiQ07230
KOiK09230
OMAiIAHQGTH
OrthoDBiEOG091G02KC
PhylomeDBiQ07230
TreeFamiTF337913

Miscellaneous databases

EvolutionaryTraceiQ07230
PROiPR:Q07230
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038797 Expressed in 47 organ(s), highest expression level in testis
CleanExiMM_ZSCAN2
ExpressionAtlasiQ07230 baseline and differential
GenevisibleiQ07230 MM

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 14 hits
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 14 hits
SUPFAMiSSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 14 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZSCA2_MOUSE
AccessioniPrimary (citable) accession number: Q07230
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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