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UniProtKB - Q07230 (ZSCA2_MOUSE)

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Protein

Zinc finger and SCAN domain-containing protein 2

Gene

Zscan2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 244C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 552C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri558 – 580C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri586 – 608C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Spermatogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 2
Alternative name(s):
Zinc finger protein 29
Short name:
Zfp-29
Gene namesi
Name:Zscan2
Synonyms:Zfp-29, Zfp29
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:99176 Zscan2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477501 – 614Zinc finger and SCAN domain-containing protein 2Add BLAST614

Proteomic databases

PaxDbiQ07230
PRIDEiQ07230

PTM databases

iPTMnetiQ07230
PhosphoSitePlusiQ07230

Expressioni

Tissue specificityi

In the adult, predominantly found in spermatids. Also present in the embryo.1 Publication

Gene expression databases

BgeeiENSMUSG00000038797
CleanExiMM_ZSCAN2
ExpressionAtlasiQ07230 baseline and differential
GenevisibleiQ07230 MM

Interactioni

Protein-protein interaction databases

BioGridi204655, 4 interactors
STRINGi10090.ENSMUSP00000042321

Structurei

Secondary structure

1614
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni225 – 227Combined sources3
Helixi235 – 239Combined sources5
Helixi240 – 242Combined sources3
Turni253 – 255Combined sources3
Beta strandi258 – 261Combined sources4
Helixi262 – 273Combined sources12
Turni281 – 283Combined sources3
Beta strandi286 – 288Combined sources3
Helixi290 – 301Combined sources12
Turni309 – 311Combined sources3
Beta strandi314 – 317Combined sources4
Helixi318 – 329Combined sources12
Turni337 – 339Combined sources3
Beta strandi342 – 344Combined sources3
Helixi346 – 357Combined sources12
Turni365 – 367Combined sources3
Beta strandi370 – 373Combined sources4
Helixi374 – 381Combined sources8

3D structure databases

ProteinModelPortaliQ07230
SMRiQ07230
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ07230

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 127SCAN boxPROSITE-ProRule annotationAdd BLAST59

Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 244C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 552C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri558 – 580C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri586 – 608C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000148970
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiQ07230
KOiK09230
OMAiHRRTHLV
OrthoDBiEOG091G02KC
PhylomeDBiQ07230
TreeFamiTF337913

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 14 hits
SUPFAMiSSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 14 hits

Sequencei

Sequence statusi: Complete.

Q07230-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEVPAVST PLSPLVQVPQ EEDEQAEVTT MILEDDAWVQ EAVLQEDGPE 
        60         70         80         90        100
SEPFPQSAGK GSPQEEDAAE GPQGALVRFR ELCRRWLRPE VHTKEQMLTV 
       110        120        130        140        150
LPREIQAWLQ EHRPESSEEA VALVEDLTQT FRHSDFEIQS ENGENSNEDM 
       160        170        180        190        200
FEGVESHGMF LNISGGEGGQ QSDGDSDFER DCGSGGAQGH APGEDPRVVP 
       210        220        230        240        250
SEGREVGQLI GLQGTYLGEK PYECPQCGKT FSRKSHLITH ERTHTGEKYY 
       260        270        280        290        300
KCDECGKSFS DGSNFSRHQT THTGEKPYKC RDCGKSFSRS ANLITHQRIH 
       310        320        330        340        350
TGEKPFQCAE CGKSFSRSPN LIAHQRTHTG EKPYSCPECG KSFGNRSSLN 
       360        370        380        390        400
THQGIHTGEK PYACKECGES FSYNSNLIRH QRIHTGEKPY KCTECGQKFS 
       410        420        430        440        450
QSSALITHRR THTGEKPYQC GECGKNFSRS SNLATHRRTH LVEKPYKCGL 
       460        470        480        490        500
CGKSFSQSSS LIAHQGTHTG EKPYECLTCG ESFSWSSNLI KHQRTHTGEK 
       510        520        530        540        550
PYRCGDCGKG FSQRSQLVVH QRTHTGEKPY KCLMCGKSFS RGSILVMHQR 
       560        570        580        590        600
AHLGDKPYRC PECGKGFSWN SVLIIHQRIH TGEKPYRCPE CGKGFSNSSN 
       610 
FITHQRTHLK EKLY
Length:614
Mass (Da):68,714
Last modified:November 1, 1996 - v1
Checksum:i738156A0A9413DF7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55126 mRNA Translation: CAA38920.1
BC046961 mRNA Translation: AAH46961.1
CCDSiCCDS21399.1
PIRiJH0500
RefSeqiNP_033579.1, NM_009553.2
XP_006540868.1, XM_006540805.3
XP_006540869.1, XM_006540806.3
XP_006540870.1, XM_006540807.3
XP_006540871.1, XM_006540808.3
XP_006540872.1, XM_006540809.3
XP_006540873.1, XM_006540810.3
XP_006540874.1, XM_006540811.3
XP_006540875.1, XM_006540812.3
UniGeneiMm.358645

Genome annotation databases

EnsembliENSMUST00000044115; ENSMUSP00000042321; ENSMUSG00000038797
GeneIDi22691
KEGGimmu:22691
UCSCiuc009ibh.1 mouse

Similar proteinsi

Entry informationi

Entry nameiZSCA2_MOUSE
AccessioniPrimary (citable) accession number: Q07230
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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