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Entry version 166 (29 Sep 2021)
Sequence version 2 (01 Jun 2000)
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Protein

Gelsolin

Gene

Gel

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed.

1 Publication

Caution

Lacks one of the cysteines to make the disulfide bridge in isoform 1. It is replaced by Val-233.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi599Calcium 1By similarity1
Metal bindingi623Calcium 1By similarity1
Metal bindingi705Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi706Calcium 2By similarity1
Metal bindingi728Calcium 2By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gelsolin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Gel
ORF Names:CG1106
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

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FlyBasei
FBgn0010225, Gel

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
VectorBase:FBgn0010225

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003639329 – 798GelsolinAdd BLAST770

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei90Phosphotyrosine; by SRCCurated1
Modified residuei612Phosphotyrosine; by SRCCurated1
Modified residuei662Phosphotyrosine; by SRCCurated1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q07171

PRoteomics IDEntifications database

More...
PRIDEi
Q07171

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 and isoform 2 are ubiquitously expressed in early embryo. Isoform 1 is expressed in the fat body, and is abundant in hemolymph. Isoform 2 is expressed in parts of the gut.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
FBgn0010225, Expressed in arthropod fat body and 23 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q07171, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q07171, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to actin and to fibronectin.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
70060, 6 interactors

Protein interaction database and analysis system

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IntActi
Q07171, 4 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0078607

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q07171

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati78 – 131Gelsolin-like 1Add BLAST54
Repeati203 – 243Gelsolin-like 2Add BLAST41
Repeati322 – 365Gelsolin-like 3Add BLAST44
Repeati474 – 524Gelsolin-like 4Add BLAST51
Repeati583 – 625Gelsolin-like 5Add BLAST43
Repeati689 – 730Gelsolin-like 6Add BLAST42

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni57 – 181Actin-severingSequence analysisAdd BLAST125
Regioni128 – 131Actin-actin interfilament contact pointBy similarity4
Regioni167 – 174Polyphosphoinositide bindingBy similarity8
Regioni193 – 201Polyphosphoinositide bindingBy similarity9
Regioni451 – 792Actin-binding, Ca-sensitiveSequence analysisAdd BLAST342

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the villin/gelsolin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0443, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000173475

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q07171

Identification of Orthologs from Complete Genome Data

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OMAi
DNRTKTH

Database for complete collections of gene phylogenies

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PhylomeDBi
Q07171

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.20.10, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029006, ADF-H/Gelsolin-like_dom_sf
IPR007123, Gelsolin-like_dom
IPR007122, Villin/Gelsolin

The PANTHER Classification System

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PANTHERi
PTHR11977, PTHR11977, 3 hits

Pfam protein domain database

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Pfami
View protein in Pfam
PF00626, Gelsolin, 5 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00597, GELSOLIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00262, GEL, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1Curated1 Publication (identifier: Q07171-1) [UniParc]FASTAAdd to basket
Also known as: BCurated1 Publication, DImported, FImported, SecretedCurated1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDASGAATMA VLSSLLVFLA LSSSLCSAGT LNARPAFPVQ SGEIQPSGQN
60 70 80 90 100
SKQAARRVMH PSFANAGRTP GLEIWRIENF EPVIYPKTNY GKFYTGDSFI
110 120 130 140 150
VLNTIENKKD KKLSWDVHFW LGLETSTDEA GAAAILTVQL DDLLNGGPVQ
160 170 180 190 200
HREVQDHESQ LFLSYFKNGI RYEQGGVGTG FKHVETNAQG ETRLFQVKGK
210 220 230 240 250
RNVRVRQVNL SVSSMNTGDC FILDAGSDIY VYVGSQAKRV EKLKAISAAN
260 270 280 290 300
QIRDQDHNGR ARVQIVDDFS TDADKQHFFD VLGSGSADQV PDESTADEDS
310 320 330 340 350
AFERTDAAAV SLYKVSDASG KLKVDIIGQK PLTQAMLDTR ECFILDTGSG
360 370 380 390 400
IFVWVGKGAT QKEKTDAMAK AQEFLRTKKY PAWTQIHRIV EGSESAPFKQ
410 420 430 440 450
YFDTWRDAGM SHSRLIRSAL GIGSDELLND DEIDSVVTQL KKSGGRAFGF
460 470 480 490 500
MPDHGQNVIE TITQYVAKPG SDEIVVSTVP FDEKLPLLGF ASYVLTYNYE
510 520 530 540 550
ANNGDTGSLT YVWHGVKASA AARKRAFEEG LVGSKDGLLV QTNQGHEPRH
560 570 580 590 600
FYKIFKGKLL TSFTALPVTA QLFRIRGTVE SDVHASEVAA DSSSLASSDA
610 620 630 640 650
FVLHSGKSHK IYIWNGLGAS AFEKQAAVDR FSDYWDDVEL EQVEEGAEPD
660 670 680 690 700
EFWEELNGEG QYDRSLGDDG APLLESRLFH CHLSSGGFLK VEEVAQYEQE
710 720 730 740 750
DLDSDDIMLL DAGDEIYLWV GYGVSEEENG KLLDTAKLYF NLEPTARSFD
760 770 780 790
TVSIIRVPQG KEPRVFKRMF PNWDDNYWQN QPSYEDMKQL VIDANNEV
Length:798
Mass (Da):88,375
Last modified:June 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i79828666DC0965CC
GO
Isoform 2Curated1 Publication (identifier: Q07171-2) [UniParc]FASTAAdd to basket
Also known as: ACurated1 Publication, CytoplasmicCurated1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: Missing.

Show »
Length:740
Mass (Da):82,528
Checksum:i7B7B6F466F979632
GO
Isoform KImported (identifier: Q07171-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MDASGAATMAVLSS → MF

Show »
Length:786
Mass (Da):87,359
Checksum:i399CAFEE4734F7F9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DHG2A0A0C4DHG2_DROME
Gelsolin, isoform J
Gel DGS, Dmel\CG1106, gel, CG1106, Dmel_CG1106
798Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DHG6A0A0C4DHG6_DROME
Gelsolin, isoform L
Gel DGS, Dmel\CG1106, gel, CG1106, Dmel_CG1106
740Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA28568 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAM50316 differs from that shown. Intron retention.Curated
The sequence AAM50316 differs from that shown. Reason: Frameshift.Curated
The sequence AAM50316 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence ABY20529 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence CAA53295 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti498N → S in CAA53294 (PubMed:8175883).Curated1
Sequence conflicti498N → S in CAA53295 (PubMed:8175883).Curated1
Sequence conflicti646G → S in CAA53294 (PubMed:8175883).Curated1
Sequence conflicti646G → S in CAA53295 (PubMed:8175883).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0070101 – 58Missing in isoform 2. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_0583641 – 14MDASG…AVLSS → MF in isoform K. Add BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L08794 mRNA Translation: AAA28568.1 Different initiation.
X75629 mRNA Translation: CAA53294.1
X75630 mRNA Translation: CAA53295.1 Different initiation.
AE014297 Genomic DNA Translation: AAF52162.2
AE014297 Genomic DNA Translation: AAF52163.1
AE014297 Genomic DNA Translation: AAF52164.3
AE014297 Genomic DNA Translation: AAN13333.3
AE014297 Genomic DNA Translation: AAO41510.1
AY119662 mRNA Translation: AAM50316.1 Sequence problems.
BT031288 mRNA Translation: ABY20529.1 Different initiation.

Protein sequence database of the Protein Information Resource

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PIRi
A53909

NCBI Reference Sequences

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RefSeqi
NP_001036657.2, NM_001043192.3 [Q07171-2]
NP_524865.2, NM_080126.4 [Q07171-1]
NP_730788.1, NM_164319.4 [Q07171-2]
NP_730790.2, NM_164321.5 [Q07171-1]
NP_788571.1, NM_176394.3 [Q07171-1]
NP_996148.2, NM_206426.4 [Q07171-6]
NP_996149.3, NM_206427.4 [Q07171-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0078968; FBpp0078607; FBgn0010225 [Q07171-1]
FBtr0078969; FBpp0078608; FBgn0010225 [Q07171-1]
FBtr0078971; FBpp0078610; FBgn0010225 [Q07171-2]
FBtr0078973; FBpp0078612; FBgn0010225 [Q07171-1]
FBtr0309256; FBpp0301195; FBgn0010225 [Q07171-1]
FBtr0309257; FBpp0301196; FBgn0010225 [Q07171-6]
FBtr0336707; FBpp0307688; FBgn0010225 [Q07171-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
46008

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG1106

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08794 mRNA Translation: AAA28568.1 Different initiation.
X75629 mRNA Translation: CAA53294.1
X75630 mRNA Translation: CAA53295.1 Different initiation.
AE014297 Genomic DNA Translation: AAF52162.2
AE014297 Genomic DNA Translation: AAF52163.1
AE014297 Genomic DNA Translation: AAF52164.3
AE014297 Genomic DNA Translation: AAN13333.3
AE014297 Genomic DNA Translation: AAO41510.1
AY119662 mRNA Translation: AAM50316.1 Sequence problems.
BT031288 mRNA Translation: ABY20529.1 Different initiation.
PIRiA53909
RefSeqiNP_001036657.2, NM_001043192.3 [Q07171-2]
NP_524865.2, NM_080126.4 [Q07171-1]
NP_730788.1, NM_164319.4 [Q07171-2]
NP_730790.2, NM_164321.5 [Q07171-1]
NP_788571.1, NM_176394.3 [Q07171-1]
NP_996148.2, NM_206426.4 [Q07171-6]
NP_996149.3, NM_206427.4 [Q07171-1]

3D structure databases

SMRiQ07171
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi70060, 6 interactors
IntActiQ07171, 4 interactors
STRINGi7227.FBpp0078607

Proteomic databases

PaxDbiQ07171
PRIDEiQ07171

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
46008

Genome annotation databases

EnsemblMetazoaiFBtr0078968; FBpp0078607; FBgn0010225 [Q07171-1]
FBtr0078969; FBpp0078608; FBgn0010225 [Q07171-1]
FBtr0078971; FBpp0078610; FBgn0010225 [Q07171-2]
FBtr0078973; FBpp0078612; FBgn0010225 [Q07171-1]
FBtr0309256; FBpp0301195; FBgn0010225 [Q07171-1]
FBtr0309257; FBpp0301196; FBgn0010225 [Q07171-6]
FBtr0336707; FBpp0307688; FBgn0010225 [Q07171-2]
GeneIDi46008
KEGGidme:Dmel_CG1106

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
46008
FlyBaseiFBgn0010225, Gel
VEuPathDBiVectorBase:FBgn0010225

Phylogenomic databases

eggNOGiKOG0443, Eukaryota
GeneTreeiENSGT00940000173475
InParanoidiQ07171
OMAiDNRTKTH
PhylomeDBiQ07171

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
46008, 0 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Bsg, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
46008

Protein Ontology

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PROi
PR:Q07171

Gene expression databases

BgeeiFBgn0010225, Expressed in arthropod fat body and 23 other tissues
ExpressionAtlasiQ07171, baseline and differential
GenevisibleiQ07171, DM

Family and domain databases

Gene3Di3.40.20.10, 6 hits
InterProiView protein in InterPro
IPR029006, ADF-H/Gelsolin-like_dom_sf
IPR007123, Gelsolin-like_dom
IPR007122, Villin/Gelsolin
PANTHERiPTHR11977, PTHR11977, 3 hits
PfamiView protein in Pfam
PF00626, Gelsolin, 5 hits
PRINTSiPR00597, GELSOLIN
SMARTiView protein in SMART
SM00262, GEL, 6 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGELS_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q07171
Secondary accession number(s): A4V2C8
, A9UNC4, Q0KIE3, Q0KIE4, Q8MRF9, Q9VMZ1, Q9VMZ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: June 1, 2000
Last modified: September 29, 2021
This is version 166 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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