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Protein

Fructose-bisphosphate aldolase class 1

Gene

fda

Organism
Staphylococcus carnosus (strain TM300)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgiA)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. Fructose-bisphosphate aldolase class 1 (fda)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei175Proton acceptorBy similarity1
Active sitei212Schiff-base intermediate with dihydroxyacetone-PBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processGlycolysis
LigandSchiff base

Enzyme and pathway databases

BioCyciSCAR396513:G1G1Q-2180-MONOMER
UniPathwayiUPA00109; UER00183

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase class 1 (EC:4.1.2.13)
Alternative name(s):
Fructose-bisphosphate aldolase class I
Short name:
FBP aldolase
Gene namesi
Name:fda
Ordered Locus Names:Sca_2144
OrganismiStaphylococcus carnosus (strain TM300)
Taxonomic identifieri396513 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000444 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002169092 – 296Fructose-bisphosphate aldolase class 1Add BLAST295

Proteomic databases

PRIDEiQ07159

Interactioni

Protein-protein interaction databases

STRINGi396513.Sca_2144

Structurei

3D structure databases

ProteinModelPortaliQ07159
SMRiQ07159
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105WYW Bacteria
COG3588 LUCA
HOGENOMiHOG000073502
KOiK01623
OMAiVFGTKER

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00729 FBP_aldolase_1, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR000741 FBA_I
IPR023014 FBA_I_Gram+-type
PfamiView protein in Pfam
PF00274 Glycolytic, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07159-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQEQFDKIK NGKGFIAALD QSGGSTPKAL KDYGVEENEY SNDEEMFNLV
60 70 80 90 100
HDMRTRIITS PAFNGEKILG AILFEQTMDR EVEGKYTGSY LADKGIVPFL
110 120 130 140 150
KVDKGLAEEA DGVQLMKPIP DLDKLLDRAN ERGIFGTKMR SNILENNKEA
160 170 180 190 200
IEKVVKQQFE VAKEIIAAGL VPIIEPEVNI NAKDKEAIEA NLAEAIKAEL
210 220 230 240 250
DNLKKDQYVM LKLTIPTKVN AYSELIEHPQ VIRVVALSGG YSRDEANKIL
260 270 280 290
KQNDGLIASF SRALVSDLNA QQSDAEFNEK LQEAIDTIFD ASVNKA
Length:296
Mass (Da):32,851
Last modified:January 23, 2007 - v3
Checksum:i13B5033BE67BF7E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71729 Genomic DNA Translation: CAA50663.1
AM295250 Genomic DNA Translation: CAL29049.1
PIRiA49943
RefSeqiWP_015901385.1, NC_012121.1

Genome annotation databases

KEGGisca:SCA_2144

Similar proteinsi

Entry informationi

Entry nameiALF1_STACT
AccessioniPrimary (citable) accession number: Q07159
Secondary accession number(s): B9DJW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 103 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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