UniProtKB - Q07157 (ZO1_HUMAN)
Tight junction protein ZO-1
TJP1
Functioni
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- calmodulin binding Source: UniProtKB-KW
- cell adhesion molecule binding Source: GO_Central
GO - Biological processi
- actomyosin structure organization Source: ARUK-UCL
- adherens junction maintenance Source: ARUK-UCL
- cell-cell adhesion Source: GO_Central
- cell-cell junction assembly Source: ProtInc
- cell-cell junction organization Source: ARUK-UCL
- establishment of endothelial intestinal barrier Source: UniProtKB
- hippo signaling Source: Reactome
- maintenance of blood-brain barrier Source: ARUK-UCL
- negative regulation of actin cytoskeleton reorganization Source: ARUK-UCL
- negative regulation of apoptotic process Source: ARUK-UCL
- negative regulation of stress fiber assembly Source: ARUK-UCL
- positive regulation of blood-brain barrier permeability Source: ARUK-UCL
- positive regulation of cell-cell adhesion mediated by cadherin Source: ARUK-UCL
- positive regulation of cell migration Source: ARUK-UCL
- positive regulation of cell population proliferation Source: ARUK-UCL
- positive regulation of sprouting angiogenesis Source: ARUK-UCL
- protein localization to adherens junction Source: ARUK-UCL
- protein localization to bicellular tight junction Source: ARUK-UCL
- protein localization to cell-cell junction Source: ARUK-UCL
- regulation of bicellular tight junction assembly Source: ARUK-UCL
- regulation of cell junction assembly Source: ARUK-UCL
- regulation of cytoskeleton organization Source: ARUK-UCL
Keywordsi
Molecular function | Calmodulin-binding |
Enzyme and pathway databases
PathwayCommonsi | Q07157 |
Reactomei | R-HSA-191650, Regulation of gap junction activity R-HSA-2028269, Signaling by Hippo R-HSA-351906, Apoptotic cleavage of cell adhesion proteins R-HSA-8935964, RUNX1 regulates expression of components of tight junctions |
SIGNORi | Q07157 |
Protein family/group databases
TCDBi | 8.A.24.1.9, the ezrin/radixin/moesin-binding phosphoprotein 50 (ebp50) family |
Names & Taxonomyi
Protein namesi | Recommended name: Tight junction protein ZO-1Alternative name(s): Tight junction protein 1 Zona occludens protein 1 Zonula occludens protein 1 |
Gene namesi | Name:TJP1 Synonyms:ZO1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000104067.16 |
HGNCi | HGNC:11827, TJP1 |
MIMi | 601009, gene |
neXtProti | NX_Q07157 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
Other locations
- tight junction 1 Publication
- Cell junction 1 Publication
- gap junction
- podosome 1 Publication
Note: Moves from the cytoplasm to the cell membrane concurrently with cell-cell contact (PubMed:7798316). At podosomal sites, is predominantly localized in the ring structure surrounding the actin core (PubMed:20930113). Colocalizes with SPEF1 at sites of cell-cell contact in intestinal epithelial cells (PubMed:31473225).3 Publications
Cytoskeleton
- podosome Source: UniProtKB-SubCell
Cytosol
- cytosol Source: HPA
Plasma Membrane
- basolateral plasma membrane Source: MGI
- plasma membrane Source: ARUK-UCL
Other locations
- adherens junction Source: ProtInc
- apical junction complex Source: MGI
- apical part of cell Source: MGI
- bicellular tight junction Source: UniProtKB
- cell junction Source: UniProtKB
- cell projection Source: UniProtKB-KW
- cytoplasm Source: UniProtKB
- gap junction Source: UniProtKB
- protein-containing complex Source: ARUK-UCL
- tight junction Source: ARUK-UCL
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Gap junction, Membrane, Tight junctionPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 201 | R → A: Strongly reduced interaction with GJA1. 1 Publication | 1 | |
Mutagenesisi | 209 | K → A: Abolishes interaction with GJA1. 1 Publication | 1 | |
Mutagenesisi | 1699 – 1700 | MC → AA: Abolishes interaction with CDC42BPB. 1 Publication | 2 | |
Mutagenesisi | 1748 | Missing : Abolishes interaction with CDC42BPB and MYZAP. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 7082 |
OpenTargetsi | ENSG00000104067 |
PharmGKBi | PA36532 |
Miscellaneous databases
Pharosi | Q07157, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4296026 |
Polymorphism and mutation databases
BioMutai | TJP1 |
DMDMi | 85700443 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000094540 | 1 – 1748 | Tight junction protein ZO-1Add BLAST | 1748 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 125 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 132 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 175 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 178 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 179 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 185 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 212 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 241 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 267 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 275 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 277 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 280 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 284 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 290 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 294 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 297 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 300 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 323 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 329 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 334 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 337 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 353 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 354 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 617 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 622 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 809 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 810 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 821 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 822 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 824 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 828 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 837 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 846 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 848 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 854 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 861 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 868 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 912 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 968 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1071 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1111 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1139 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1140 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 1165 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 1354 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 1366 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1413 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1545 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1617 | PhosphoserineCombined sources | 1 | ||
Isoform Short (identifier: Q07157-2) | |||||
Modified residuei | 912 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q07157 |
jPOSTi | Q07157 |
MassIVEi | Q07157 |
MaxQBi | Q07157 |
PaxDbi | Q07157 |
PeptideAtlasi | Q07157 |
PRIDEi | Q07157 |
ProteomicsDBi | 58506 [Q07157-1] 58507 [Q07157-2] |
PTM databases
GlyGeni | Q07157, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q07157 |
PhosphoSitePlusi | Q07157 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000104067, Expressed in brain and 250 other tissues |
ExpressionAtlasi | Q07157, baseline and differential |
Genevisiblei | Q07157, HS |
Organism-specific databases
HPAi | ENSG00000104067, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer (PubMed:17928286). Forms heterodimers (via the PDZ2 domain) with TJP2 and TJP3 (PubMed:9792688, PubMed:17928286, PubMed:16737969).
Interacts with OCLN, CALM, claudins, CGN/cingulin, CXADR, GJA12, GJD3 and UBN1 (PubMed:7798316, PubMed:11734628, PubMed:12023291, PubMed:12154091, PubMed:15183511, PubMed:18823282, PubMed:20200156).
Interacts (via ZU5 domain) with CDC42BPB and MYZAP (PubMed:20093627, PubMed:21240187).
Interacts (via PDZ domain) with GJA1 (PubMed:18636092).
Interacts (via PDZ domains) with ANKRD2 (PubMed:22016770).
Interacts with BVES (via the C-terminus cytoplasmic tail) (By similarity).
Interacts with HSPA4 and KIRREL1 (By similarity).
Interacts with DLL1 (By similarity).
Interacts with USP53 (via the C-terminal region) (By similarity).
Interacts (via ABR region) with F-actin (PubMed:9792688, PubMed:12354695, PubMed:20930113).
Interacts with DNMBP (via C-terminal domain); required for the apical cell-cell junction localization of DNMBP (PubMed:17015620).
Interacts with SPEF1 (PubMed:31473225).
By similarity17 PublicationsBinary interactionsi
Hide detailsQ07157
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- calmodulin binding Source: UniProtKB-KW
- cell adhesion molecule binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 112937, 146 interactors |
CORUMi | Q07157 |
ELMi | Q07157 |
IntActi | Q07157, 72 interactors |
MINTi | Q07157 |
STRINGi | 9606.ENSP00000281537 |
Miscellaneous databases
RNActi | Q07157, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q07157 |
SMRi | Q07157 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q07157 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 110 | PDZ 1PROSITE-ProRule annotationAdd BLAST | 88 | |
Domaini | 186 – 264 | PDZ 2PROSITE-ProRule annotationAdd BLAST | 79 | |
Domaini | 421 – 502 | PDZ 3PROSITE-ProRule annotationAdd BLAST | 82 | |
Domaini | 516 – 584 | SH3PROSITE-ProRule annotationAdd BLAST | 69 | |
Domaini | 598 – 779 | Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST | 182 | |
Domaini | 1634 – 1748 | ZU5PROSITE-ProRule annotationAdd BLAST | 115 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 633 – 876 | Occludin (OCLN)-binding region1 PublicationAdd BLAST | 244 | |
Regioni | 1151 – 1371 | Actin-binding region (ABR)1 PublicationAdd BLAST | 221 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1243 – 1248 | Poly-Pro | 6 | |
Compositional biasi | 1426 – 1432 | Poly-Pro | 7 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, SH3 domainPhylogenomic databases
eggNOGi | KOG3580, Eukaryota |
GeneTreei | ENSGT00940000155164 |
InParanoidi | Q07157 |
OrthoDBi | 179316at2759 |
PhylomeDBi | Q07157 |
TreeFami | TF315957 |
Family and domain databases
CDDi | cd12026, SH3_ZO-1, 1 hit |
Gene3Di | 2.30.42.10, 3 hits |
InterProi | View protein in InterPro IPR008145, GK/Ca_channel_bsu IPR008144, Guanylate_kin-like_dom IPR027417, P-loop_NTPase IPR001478, PDZ IPR036034, PDZ_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR005417, ZO IPR005418, ZO-1 IPR035597, ZO-1_SH3 IPR000906, ZU5_dom |
PANTHERi | PTHR13865:SF25, PTHR13865:SF25, 1 hit |
Pfami | View protein in Pfam PF00625, Guanylate_kin, 1 hit PF00595, PDZ, 3 hits PF07653, SH3_2, 1 hit PF00791, ZU5, 1 hit |
PRINTSi | PR01597, ZONOCCLUDNS PR01598, ZONOCCLUDNS1 |
SMARTi | View protein in SMART SM00072, GuKc, 1 hit SM00228, PDZ, 3 hits SM00218, ZU5, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF50156, SSF50156, 3 hits SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50052, GUANYLATE_KINASE_2, 1 hit PS50106, PDZ, 3 hits PS50002, SH3, 1 hit PS51145, ZU5, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSARAAAAKS TAMEETAIWE QHTVTLHRAP GFGFGIAISG GRDNPHFQSG
60 70 80 90 100
ETSIVISDVL KGGPAEGQLQ ENDRVAMVNG VSMDNVEHAF AVQQLRKSGK
110 120 130 140 150
NAKITIRRKK KVQIPVSRPD PEPVSDNEED SYDEEIHDPR SGRSGVVNRR
160 170 180 190 200
SEKIWPRDRS ASRERSLSPR SDRRSVASSQ PAKPTKVTLV KSRKNEEYGL
210 220 230 240 250
RLASHIFVKE ISQDSLAARD GNIQEGDVVL KINGTVTENM SLTDAKTLIE
260 270 280 290 300
RSKGKLKMVV QRDERATLLN VPDLSDSIHS ANASERDDIS EIQSLASDHS
310 320 330 340 350
GRSHDRPPRR SRSRSPDQRS EPSDHSRHSP QQPSNGSLRS RDEERISKPG
360 370 380 390 400
AVSTPVKHAD DHTPKTVEEV TVERNEKQTP SLPEPKPVYA QVGQPDVDLP
410 420 430 440 450
VSPSDGVLPN STHEDGILRP SMKLVKFRKG DSVGLRLAGG NDVGIFVAGV
460 470 480 490 500
LEDSPAAKEG LEEGDQILRV NNVDFTNIIR EEAVLFLLDL PKGEEVTILA
510 520 530 540 550
QKKKDVYRRI VESDVGDSFY IRTHFEYEKE SPYGLSFNKG EVFRVVDTLY
560 570 580 590 600
NGKLGSWLAI RIGKNHKEVE RGIIPNKNRA EQLASVQYTL PKTAGGDRAD
610 620 630 640 650
FWRFRGLRSS KRNLRKSRED LSAQPVQTKF PAYERVVLRE AGFLRPVTIF
660 670 680 690 700
GPIADVAREK LAREEPDIYQ IAKSEPRDAG TDQRSSGIIR LHTIKQIIDQ
710 720 730 740 750
DKHALLDVTP NAVDRLNYAQ WYPIVVFLNP DSKQGVKTMR MRLCPESRKS
760 770 780 790 800
ARKLYERSHK LRKNNHHLFT TTINLNSMND GWYGALKEAI QQQQNQLVWV
810 820 830 840 850
SEGKADGATS DDLDLHDDRL SYLSAPGSEY SMYSTDSRHT SDYEDTDTEG
860 870 880 890 900
GAYTDQELDE TLNDEVGTPP ESAITRSSEP VREDSSGMHH ENQTYPPYSP
910 920 930 940 950
QAQPQPIHRI DSPGFKPASQ QKAEASSPVP YLSPETNPAS STSAVNHNVN
960 970 980 990 1000
LTNVRLEEPT PAPSTSYSPQ ADSLRTPSTE AAHIMLRDQE PSLSSHVDPT
1010 1020 1030 1040 1050
KVYRKDPYPE EMMRQNHVLK QPAVSHPGHR PDKEPNLTYE PQLPYVEKQA
1060 1070 1080 1090 1100
SRDLEQPTYR YESSSYTDQF SRNYEHRLRY EDRVPMYEEQ WSYYDDKQPY
1110 1120 1130 1140 1150
PSRPPFDNQH SQDLDSRQHP EESSERGYFP RFEEPAPLSY DSRPRYEQAP
1160 1170 1180 1190 1200
RASALRHEEQ PAPGYDTHGR LRPEAQPHPS AGPKPAESKQ YFEQYSRSYE
1210 1220 1230 1240 1250
QVPPQGFTSR AGHFEPLHGA AAVPPLIPSS QHKPEALPSN TKPLPPPPTQ
1260 1270 1280 1290 1300
TEEEEDPAMK PQSVLTRVKM FENKRSASLE TKKDVNDTGS FKPPEVASKP
1310 1320 1330 1340 1350
SGAPIIGPKP TSQNQFSEHD KTLYRIPEPQ KPQLKPPEDI VRSNHYDPEE
1360 1370 1380 1390 1400
DEEYYRKQLS YFDRRSFENK PPAHIAASHL SEPAKPAHSQ NQSNFSSYSS
1410 1420 1430 1440 1450
KGKPPEADGV DRSFGEKRYE PIQATPPPPP LPSQYAQPSQ PVTSASLHIH
1460 1470 1480 1490 1500
SKGAHGEGNS VSLDFQNSLV SKPDPPPSQN KPATFRPPNR EDTAQAAFYP
1510 1520 1530 1540 1550
QKSFPDKAPV NGTEQTQKTV TPAYNRFTPK PYTSSARPFE RKFESPKFNH
1560 1570 1580 1590 1600
NLLPSETAHK PDLSSKTPTS PKTLVKSHSL AQPPEFDSGV ETFSIHAEKP
1610 1620 1630 1640 1650
KYQINNISTV PKAIPVSPSA VEEDEDEDGH TVVATARGIF NSNGGVLSSI
1660 1670 1680 1690 1700
ETGVSIIIPQ GAIPEGVEQE IYFKVCRDNS ILPPLDKEKG ETLLSPLVMC
1710 1720 1730 1740
GPHGLKFLKP VELRLPHCDP KTWQNKCLPG DPNYLVGANC VSVLIDHF
The sequence of this isoform differs from the canonical sequence as follows:
922-1001: Missing.
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3V1L9 | G3V1L9_HUMAN | Tight junction protein 1 (Zona occl... | TJP1 hCG_27621 | 1,768 | Annotation score: | ||
G5E9E7 | G5E9E7_HUMAN | Tight junction protein 1 (Zona occl... | TJP1 hCG_27621 | 1,692 | Annotation score: | ||
A0A087X0K9 | A0A087X0K9_HUMAN | Tight junction protein ZO-1 | TJP1 | 1,676 | Annotation score: | ||
H0YKB1 | H0YKB1_HUMAN | Tight junction protein 1 (Zona occl... | TJP1 hCG_27621 | 383 | Annotation score: | ||
H0YLT6 | H0YLT6_HUMAN | Tight junction protein ZO-1 | TJP1 | 231 | Annotation score: | ||
H0Y3R8 | H0Y3R8_HUMAN | Tight junction protein ZO-1 | TJP1 | 227 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 394 – 417 | QPDVD…HEDGI → NQMWIYLSVHLMVSYLIQLM KMGF in AAA02891 (PubMed:8395056).CuratedAdd BLAST | 24 | |
Sequence conflicti | 545 | V → A in AAA02891 (PubMed:8395056).Curated | 1 | |
Sequence conflicti | 688 | I → Y in AAA02891 (PubMed:8395056).Curated | 1 | |
Sequence conflicti | 762 | R → A in AAA02891 (PubMed:8395056).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_025153 | 471 | N → S1 PublicationCorresponds to variant dbSNP:rs2229517EnsemblClinVar. | 1 | |
Natural variantiVAR_025154 | 790 | I → V3 PublicationsCorresponds to variant dbSNP:rs2229515Ensembl. | 1 | |
Natural variantiVAR_025155 | 930 | P → L1 PublicationCorresponds to variant dbSNP:rs45529137Ensembl. | 1 | |
Natural variantiVAR_025156 | 1110 | H → R1 PublicationCorresponds to variant dbSNP:rs45567033Ensembl. | 1 | |
Natural variantiVAR_025157 | 1347 | D → A1 PublicationCorresponds to variant dbSNP:rs2291166Ensembl. | 1 | |
Natural variantiVAR_025158 | 1605 | N → S1 PublicationCorresponds to variant dbSNP:rs45578638Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_003148 | 922 – 1001 | Missing in isoform Short. CuratedAdd BLAST | 80 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L14837 mRNA Translation: AAA02891.1 Different initiation. AK304758 mRNA Translation: BAG65513.1 DQ015919 Genomic DNA Translation: AAY22179.1 AC022613 Genomic DNA No translation available. BC111712 mRNA Translation: AAI11713.1 |
CCDSi | CCDS42007.1 [Q07157-1] CCDS45199.1 [Q07157-2] |
PIRi | A47747 |
RefSeqi | NP_003248.3, NM_003257.4 [Q07157-1] NP_783297.2, NM_175610.3 [Q07157-2] |
Genome annotation databases
Ensembli | ENST00000346128; ENSP00000281537; ENSG00000104067 [Q07157-1] ENST00000545208; ENSP00000441202; ENSG00000104067 [Q07157-2] ENST00000621049; ENSP00000484535; ENSG00000277401 |
GeneIDi | 7082 |
KEGGi | hsa:7082 |
UCSCi | uc001zcr.4, human [Q07157-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L14837 mRNA Translation: AAA02891.1 Different initiation. AK304758 mRNA Translation: BAG65513.1 DQ015919 Genomic DNA Translation: AAY22179.1 AC022613 Genomic DNA No translation available. BC111712 mRNA Translation: AAI11713.1 |
CCDSi | CCDS42007.1 [Q07157-1] CCDS45199.1 [Q07157-2] |
PIRi | A47747 |
RefSeqi | NP_003248.3, NM_003257.4 [Q07157-1] NP_783297.2, NM_175610.3 [Q07157-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2H2B | X-ray | 1.60 | A | 18-110 | [»] | |
2H2C | X-ray | 2.00 | A | 18-110 | [»] | |
2H3M | X-ray | 2.90 | A | 18-110 | [»] | |
2JWE | NMR | - | A/B | 185-264 | [»] | |
2KXR | NMR | - | A | 1631-1748 | [»] | |
2KXS | NMR | - | A | 1631-1748 | [»] | |
2RCZ | X-ray | 1.70 | A/B | 186-264 | [»] | |
3CYY | X-ray | 2.40 | A/B | 182-273 | [»] | |
3LH5 | X-ray | 2.60 | A | 516-803 | [»] | |
3SHU | X-ray | 2.75 | A/B | 421-512 | [»] | |
3SHW | X-ray | 2.90 | A | 421-888 | [»] | |
3TSV | X-ray | 1.99 | A | 417-516 | [»] | |
3TSW | X-ray | 2.85 | A/B/C/D | 417-803 | [»] | |
3TSZ | X-ray | 2.50 | A | 417-803 | [»] | |
4OEO | X-ray | 1.90 | A/B/C | 18-110 | [»] | |
4OEP | X-ray | 2.35 | A/B | 18-110 | [»] | |
4Q2Q | X-ray | 1.45 | A | 419-504 | [»] | |
4YYX | X-ray | 1.79 | A/B | 18-110 | [»] | |
BMRBi | Q07157 | |||||
SMRi | Q07157 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112937, 146 interactors |
CORUMi | Q07157 |
ELMi | Q07157 |
IntActi | Q07157, 72 interactors |
MINTi | Q07157 |
STRINGi | 9606.ENSP00000281537 |
Chemistry databases
ChEMBLi | CHEMBL4296026 |
Protein family/group databases
TCDBi | 8.A.24.1.9, the ezrin/radixin/moesin-binding phosphoprotein 50 (ebp50) family |
PTM databases
GlyGeni | Q07157, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q07157 |
PhosphoSitePlusi | Q07157 |
Polymorphism and mutation databases
BioMutai | TJP1 |
DMDMi | 85700443 |
Proteomic databases
EPDi | Q07157 |
jPOSTi | Q07157 |
MassIVEi | Q07157 |
MaxQBi | Q07157 |
PaxDbi | Q07157 |
PeptideAtlasi | Q07157 |
PRIDEi | Q07157 |
ProteomicsDBi | 58506 [Q07157-1] 58507 [Q07157-2] |
Protocols and materials databases
Antibodypediai | 783, 412 antibodies |
DNASUi | 7082 |
Genome annotation databases
Ensembli | ENST00000346128; ENSP00000281537; ENSG00000104067 [Q07157-1] ENST00000545208; ENSP00000441202; ENSG00000104067 [Q07157-2] ENST00000621049; ENSP00000484535; ENSG00000277401 |
GeneIDi | 7082 |
KEGGi | hsa:7082 |
UCSCi | uc001zcr.4, human [Q07157-1] |
Organism-specific databases
CTDi | 7082 |
DisGeNETi | 7082 |
EuPathDBi | HostDB:ENSG00000104067.16 |
GeneCardsi | TJP1 |
HGNCi | HGNC:11827, TJP1 |
HPAi | ENSG00000104067, Low tissue specificity |
MIMi | 601009, gene |
neXtProti | NX_Q07157 |
OpenTargetsi | ENSG00000104067 |
PharmGKBi | PA36532 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3580, Eukaryota |
GeneTreei | ENSGT00940000155164 |
InParanoidi | Q07157 |
OrthoDBi | 179316at2759 |
PhylomeDBi | Q07157 |
TreeFami | TF315957 |
Enzyme and pathway databases
PathwayCommonsi | Q07157 |
Reactomei | R-HSA-191650, Regulation of gap junction activity R-HSA-2028269, Signaling by Hippo R-HSA-351906, Apoptotic cleavage of cell adhesion proteins R-HSA-8935964, RUNX1 regulates expression of components of tight junctions |
SIGNORi | Q07157 |
Miscellaneous databases
BioGRID-ORCSi | 7082, 12 hits in 849 CRISPR screens |
ChiTaRSi | TJP1, human |
EvolutionaryTracei | Q07157 |
GeneWikii | Tight_junction_protein_1 |
GenomeRNAii | 7082 |
Pharosi | Q07157, Tbio |
PROi | PR:Q07157 |
RNActi | Q07157, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000104067, Expressed in brain and 250 other tissues |
ExpressionAtlasi | Q07157, baseline and differential |
Genevisiblei | Q07157, HS |
Family and domain databases
CDDi | cd12026, SH3_ZO-1, 1 hit |
Gene3Di | 2.30.42.10, 3 hits |
InterProi | View protein in InterPro IPR008145, GK/Ca_channel_bsu IPR008144, Guanylate_kin-like_dom IPR027417, P-loop_NTPase IPR001478, PDZ IPR036034, PDZ_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR005417, ZO IPR005418, ZO-1 IPR035597, ZO-1_SH3 IPR000906, ZU5_dom |
PANTHERi | PTHR13865:SF25, PTHR13865:SF25, 1 hit |
Pfami | View protein in Pfam PF00625, Guanylate_kin, 1 hit PF00595, PDZ, 3 hits PF07653, SH3_2, 1 hit PF00791, ZU5, 1 hit |
PRINTSi | PR01597, ZONOCCLUDNS PR01598, ZONOCCLUDNS1 |
SMARTi | View protein in SMART SM00072, GuKc, 1 hit SM00228, PDZ, 3 hits SM00218, ZU5, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF50156, SSF50156, 3 hits SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50052, GUANYLATE_KINASE_2, 1 hit PS50106, PDZ, 3 hits PS50002, SH3, 1 hit PS51145, ZU5, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZO1_HUMAN | |
Accessioni | Q07157Primary (citable) accession number: Q07157 Secondary accession number(s): B4E3K1, Q2NKP3, Q4ZGJ6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | January 24, 2006 | |
Last modified: | December 2, 2020 | |
This is version 225 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations