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Entry version 166 (29 Sep 2021)
Sequence version 2 (16 Nov 2011)
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Protein

Protein ECT2

Gene

Ect2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Autoinhibited by the C-terminal PH domain which folds back and binds to the surface of the DH domain, blocking binding of RHOA to the catalytic center of the DH domain. The 2nd BRCT domain is also involved in inhibition, probably by helping to impede RHOA binding. Allosterically activated by binding of activated GTP-bound RHOA to the PH domain which stimulates the release of PH inhibition and promotes the binding of substrate RHOA to the catalytic center. Binding of phosphorylated RACGAP1 to the N-terminal BRCT domain-containing region also releases autoinhibition.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processCell cycle, Cell division, Differentiation, Neurogenesis, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-193648, NRAGE signals death through JNK
R-MMU-416482, G alpha (12/13) signalling events
R-MMU-8980692, RHOA GTPase cycle
R-MMU-9013026, RHOB GTPase cycle
R-MMU-9013148, CDC42 GTPase cycle
R-MMU-9013149, RAC1 GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein ECT2
Alternative name(s):
Epithelial cell-transforming sequence 2 oncogene
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ect2
Synonyms:mKIAA4037
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:95281, Ect2

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSMUSG00000027699

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Nucleus, Tight junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000809392 – 913Protein ECT2Add BLAST912

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei359Phosphothreonine; by PKC/PRKCIBy similarity1
Modified residuei367PhosphoserineBy similarity1
Modified residuei370PhosphoserineBy similarity1
Modified residuei373PhosphothreonineCombined sources1
Modified residuei376PhosphoserineCombined sources1
Modified residuei444Phosphothreonine; by CDK1By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki611Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei716PhosphoserineBy similarity1
Modified residuei842PhosphoserineBy similarity1
Modified residuei846Phosphothreonine; by CDK1By similarity1
Modified residuei861PhosphoserineBy similarity1
Modified residuei865PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by PLK1 in vitro. Hyperphosphorylated during the G2 phase of the cell cycle. Phosphorylation at Thr-373 occurs during the G2/M phase, relieves its auto-inhibition status and stimulates its GEF activity. Phosphorylation at Thr-444 in G2/M phase is required for subsequent binding with PLK1 and Rho exchange activation. Dephosphorylated at the time of cytokinesis. Phosphorylation at Thr-359 is required for its transformation activity in cancer cells (By similarity).By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q07139

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q07139

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q07139

PeptideAtlas

More...
PeptideAtlasi
Q07139

PRoteomics IDEntifications database

More...
PRIDEi
Q07139

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
277440 [Q07139-1]
277441 [Q07139-2]
277442 [Q07139-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q07139

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q07139

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest expression in testis. Also detectable in brain, kidney, liver and spleen.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the embryo at 16 dpc.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by phenobarbital in the nucleus and cytoplasm of the liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000027699, Expressed in secondary oocyte and 248 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q07139, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (By similarity). Homooligomer (By similarity).

Found in the centralspindlin complex (By similarity).

Interacts with NR1I3 (PubMed:17904126).

Interacts (Thr-359 phosphorylated form) with PARD6A; the interaction is observed in cancer cells (By similarity).

Interacts (Thr-359 phosphorylated form) with PRKCI; the interaction is observed in cancer cells (By similarity).

Interacts with PKP4; the interaction is observed at the midbody (By similarity).

Interacts with RACGAP1; the interaction is direct, occurs in a microtubule-dependent manner, occurs at anaphase and during cytokinesis, is inhibited in metaphase by phosphorylation of ECT2 on Thr-373 and is stimulated in early anaphase by dephosphorylation of ECT2 probably on Thr-373 through CDK1 activity (By similarity).

Interacts with PLK1; the interaction is stimulated upon its phosphorylation on Thr-444 (By similarity).

Interacts with RHOA; the interaction results in allosteric activation of ECT2 (By similarity).

Interacts with KIF23, PARD3, PARD6B and PRKCQ (By similarity).

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
199370, 47 interactors

Protein interaction database and analysis system

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IntActi
Q07139, 27 interactors

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000103935

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q07139, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1913
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q07139

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q07139

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini176 – 260BRCT 1PROSITE-ProRule annotationAdd BLAST85
Domaini266 – 354BRCT 2PROSITE-ProRule annotationAdd BLAST89
Domaini452 – 641DHPROSITE-ProRule annotationAdd BLAST190
Domaini675 – 794PHAdd BLAST120

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni389 – 415DisorderedSequence analysisAdd BLAST27
Regioni427 – 450DisorderedSequence analysisAdd BLAST24
Regioni853 – 874DisorderedSequence analysisAdd BLAST22

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi378 – 382Nuclear localization signalBy similarity5
Motifi401 – 405Nuclear localization signalBy similarity5

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The BRCT domain 1 and 2 are required for the intramolecular interaction, but not for the intermolecular oligomerization. The BRCT domains negatively inhibit its GEF activity in interphase cells. The same BRCT domains may act as a positive regulatory motif for the completion of cytokinesis after the breakdown of nuclear membrane during mitosis (By similarity).By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3524, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156299

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_008187_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q07139

Identification of Orthologs from Complete Genome Data

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OMAi
CKAKESN

Database of Orthologous Groups

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OrthoDBi
557169at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q07139

TreeFam database of animal gene trees

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TreeFami
TF101161

Family and domain databases

Conserved Domains Database

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CDDi
cd00160, RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 1 hit
3.40.50.10190, 3 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001357, BRCT_dom
IPR036420, BRCT_dom_sf
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR026817, Ect2
IPR001331, GDS_CDC24_CS
IPR011993, PH-like_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR16777, PTHR16777, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00533, BRCT, 1 hit
PF12738, PTCB-BRCT, 1 hit
PF00621, RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00292, BRCT, 2 hits
SM00325, RhoGEF, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48065, SSF48065, 1 hit
SSF52113, SSF52113, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50172, BRCT, 2 hits
PS00741, DH_1, 1 hit
PS50010, DH_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q07139-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADDSVLPSP SEITSLADSS VFDSKVAEMS KENLCLASTS NVDEEMPQVE
60 70 80 90 100
ARVIMVQDAG KQEELLKALK TIKIMEVPVI KIKESCPGKS EEKLIKSIIN
110 120 130 140 150
MEMKVPCVKM DSMEEFESLD SPEFENIFVV TDFQNSVFND LYKADCRIVG
160 170 180 190 200
PPVILNCAQR GEPLPFSCRP LYCTSMLNLV LCFTGFRKKE ELVKLVTLVH
210 220 230 240 250
HMGGVIRKEC NSKVTHLVAN CTQGEKFRVA VSLGTPIMKP EWIYKAWERR
260 270 280 290 300
NEQCFCAAVD DFRNEFKVPP FQDCILSFLG FSDEEKHSME EMTEMQGGSY
310 320 330 340 350
LPVGDERCTH LIVEENTVKD LPFEPSKKLF VVKQEWFWGS IQMDARAGET
360 370 380 390 400
MYLYEKANTP ELKKSVSLLS LSTPNSNRKR RRLKETLAQL SRETDLSPFP
410 420 430 440 450
PRKRPSAEHS LSIGSLLDIS NTPESSIHYG ETPKSCAKSS RSSTPVPPKQ
460 470 480 490 500
SARWQVAKEL YQTESNYVNI LATIIQLFQV PLEEEGQRGG PILAPEEIKT
510 520 530 540 550
IFGSIPDIFD VHMKIKDDLE DLIANWDESR SIGDIFLKYA KDLVKTYPPF
560 570 580 590 600
VNFFEMSKEM IIKCEKQKPR FHAFLKINQA KPECGRQSLV ELLIRPVQRL
610 620 630 640 650
PSVALLLNDL KKHTADENPD KSTLEKAIGS LKEVMTHINE DKRKTEAQKQ
660 670 680 690 700
IFDVVYEVDG CPANLLSSHR SLVQRVETVS LGEHPCDRGE QVTLFLFNDC
710 720 730 740 750
LEIARKRHKV IGTFRSPHDR TRPPASLKHI HLMPLSQIKK VLDIRETEDC
760 770 780 790 800
HNAFALLVRP PTEQANVLLS FQMTSEELPK ESWLKMLCRH VANTICKADA
810 820 830 840 850
ENLMYVADPE SFEVNTKDMD STLSRASRAI KKTSKKVTRA FSFSKTPKRA
860 870 880 890 900
LRMALSSSHS SEGRSPPSSG KLAVSRLSST SSLAGIPSPS LVSLPSFFER
910
RSHTLSRSTT HLI
Length:913
Mass (Da):103,131
Last modified:November 16, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2F0CC71DBF9D8280
GO
Isoform 2 (identifier: Q07139-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-101: Missing.

Show »
Length:882
Mass (Da):99,648
Checksum:iB4D4033B955AE6BC
GO
Isoform 3 (identifier: Q07139-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     49-52: VEAR → LKQE
     53-913: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:52
Mass (Da):5,605
Checksum:i46E34DBE58839C23
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BIZ5H3BIZ5_MOUSE
Protein ECT2
Ect2
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BIW1H3BIW1_MOUSE
Protein ECT2
Ect2
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BL29H3BL29_MOUSE
Protein ECT2
Ect2
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BK10H3BK10_MOUSE
Protein ECT2
Ect2
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GXV8V9GXV8_MOUSE
Protein ECT2
Ect2
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BL18H3BL18_MOUSE
Protein ECT2
Ect2
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA37536 differs from that shown. Erroneous CDS prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti11S → T in AAH32155 (PubMed:15489334).Curated1
Sequence conflicti28E → G in AAH32155 (PubMed:15489334).Curated1
Sequence conflicti147R → S in AAH23881 (PubMed:15489334).Curated1
Sequence conflicti555E → K in AAH45614 (PubMed:15489334).Curated1
Sequence conflicti872L → V in AAH32155 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04197949 – 52VEAR → LKQE in isoform 3. 1 Publication4
Alternative sequenceiVSP_04198053 – 913Missing in isoform 3. 1 PublicationAdd BLAST861
Alternative sequenceiVSP_04198171 – 101Missing in isoform 2. 3 PublicationsAdd BLAST31

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
L11316 mRNA Translation: AAA37536.1 Sequence problems.
AK157718 mRNA Translation: BAE34166.1
AK220452 mRNA Translation: BAD90277.1
AC121099 Genomic DNA No translation available.
AC165280 Genomic DNA No translation available.
CH466530 Genomic DNA Translation: EDL34919.1
CH466530 Genomic DNA Translation: EDL34920.1
BC023881 mRNA Translation: AAH23881.1
BC025565 mRNA Translation: AAH25565.1
BC032155 mRNA Translation: AAH32155.1
BC045614 mRNA Translation: AAH45614.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS17270.2 [Q07139-1]
CCDS50875.1 [Q07139-2]

Protein sequence database of the Protein Information Resource

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PIRi
S32372

NCBI Reference Sequences

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RefSeqi
NP_001171096.1, NM_001177625.1 [Q07139-2]
NP_001171097.1, NM_001177626.1 [Q07139-2]
NP_031926.2, NM_007900.3 [Q07139-1]
XP_006535448.1, XM_006535385.3 [Q07139-1]
XP_006535449.1, XM_006535386.3 [Q07139-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000108298; ENSMUSP00000103933; ENSMUSG00000027699 [Q07139-2]
ENSMUST00000108300; ENSMUSP00000103935; ENSMUSG00000027699 [Q07139-1]
ENSMUST00000176242; ENSMUSP00000135740; ENSMUSG00000027699 [Q07139-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
13605

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:13605

UCSC genome browser

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UCSCi
uc008oth.2, mouse [Q07139-1]
uc008oti.2, mouse [Q07139-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11316 mRNA Translation: AAA37536.1 Sequence problems.
AK157718 mRNA Translation: BAE34166.1
AK220452 mRNA Translation: BAD90277.1
AC121099 Genomic DNA No translation available.
AC165280 Genomic DNA No translation available.
CH466530 Genomic DNA Translation: EDL34919.1
CH466530 Genomic DNA Translation: EDL34920.1
BC023881 mRNA Translation: AAH23881.1
BC025565 mRNA Translation: AAH25565.1
BC032155 mRNA Translation: AAH32155.1
BC045614 mRNA Translation: AAH45614.1
CCDSiCCDS17270.2 [Q07139-1]
CCDS50875.1 [Q07139-2]
PIRiS32372
RefSeqiNP_001171096.1, NM_001177625.1 [Q07139-2]
NP_001171097.1, NM_001177626.1 [Q07139-2]
NP_031926.2, NM_007900.3 [Q07139-1]
XP_006535448.1, XM_006535385.3 [Q07139-1]
XP_006535449.1, XM_006535386.3 [Q07139-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2COUNMR-A266-361[»]
SMRiQ07139
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi199370, 47 interactors
IntActiQ07139, 27 interactors
STRINGi10090.ENSMUSP00000103935

PTM databases

iPTMnetiQ07139
PhosphoSitePlusiQ07139

Proteomic databases

jPOSTiQ07139
MaxQBiQ07139
PaxDbiQ07139
PeptideAtlasiQ07139
PRIDEiQ07139
ProteomicsDBi277440 [Q07139-1]
277441 [Q07139-2]
277442 [Q07139-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
33733, 378 antibodies

The DNASU plasmid repository

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DNASUi
13605

Genome annotation databases

EnsembliENSMUST00000108298; ENSMUSP00000103933; ENSMUSG00000027699 [Q07139-2]
ENSMUST00000108300; ENSMUSP00000103935; ENSMUSG00000027699 [Q07139-1]
ENSMUST00000176242; ENSMUSP00000135740; ENSMUSG00000027699 [Q07139-2]
GeneIDi13605
KEGGimmu:13605
UCSCiuc008oth.2, mouse [Q07139-1]
uc008oti.2, mouse [Q07139-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1894
MGIiMGI:95281, Ect2
VEuPathDBiHostDB:ENSMUSG00000027699

Phylogenomic databases

eggNOGiKOG3524, Eukaryota
GeneTreeiENSGT00940000156299
HOGENOMiCLU_008187_0_0_1
InParanoidiQ07139
OMAiCKAKESN
OrthoDBi557169at2759
PhylomeDBiQ07139
TreeFamiTF101161

Enzyme and pathway databases

ReactomeiR-MMU-193648, NRAGE signals death through JNK
R-MMU-416482, G alpha (12/13) signalling events
R-MMU-8980692, RHOA GTPase cycle
R-MMU-9013026, RHOB GTPase cycle
R-MMU-9013148, CDC42 GTPase cycle
R-MMU-9013149, RAC1 GTPase cycle

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
13605, 22 hits in 61 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Ect2, mouse
EvolutionaryTraceiQ07139

Protein Ontology

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PROi
PR:Q07139
RNActiQ07139, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000027699, Expressed in secondary oocyte and 248 other tissues
GenevisibleiQ07139, MM

Family and domain databases

CDDicd00160, RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
3.40.50.10190, 3 hits
InterProiView protein in InterPro
IPR001357, BRCT_dom
IPR036420, BRCT_dom_sf
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR026817, Ect2
IPR001331, GDS_CDC24_CS
IPR011993, PH-like_dom_sf
PANTHERiPTHR16777, PTHR16777, 1 hit
PfamiView protein in Pfam
PF00533, BRCT, 1 hit
PF12738, PTCB-BRCT, 1 hit
PF00621, RhoGEF, 1 hit
SMARTiView protein in SMART
SM00292, BRCT, 2 hits
SM00325, RhoGEF, 1 hit
SUPFAMiSSF48065, SSF48065, 1 hit
SSF52113, SSF52113, 2 hits
PROSITEiView protein in PROSITE
PS50172, BRCT, 2 hits
PS00741, DH_1, 1 hit
PS50010, DH_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiECT2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q07139
Secondary accession number(s): Q3TZP2
, Q5DTR8, Q80VE4, Q8CIH2, Q8K2A0, Q8R3E2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 16, 2011
Last modified: September 29, 2021
This is version 166 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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