UniProtKB - Q07133 (H1T_MOUSE)
Histone H1t
H1-6
Functioni
Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes. Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination. Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration.
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 54 | Important for nucleosome binding propertiesBy similarity | 1 |
GO - Molecular functioni
- DNA binding Source: MGI
- double-stranded DNA binding Source: CAFA
- nucleosomal DNA binding Source: GO_Central
GO - Biological processi
- binding of sperm to zona pellucida Source: MGI
- cell differentiation Source: UniProtKB-KW
- chromosome condensation Source: GO_Central
- flagellated sperm motility Source: MGI
- negative regulation of DNA recombination Source: GO_Central
- nucleosome assembly Source: InterPro
- nucleosome positioning Source: GO_Central
- spermatogenesis Source: MGI
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Differentiation, Spermatogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: Histone H1tAlternative name(s): Testicular H1 histone |
Gene namesi | Name:H1-6By similarity Synonyms:H1f6Imported, H1ft, H1t, Hist1h1tImported |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1888530, H1f6 |
Subcellular locationi
Nucleus
- Nucleus Curated
Other locations
- Chromosome Curated
Nucleus
- condensed nuclear chromosome Source: MGI
- nucleus Source: GO_Central
Other locations
- nucleosome Source: InterPro
Keywords - Cellular componenti
Chromosome, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000195919 | 2 – 208 | Histone H1tAdd BLAST | 207 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 9 | Phosphoserine1 Publication | 1 | |
Modified residuei | 56 | CitrullineBy similarity | 1 | |
Modified residuei | 141 | Phosphoserine2 Publications | 1 | |
Modified residuei | 156 | Phosphothreonine2 Publications | 1 | |
Modified residuei | 163 | Phosphoserine1 Publication | 1 | |
Modified residuei | 178 | Phosphoserine2 Publications | 1 |
Post-translational modificationi
Keywords - PTMi
Citrullination, PhosphoproteinProteomic databases
jPOSTi | Q07133 |
MaxQBi | Q07133 |
PaxDbi | Q07133 |
PRIDEi | Q07133 |
ProteomicsDBi | 270907 |
PTM databases
iPTMneti | Q07133 |
PhosphoSitePlusi | Q07133 |
Expressioni
Tissue specificityi
Developmental stagei
Interactioni
Protein-protein interaction databases
BioGRIDi | 223727, 4 interactors |
STRINGi | 10090.ENSMUSP00000037304 |
Miscellaneous databases
RNActi | Q07133, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 38 – 111 | H15PROSITE-ProRule annotationAdd BLAST | 74 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 39 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 95 – 208 | DisorderedSequence analysisAdd BLAST | 114 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 97 – 111 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4012, Eukaryota |
InParanoidi | Q07133 |
OrthoDBi | 1565299at2759 |
PhylomeDBi | Q07133 |
Family and domain databases
CDDi | cd00073, H15, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR005819, H1/H5 IPR005818, Histone_H1/H5_H15 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00538, Linker_histone, 1 hit |
PRINTSi | PR00624, HISTONEH5 |
SMARTi | View protein in SMART SM00526, H15, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS51504, H15, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MSETAPAASS TLVPAPVEKP SSKRRGKKPG LAPARKPRGF SVSKLIPEAL
60 70 80 90 100
STSQERAGMS LAALKKALAA AGYDVEKNNS RIKLALKRLV NKGVLVQTKG
110 120 130 140 150
TGASGSFKLS KKAASGNDKG KGKKSASAKA KKMGLPRASR SPKSSKTKAV
160 170 180 190 200
KKPKATPTKA SGSGRKTKGA KGVQQRKSPA KARAANPNSG KAKMVMQKTD
LRKAAGRK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketI7HFT9 | I7HFT9_MOUSE | H1.6 linker histone, cluster member | H1f6 Hist1h1t, RP23-283N14.20-001 | 209 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 18 | E → EE in AAO06219 (PubMed:12408966).Curated | 1 | |
Sequence conflicti | 164 | G → R in AAB38417 (Ref. 2) Curated | 1 | |
Sequence conflicti | 164 | G → R in AAA18359 (Ref. 2) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L28753 Genomic DNA Translation: AAB38417.1 X72805 Genomic DNA Translation: CAA51325.1 U06232 Unassigned DNA Translation: AAA18359.1 AY158908 Genomic DNA Translation: AAO06219.1 BC119305 mRNA Translation: AAI19306.1 BC119307 mRNA Translation: AAI19308.1 |
PIRi | S43434 |
RefSeqi | NP_034507.2, NM_010377.3 |
Genome annotation databases
GeneIDi | 107970 |
KEGGi | mmu:107970 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L28753 Genomic DNA Translation: AAB38417.1 X72805 Genomic DNA Translation: CAA51325.1 U06232 Unassigned DNA Translation: AAA18359.1 AY158908 Genomic DNA Translation: AAO06219.1 BC119305 mRNA Translation: AAI19306.1 BC119307 mRNA Translation: AAI19308.1 |
PIRi | S43434 |
RefSeqi | NP_034507.2, NM_010377.3 |
3D structure databases
AlphaFoldDBi | Q07133 |
SMRi | Q07133 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 223727, 4 interactors |
STRINGi | 10090.ENSMUSP00000037304 |
PTM databases
iPTMneti | Q07133 |
PhosphoSitePlusi | Q07133 |
Proteomic databases
jPOSTi | Q07133 |
MaxQBi | Q07133 |
PaxDbi | Q07133 |
PRIDEi | Q07133 |
ProteomicsDBi | 270907 |
Protocols and materials databases
DNASUi | 107970 |
Genome annotation databases
GeneIDi | 107970 |
KEGGi | mmu:107970 |
Organism-specific databases
CTDi | 107970 |
MGIi | MGI:1888530, H1f6 |
Phylogenomic databases
eggNOGi | KOG4012, Eukaryota |
InParanoidi | Q07133 |
OrthoDBi | 1565299at2759 |
PhylomeDBi | Q07133 |
Miscellaneous databases
BioGRID-ORCSi | 107970, 3 hits in 71 CRISPR screens |
PROi | PR:Q07133 |
RNActi | Q07133, protein |
SOURCEi | Search... |
Family and domain databases
CDDi | cd00073, H15, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR005819, H1/H5 IPR005818, Histone_H1/H5_H15 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00538, Linker_histone, 1 hit |
PRINTSi | PR00624, HISTONEH5 |
SMARTi | View protein in SMART SM00526, H15, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS51504, H15, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | H1T_MOUSE | |
Accessioni | Q07133Primary (citable) accession number: Q07133 Secondary accession number(s): Q0VEA3, Q8CGP8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 153 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families