UniProtKB - Q07116 (SUOX_RAT)
Protein
Sulfite oxidase, mitochondrial
Gene
Suox
Organism
Rattus norvegicus (Rat)
Status
Functioni
Catalytic activityi
- EC:1.8.3.1
Cofactori
Protein has several cofactor binding sites:- heme b1 PublicationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.1 Publication
- Mo-molybdopterin1 PublicationNote: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.1 Publication
: sulfur metabolism Pathwayi
This protein is involved in the pathway sulfur metabolism, which is part of Energy metabolism.View all proteins of this organism that are known to be involved in the pathway sulfur metabolism and in Energy metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 119 | Iron (heme axial ligand)PROSITE-ProRule annotation | 1 | |
Metal bindingi | 144 | Iron (heme axial ligand)PROSITE-ProRule annotation | 1 | |
Binding sitei | 146 | Heme bBy similarity | 1 | |
Binding sitei | 148 | Heme bBy similarity | 1 | |
Metal bindingi | 265 | MolybdenumBy similarity | 1 | |
Binding sitei | 323 | MolybdopterinBy similarity | 1 | |
Binding sitei | 362 | MolybdopterinBy similarity | 1 | |
Binding sitei | 367 | MolybdopterinBy similarity | 1 |
GO - Molecular functioni
- heme binding Source: RGD
- molybdenum ion binding Source: InterPro
- molybdopterin cofactor binding Source: RGD
- sulfite oxidase activity Source: RGD
GO - Biological processi
- response to nutrient Source: RGD
- sulfur compound metabolic process Source: GO_Central
Keywordsi
Molecular function | Oxidoreductase |
Ligand | Heme, Iron, Metal-binding, Molybdenum |
Enzyme and pathway databases
Reactomei | R-RNO-1614517, Sulfide oxidation to sulfate |
UniPathwayi | UPA00096 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Suox |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 619994, Suox |
Subcellular locationi
Mitochondrion
Cytosol
- cytosol Source: RGD
Mitochondrion
- mitochondrial intermembrane space Source: RGD
- mitochondrion Source: GO_Central
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 80 | MitochondrionAdd BLAST | 80 | |
ChainiPRO_0000006484 | 81 – 546 | Sulfite oxidase, mitochondrialAdd BLAST | 466 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 124 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q07116 |
PaxDbi | Q07116 |
PRIDEi | Q07116 |
PTM databases
CarbonylDBi | Q07116 |
iPTMneti | Q07116 |
PhosphoSitePlusi | Q07116 |
Interactioni
Subunit structurei
Homodimer.
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000008018 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 83 – 162 | Cytochrome b5 heme-bindingPROSITE-ProRule annotationAdd BLAST | 80 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 166 – 175 | HingeBy similarity | 10 | |
Regioni | 176 – 402 | Moco domainBy similarityAdd BLAST | 227 | |
Regioni | 216 – 220 | Molybdopterin-bindingBy similarity | 5 | |
Regioni | 378 – 380 | Molybdopterin-bindingBy similarity | 3 | |
Regioni | 403 – 539 | HomodimerizationBy similarityAdd BLAST | 137 |
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG0535, Eukaryota KOG4576, Eukaryota |
InParanoidi | Q07116 |
PhylomeDBi | Q07116 |
Family and domain databases
Gene3Di | 3.10.120.10, 1 hit 3.90.420.10, 1 hit |
InterProi | View protein in InterPro IPR001199, Cyt_B5-like_heme/steroid-bd IPR036400, Cyt_B5-like_heme/steroid_sf IPR018506, Cyt_B5_heme-BS IPR014756, Ig_E-set IPR005066, MoCF_OxRdtse_dimer IPR008335, Mopterin_OxRdtase_euk IPR000572, OxRdtase_Mopterin-bd_dom IPR036374, OxRdtase_Mopterin-bd_sf IPR022407, OxRdtase_Mopterin_BS |
Pfami | View protein in Pfam PF00173, Cyt-b5, 1 hit PF03404, Mo-co_dimer, 1 hit PF00174, Oxidored_molyb, 1 hit |
PRINTSi | PR00363, CYTOCHROMEB5 PR00407, EUMOPTERIN |
SMARTi | View protein in SMART SM01117, Cyt-b5, 1 hit |
SUPFAMi | SSF55856, SSF55856, 1 hit SSF56524, SSF56524, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS00191, CYTOCHROME_B5_1, 1 hit PS50255, CYTOCHROME_B5_2, 1 hit PS00559, MOLYBDOPTERIN_EUK, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q07116-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLPRLYRSVA VGLPRAIRAK STPLRLCIQA CSSSDSLKPQ HPSLTFSDDN
60 70 80 90 100
SRTRGWKVMG TLIGLGAVLA YHDHRCRASQ ESPRIYSKED VRSHNNLKTG
110 120 130 140 150
VWVTLGSEVF DVTKFVDLHP GGQSKLMLAA GGPLEPFWAL YAVHNQPHVR
160 170 180 190 200
ELLAEYKIGE LNPEDRMSPP LEASDPYSND PMRHPALRIN SQRPFNAEPP
210 220 230 240 250
PELLTESYIT PNPIFFTRNH LPVPNLDPDT YRLHVVGAPG GQSLSLSLDD
260 270 280 290 300
LHKFPKHEVT VTLQCAGNRR SEMNKVKEVK GLEWRTGAIS TARWAGARLC
310 320 330 340 350
DVLAQAGHRL RETEAHVCFE GLDSDPTGTA YGASIPLARA MDPQAEVLLA
360 370 380 390 400
YEMNGQPLPR DHGFPVRVVV PGVVGARHVK WLGRVSVESE ESYSHWQRRD
410 420 430 440 450
YKGFSPSVDW DTVDFDLAPS IQELPIQSAI TQPQDGTTVE SGEVIIKGYA
460 470 480 490 500
WSGGGRAVIR VDVSMDGGLT WQEAELEGEE QHPRKAWAWR IWQLKAHVPA
510 520 530 540
EQKELNIICK AVDDSYNVQP DTVAPIWNLR GVLSNAWHRV HVQVVP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V6R5 | G3V6R5_RAT | Sulfite oxidase | Suox rCG_42455 | 546 | Annotation score: |
Sequence cautioni
The sequence AAA16618 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 98 | K → Q in AAA16618 (PubMed:8276806).Curated | 1 | |
Sequence conflicti | 178 | S → T AA sequence (PubMed:2249998).Curated | 1 | |
Sequence conflicti | 294 | W → R AA sequence (PubMed:2249998).Curated | 1 | |
Sequence conflicti | 318 | C → Q AA sequence (PubMed:2249998).Curated | 1 | |
Sequence conflicti | 338 | A → G AA sequence (PubMed:2249998).Curated | 1 | |
Sequence conflicti | 362 | H → S AA sequence (PubMed:2249998).Curated | 1 | |
Sequence conflicti | 362 | H → S AA sequence (PubMed:3393528).Curated | 1 | |
Sequence conflicti | 394 – 396 | SHW → HYL AA sequence (PubMed:2249998).Curated | 3 | |
Sequence conflicti | 432 | Q → V AA sequence (PubMed:2249998).Curated | 1 | |
Sequence conflicti | 514 | D → A AA sequence (PubMed:2249998).Curated | 1 | |
Sequence conflicti | 527 | W → A AA sequence (PubMed:2249998).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC061991 mRNA Translation: AAH61991.2 L05084 mRNA Translation: AAA16618.1 Different initiation. |
PIRi | A53107 |
RefSeqi | NP_112389.3, NM_031127.3 |
Genome annotation databases
GeneIDi | 81805 |
KEGGi | rno:81805 |
UCSCi | RGD:619994, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC061991 mRNA Translation: AAH61991.2 L05084 mRNA Translation: AAA16618.1 Different initiation. |
PIRi | A53107 |
RefSeqi | NP_112389.3, NM_031127.3 |
3D structure databases
SMRi | Q07116 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000008018 |
PTM databases
CarbonylDBi | Q07116 |
iPTMneti | Q07116 |
PhosphoSitePlusi | Q07116 |
Proteomic databases
jPOSTi | Q07116 |
PaxDbi | Q07116 |
PRIDEi | Q07116 |
Genome annotation databases
GeneIDi | 81805 |
KEGGi | rno:81805 |
UCSCi | RGD:619994, rat |
Organism-specific databases
CTDi | 6821 |
RGDi | 619994, Suox |
Phylogenomic databases
eggNOGi | KOG0535, Eukaryota KOG4576, Eukaryota |
InParanoidi | Q07116 |
PhylomeDBi | Q07116 |
Enzyme and pathway databases
UniPathwayi | UPA00096 |
Reactomei | R-RNO-1614517, Sulfide oxidation to sulfate |
Miscellaneous databases
PROi | PR:Q07116 |
Family and domain databases
Gene3Di | 3.10.120.10, 1 hit 3.90.420.10, 1 hit |
InterProi | View protein in InterPro IPR001199, Cyt_B5-like_heme/steroid-bd IPR036400, Cyt_B5-like_heme/steroid_sf IPR018506, Cyt_B5_heme-BS IPR014756, Ig_E-set IPR005066, MoCF_OxRdtse_dimer IPR008335, Mopterin_OxRdtase_euk IPR000572, OxRdtase_Mopterin-bd_dom IPR036374, OxRdtase_Mopterin-bd_sf IPR022407, OxRdtase_Mopterin_BS |
Pfami | View protein in Pfam PF00173, Cyt-b5, 1 hit PF03404, Mo-co_dimer, 1 hit PF00174, Oxidored_molyb, 1 hit |
PRINTSi | PR00363, CYTOCHROMEB5 PR00407, EUMOPTERIN |
SMARTi | View protein in SMART SM01117, Cyt-b5, 1 hit |
SUPFAMi | SSF55856, SSF55856, 1 hit SSF56524, SSF56524, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS00191, CYTOCHROME_B5_1, 1 hit PS50255, CYTOCHROME_B5_2, 1 hit PS00559, MOLYBDOPTERIN_EUK, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SUOX_RAT | |
Accessioni | Q07116Primary (citable) accession number: Q07116 Secondary accession number(s): Q6P6W0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | July 10, 2007 | |
Last modified: | December 2, 2020 | |
This is version 151 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways