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Protein

Cation-independent mannose-6-phosphate receptor

Gene

Igf2r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a positive regulator of T-cell coactivation, by binding DPP4 (By similarity). Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • enzyme binding Source: MGI
  • G-protein alpha-subunit binding Source: MGI
  • identical protein binding Source: MGI
  • insulin-like growth factor binding Source: MGI
  • insulin-like growth factor II binding Source: MGI
  • kringle domain binding Source: GO_Central
  • mannose binding Source: MGI
  • phosphoprotein binding Source: UniProtKB
  • retinoic acid binding Source: MGI
  • signaling receptor activity Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processTransport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-432722 Golgi Associated Vesicle Biogenesis
R-MMU-6798695 Neutrophil degranulation
R-MMU-6811440 Retrograde transport at the Trans-Golgi-Network
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828 Clathrin-mediated endocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cation-independent mannose-6-phosphate receptor
Short name:
CI Man-6-P receptor
Short name:
CI-MPR
Short name:
M6PR
Alternative name(s):
300 kDa mannose 6-phosphate receptor
Short name:
MPR 300
Insulin-like growth factor 2 receptor
Insulin-like growth factor II receptor
Short name:
IGF-II receptor
M6P/IGF2 receptor
Short name:
M6P/IGF2R
CD_antigen: CD222
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Igf2r
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:96435 Igf2r

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini36 – 2295LumenalSequence analysisAdd BLAST2260
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2296 – 2316HelicalSequence analysisAdd BLAST21
Topological domaini2317 – 2483CytoplasmicSequence analysisAdd BLAST167

Keywords - Cellular componenti

Lysosome, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 35Sequence analysisAdd BLAST35
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001923036 – 2483Cation-independent mannose-6-phosphate receptorAdd BLAST2448

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi44 ↔ 64PROSITE-ProRule annotation
Disulfide bondi72 ↔ 79PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi107N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi112 ↔ 144PROSITE-ProRule annotation
Disulfide bondi129 ↔ 156PROSITE-ProRule annotation
Disulfide bondi169 ↔ 207PROSITE-ProRule annotation
Disulfide bondi223 ↔ 230PROSITE-ProRule annotation
Disulfide bondi270 ↔ 301PROSITE-ProRule annotation
Disulfide bondi283 ↔ 313PROSITE-ProRule annotation
Disulfide bondi323 ↔ 361PROSITE-ProRule annotation
Disulfide bondi369 ↔ 377PROSITE-ProRule annotation
Glycosylationi395N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi415 ↔ 449PROSITE-ProRule annotation
Disulfide bondi429 ↔ 461PROSITE-ProRule annotation
Glycosylationi430N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi537N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi575N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi620N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi621 ↔ 658PROSITE-ProRule annotation
Disulfide bondi666 ↔ 673PROSITE-ProRule annotation
Disulfide bondi724 ↔ 753PROSITE-ProRule annotation
Glycosylationi740N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi864N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi944N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1157N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1239N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1305N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1358N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1423N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1509 ↔ 1546PROSITE-ProRule annotation
Glycosylationi1532N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi1552 ↔ 1559PROSITE-ProRule annotation
Disulfide bondi1591 ↔ 1627PROSITE-ProRule annotation
Disulfide bondi1607 ↔ 1639PROSITE-ProRule annotation
Disulfide bondi1645 ↔ 1688PROSITE-ProRule annotation
Glycosylationi1649N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1699 ↔ 1706PROSITE-ProRule annotation
Disulfide bondi1743 ↔ 1776PROSITE-ProRule annotation
Glycosylationi1750N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi1759 ↔ 1788PROSITE-ProRule annotation
Disulfide bondi1797 ↔ 1832PROSITE-ProRule annotation
Glycosylationi1809N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1843 ↔ 1849PROSITE-ProRule annotation
Disulfide bondi1886 ↔ 1968PROSITE-ProRule annotation
Disulfide bondi1896 ↔ 1920PROSITE-ProRule annotation
Disulfide bondi1910 ↔ 1935PROSITE-ProRule annotation
Disulfide bondi1950 ↔ 1980PROSITE-ProRule annotation
Disulfide bondi1987 ↔ 2022PROSITE-ProRule annotation
Disulfide bondi2032 ↔ 2039PROSITE-ProRule annotation
Disulfide bondi2075 ↔ 2106PROSITE-ProRule annotation
Glycosylationi2078N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2089 ↔ 2118PROSITE-ProRule annotation
Glycosylationi2129N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2342N6-acetyllysineBy similarity1
Modified residuei2401PhosphoserineCombined sources1
Modified residuei2417Omega-N-methylarginineCombined sources1
Modified residuei2471PhosphoserineCombined sources1
Modified residuei2476PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q07113

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q07113

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q07113

PeptideAtlas

More...
PeptideAtlasi
Q07113

PRoteomics IDEntifications database

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PRIDEi
Q07113

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q07113

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q07113

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q07113

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000023830 Expressed in 290 organ(s), highest expression level in heart

CleanEx database of gene expression profiles

More...
CleanExi
MM_IGF2R

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q07113 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q07113 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DPP4; the interaction is direct. Binds GGA1, GGA2 and GGA3. Binds HA-I and HA-II plasma membrane adapters (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
200550, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q07113, 6 interactors

Molecular INTeraction database

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MINTi
Q07113

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000024599

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q07113

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q07113

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati35 – 1841Add BLAST150
Repeati185 – 3392Add BLAST155
Repeati340 – 4843Add BLAST145
Repeati485 – 6374Add BLAST153
Repeati638 – 7765Add BLAST139
Repeati777 – 9436Add BLAST167
Repeati945 – 10927Add BLAST148
Repeati1093 – 12368Add BLAST144
Repeati1237 – 13779Add BLAST141
Repeati1378 – 152510Add BLAST148
Repeati1526 – 165911Add BLAST134
Repeati1660 – 181312Add BLAST154
Repeati1814 – 200113Add BLAST188
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1891 – 1937Fibronectin type-IIPROSITE-ProRule annotationAdd BLAST47
Repeati2002 – 213014Add BLAST129
Repeati2158 – 228215Add BLAST125

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MRL1/IGF2R family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4504 Eukaryota
ENOG410ZWHP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013943

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113638

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000334

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q07113

KEGG Orthology (KO)

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KOi
K06564

Identification of Orthologs from Complete Genome Data

More...
OMAi
CPDQIRK

Database of Orthologous Groups

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OrthoDBi
EOG091G116D

Database for complete collections of gene phylogenies

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PhylomeDBi
Q07113

TreeFam database of animal gene trees

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TreeFami
TF328963

Family and domain databases

Conserved Domains Database

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CDDi
cd00062 FN2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.10.10, 1 hit
2.70.130.10, 15 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000479 CIMR
IPR000562 FN_type2_dom
IPR036943 FN_type2_sf
IPR013806 Kringle-like
IPR009011 Man6P_isomerase_rcpt-bd_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00878 CIMR, 14 hits
PF00040 fn2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00059 FN2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57440 SSF57440, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00023 FN2_1, 1 hit
PS51092 FN2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q07113-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRAVQLGPVP SGPRVALLPP LLLLLLLAAA GSAQAQAVDL DALCSYTWEA
60 70 80 90 100
VDSKNNAVYK INVCGNVGIS SCGPTSAICM CDLKTENCRS VGDSLLRSSA
110 120 130 140 150
RSLLEFNTTM GCQPSDSQHR IQTSITFLCG KTLGTPEFVT ATDCVHYFEW
160 170 180 190 200
RTTAACKKDI FKADKEVPCY AFDDKLQKHD LNPLIKLNGG YLVDDSDPDT
210 220 230 240 250
SLFINVCRDI DSLRDPSTQL RVCPAGTAAC LLKGNQAFDV GRPKEGLKLL
260 270 280 290 300
SKDRLVLTYV KEEGEKPDFC NGHSPAVTVT FVCPSERREG TIPKLTAKSN
310 320 330 340 350
CRYEVEWITE YACHRDYLQS ESCSLSSEQH DITIDLSPLA QYGGSPYVSD
360 370 380 390 400
GREYTFFINV CGDTKVSLCN NKEAAVCQEK KADSTQVKIA GRHQNQTLRY
410 420 430 440 450
SDGDLTLIYS GGDECSSGFQ RMSVINFECN KTAGKDGRGE PVFTGEVDCT
460 470 480 490 500
YFFTWDTKYA CIKEKEDLLC GAINGKKRYD LSVLARHSES EQNWEAVDGS
510 520 530 540 550
QAESEKYFFI NVCHRVLQEG KARNCPEDAA VCAVDKNGSK NLGKFVSSPT
560 570 580 590 600
KEKGHIQLSY TDGDDCGSDK KISTNITLVC KPGDLESAPV LRAARSDGCF
610 620 630 640 650
YEFEWHTAAA CVLSKTEGEN CTVLDAQAGF SFDLSLLTKK NGAYKVETEK
660 670 680 690 700
YDFYINVCGP VSMDPCQSNS GACQVAKSGK SWNLGLSSTK LTYYDGMIQL
710 720 730 740 750
SYRNGTPYNN EKHTPRATLI TFLCDRDAGV GFPEYQEEDN STYNFRWYTS
760 770 780 790 800
YACPEEPLEC MVTDPSMMEQ YDLSSLVKSE GGSGGNWYAM ENSREHVTRR
810 820 830 840 850
KYYLNVCRPL NPVPGCDRYA SACQMKYENH EGSLAETVSI SNLGVAKIGP
860 870 880 890 900
VVEESGSLLL EYVNGSACTT SDGQLTTYST RIHLVCGRGF MNSHPIFTFN
910 920 930 940 950
WECVVSFLWN TEAACPIQTI TETDQACSIR DPSSGFVFNL SPLNDSAQGH
960 970 980 990 1000
VVLGIGKTFV FNICGAMPAC GTVAGKPAYG CEAETQIEDI KDLRPQRPVG
1010 1020 1030 1040 1050
MERSLQLSAE GFLTLTYKGS SPSDRGTAFI IRFICNDDIY PGAPKFLHQD
1060 1070 1080 1090 1100
IDSTRGIRNT YFEFETALAC TPSLVDCQVT DPAGNEYDLS ALSMVRKPWT
1110 1120 1130 1140 1150
AVDTSAYGKR RHFYLSVCNP LPYIPGCHGI ALGSCMVSED NSFNLGVVQI
1160 1170 1180 1190 1200
SPQATGNGSL SILYVNGDRC GDQRFSTRIV FECAQTSGSP MFQFVNNCEY
1210 1220 1230 1240 1250
VFVWRTVEAC PVIREEGDNC QVKDPRHGNL YDLKPLGLND TIVSVGEYTY
1260 1270 1280 1290 1300
YLRVCGKLSS DVCSAHDGSK AVSSCQEKKG PQGFQKVAGL LSQKLTFENG
1310 1320 1330 1340 1350
LLKMNYTGGD TCHKVYQRST TIYFYCDRTT QKPVFLKETS DCSYMFEWRT
1360 1370 1380 1390 1400
QYACPPFNVT ECSVQDAAGN SIDLSSLSRY SDNWEAVTRT GATEHYLINV
1410 1420 1430 1440 1450
CKSLSPHAGT EPCPPEAAVC LLNGSKPVNL GKVRDGPQWT DGVTVLQYVD
1460 1470 1480 1490 1500
GDLCPDKIRR RSTIIRFTCS DNQVNSRPLF ISAVQDCEYT FSWPTPSACP
1510 1520 1530 1540 1550
VKSNTHDDCQ VTNPSTGHLF DLSSLSGRAG INASYSEKGL VFMSICEENE
1560 1570 1580 1590 1600
NCGPGVGACF GQTRISVGKA SKRLSYKDQV LQLVYENGSP CPSLSDLRYK
1610 1620 1630 1640 1650
SVISFVCRPE AGPTNRPMLI SLDKQTCTLF FSWHTPLACE QATECTVRNG
1660 1670 1680 1690 1700
SSIIDLSPLI HRTGGYEAYD ESEDDTSDTT PDFYINICQP LNPMHGVPCP
1710 1720 1730 1740 1750
AGASVCKVPV DGPPIDIGRV TGPPIFNPVA NEVYLNFESS THCLADRYMN
1760 1770 1780 1790 1800
YTSLITFHCK RGVSMGTPKL IRTNDCDFVF EWETPIVCPD EVKTQGCAVT
1810 1820 1830 1840 1850
DEQLLYSFNL TSLSTSTFKV TRDARTYSIG VCTAAAGLGQ EGCKDGGVCL
1860 1870 1880 1890 1900
LSGNKGASFG RLASMQLDYR HQDEAVILSY VNGDPCPPET DDGEPCVFPF
1910 1920 1930 1940 1950
IYKGKSYDEC VLEGRAKLWC SKTANYDRDH EWGFCRQTNS YRMSAIIFTC
1960 1970 1980 1990 2000
DESEDIGRPQ VFSEDRGCEV TFEWKTKVVC PPKKMECKFV QKHKTYDLRL
2010 2020 2030 2040 2050
LSSLTGSWDF VHEGNSYFIN LCQRVYKGPL DCSERASICK KSATGQVQVL
2060 2070 2080 2090 2100
GLVHTQKLEV IDETVIVTYS KGYPCGGNKT ASSVIELTCA KTVGRPAFKR
2110 2120 2130 2140 2150
FDSVSCTYYF YWYSRAACAV RPQEVTMVNG TLTNPVTGKS FSLGEIYFKL
2160 2170 2180 2190 2200
FSASGDMRTN GDNYLYEIQL SSITSSSYPA CAGANICQVK PNDQHFSRKV
2210 2220 2230 2240 2250
GTSDMTKYYV QDGDLDVVFT SSSKCGKDKT KSVSSTIFFH CDPLVKDGIP
2260 2270 2280 2290 2300
EFSHETADCQ YLFSWYTSAV CPLGVDFEDE SAGPEYKGLS ERSQAVGAVL
2310 2320 2330 2340 2350
SLLLVALTGC LLALLLHKKE RRETVINKLT SCCRRSSGVS YKYSKVSKEE
2360 2370 2380 2390 2400
ETDENETEWL MEEIQVPAPR LGKDGQENGH ITTKAVKAEA LSSLHGDDQD
2410 2420 2430 2440 2450
SEDEVLTVPE VKVHSGRGAE VESSQPLRNP QRKVLKEREG ERLGLVRGEK
2460 2470 2480
ARKGKFRPGQ RKPTAPAKLV SFHDDSDEDL LHI
Length:2,483
Mass (Da):273,815
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8F64F6189FD05CD1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti10 – 11PS → RP (PubMed:8194771).Curated2
Sequence conflicti13Missing (PubMed:8194771).Curated1
Sequence conflicti209D → V in AAA19568 (PubMed:8194771).Curated1
Sequence conflicti456 – 457DT → VS (PubMed:8194771).Curated2
Sequence conflicti1626 – 1631TCTLFF → GSTFFS in CAA42940 (Ref. 6) Curated6
Sequence conflicti1694 – 1695MH → TC in CAA42940 (Ref. 6) Curated2
Sequence conflicti1699C → R in CAA42940 (Ref. 6) Curated1
Sequence conflicti1759C → Y in AAA19568 (PubMed:8194771).Curated1
Sequence conflicti2028G → V in CAA42940 (Ref. 6) Curated1
Sequence conflicti2032C → S in CAA42940 (Ref. 6) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
L22143
, L22096, L22097, L22098, L22099, L22100, L22101, L22102, L22103, L22104, L22105, L22106, L22107, L22108, L22109, L22110, L22111, L22112, L22113, L22114, L22115, L22116, L22117, L22118, L22119, L22120, L22121, L22122, L22123, L22124, L22125, L22126, L22127, L22128, L22129, L22130, L22131, L22132, L22133, L22134, L22135, L22136, L22137, L22138, L22139, L22140, L22141, L22142 Genomic DNA Translation: AAA39320.1
U04710 mRNA Translation: AAA19568.1
L06445 Genomic DNA Translation: AAA37921.1
L06446 Genomic DNA Translation: AAA37922.1
U26348 Genomic DNA Translation: AAA98844.1
M58586 Genomic DNA Translation: AAA39483.1
X60389 mRNA Translation: CAA42940.1
L19500 mRNA Translation: AAA16037.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS37436.1

Protein sequence database of the Protein Information Resource

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PIRi
A49617
I48922

NCBI Reference Sequences

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RefSeqi
NP_034645.2, NM_010515.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.26553
Mm.486511

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000024599; ENSMUSP00000024599; ENSMUSG00000023830

Database of genes from NCBI RefSeq genomes

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GeneIDi
16004

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:16004

UCSC genome browser

More...
UCSCi
uc008aky.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22143
, L22096, L22097, L22098, L22099, L22100, L22101, L22102, L22103, L22104, L22105, L22106, L22107, L22108, L22109, L22110, L22111, L22112, L22113, L22114, L22115, L22116, L22117, L22118, L22119, L22120, L22121, L22122, L22123, L22124, L22125, L22126, L22127, L22128, L22129, L22130, L22131, L22132, L22133, L22134, L22135, L22136, L22137, L22138, L22139, L22140, L22141, L22142 Genomic DNA Translation: AAA39320.1
U04710 mRNA Translation: AAA19568.1
L06445 Genomic DNA Translation: AAA37921.1
L06446 Genomic DNA Translation: AAA37922.1
U26348 Genomic DNA Translation: AAA98844.1
M58586 Genomic DNA Translation: AAA39483.1
X60389 mRNA Translation: CAA42940.1
L19500 mRNA Translation: AAA16037.1
CCDSiCCDS37436.1
PIRiA49617
I48922
RefSeqiNP_034645.2, NM_010515.2
UniGeneiMm.26553
Mm.486511

3D structure databases

ProteinModelPortaliQ07113
SMRiQ07113
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200550, 5 interactors
IntActiQ07113, 6 interactors
MINTiQ07113
STRINGi10090.ENSMUSP00000024599

PTM databases

iPTMnetiQ07113
PhosphoSitePlusiQ07113
SwissPalmiQ07113

Proteomic databases

EPDiQ07113
MaxQBiQ07113
PaxDbiQ07113
PeptideAtlasiQ07113
PRIDEiQ07113

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024599; ENSMUSP00000024599; ENSMUSG00000023830
GeneIDi16004
KEGGimmu:16004
UCSCiuc008aky.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3482
MGIiMGI:96435 Igf2r

Phylogenomic databases

eggNOGiKOG4504 Eukaryota
ENOG410ZWHP LUCA
GeneTreeiENSGT00390000013943
HOGENOMiHOG000113638
HOVERGENiHBG000334
InParanoidiQ07113
KOiK06564
OMAiCPDQIRK
OrthoDBiEOG091G116D
PhylomeDBiQ07113
TreeFamiTF328963

Enzyme and pathway databases

ReactomeiR-MMU-432722 Golgi Associated Vesicle Biogenesis
R-MMU-6798695 Neutrophil degranulation
R-MMU-6811440 Retrograde transport at the Trans-Golgi-Network
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q07113

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000023830 Expressed in 290 organ(s), highest expression level in heart
CleanExiMM_IGF2R
ExpressionAtlasiQ07113 baseline and differential
GenevisibleiQ07113 MM

Family and domain databases

CDDicd00062 FN2, 1 hit
Gene3Di2.10.10.10, 1 hit
2.70.130.10, 15 hits
InterProiView protein in InterPro
IPR000479 CIMR
IPR000562 FN_type2_dom
IPR036943 FN_type2_sf
IPR013806 Kringle-like
IPR009011 Man6P_isomerase_rcpt-bd_dom_sf
PfamiView protein in Pfam
PF00878 CIMR, 14 hits
PF00040 fn2, 1 hit
SMARTiView protein in SMART
SM00059 FN2, 1 hit
SUPFAMiSSF57440 SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS00023 FN2_1, 1 hit
PS51092 FN2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMPRI_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q07113
Secondary accession number(s): Q61822, Q6LED1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 173 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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