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Protein

Early activation antigen CD69

Gene

CD69

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.

GO - Molecular functioni

  • calcium ion binding Source: Ensembl
  • carbohydrate binding Source: UniProtKB-KW
  • protein homodimerization activity Source: CAFA
  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

LigandLectin

Enzyme and pathway databases

SIGNORiQ07108

Names & Taxonomyi

Protein namesi
Recommended name:
Early activation antigen CD69
Alternative name(s):
Activation inducer molecule
Short name:
AIM
BL-AC/P26
C-type lectin domain family 2 member C
EA1
Early T-cell activation antigen p60
GP32/28
Leukocyte surface antigen Leu-23
MLR-3
CD_antigen: CD69
Gene namesi
Name:CD69
Synonyms:CLEC2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000110848.8
HGNCiHGNC:1694 CD69
MIMi107273 gene
neXtProtiNX_Q07108

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 40CytoplasmicSequence analysisAdd BLAST40
Transmembranei41 – 61Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini62 – 199ExtracellularSequence analysisAdd BLAST138

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi969
OpenTargetsiENSG00000110848
PharmGKBiPA26233

Chemistry databases

ChEMBLiCHEMBL3308911

Polymorphism and mutation databases

BioMutaiCD69
DMDMi584906

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000465831 – 199Early activation antigen CD69Add BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi68InterchainCurated
Disulfide bondi85 ↔ 96
Disulfide bondi113 ↔ 194
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi173 ↔ 186

Post-translational modificationi

Constitutive Ser/Thr phosphorylation in both mature thymocytes and activated T-lymphocytes.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ07108
PeptideAtlasiQ07108
PRIDEiQ07108
ProteomicsDBi58505

PTM databases

iPTMnetiQ07108
PhosphoSitePlusiQ07108
SwissPalmiQ07108

Expressioni

Tissue specificityi

Expressed on the surface of activated T-cells, B-cells, natural killer cells, neutrophils, eosinophils, epidermal Langerhans cells and platelets.

Developmental stagei

Earliest inducible cell surface glycoprotein acquired during lymphoid activation.

Inductioni

By antigens, mitogens or activators of PKC on the surface of T and B-lymphocytes. By interaction of IL-2 with the p75 IL-2R on the surface of NK cells.

Gene expression databases

BgeeiENSG00000110848 Expressed in 154 organ(s), highest expression level in vermiform appendix
CleanExiHS_CD69
ExpressionAtlasiQ07108 baseline and differential
GenevisibleiQ07108 HS

Organism-specific databases

HPAiCAB002503
HPA050525

Interactioni

Subunit structurei

Homodimer; disulfide-linked.3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107407, 9 interactors
DIPiDIP-60426N
ELMiQ07108
IntActiQ07108, 16 interactors
STRINGi9606.ENSP00000228434

Structurei

Secondary structure

1199
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00306
ProteinModelPortaliQ07108
SMRiQ07108
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ07108

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini92 – 195C-type lectinPROSITE-ProRule annotationAdd BLAST104

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00710000106527
HOGENOMiHOG000111491
HOVERGENiHBG005288
InParanoidiQ07108
KOiK06502
OMAiQTWKWSN
OrthoDBiEOG091G0PON
PhylomeDBiQ07108
TreeFamiTF351467

Family and domain databases

CDDicd03593 CLECT_NK_receptors_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR033992 NKR-like_CTLD
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q07108-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSENCFVAE NSSLHPESGQ ENDATSPHFS TRHEGSFQVP VLCAVMNVVF
60 70 80 90 100
ITILIIALIA LSVGQYNCPG QYTFSMPSDS HVSSCSEDWV GYQRKCYFIS
110 120 130 140 150
TVKRSWTSAQ NACSEHGATL AVIDSEKDMN FLKRYAGREE HWVGLKKEPG
160 170 180 190
HPWKWSNGKE FNNWFNVTGS DKCVFLKNTE VSSMECEKNL YWICNKPYK
Length:199
Mass (Da):22,559
Last modified:October 1, 1994 - v1
Checksum:i172E2699D2FB8DFB
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4E009B4E009_HUMAN
cDNA FLJ55409, highly similar to Ea...
CD69
164Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07555 mRNA Translation: AAB46359.1
Z22576 mRNA Translation: CAA80298.1
Z30426
, Z30430, Z30427, Z30429, Z30428 Genomic DNA Translation: CAA83017.1
BC007037 mRNA Translation: AAH07037.1
CCDSiCCDS8604.1
PIRiJH0822
RefSeqiNP_001772.1, NM_001781.2
UniGeneiHs.208854

Genome annotation databases

EnsembliENST00000228434; ENSP00000228434; ENSG00000110848
GeneIDi969
KEGGihsa:969

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

CD69

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07555 mRNA Translation: AAB46359.1
Z22576 mRNA Translation: CAA80298.1
Z30426
, Z30430, Z30427, Z30429, Z30428 Genomic DNA Translation: CAA83017.1
BC007037 mRNA Translation: AAH07037.1
CCDSiCCDS8604.1
PIRiJH0822
RefSeqiNP_001772.1, NM_001781.2
UniGeneiHs.208854

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E87X-ray1.50A82-199[»]
1E8IX-ray1.95A/B82-199[»]
1FM5X-ray2.27A64-199[»]
3CCKX-ray1.80A/B82-199[»]
3HUPX-ray1.37A/B70-199[»]
DisProtiDP00306
ProteinModelPortaliQ07108
SMRiQ07108
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107407, 9 interactors
DIPiDIP-60426N
ELMiQ07108
IntActiQ07108, 16 interactors
STRINGi9606.ENSP00000228434

Chemistry databases

ChEMBLiCHEMBL3308911

PTM databases

iPTMnetiQ07108
PhosphoSitePlusiQ07108
SwissPalmiQ07108

Polymorphism and mutation databases

BioMutaiCD69
DMDMi584906

Proteomic databases

PaxDbiQ07108
PeptideAtlasiQ07108
PRIDEiQ07108
ProteomicsDBi58505

Protocols and materials databases

DNASUi969
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000228434; ENSP00000228434; ENSG00000110848
GeneIDi969
KEGGihsa:969

Organism-specific databases

CTDi969
DisGeNETi969
EuPathDBiHostDB:ENSG00000110848.8
GeneCardsiCD69
HGNCiHGNC:1694 CD69
HPAiCAB002503
HPA050525
MIMi107273 gene
neXtProtiNX_Q07108
OpenTargetsiENSG00000110848
PharmGKBiPA26233
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00710000106527
HOGENOMiHOG000111491
HOVERGENiHBG005288
InParanoidiQ07108
KOiK06502
OMAiQTWKWSN
OrthoDBiEOG091G0PON
PhylomeDBiQ07108
TreeFamiTF351467

Enzyme and pathway databases

SIGNORiQ07108

Miscellaneous databases

ChiTaRSiCD69 human
EvolutionaryTraceiQ07108
GeneWikiiCD69
GenomeRNAii969
PROiPR:Q07108
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110848 Expressed in 154 organ(s), highest expression level in vermiform appendix
CleanExiHS_CD69
ExpressionAtlasiQ07108 baseline and differential
GenevisibleiQ07108 HS

Family and domain databases

CDDicd03593 CLECT_NK_receptors_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR033992 NKR-like_CTLD
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCD69_HUMAN
AccessioniPrimary (citable) accession number: Q07108
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 7, 2018
This is version 171 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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