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Protein

Collagen alpha-1(XVI) chain

Gene

COL16A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell spreading and alterations in cell morphology.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • extracellular matrix structural constituent Source: GO_Central
  • extracellular matrix structural constituent conferring tensile strength Source: BHF-UCL
  • integrin binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1442490 Collagen degradation
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-216083 Integrin cell surface interactions
R-HSA-8948216 Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Collagen alpha-1(XVI) chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL16A1
ORF Names:FP1572
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000084636.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2193 COL16A1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
120326 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q07092

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1307

Open Targets

More...
OpenTargetsi
ENSG00000084636

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26709

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
COL16A1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
143811380

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 212 PublicationsAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000579222 – 1604Collagen alpha-1(XVI) chainAdd BLAST1583

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi327N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Glycosylated.2 Publications

Keywords - PTMi

Glycoprotein, Hydroxylation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q07092

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q07092

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q07092

PeptideAtlas

More...
PeptideAtlasi
Q07092

PRoteomics IDEntifications database

More...
PRIDEi
Q07092

ProteomicsDB human proteome resource

More...
ProteomicsDBi
58503
58504 [Q07092-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1133

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q07092

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q07092

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In papillary dermis, is a component of specialized fibrillin-1-containing microfibrils, whereas in territorial cartilage matrix, it is localized to a discrete population of thin, weakly banded collagen fibrils in association with other collagens (at protein level). In the placenta, where it is found in the amnion, a membranous tissue lining the amniotic cavity. Within the amnion, it is found in an acellular, relatively dense layer of a complex network of reticular fibers. Also located to a fibroblast layer beneath this dense layer. Exists in tissues in association with other types of collagen.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Transiently elevated expression during gestation, and decrease at term.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000084636 Expressed in 228 organ(s), highest expression level in right ovary

CleanEx database of gene expression profiles

More...
CleanExi
HS_COL16A1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q07092 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q07092 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA027235
HPA027237

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer. Interacts with FBN1, fibronectin and integrins ITGA1/ITGB1 and ITGA2/ITGB1. Integrin ITGA1/ITGB1 binds to a unique site within COL16A1 located close to its C-terminal end between collagenous domains COL1-COL3.4 Publications

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1757 Collagen type XVI trimer

Protein interaction database and analysis system

More...
IntActi
Q07092, 3 interactors

Molecular INTeraction database

More...
MINTi
Q07092

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362776

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q07092

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q07092

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini50 – 231Laminin G-likeAdd BLAST182
Domaini375 – 423Collagen-like 1Add BLAST49
Domaini573 – 633Collagen-like 2Add BLAST61
Domaini667 – 721Collagen-like 3Add BLAST55
Domaini788 – 840Collagen-like 4Add BLAST53
Domaini888 – 938Collagen-like 5Add BLAST51
Domaini1018 – 1075Collagen-like 6Add BLAST58
Domaini1472 – 1524Collagen-like 7Add BLAST53
Domaini1528 – 1576Collagen-like 8Add BLAST49

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni232 – 374Nonhelical region 10 (NC10)Add BLAST143
Regioni375 – 506Triple-helical region 9 (COL9) with 3 imperfectionsAdd BLAST132
Regioni507 – 521Nonhelical region 9 (NC9)Add BLAST15
Regioni522 – 555Triple-helical region 8 (COL8) with 1 imperfectionAdd BLAST34
Regioni556 – 572Nonhelical region 8 (NC8)Add BLAST17
Regioni573 – 631Triple-helical region 7 (COL7) with 1 imperfectionAdd BLAST59
Regioni632 – 652Nonhelical region 7 (NC7)Add BLAST21
Regioni653 – 723Triple-helical region 6 (COL6) with 1 imperfectionAdd BLAST71
Regioni724 – 738Nonhelical region 6 (NC6)Add BLAST15
Regioni739 – 876Triple-helical region 5 (COL5) with 3 imperfectionsAdd BLAST138
Regioni877 – 887Nonhelical region 5 (NC5)Add BLAST11
Regioni888 – 939Triple-helical region 4 (COL4) with 2 imperfectionsAdd BLAST52
Regioni940 – 973Nonhelical region 4 (NC4)Add BLAST34
Regioni974 – 988Triple-helical region 3 (COL3)Add BLAST15
Regioni989 – 1011Nonhelical region 3 (NC3)Add BLAST23
Regioni1012 – 1433Triple-helical region 2 (COL2) with 2 imperfectionsAdd BLAST422
Regioni1434 – 1472Nonhelical region 2 (NC2)Add BLAST39
Regioni1473 – 1578Triple-helical region 1 (COL1) with 2 imperfectionsAdd BLAST106
Regioni1579 – 1604Nonhelical region 1 (NC1)Add BLAST26

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi540 – 542Cell attachment siteSequence analysis3
Motifi1006 – 1008Cell attachment siteSequence analysis3
Motifi1227 – 1229Cell attachment siteSequence analysis3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

This sequence defines eighteen different domains, nine triple-helical domains (COL9 to COL1) and ten non-triple-helical domains (NC10 to NC1). The numerous interruptions in the triple helix may make this molecule either elastic or flexible.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3544 Eukaryota
ENOG411131D LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161782

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000085653

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG071631

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q07092

Identification of Orthologs from Complete Genome Data

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OMAi
VHVDCTS

Database of Orthologous Groups

More...
OrthoDBi
1295141at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q07092

TreeFam database of animal gene trees

More...
TreeFami
TF332900

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01391 Collagen, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00210 TSPN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q07092-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWVSWAPGLW LLGLWATFGH GANTGAQCPP SQQEGLKLEH SSSLPANVTG
60 70 80 90 100
FNLIHRLSLM KTSAIKKIRN PKGPLILRLG AAPVTQPTRR VFPRGLPEEF
110 120 130 140 150
ALVLTLLLKK HTHQKTWYLF QVTDANGYPQ ISLEVNSQER SLELRAQGQD
160 170 180 190 200
GDFVSCIFPV PQLFDLRWHK LMLSVAGRVA SVHVDCSSAS SQPLGPRRPM
210 220 230 240 250
RPVGHVFLGL DAEQGKPVSF DLQQVHIYCD PELVLEEGCC EILPAGCPPE
260 270 280 290 300
TSKARRDTQS NELIEINPQS EGKVYTRCFC LEEPQNSEVD AQLTGRISQK
310 320 330 340 350
AERGAKVHQE TAADECPPCV HGARDSNVTL APSGPKGGKG ERGLPGPPGS
360 370 380 390 400
KGEKGARGND CVRISPDAPL QCAEGPKGEK GESGALGPSG LPGSTGEKGQ
410 420 430 440 450
KGEKGDGGIK GVPGKPGRDG RPGEICVIGP KGQKGDPGFV GPEGLAGEPG
460 470 480 490 500
PPGLPGPPGI GLPGTPGDPG GPPGPKGDKG SSGIPGKEGP GGKPGKPGVK
510 520 530 540 550
GEKGDPCEVC PTLPEGFQNF VGLPGKPGPK GEPGDPVPAR GDPGIQGIKG
560 570 580 590 600
EKGEPCLSCS SVVGAQHLVS STGASGDVGS PGFGLPGLPG RAGVPGLKGE
610 620 630 640 650
KGNFGEAGPA GSPGPPGPVG PAGIKGAKGE PCEPCPALSN LQDGDVRVVA
660 670 680 690 700
LPGPSGEKGE PGPPGFGLPG KQGKAGERGL KGQKGDAGNP GDPGTPGTTG
710 720 730 740 750
RPGLSGEPGV QGPAGPKGEK GDGCTACPSL QGTVTDMAGR PGQPGPKGEQ
760 770 780 790 800
GPEGVGRPGK PGQPGLPGVQ GPPGLKGVQG EPGPPGRGVQ GPQGEPGAPG
810 820 830 840 850
LPGIQGLPGP RGPPGPTGEK GAQGSPGVKG ATGPVGPPGA SVSGPPGRDG
860 870 880 890 900
QQGQTGLRGT PGEKGPRGEK GEPGECSCPS QGDLIFSGMP GAPGLWMGSS
910 920 930 940 950
WQPGPQGPPG IPGPPGPPGV PGLQGVPGNN GLPGQPGLTA ELGSLPIEQH
960 970 980 990 1000
LLKSICGDCV QGQRAHPGYL VEKGEKGDQG IPGVPGLDNC AQCFLSLERP
1010 1020 1030 1040 1050
RAEEARGDNS EGDPGCVGSP GLPGPPGLPG QRGEEGPPGM RGSPGPPGPI
1060 1070 1080 1090 1100
GPPGFPGAVG SPGLPGLQGE RGLTGLTGDK GEPGPPGQPG YPGATGPPGL
1110 1120 1130 1140 1150
PGIKGERGYT GSAGEKGEPG PPGSEGLPGP PGPAGPRGER GPQGNSGEKG
1160 1170 1180 1190 1200
DQGFQGQPGF PGPPGPPGFP GKVGSPGPPG PQAEKGSEGI RGPSGLPGSP
1210 1220 1230 1240 1250
GPPGPPGIQG PAGLDGLDGK DGKPGLRGDP GPAGPPGLMG PPGFKGKTGH
1260 1270 1280 1290 1300
PGLPGPKGDC GKPGPPGSTG RPGAEGEPGA MGPQGRPGPP GHVGPPGPPG
1310 1320 1330 1340 1350
QPGPAGISAV GLKGDRGATG ERGLAGLPGQ PGPPGHPGPP GEPGTDGAAG
1360 1370 1380 1390 1400
KEGPPGKQGF YGPPGPKGDP GAAGQKGQAG EKGRAGMPGG PGKSGSMGPV
1410 1420 1430 1440 1450
GPPGPAGERG HPGAPGPSGS PGLPGVPGSM GDMVNYDEIK RFIRQEIIKM
1460 1470 1480 1490 1500
FDERMAYYTS RMQFPMEMAA APGRPGPPGK DGAPGRPGAP GSPGLPGQIG
1510 1520 1530 1540 1550
REGRQGLPGV RGLPGTKGEK GDIGIGIAGE NGLPGPPGPQ GPPGYGKMGA
1560 1570 1580 1590 1600
TGPMGQQGIP GIPGPPGPMG QPGKAGHCNP SDCFGAMPME QQYPPMKTMK

GPFG
Length:1,604
Mass (Da):157,751
Last modified:April 3, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5FAA1950DFC6CA3C
GO
Isoform 2 (identifier: Q07092-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1052-1052: Missing.
     1161-1161: Missing.

Note: No experimental confirmation available.
Show »
Length:1,602
Mass (Da):157,557
Checksum:iC0F8388B57BBA080
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NCT7A6NCT7_HUMAN
Collagen alpha-1(XVI) chain
COL16A1
966Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BY97H7BY97_HUMAN
Collagen alpha-1(XVI) chain
COL16A1
308Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZL8H7BZL8_HUMAN
Collagen alpha-1(XVI) chain
COL16A1
224Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3F0H7C3F0_HUMAN
Collagen alpha-1(XVI) chain
COL16A1
235Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti419D → G in AAB25797 (PubMed:1284248).Curated1
Sequence conflicti420 – 421GR → A in AAA58427 (PubMed:1631157).Curated2
Sequence conflicti538P → R in AAA58427 (PubMed:1631157).Curated1
Sequence conflicti848 – 849RD → VM in CAA33142 (Ref. 6) Curated2
Sequence conflicti848 – 849RD → VM in CAA33085 (Ref. 6) Curated2
Sequence conflicti1161P → T in AAA58427 (PubMed:1631157).Curated1
Sequence conflicti1164P → T in AAA58427 (PubMed:1631157).Curated1
Sequence conflicti1166P → S in AAA58427 (PubMed:1631157).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03144062T → K1 PublicationCorresponds to variant dbSNP:rs2228552Ensembl.1
Natural variantiVAR_048778418R → Q. Corresponds to variant dbSNP:rs6699645Ensembl.1
Natural variantiVAR_048779745G → S. Corresponds to variant dbSNP:rs34770879Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0242591052Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_0242601161Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M92642 mRNA Translation: AAA58427.1
AC114488 Genomic DNA No translation available.
AB209571 mRNA Translation: BAD92808.1
X14963 mRNA Translation: CAA33085.1
X15038 mRNA Translation: CAA33142.1
S57132 mRNA Translation: AAB25797.1
AF370368 mRNA Translation: AAQ15204.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS41297.1 [Q07092-1]

Protein sequence database of the Protein Information Resource

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PIRi
S23810

NCBI Reference Sequences

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RefSeqi
NP_001847.3, NM_001856.3 [Q07092-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.368921

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000373672; ENSP00000362776; ENSG00000084636 [Q07092-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
1307

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1307

UCSC genome browser

More...
UCSCi
uc001btk.2 human [Q07092-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92642 mRNA Translation: AAA58427.1
AC114488 Genomic DNA No translation available.
AB209571 mRNA Translation: BAD92808.1
X14963 mRNA Translation: CAA33085.1
X15038 mRNA Translation: CAA33142.1
S57132 mRNA Translation: AAB25797.1
AF370368 mRNA Translation: AAQ15204.1
CCDSiCCDS41297.1 [Q07092-1]
PIRiS23810
RefSeqiNP_001847.3, NM_001856.3 [Q07092-1]
UniGeneiHs.368921

3D structure databases

ProteinModelPortaliQ07092
SMRiQ07092
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-1757 Collagen type XVI trimer
IntActiQ07092, 3 interactors
MINTiQ07092
STRINGi9606.ENSP00000362776

PTM databases

GlyConnecti1133
iPTMnetiQ07092
PhosphoSitePlusiQ07092

Polymorphism and mutation databases

BioMutaiCOL16A1
DMDMi143811380

Proteomic databases

jPOSTiQ07092
MaxQBiQ07092
PaxDbiQ07092
PeptideAtlasiQ07092
PRIDEiQ07092
ProteomicsDBi58503
58504 [Q07092-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1307
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373672; ENSP00000362776; ENSG00000084636 [Q07092-1]
GeneIDi1307
KEGGihsa:1307
UCSCiuc001btk.2 human [Q07092-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1307
DisGeNETi1307
EuPathDBiHostDB:ENSG00000084636.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
COL16A1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0028602
HGNCiHGNC:2193 COL16A1
HPAiHPA027235
HPA027237
MIMi120326 gene
neXtProtiNX_Q07092
OpenTargetsiENSG00000084636
PharmGKBiPA26709

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG411131D LUCA
GeneTreeiENSGT00940000161782
HOGENOMiHOG000085653
HOVERGENiHBG071631
InParanoidiQ07092
OMAiVHVDCTS
OrthoDBi1295141at2759
PhylomeDBiQ07092
TreeFamiTF332900

Enzyme and pathway databases

ReactomeiR-HSA-1442490 Collagen degradation
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-216083 Integrin cell surface interactions
R-HSA-8948216 Collagen chain trimerization

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
COL16A1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Collagen,_type_XVI,_alpha_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1307

Protein Ontology

More...
PROi
PR:Q07092

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000084636 Expressed in 228 organ(s), highest expression level in right ovary
CleanExiHS_COL16A1
ExpressionAtlasiQ07092 baseline and differential
GenevisibleiQ07092 HS

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR001791 Laminin_G
PfamiView protein in Pfam
PF01391 Collagen, 6 hits
SMARTiView protein in SMART
SM00210 TSPN, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOGA1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q07092
Secondary accession number(s): Q16593, Q59F89, Q71RG9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: April 3, 2007
Last modified: January 16, 2019
This is version 175 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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