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Protein

Collagen alpha-1(XVI) chain

Gene

COL16A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell spreading and alterations in cell morphology.1 Publication

GO - Molecular functioni

  • extracellular matrix structural constituent Source: GO_Central
  • extracellular matrix structural constituent conferring tensile strength Source: BHF-UCL
  • integrin binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-1442490 Collagen degradation
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-216083 Integrin cell surface interactions
R-HSA-8948216 Collagen chain trimerization

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(XVI) chain
Gene namesi
Name:COL16A1
ORF Names:FP1572
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000084636.17
HGNCiHGNC:2193 COL16A1
MIMi120326 gene
neXtProtiNX_Q07092

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1307
OpenTargetsiENSG00000084636
PharmGKBiPA26709

Polymorphism and mutation databases

BioMutaiCOL16A1
DMDMi143811380

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 212 PublicationsAdd BLAST21
ChainiPRO_000000579222 – 1604Collagen alpha-1(XVI) chainAdd BLAST1583

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi327N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Glycosylated.2 Publications

Keywords - PTMi

Glycoprotein, Hydroxylation

Proteomic databases

MaxQBiQ07092
PaxDbiQ07092
PeptideAtlasiQ07092
PRIDEiQ07092
ProteomicsDBi58503
58504 [Q07092-2]

PTM databases

GlyConnecti1133
iPTMnetiQ07092
PhosphoSitePlusiQ07092

Expressioni

Tissue specificityi

In papillary dermis, is a component of specialized fibrillin-1-containing microfibrils, whereas in territorial cartilage matrix, it is localized to a discrete population of thin, weakly banded collagen fibrils in association with other collagens (at protein level). In the placenta, where it is found in the amnion, a membranous tissue lining the amniotic cavity. Within the amnion, it is found in an acellular, relatively dense layer of a complex network of reticular fibers. Also located to a fibroblast layer beneath this dense layer. Exists in tissues in association with other types of collagen.1 Publication

Developmental stagei

Transiently elevated expression during gestation, and decrease at term.

Gene expression databases

BgeeiENSG00000084636 Expressed in 228 organ(s), highest expression level in right ovary
CleanExiHS_COL16A1
ExpressionAtlasiQ07092 baseline and differential
GenevisibleiQ07092 HS

Organism-specific databases

HPAiHPA027235
HPA027237

Interactioni

Subunit structurei

Homotrimer. Interacts with FBN1, fibronectin and integrins ITGA1/ITGB1 and ITGA2/ITGB1. Integrin ITGA1/ITGB1 binds to a unique site within COL16A1 located close to its C-terminal end between collagenous domains COL1-COL3.4 Publications

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortaliCPX-1757 Collagen type XVI trimer
IntActiQ07092, 3 interactors
MINTiQ07092
STRINGi9606.ENSP00000362776

Structurei

3D structure databases

ProteinModelPortaliQ07092
SMRiQ07092
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 231Laminin G-likeAdd BLAST182
Domaini375 – 423Collagen-like 1Add BLAST49
Domaini573 – 633Collagen-like 2Add BLAST61
Domaini667 – 721Collagen-like 3Add BLAST55
Domaini788 – 840Collagen-like 4Add BLAST53
Domaini888 – 938Collagen-like 5Add BLAST51
Domaini1018 – 1075Collagen-like 6Add BLAST58
Domaini1472 – 1524Collagen-like 7Add BLAST53
Domaini1528 – 1576Collagen-like 8Add BLAST49

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni232 – 374Nonhelical region 10 (NC10)Add BLAST143
Regioni375 – 506Triple-helical region 9 (COL9) with 3 imperfectionsAdd BLAST132
Regioni507 – 521Nonhelical region 9 (NC9)Add BLAST15
Regioni522 – 555Triple-helical region 8 (COL8) with 1 imperfectionAdd BLAST34
Regioni556 – 572Nonhelical region 8 (NC8)Add BLAST17
Regioni573 – 631Triple-helical region 7 (COL7) with 1 imperfectionAdd BLAST59
Regioni632 – 652Nonhelical region 7 (NC7)Add BLAST21
Regioni653 – 723Triple-helical region 6 (COL6) with 1 imperfectionAdd BLAST71
Regioni724 – 738Nonhelical region 6 (NC6)Add BLAST15
Regioni739 – 876Triple-helical region 5 (COL5) with 3 imperfectionsAdd BLAST138
Regioni877 – 887Nonhelical region 5 (NC5)Add BLAST11
Regioni888 – 939Triple-helical region 4 (COL4) with 2 imperfectionsAdd BLAST52
Regioni940 – 973Nonhelical region 4 (NC4)Add BLAST34
Regioni974 – 988Triple-helical region 3 (COL3)Add BLAST15
Regioni989 – 1011Nonhelical region 3 (NC3)Add BLAST23
Regioni1012 – 1433Triple-helical region 2 (COL2) with 2 imperfectionsAdd BLAST422
Regioni1434 – 1472Nonhelical region 2 (NC2)Add BLAST39
Regioni1473 – 1578Triple-helical region 1 (COL1) with 2 imperfectionsAdd BLAST106
Regioni1579 – 1604Nonhelical region 1 (NC1)Add BLAST26

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi540 – 542Cell attachment siteSequence analysis3
Motifi1006 – 1008Cell attachment siteSequence analysis3
Motifi1227 – 1229Cell attachment siteSequence analysis3

Domaini

This sequence defines eighteen different domains, nine triple-helical domains (COL9 to COL1) and ten non-triple-helical domains (NC10 to NC1). The numerous interruptions in the triple helix may make this molecule either elastic or flexible.

Sequence similaritiesi

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG411131D LUCA
GeneTreeiENSGT00900000140804
HOGENOMiHOG000085653
HOVERGENiHBG071631
InParanoidiQ07092
OMAiVHVDCTS
OrthoDBiEOG091G026Z
PhylomeDBiQ07092
TreeFamiTF332900

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR001791 Laminin_G
PfamiView protein in Pfam
PF01391 Collagen, 6 hits
SMARTiView protein in SMART
SM00210 TSPN, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q07092-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWVSWAPGLW LLGLWATFGH GANTGAQCPP SQQEGLKLEH SSSLPANVTG
60 70 80 90 100
FNLIHRLSLM KTSAIKKIRN PKGPLILRLG AAPVTQPTRR VFPRGLPEEF
110 120 130 140 150
ALVLTLLLKK HTHQKTWYLF QVTDANGYPQ ISLEVNSQER SLELRAQGQD
160 170 180 190 200
GDFVSCIFPV PQLFDLRWHK LMLSVAGRVA SVHVDCSSAS SQPLGPRRPM
210 220 230 240 250
RPVGHVFLGL DAEQGKPVSF DLQQVHIYCD PELVLEEGCC EILPAGCPPE
260 270 280 290 300
TSKARRDTQS NELIEINPQS EGKVYTRCFC LEEPQNSEVD AQLTGRISQK
310 320 330 340 350
AERGAKVHQE TAADECPPCV HGARDSNVTL APSGPKGGKG ERGLPGPPGS
360 370 380 390 400
KGEKGARGND CVRISPDAPL QCAEGPKGEK GESGALGPSG LPGSTGEKGQ
410 420 430 440 450
KGEKGDGGIK GVPGKPGRDG RPGEICVIGP KGQKGDPGFV GPEGLAGEPG
460 470 480 490 500
PPGLPGPPGI GLPGTPGDPG GPPGPKGDKG SSGIPGKEGP GGKPGKPGVK
510 520 530 540 550
GEKGDPCEVC PTLPEGFQNF VGLPGKPGPK GEPGDPVPAR GDPGIQGIKG
560 570 580 590 600
EKGEPCLSCS SVVGAQHLVS STGASGDVGS PGFGLPGLPG RAGVPGLKGE
610 620 630 640 650
KGNFGEAGPA GSPGPPGPVG PAGIKGAKGE PCEPCPALSN LQDGDVRVVA
660 670 680 690 700
LPGPSGEKGE PGPPGFGLPG KQGKAGERGL KGQKGDAGNP GDPGTPGTTG
710 720 730 740 750
RPGLSGEPGV QGPAGPKGEK GDGCTACPSL QGTVTDMAGR PGQPGPKGEQ
760 770 780 790 800
GPEGVGRPGK PGQPGLPGVQ GPPGLKGVQG EPGPPGRGVQ GPQGEPGAPG
810 820 830 840 850
LPGIQGLPGP RGPPGPTGEK GAQGSPGVKG ATGPVGPPGA SVSGPPGRDG
860 870 880 890 900
QQGQTGLRGT PGEKGPRGEK GEPGECSCPS QGDLIFSGMP GAPGLWMGSS
910 920 930 940 950
WQPGPQGPPG IPGPPGPPGV PGLQGVPGNN GLPGQPGLTA ELGSLPIEQH
960 970 980 990 1000
LLKSICGDCV QGQRAHPGYL VEKGEKGDQG IPGVPGLDNC AQCFLSLERP
1010 1020 1030 1040 1050
RAEEARGDNS EGDPGCVGSP GLPGPPGLPG QRGEEGPPGM RGSPGPPGPI
1060 1070 1080 1090 1100
GPPGFPGAVG SPGLPGLQGE RGLTGLTGDK GEPGPPGQPG YPGATGPPGL
1110 1120 1130 1140 1150
PGIKGERGYT GSAGEKGEPG PPGSEGLPGP PGPAGPRGER GPQGNSGEKG
1160 1170 1180 1190 1200
DQGFQGQPGF PGPPGPPGFP GKVGSPGPPG PQAEKGSEGI RGPSGLPGSP
1210 1220 1230 1240 1250
GPPGPPGIQG PAGLDGLDGK DGKPGLRGDP GPAGPPGLMG PPGFKGKTGH
1260 1270 1280 1290 1300
PGLPGPKGDC GKPGPPGSTG RPGAEGEPGA MGPQGRPGPP GHVGPPGPPG
1310 1320 1330 1340 1350
QPGPAGISAV GLKGDRGATG ERGLAGLPGQ PGPPGHPGPP GEPGTDGAAG
1360 1370 1380 1390 1400
KEGPPGKQGF YGPPGPKGDP GAAGQKGQAG EKGRAGMPGG PGKSGSMGPV
1410 1420 1430 1440 1450
GPPGPAGERG HPGAPGPSGS PGLPGVPGSM GDMVNYDEIK RFIRQEIIKM
1460 1470 1480 1490 1500
FDERMAYYTS RMQFPMEMAA APGRPGPPGK DGAPGRPGAP GSPGLPGQIG
1510 1520 1530 1540 1550
REGRQGLPGV RGLPGTKGEK GDIGIGIAGE NGLPGPPGPQ GPPGYGKMGA
1560 1570 1580 1590 1600
TGPMGQQGIP GIPGPPGPMG QPGKAGHCNP SDCFGAMPME QQYPPMKTMK

GPFG
Length:1,604
Mass (Da):157,751
Last modified:April 3, 2007 - v2
Checksum:i5FAA1950DFC6CA3C
GO
Isoform 2 (identifier: Q07092-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1052-1052: Missing.
     1161-1161: Missing.

Note: No experimental confirmation available.
Show »
Length:1,602
Mass (Da):157,557
Checksum:iC0F8388B57BBA080
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NCT7A6NCT7_HUMAN
Collagen alpha-1(XVI) chain
COL16A1
966Annotation score:
H7BY97H7BY97_HUMAN
Collagen alpha-1(XVI) chain
COL16A1
308Annotation score:
H7BZL8H7BZL8_HUMAN
Collagen alpha-1(XVI) chain
COL16A1
224Annotation score:
H7C3F0H7C3F0_HUMAN
Collagen alpha-1(XVI) chain
COL16A1
235Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti419D → G in AAB25797 (PubMed:1284248).Curated1
Sequence conflicti420 – 421GR → A in AAA58427 (PubMed:1631157).Curated2
Sequence conflicti538P → R in AAA58427 (PubMed:1631157).Curated1
Sequence conflicti848 – 849RD → VM in CAA33142 (Ref. 6) Curated2
Sequence conflicti848 – 849RD → VM in CAA33085 (Ref. 6) Curated2
Sequence conflicti1161P → T in AAA58427 (PubMed:1631157).Curated1
Sequence conflicti1164P → T in AAA58427 (PubMed:1631157).Curated1
Sequence conflicti1166P → S in AAA58427 (PubMed:1631157).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03144062T → K1 PublicationCorresponds to variant dbSNP:rs2228552Ensembl.1
Natural variantiVAR_048778418R → Q. Corresponds to variant dbSNP:rs6699645Ensembl.1
Natural variantiVAR_048779745G → S. Corresponds to variant dbSNP:rs34770879Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0242591052Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_0242601161Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92642 mRNA Translation: AAA58427.1
AC114488 Genomic DNA No translation available.
AB209571 mRNA Translation: BAD92808.1
X14963 mRNA Translation: CAA33085.1
X15038 mRNA Translation: CAA33142.1
S57132 mRNA Translation: AAB25797.1
AF370368 mRNA Translation: AAQ15204.1
CCDSiCCDS41297.1 [Q07092-1]
PIRiS23810
RefSeqiNP_001847.3, NM_001856.3 [Q07092-1]
UniGeneiHs.368921

Genome annotation databases

EnsembliENST00000373672; ENSP00000362776; ENSG00000084636 [Q07092-1]
GeneIDi1307
KEGGihsa:1307
UCSCiuc001btk.2 human [Q07092-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92642 mRNA Translation: AAA58427.1
AC114488 Genomic DNA No translation available.
AB209571 mRNA Translation: BAD92808.1
X14963 mRNA Translation: CAA33085.1
X15038 mRNA Translation: CAA33142.1
S57132 mRNA Translation: AAB25797.1
AF370368 mRNA Translation: AAQ15204.1
CCDSiCCDS41297.1 [Q07092-1]
PIRiS23810
RefSeqiNP_001847.3, NM_001856.3 [Q07092-1]
UniGeneiHs.368921

3D structure databases

ProteinModelPortaliQ07092
SMRiQ07092
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-1757 Collagen type XVI trimer
IntActiQ07092, 3 interactors
MINTiQ07092
STRINGi9606.ENSP00000362776

PTM databases

GlyConnecti1133
iPTMnetiQ07092
PhosphoSitePlusiQ07092

Polymorphism and mutation databases

BioMutaiCOL16A1
DMDMi143811380

Proteomic databases

MaxQBiQ07092
PaxDbiQ07092
PeptideAtlasiQ07092
PRIDEiQ07092
ProteomicsDBi58503
58504 [Q07092-2]

Protocols and materials databases

DNASUi1307
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373672; ENSP00000362776; ENSG00000084636 [Q07092-1]
GeneIDi1307
KEGGihsa:1307
UCSCiuc001btk.2 human [Q07092-1]

Organism-specific databases

CTDi1307
DisGeNETi1307
EuPathDBiHostDB:ENSG00000084636.17
GeneCardsiCOL16A1
H-InvDBiHIX0028602
HGNCiHGNC:2193 COL16A1
HPAiHPA027235
HPA027237
MIMi120326 gene
neXtProtiNX_Q07092
OpenTargetsiENSG00000084636
PharmGKBiPA26709
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG411131D LUCA
GeneTreeiENSGT00900000140804
HOGENOMiHOG000085653
HOVERGENiHBG071631
InParanoidiQ07092
OMAiVHVDCTS
OrthoDBiEOG091G026Z
PhylomeDBiQ07092
TreeFamiTF332900

Enzyme and pathway databases

ReactomeiR-HSA-1442490 Collagen degradation
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-216083 Integrin cell surface interactions
R-HSA-8948216 Collagen chain trimerization

Miscellaneous databases

ChiTaRSiCOL16A1 human
GeneWikiiCollagen,_type_XVI,_alpha_1
GenomeRNAii1307
PROiPR:Q07092
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000084636 Expressed in 228 organ(s), highest expression level in right ovary
CleanExiHS_COL16A1
ExpressionAtlasiQ07092 baseline and differential
GenevisibleiQ07092 HS

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR001791 Laminin_G
PfamiView protein in Pfam
PF01391 Collagen, 6 hits
SMARTiView protein in SMART
SM00210 TSPN, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOGA1_HUMAN
AccessioniPrimary (citable) accession number: Q07092
Secondary accession number(s): Q16593, Q59F89, Q71RG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: April 3, 2007
Last modified: November 7, 2018
This is version 173 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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