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Protein

Insulin-like growth factor-binding protein 5

Gene

Igfbp5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

GO - Molecular functioni

  • fibronectin binding Source: MGI
  • insulin-like growth factor binding Source: MGI
  • insulin-like growth factor I binding Source: MGI
  • insulin-like growth factor II binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionGrowth factor binding

Enzyme and pathway databases

ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Protein family/group databases

MEROPSiI31.952

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 5
Short name:
IBP-5
Short name:
IGF-binding protein 5
Short name:
IGFBP-5
Gene namesi
Name:Igfbp5
Synonyms:Igfbp-5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:96440 Igfbp5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001438620 – 271Insulin-like growth factor-binding protein 5Add BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 58PROSITE-ProRule annotation
Disulfide bondi66 ↔ 79PROSITE-ProRule annotation
Modified residuei115PhosphoserineBy similarity1
Disulfide bondi191 ↔ 218PROSITE-ProRule annotation
Disulfide bondi229 ↔ 240PROSITE-ProRule annotation
Disulfide bondi242 ↔ 262PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ07079
PeptideAtlasiQ07079
PRIDEiQ07079

PTM databases

iPTMnetiQ07079
PhosphoSitePlusiQ07079

Miscellaneous databases

PMAP-CutDBiQ07079

Expressioni

Tissue specificityi

Most abundant in kidney, uterus and gastrocnemius muscle.

Gene expression databases

BgeeiENSMUSG00000026185 Expressed in 314 organ(s), highest expression level in cochlea
CleanExiMM_IGFBP5
ExpressionAtlasiQ07079 baseline and differential
GenevisibleiQ07079 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ07079, 1 interactor
STRINGi10090.ENSMUSP00000027377

Structurei

3D structure databases

ProteinModelPortaliQ07079
SMRiQ07079
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 102IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST81
Domaini188 – 262Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST75

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJJ2 Eukaryota
ENOG4111GGG LUCA
GeneTreeiENSGT00550000074457
HOGENOMiHOG000253012
HOVERGENiHBG002631
InParanoidiQ07079
OMAiLPIDKHE
OrthoDBiEOG091G0EIN
PhylomeDBiQ07079
TreeFamiTF331211

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR012213 IGFBP-5
IPR000867 IGFBP-like
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PTHR11551:SF4 PTHR11551:SF4, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01981 IGFBPFAMILY5
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07079-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVISVVLLLL AAYAVPAQGL GSFVHCEPCD EKALSMCPPS PLGCELVKEP
60 70 80 90 100
GCGCCMTCAL AEGQSCGVYT ERCAQGLRCL PRQDEEKPLH ALLHGRGVCL
110 120 130 140 150
NEKSYGEQTK IERDSREHEE PTTSEMAEET YSPKVFRPKH TRISELKAEA
160 170 180 190 200
VKKDRRKKLT QSKFVGGAEN TAHPRVIPAP EMRQESEQGP CRRHMEASLQ
210 220 230 240 250
EFKASPRMVP RAVYLPNCDR KGFYKRKQCK PSRGRKRGIC WCVDKYGMKL
260 270
PGMEYVDGDF QCHAFDSSNV E
Length:271
Mass (Da):30,372
Last modified:October 1, 1994 - v1
Checksum:iF55A58729861F6F0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti112Missing in AAC01750 (PubMed:7518410).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12447 mRNA Translation: AAC37636.1
U02025
, U02023, U02027, U02024 Genomic DNA Translation: AAC01750.1
X81583 mRNA Translation: CAA57273.1
BC054812 mRNA Translation: AAH54812.1
BC057447 mRNA Translation: AAH57447.1
CCDSiCCDS15037.1
PIRiI48604
RefSeqiNP_034648.2, NM_010518.2
UniGeneiMm.405761

Genome annotation databases

EnsembliENSMUST00000027377; ENSMUSP00000027377; ENSMUSG00000026185
GeneIDi16011
KEGGimmu:16011
UCSCiuc007bkx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12447 mRNA Translation: AAC37636.1
U02025
, U02023, U02027, U02024 Genomic DNA Translation: AAC01750.1
X81583 mRNA Translation: CAA57273.1
BC054812 mRNA Translation: AAH54812.1
BC057447 mRNA Translation: AAH57447.1
CCDSiCCDS15037.1
PIRiI48604
RefSeqiNP_034648.2, NM_010518.2
UniGeneiMm.405761

3D structure databases

ProteinModelPortaliQ07079
SMRiQ07079
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ07079, 1 interactor
STRINGi10090.ENSMUSP00000027377

Protein family/group databases

MEROPSiI31.952

PTM databases

iPTMnetiQ07079
PhosphoSitePlusiQ07079

Proteomic databases

PaxDbiQ07079
PeptideAtlasiQ07079
PRIDEiQ07079

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027377; ENSMUSP00000027377; ENSMUSG00000026185
GeneIDi16011
KEGGimmu:16011
UCSCiuc007bkx.1 mouse

Organism-specific databases

CTDi3488
MGIiMGI:96440 Igfbp5

Phylogenomic databases

eggNOGiENOG410IJJ2 Eukaryota
ENOG4111GGG LUCA
GeneTreeiENSGT00550000074457
HOGENOMiHOG000253012
HOVERGENiHBG002631
InParanoidiQ07079
OMAiLPIDKHE
OrthoDBiEOG091G0EIN
PhylomeDBiQ07079
TreeFamiTF331211

Enzyme and pathway databases

ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Miscellaneous databases

ChiTaRSiIgfbp5 mouse
PMAP-CutDBiQ07079
PROiPR:Q07079
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026185 Expressed in 314 organ(s), highest expression level in cochlea
CleanExiMM_IGFBP5
ExpressionAtlasiQ07079 baseline and differential
GenevisibleiQ07079 MM

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR012213 IGFBP-5
IPR000867 IGFBP-like
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PTHR11551:SF4 PTHR11551:SF4, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01981 IGFBPFAMILY5
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIBP5_MOUSE
AccessioniPrimary (citable) accession number: Q07079
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 7, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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