UniProtKB - Q07076 (ANXA7_MOUSE)
Protein
Annexin A7
Gene
Anxa7
Organism
Mus musculus (Mouse)
Status
Functioni
Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.
GO - Molecular functioni
- calcium-dependent phospholipid binding Source: MGI
- calcium-dependent protein binding Source: MGI
- calcium ion binding Source: GO_Central
- integrin binding Source: MGI
GO - Biological processi
- autophagy Source: MGI
- cell population proliferation Source: MGI
- cellular calcium ion homeostasis Source: MGI
- cellular water homeostasis Source: MGI
- epithelial cell differentiation Source: Ensembl
- hemostasis Source: MGI
- membrane fusion Source: MGI
- negative regulation of gene expression Source: MGI
- regulation of cell shape Source: MGI
- response to calcium ion Source: MGI
- response to organic cyclic compound Source: MGI
- response to salt stress Source: MGI
Keywordsi
Ligand | Calcium, Calcium/phospholipid-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Annexin A7Alternative name(s): Annexin VII Annexin-7 Synexin |
Gene namesi | Name:Anxa7 Synonyms:Anx7 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:88031, Anxa7 |
Subcellular locationi
Cytosol
- cytosol Source: MGI
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: MGI
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
Nucleus
- nuclear envelope Source: MGI
- nucleus Source: MGI
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- chromaffin granule membrane Source: Ensembl
- cytoplasm Source: GO_Central
- vesicle Source: MGI
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000067500 | 1 – 463 | Annexin A7Add BLAST | 463 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 208 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q07076 |
jPOSTi | Q07076 |
MaxQBi | Q07076 |
PaxDbi | Q07076 |
PeptideAtlasi | Q07076 |
PRIDEi | Q07076 |
2D gel databases
REPRODUCTION-2DPAGEi | Q07076 |
PTM databases
iPTMneti | Q07076 |
PhosphoSitePlusi | Q07076 |
SwissPalmi | Q07076 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000021814, Expressed in secondary oocyte and 310 other tissues |
ExpressionAtlasi | Q07076, baseline and differential |
Genevisiblei | Q07076, MM |
Interactioni
Subunit structurei
Interacts with PDCD6.
By similarityBinary interactionsi
Q07076
With | #Exp. | IntAct |
---|---|---|
SRI [P05044] from Cricetulus griseus. | 2 | EBI-10824194,EBI-10816377 |
GO - Molecular functioni
- calcium-dependent protein binding Source: MGI
- integrin binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 198113, 13 interactors |
IntActi | Q07076, 1 interactor |
STRINGi | 10090.ENSMUSP00000098405 |
Miscellaneous databases
RNActi | Q07076, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 160 – 231 | Annexin 1PROSITE-ProRule annotationAdd BLAST | 72 | |
Repeati | 232 – 303 | Annexin 2PROSITE-ProRule annotationAdd BLAST | 72 | |
Repeati | 315 – 387 | Annexin 3PROSITE-ProRule annotationAdd BLAST | 73 | |
Repeati | 391 – 462 | Annexin 4PROSITE-ProRule annotationAdd BLAST | 72 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 143 | Repeat-rich regionAdd BLAST | 143 | |
Regioni | 5 – 20 | 3 X 5 AA tandem repeats of G-Y-P-P-XAdd BLAST | 16 |
Domaini
A pair of annexin repeats may form one binding site for calcium and phospholipid.
Sequence similaritiesi
Keywords - Domaini
Annexin, RepeatPhylogenomic databases
eggNOGi | KOG0819, Eukaryota |
GeneTreei | ENSGT00940000155278 |
HOGENOMi | CLU_025300_6_1_1 |
InParanoidi | Q07076 |
OMAi | NADMNAI |
TreeFami | TF105452 |
Family and domain databases
Gene3Di | 1.10.220.10, 4 hits |
InterProi | View protein in InterPro IPR001464, Annexin IPR018502, Annexin_repeat IPR018252, Annexin_repeat_CS IPR037104, Annexin_sf |
Pfami | View protein in Pfam PF00191, Annexin, 4 hits |
PRINTSi | PR00196, ANNEXIN |
SMARTi | View protein in SMART SM00335, ANX, 4 hits |
SUPFAMi | SSF47874, SSF47874, 1 hit |
PROSITEi | View protein in PROSITE PS00223, ANNEXIN_1, 4 hits PS51897, ANNEXIN_2, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q07076-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSYPGYPPTG YPPFPGYPPA GQESSFPTAG QYPYPSGFPP MGGGAYPPAP
60 70 80 90 100
SGGYPGAGGY PAPGGYPAPG GYPGALSPGG PPAYPGGQGF GAPPGGAGFS
110 120 130 140 150
GYPQPPAQSY GGGPAQVPVP GGFPGGQMPS QYPGGQAPYP SQPASMTQGT
160 170 180 190 200
QGTILPASNF DAMRDAEILR KAMKGFGTDE QAIVDVVSNR SNDQRQQIKA
210 220 230 240 250
AFKTMYGKDL IKDLKSELSG NMEELILALF MPSTYYDAWS LRKAMQGAGT
260 270 280 290 300
QERVLIEILC TRTNQEIRDI VRCYQLEFGR DLEKDIRSDT SGHFERLLVS
310 320 330 340 350
MCQGNRDERQ SVNHQMAQED AQRLYQAGEG RLGTDESCFN MILATRSFPQ
360 370 380 390 400
LKATMEAYSR MANRDLLSSV SREFSGYVES GLKTILQCAL NRPAFFAERL
410 420 430 440 450
YYSMKGAGTD DSTLVRIVVT RSEIDLVQIK QMFTQMYQKT LSTMIASDTS
460
GDYRKLLLAI VGQ
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2C9F2D2 | A0A2C9F2D2_MOUSE | Annexin | Anxa7 | 485 | Annotation score: | ||
A0A286YCW4 | A0A286YCW4_MOUSE | Annexin A7 | Anxa7 | 72 | Annotation score: | ||
A0A286YCS5 | A0A286YCS5_MOUSE | Annexin A7 | Anxa7 | 86 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 304 | G → A in AAA37238 (PubMed:7916616).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L13129 mRNA Translation: AAA37238.1 AK151438 mRNA Translation: BAE30401.1 AK161613 mRNA Translation: BAE36492.1 AK169199 mRNA Translation: BAE40974.1 CH466613 Genomic DNA Translation: EDL01512.1 |
CCDSi | CCDS26845.1 |
RefSeqi | NP_001104264.1, NM_001110794.1 NP_033804.2, NM_009674.3 |
Genome annotation databases
Ensembli | ENSMUST00000065504; ENSMUSP00000066035; ENSMUSG00000021814 ENSMUST00000224975; ENSMUSP00000153669; ENSMUSG00000021814 |
GeneIDi | 11750 |
KEGGi | mmu:11750 |
UCSCi | uc007sjr.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L13129 mRNA Translation: AAA37238.1 AK151438 mRNA Translation: BAE30401.1 AK161613 mRNA Translation: BAE36492.1 AK169199 mRNA Translation: BAE40974.1 CH466613 Genomic DNA Translation: EDL01512.1 |
CCDSi | CCDS26845.1 |
RefSeqi | NP_001104264.1, NM_001110794.1 NP_033804.2, NM_009674.3 |
3D structure databases
SMRi | Q07076 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198113, 13 interactors |
IntActi | Q07076, 1 interactor |
STRINGi | 10090.ENSMUSP00000098405 |
PTM databases
iPTMneti | Q07076 |
PhosphoSitePlusi | Q07076 |
SwissPalmi | Q07076 |
2D gel databases
REPRODUCTION-2DPAGEi | Q07076 |
Proteomic databases
EPDi | Q07076 |
jPOSTi | Q07076 |
MaxQBi | Q07076 |
PaxDbi | Q07076 |
PeptideAtlasi | Q07076 |
PRIDEi | Q07076 |
Protocols and materials databases
Antibodypediai | 3809, 340 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000065504; ENSMUSP00000066035; ENSMUSG00000021814 ENSMUST00000224975; ENSMUSP00000153669; ENSMUSG00000021814 |
GeneIDi | 11750 |
KEGGi | mmu:11750 |
UCSCi | uc007sjr.2, mouse |
Organism-specific databases
CTDi | 310 |
MGIi | MGI:88031, Anxa7 |
Phylogenomic databases
eggNOGi | KOG0819, Eukaryota |
GeneTreei | ENSGT00940000155278 |
HOGENOMi | CLU_025300_6_1_1 |
InParanoidi | Q07076 |
OMAi | NADMNAI |
TreeFami | TF105452 |
Miscellaneous databases
BioGRID-ORCSi | 11750, 0 hits in 17 CRISPR screens |
ChiTaRSi | Anxa7, mouse |
PROi | PR:Q07076 |
RNActi | Q07076, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000021814, Expressed in secondary oocyte and 310 other tissues |
ExpressionAtlasi | Q07076, baseline and differential |
Genevisiblei | Q07076, MM |
Family and domain databases
Gene3Di | 1.10.220.10, 4 hits |
InterProi | View protein in InterPro IPR001464, Annexin IPR018502, Annexin_repeat IPR018252, Annexin_repeat_CS IPR037104, Annexin_sf |
Pfami | View protein in Pfam PF00191, Annexin, 4 hits |
PRINTSi | PR00196, ANNEXIN |
SMARTi | View protein in SMART SM00335, ANX, 4 hits |
SUPFAMi | SSF47874, SSF47874, 1 hit |
PROSITEi | View protein in PROSITE PS00223, ANNEXIN_1, 4 hits PS51897, ANNEXIN_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ANXA7_MOUSE | |
Accessioni | Q07076Primary (citable) accession number: Q07076 Secondary accession number(s): Q3TT33 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families