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Protein

Peroxisomal membrane protein 2

Gene

Pxmp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein 2
Alternative name(s):
22 kDa peroxisomal membrane protein
Gene namesi
Name:Pxmp2
Synonyms:Pmp22
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi61812 Pxmp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 30CytoplasmicSequence analysisAdd BLAST29
Transmembranei31 – 51HelicalSequence analysisAdd BLAST21
Topological domaini52 – 74PeroxisomalSequence analysisAdd BLAST23
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21
Topological domaini96 – 113CytoplasmicSequence analysisAdd BLAST18
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Topological domaini135 – 172PeroxisomalSequence analysisAdd BLAST38
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002189312 – 194Peroxisomal membrane protein 2Add BLAST193

Proteomic databases

PaxDbiQ07066
PRIDEiQ07066

Interactioni

Subunit structurei

Interacts with PEX19 and SIVA1.By similarity

Protein-protein interaction databases

BioGridi248168, 1 interactor
STRINGi10116.ENSRNOP00000053518

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1944 Eukaryota
ENOG4111SYH LUCA
HOGENOMiHOG000008014
HOVERGENiHBG052506
InParanoidiQ07066
KOiK13347
PhylomeDBiQ07066

Family and domain databases

InterProiView protein in InterPro
IPR007248 Mpv17_PMP22
PANTHERiPTHR11266 PTHR11266, 1 hit
PfamiView protein in Pfam
PF04117 Mpv17_PMP22, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q07066-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPAASRLRV ESELRSLPKR ALAQYLLFLK FYPVVTKAVS SGILSALGNL
60 70 80 90 100
LAQMIEKKQK KDSRSLEVSG LLRYLVYGLF VTGPLSHYLY LFMEYWVPPE
110 120 130 140 150
VPWARVKRLL LDRLFFAPTF LLLFFFVMNL LEGKNISVFV AKMRSGFWPA
160 170 180 190
LQMNWRMWTP LQFININYVP LQFRVLFANM AALFWYAYLA SLGK
Length:194
Mass (Da):22,577
Last modified:January 23, 2007 - v2
Checksum:i4BEDB2CEBE52EAAC
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V9N2G3V9N2_RAT
Peroxisomal membrane protein 2
Pxmp2 rCG_21239
194Annotation score:
A0A0G2KAQ8A0A0G2KAQ8_RAT
Peroxisomal membrane protein 2
Pxmp2
88Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70223 mRNA Translation: CAA49756.1
PIRiS28850
RefSeqiNP_113775.1, NM_031587.1
UniGeneiRn.10292

Genome annotation databases

GeneIDi29533
KEGGirno:29533
UCSCiRGD:61812 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70223 mRNA Translation: CAA49756.1
PIRiS28850
RefSeqiNP_113775.1, NM_031587.1
UniGeneiRn.10292

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248168, 1 interactor
STRINGi10116.ENSRNOP00000053518

Proteomic databases

PaxDbiQ07066
PRIDEiQ07066

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29533
KEGGirno:29533
UCSCiRGD:61812 rat

Organism-specific databases

CTDi5827
RGDi61812 Pxmp2

Phylogenomic databases

eggNOGiKOG1944 Eukaryota
ENOG4111SYH LUCA
HOGENOMiHOG000008014
HOVERGENiHBG052506
InParanoidiQ07066
KOiK13347
PhylomeDBiQ07066

Miscellaneous databases

PROiPR:Q07066

Family and domain databases

InterProiView protein in InterPro
IPR007248 Mpv17_PMP22
PANTHERiPTHR11266 PTHR11266, 1 hit
PfamiView protein in Pfam
PF04117 Mpv17_PMP22, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPXMP2_RAT
AccessioniPrimary (citable) accession number: Q07066
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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