CKAP4

Functionⁱ

High-affinity epithelial cell surface receptor for APF.

Mediates the anchoring of the endoplasmic reticulum to microtubules.

GO - Molecular functionⁱ

RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular protein metabolic process Source: Reactome
neutrophil degranulation Source: Reactome
post-translational protein modification Source: Reactome

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-5683826 Surfactant metabolism R-HSA-6798695 Neutrophil degranulation R-HSA-8957275 Post-translational protein phosphorylation

Reactomeⁱ

R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-5683826 Surfactant metabolism
R-HSA-6798695 Neutrophil degranulation
R-HSA-8957275 Post-translational protein phosphorylation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cytoskeleton-associated protein 4 Alternative name(s): 63-kDa cytoskeleton-linking membrane protein Short name: Climp-63 Short name: p63
Gene namesⁱ	Name:CKAP4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000136026.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16991 CKAP4
neXtProtⁱ	NX_Q07065

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 106	CytoplasmicSequence analysisAdd BLAST	106
Transmembraneⁱ	107 – 127	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	128 – 602	ExtracellularSequence analysisAdd BLAST	475

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10970
Open Targets More...OpenTargetsⁱ	ENSG00000136026
PharmGKBⁱ	PA26527

Polymorphism and mutation databases

BioMutaⁱ	CKAP4
DMDMⁱ	74735614

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000252417	1 – 602	Cytoskeleton-associated protein 4Add BLAST		602

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	3	Phosphoserine1 Publication	1
Modified residueⁱ	17	PhosphoserineCombined sources1 Publication	1
Modified residueⁱ	19	Phosphoserine1 Publication	1
Modified residueⁱ	21	N6-acetyllysineBy similarity	1
Lipidationⁱ	100	S-palmitoyl cysteine; by ZDHHC21 Publication	1
Modified residueⁱ	232	Phosphoserine; by FAM20C1 Publication	1
Modified residueⁱ	312	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Reversibly palmitoylated. Palmitoylation at Cys-100 by DHHC2 is required for its trafficking from the ER to the plasma membrane and for its perinuclear localization.2 Publications

Increased phosphorylation during mitosis prevents binding to microtubules.1 Publication

Keywords - PTMⁱ

Acetylation, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDⁱ	Q07065
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q07065
PaxDbⁱ	Q07065
PeptideAtlas More...PeptideAtlasⁱ	Q07065
PRIDEⁱ	Q07065
ProteomicsDBⁱ	58501

PTM databases

iPTMnetⁱ	Q07065
PhosphoSitePlusⁱ	Q07065
SwissPalmⁱ	Q07065

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000136026 Expressed in 243 organ(s), highest expression level in tibia
CleanExⁱ	HS_CKAP4
ExpressionAtlasⁱ	Q07065 baseline and differential
Genevisibleⁱ	Q07065 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA000278 HPA000792 HPA001225

HPAⁱ

HPA000278
HPA000792
HPA001225

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	116167, 107 interactors
IntActⁱ	Q07065, 63 interactors
Molecular INTeraction database More...MINTⁱ	Q07065
STRINGⁱ	9606.ENSP00000367265

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q07065
SMRⁱ	Q07065
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Length
Coiled coilⁱ	130 – 214	Sequence analysisAdd BLAST	85
Coiled coilⁱ	256 – 460	Sequence analysisAdd BLAST	205
Coiled coilⁱ	533 – 602	Sequence analysisAdd BLAST	70

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	36 – 59	Pro-richAdd BLAST	24
Compositional biasⁱ	71 – 77	Poly-Gly	7
Compositional biasⁱ	85 – 94	Poly-Ala	10
Compositional biasⁱ	118 – 121	Poly-Ala	4

Keywords - Domainⁱ

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IIRS Eukaryota ENOG4111Q54 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000015968
HOGENOMⁱ	HOG000060146
HOVERGENⁱ	HBG101940
InParanoidⁱ	Q07065
KEGG Orthology (KO) More...KOⁱ	K13999
OMAⁱ	HQDFSRQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G067G
PhylomeDBⁱ	Q07065
TreeFamⁱ	TF332395

Family and domain databases

InterProⁱ	View protein in InterPro IPR028428 Ckap4
PANTHERⁱ	PTHR45161 PTHR45161, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q07065-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPSAKQRGSK GGHGAASPSE KGAHPSGGAD DVAKKPPPAP QQPPPPPAPH 
        60         70         80         90        100
PQQHPQQHPQ NQAHGKGGHR GGGGGGGKSS SSSSASAAAA AAAASSSASC 
       110        120        130        140        150
SRRLGRALNF LFYLALVAAA AFSGWCVHHV LEEVQQVRRS HQDFSRQREE 
       160        170        180        190        200
LGQGLQGVEQ KVQSLQATFG TFESILRSSQ HKQDLTEKAV KQGESEVSRI 
       210        220        230        240        250
SEVLQKLQNE ILKDLSDGIH VVKDARERDF TSLENTVEER LTELTKSIND 
       260        270        280        290        300
NIAIFTEVQK RSQKEINDMK AKVASLEESE GNKQDLKALK EAVKEIQTSA 
       310        320        330        340        350
KSREWDMEAL RSTLQTMESD IYTEVRELVS LKQEQQAFKE AADTERLALQ 
       360        370        380        390        400
ALTEKLLRSE ESVSRLPEEI RRLEEELRQL KSDSHGPKED GGFRHSEAFE 
       410        420        430        440        450
ALQQKSQGLD SRLQHVEDGV LSMQVASARQ TESLESLLSK SQEHEQRLAA 
       460        470        480        490        500
LQGRLEGLGS SEADQDGLAS TVRSLGETQL VLYGDVEELK RSVGELPSTV 
       510        520        530        540        550
ESLQKVQEQV HTLLSQDQAQ AARLPPQDFL DRLSSLDNLK ASVSQVEADL 
       560        570        580        590        600
KMLRTAVDSL VAYSVKIETN ENNLESAKGL LDDLRNDLDR LFVKVEKIHE 

KV

Length:602

Mass (Da):66,022

Last modified:June 1, 2002 - v2

Checksum:ⁱ216E6A92ED5E058A

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	F8VVU0	F8VVU0_HUMAN		Cytoskeleton-associated protein 4 Cytoskeleton-associated protein 4	CKAP4	26	Annotation score:

Sequence cautionⁱ

The sequence AAH94824 differs from that shown. Aberrant splicing.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	60	Q → R in BAD97283 (Ref. 2) Curated		1
Sequence conflictⁱ	362	S → P in AAH94824 (PubMed:15489334).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_027853	348	A → T. Corresponds to variant dbSNP:rs3088113Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X69910 mRNA Translation: CAA49535.2 AK223563 mRNA Translation: BAD97283.1 AC079174 Genomic DNA No translation available. BC082972 mRNA Translation: AAH82972.1 BC094824 mRNA Translation: AAH94824.1 Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9103.1
PIRⁱ	S33377
NCBI Reference Sequences More...RefSeqⁱ	NP_006816.2, NM_006825.3
UniGeneⁱ	Hs.74368

Genome annotation databases

Ensemblⁱ	ENST00000378026; ENSP00000367265; ENSG00000136026
GeneIDⁱ	10970
KEGGⁱ	hsa:10970
UCSC genome browser More...UCSCⁱ	uc001tlk.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q07065	Cytoskeleton-associated protein 4, isoform CRA_c		HUMAN		602	UniRef100_Q07065

Protein	Similar proteins		Species	Score	Length	Source
Q07065	Cytoskeleton-associated protein 4, isoform CRA_c		HUMAN		602	UniRef90_Q07065
CKAP4 isoform 3		PANTR		602
Uncharacterized protein		RHIBE		602
Uncharacterized protein		CHLSB		598
Cytoskeleton associated protein 4		RHIRO		597
+21

Protein	Similar proteins		Species	Score	Length	Source
Q07065	Cytoskeleton-associated protein 4, isoform CRA_c		HUMAN		602	UniRef50_Q07065
Uncharacterized protein		RHIBE		602
CKAP4 isoform 3		PANTR		602
Uncharacterized protein		CHLSB		598
CKAP4 isoform 3		PONAB		597
+25

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X69910 mRNA Translation: CAA49535.2 AK223563 mRNA Translation: BAD97283.1 AC079174 Genomic DNA No translation available. BC082972 mRNA Translation: AAH82972.1 BC094824 mRNA Translation: AAH94824.1 Sequence problems.
CCDSⁱ	CCDS9103.1
PIRⁱ	S33377
RefSeqⁱ	NP_006816.2, NM_006825.3
UniGeneⁱ	Hs.74368

3D structure databases

ProteinModelPortalⁱ	Q07065
SMRⁱ	Q07065
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116167, 107 interactors
IntActⁱ	Q07065, 63 interactors
MINTⁱ	Q07065
STRINGⁱ	9606.ENSP00000367265

PTM databases

iPTMnetⁱ	Q07065
PhosphoSitePlusⁱ	Q07065
SwissPalmⁱ	Q07065

Polymorphism and mutation databases

BioMutaⁱ	CKAP4
DMDMⁱ	74735614

Proteomic databases

EPDⁱ	Q07065
MaxQBⁱ	Q07065
PaxDbⁱ	Q07065
PeptideAtlasⁱ	Q07065
PRIDEⁱ	Q07065
ProteomicsDBⁱ	58501

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000378026; ENSP00000367265; ENSG00000136026
GeneIDⁱ	10970
KEGGⁱ	hsa:10970
UCSCⁱ	uc001tlk.4 human

Organism-specific databases

CTDⁱ	10970
DisGeNETⁱ	10970
EuPathDBⁱ	HostDB:ENSG00000136026.13
GeneCardsⁱ	CKAP4
HGNCⁱ	HGNC:16991 CKAP4
HPAⁱ	HPA000278 HPA000792 HPA001225
neXtProtⁱ	NX_Q07065
OpenTargetsⁱ	ENSG00000136026
PharmGKBⁱ	PA26527
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IIRS Eukaryota ENOG4111Q54 LUCA
GeneTreeⁱ	ENSGT00390000015968
HOGENOMⁱ	HOG000060146
HOVERGENⁱ	HBG101940
InParanoidⁱ	Q07065
KOⁱ	K13999
OMAⁱ	HQDFSRQ
OrthoDBⁱ	EOG091G067G
PhylomeDBⁱ	Q07065
TreeFamⁱ	TF332395

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-5683826 Surfactant metabolism R-HSA-6798695 Neutrophil degranulation R-HSA-8957275 Post-translational protein phosphorylation

Reactomeⁱ

R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-5683826 Surfactant metabolism
R-HSA-6798695 Neutrophil degranulation
R-HSA-8957275 Post-translational protein phosphorylation

Miscellaneous databases

ChiTaRSⁱ	CKAP4 human
GeneWikiⁱ	CKAP4
GenomeRNAiⁱ	10970
Protein Ontology More...PROⁱ	PR:Q07065

Gene expression databases

Bgeeⁱ	ENSG00000136026 Expressed in 243 organ(s), highest expression level in tibia
CleanExⁱ	HS_CKAP4
ExpressionAtlasⁱ	Q07065 baseline and differential
Genevisibleⁱ	Q07065 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR028428 Ckap4
PANTHERⁱ	PTHR45161 PTHR45161, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CKAP4_HUMAN
Accessionⁱ	Q07065Primary (citable) accession number: Q07065 Secondary accession number(s): Q504S5, Q53ES6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
	Last sequence update:	June 1, 2002
	Last modified:	November 7, 2018
	This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

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UniParc

Help

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Proteomes

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Supporting data

UniProtKB - Q07065 (CKAP4_HUMAN)

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Cytoskeleton-associated protein 4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Cytoskeleton

Endoplasmic reticulum

Other locations

Cytoskeleton

Cytosol

Endoplasmic reticulum

Extracellular region or secreted

Lysosome

Nucleus

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ