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Entry version 66 (07 Oct 2020)
Sequence version 2 (01 May 1999)
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Protein

RNA-directed RNA polymerase

Gene
N/A
Organism
Saccharomyces 23S RNA narnavirus (ScNV-23S)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-directed RNA polymerase that replicates the viral (+) and (-) genome.

Miscellaneous

Yeast strains also contain a double-stranded RNA (dsRNA) called T. The (+)-strand of T is identical to the single-stranded 23S RNA. The T dsRNA seems to be a by-product of the viral RNA replication cycle.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, Ribonucleoprotein, RNA-binding, RNA-directed RNA polymerase, Transferase
Biological processViral RNA replication

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Alternative name(s):
p104
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces 23S RNA narnavirus (ScNV-23S)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri198599 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraeLenarviricotaAmabiliviricetesWolframviralesNarnaviridaeNarnavirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiSaccharomyces cerevisiae (Baker's yeast) [TaxID: 4932]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007190 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

  • Host cytoplasm 1 Publication
  • Note: The virus has no extracellular transmission pathway. It exists as a ribonucleoprotein viral particle in the host cytoplasm and can be transmitted through mating or cytoplasmic mixing (cytoduction).

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002836521 – 941RNA-directed RNA polymeraseAdd BLAST941

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q07048

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a ribonucleoprotein complex with the 23S RNA, where a single polymerase molecule binds to a single viral RNA genome. Since the viral RNA is not encapsidated, ribonucleoprotein complex formation appears to be the strategy to survive in the host as persistent virus.

2 Publications

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi884 – 890Poly-Pro7
Compositional biasi899 – 903Poly-Pro5

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR043502, DNA/RNA_pol_sf

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56672, SSF56672, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q07048-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHHKVNVKTQ REVHFPMDLL QACGASAPRP VARVSRATDL DRRYRCVLSL
60 70 80 90 100
PEERARSVGC KWSSTRAALR RGLEELGSRE FRRRLRLADD CWRAICAAVC
110 120 130 140 150
TGRKFPSFSV TDRPARARLA KVYRMGRRLL VGVVCRGESV VSDLKQECAD
160 170 180 190 200
LRRVIFEGST RIPSSSLWGL VGVLGWTSPE RAMQLTFIGR ALPYGSPDVE
210 220 230 240 250
RRALASHAAT LSIPAECHPN YLVAAEQFAK SWADDNLPRK FRIYPIAVQE
260 270 280 290 300
SSCMEYSRAQ GGLLQSFRKG FVGYDPAAPS ADPDDLELAK ERGFSRIRAS
310 320 330 340 350
WYSTFRYRGE LKSTNQSLEA RVAVVPERGF KARIVTTHSA SRVTFGHQFR
360 370 380 390 400
RYLLQGIRRH PALVDVIGGD HRRAVETMDG DFGLLRPDGR LLSADLTSAS
410 420 430 440 450
DRIPHDLVKA ILRGIFSDPD RRPPGTSLAD VFDLVLGPYH LHYPDGSEVT
460 470 480 490 500
VRQGILMGLP TTWPLLCLIH LFWVELSDWA PARPNHSRGF VLGESFRICG
510 520 530 540 550
DDLIAWWRPE RIALYNQIAV DCGAQFSAGK HLESKTWGIF TEKVFTVKPV
560 570 580 590 600
KMKVRVRSEP SLKGYVFSRS SAFSCRMGGK GITGIRAARL YTIGAMPRWS
610 620 630 640 650
RRIRDVYPGS LEHRTASQRY GEPVTVYRFG RWSSAIPLRW AVRAPTRTVG
660 670 680 690 700
NPVQSLPDWF TVGPAASSVA ADSNAFGAVS RVLRRMFPGL PRKLASAGIP
710 720 730 740 750
PYLPRVFGGG GLVKSTGLTT KIGAVASRRW MSRIGHDLYR SRERKSTLGR
760 770 780 790 800
VWTLSTSPAY AASLHEVEKF MDRPDIILTR KCRNPMLKHA RELGLFEEVF
810 820 830 840 850
ESRVGGGILW ASLNGKALVE SHSPSILQVS RNLRRSLACP SGGFLRPSAP
860 870 880 890 900
IGKLVQRHTL PRGTVWFLES SATDSARQGG MGLPPPPPPP LGGGGMAGPP
910 920 930 940
PPPFMGLRPE SSVPTSVPFT PSMFSERLAA LESLFGRPPP S
Length:941
Mass (Da):104,297
Last modified:May 1, 1999 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7FB9CED5D4442D11
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U90136 Genomic RNA Translation: AAC98708.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A38149

NCBI Reference Sequences

More...
RefSeqi
NP_660177.1, NC_004050.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
949220

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:949220

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90136 Genomic RNA Translation: AAC98708.1
PIRiA38149
RefSeqiNP_660177.1, NC_004050.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiQ07048

Genome annotation databases

GeneIDi949220
KEGGivg:949220

Family and domain databases

InterProiView protein in InterPro
IPR043502, DNA/RNA_pol_sf
SUPFAMiSSF56672, SSF56672, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRDRP_SCV23
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q07048
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: May 1, 1999
Last modified: October 7, 2020
This is version 66 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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