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UniProtKB - Q07048 (RDRP_SCV23)
Protein
RNA-directed RNA polymerase
Gene
N/A
Organism
Saccharomyces 23S RNA narnavirus (ScNV-23S)
Status
Functioni
RNA-directed RNA polymerase that replicates the viral (+) and (-) genome.
Miscellaneous
Yeast strains also contain a double-stranded RNA (dsRNA) called T. The (+)-strand of T is identical to the single-stranded 23S RNA. The T dsRNA seems to be a by-product of the viral RNA replication cycle.
Catalytic activityi
- EC:2.7.7.48
GO - Molecular functioni
- RNA binding Source: UniProtKB-KW
- RNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-KW
Keywordsi
Molecular function | Nucleotidyltransferase, Ribonucleoprotein, RNA-binding, RNA-directed RNA polymerase, Transferase |
Biological process | Viral RNA replication |
Names & Taxonomyi
Protein namesi | |
Organismi | Saccharomyces 23S RNA narnavirus (ScNV-23S) |
Taxonomic identifieri | 198599 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Lenarviricota › Amabiliviricetes › Wolframvirales › Narnaviridae › Narnavirus |
Virus hosti | Saccharomyces cerevisiae (Baker's yeast) [TaxID: 4932] |
Proteomesi |
|
Subcellular locationi
- Host cytoplasm 1 Publication Note: The virus has no extracellular transmission pathway. It exists as a ribonucleoprotein viral particle in the host cytoplasm and can be transmitted through mating or cytoplasmic mixing (cytoduction).
Keywords - Cellular componenti
Host cytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000283652 | 1 – 941 | RNA-directed RNA polymeraseAdd BLAST | 941 |
Interactioni
Subunit structurei
Forms a ribonucleoprotein complex with the 23S RNA, where a single polymerase molecule binds to a single viral RNA genome. Since the viral RNA is not encapsidated, ribonucleoprotein complex formation appears to be the strategy to survive in the host as persistent virus.
2 PublicationsStructurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 875 – 918 | DisorderedSequence analysisAdd BLAST | 44 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 881 – 908 | Pro residuesSequence analysisAdd BLAST | 28 |
Family and domain databases
InterProi | View protein in InterPro IPR043502, DNA/RNA_pol_sf |
SUPFAMi | SSF56672, SSF56672, 1 hit |
i Sequence
Sequence statusi: Complete.
Q07048-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHHKVNVKTQ REVHFPMDLL QACGASAPRP VARVSRATDL DRRYRCVLSL
60 70 80 90 100
PEERARSVGC KWSSTRAALR RGLEELGSRE FRRRLRLADD CWRAICAAVC
110 120 130 140 150
TGRKFPSFSV TDRPARARLA KVYRMGRRLL VGVVCRGESV VSDLKQECAD
160 170 180 190 200
LRRVIFEGST RIPSSSLWGL VGVLGWTSPE RAMQLTFIGR ALPYGSPDVE
210 220 230 240 250
RRALASHAAT LSIPAECHPN YLVAAEQFAK SWADDNLPRK FRIYPIAVQE
260 270 280 290 300
SSCMEYSRAQ GGLLQSFRKG FVGYDPAAPS ADPDDLELAK ERGFSRIRAS
310 320 330 340 350
WYSTFRYRGE LKSTNQSLEA RVAVVPERGF KARIVTTHSA SRVTFGHQFR
360 370 380 390 400
RYLLQGIRRH PALVDVIGGD HRRAVETMDG DFGLLRPDGR LLSADLTSAS
410 420 430 440 450
DRIPHDLVKA ILRGIFSDPD RRPPGTSLAD VFDLVLGPYH LHYPDGSEVT
460 470 480 490 500
VRQGILMGLP TTWPLLCLIH LFWVELSDWA PARPNHSRGF VLGESFRICG
510 520 530 540 550
DDLIAWWRPE RIALYNQIAV DCGAQFSAGK HLESKTWGIF TEKVFTVKPV
560 570 580 590 600
KMKVRVRSEP SLKGYVFSRS SAFSCRMGGK GITGIRAARL YTIGAMPRWS
610 620 630 640 650
RRIRDVYPGS LEHRTASQRY GEPVTVYRFG RWSSAIPLRW AVRAPTRTVG
660 670 680 690 700
NPVQSLPDWF TVGPAASSVA ADSNAFGAVS RVLRRMFPGL PRKLASAGIP
710 720 730 740 750
PYLPRVFGGG GLVKSTGLTT KIGAVASRRW MSRIGHDLYR SRERKSTLGR
760 770 780 790 800
VWTLSTSPAY AASLHEVEKF MDRPDIILTR KCRNPMLKHA RELGLFEEVF
810 820 830 840 850
ESRVGGGILW ASLNGKALVE SHSPSILQVS RNLRRSLACP SGGFLRPSAP
860 870 880 890 900
IGKLVQRHTL PRGTVWFLES SATDSARQGG MGLPPPPPPP LGGGGMAGPP
910 920 930 940
PPPFMGLRPE SSVPTSVPFT PSMFSERLAA LESLFGRPPP S
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U90136 Genomic RNA Translation: AAC98708.1 |
PIRi | A38149 |
RefSeqi | NP_660177.1, NC_004050.1 |
Genome annotation databases
GeneIDi | 949220 |
KEGGi | vg:949220 |
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U90136 Genomic RNA Translation: AAC98708.1 |
PIRi | A38149 |
RefSeqi | NP_660177.1, NC_004050.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
GeneIDi | 949220 |
KEGGi | vg:949220 |
Family and domain databases
InterProi | View protein in InterPro IPR043502, DNA/RNA_pol_sf |
SUPFAMi | SSF56672, SSF56672, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RDRP_SCV23 | |
Accessioni | Q07048Primary (citable) accession number: Q07048 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 3, 2007 |
Last sequence update: | May 1, 1999 | |
Last modified: | September 29, 2021 | |
This is version 69 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |