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UniProtKB - Q07048 (RDRP_SCV23)

Entry version 69 (29 Sep 2021)
Sequence version 2 (01 May 1999)
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Protein

RNA-directed RNA polymerase

Gene
N/A
Organism
Saccharomyces 23S RNA narnavirus (ScNV-23S)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-directed RNA polymerase that replicates the viral (+) and (-) genome.

Miscellaneous

Yeast strains also contain a double-stranded RNA (dsRNA) called T. The (+)-strand of T is identical to the single-stranded 23S RNA. The T dsRNA seems to be a by-product of the viral RNA replication cycle.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, Ribonucleoprotein, RNA-binding, RNA-directed RNA polymerase, Transferase
Biological processViral RNA replication

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Alternative name(s):
p104
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces 23S RNA narnavirus (ScNV-23S)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri198599 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Riboviria › Orthornavirae › Lenarviricota › Amabiliviricetes › Wolframvirales › Narnaviridae › Narnavirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiSaccharomyces cerevisiae (Baker's yeast) [TaxID: 4932]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007190 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

  • Host cytoplasm 1 Publication
    • Note: The virus has no extracellular transmission pathway. It exists as a ribonucleoprotein viral particle in the host cytoplasm and can be transmitted through mating or cytoplasmic mixing (cytoduction).

Keywords - Cellular componenti

Host cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002836521 – 941RNA-directed RNA polymeraseAdd BLAST941

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a ribonucleoprotein complex with the 23S RNA, where a single polymerase molecule binds to a single viral RNA genome. Since the viral RNA is not encapsidated, ribonucleoprotein complex formation appears to be the strategy to survive in the host as persistent virus.

2 Publications

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni875 – 918DisorderedSequence analysisAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi881 – 908Pro residuesSequence analysisAdd BLAST28

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR043502, DNA/RNA_pol_sf

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56672, SSF56672, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q07048-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHHKVNVKTQ REVHFPMDLL QACGASAPRP VARVSRATDL DRRYRCVLSL 
        60         70         80         90        100
PEERARSVGC KWSSTRAALR RGLEELGSRE FRRRLRLADD CWRAICAAVC 
       110        120        130        140        150
TGRKFPSFSV TDRPARARLA KVYRMGRRLL VGVVCRGESV VSDLKQECAD 
       160        170        180        190        200
LRRVIFEGST RIPSSSLWGL VGVLGWTSPE RAMQLTFIGR ALPYGSPDVE 
       210        220        230        240        250
RRALASHAAT LSIPAECHPN YLVAAEQFAK SWADDNLPRK FRIYPIAVQE 
       260        270        280        290        300
SSCMEYSRAQ GGLLQSFRKG FVGYDPAAPS ADPDDLELAK ERGFSRIRAS 
       310        320        330        340        350
WYSTFRYRGE LKSTNQSLEA RVAVVPERGF KARIVTTHSA SRVTFGHQFR 
       360        370        380        390        400
RYLLQGIRRH PALVDVIGGD HRRAVETMDG DFGLLRPDGR LLSADLTSAS 
       410        420        430        440        450
DRIPHDLVKA ILRGIFSDPD RRPPGTSLAD VFDLVLGPYH LHYPDGSEVT 
       460        470        480        490        500
VRQGILMGLP TTWPLLCLIH LFWVELSDWA PARPNHSRGF VLGESFRICG 
       510        520        530        540        550
DDLIAWWRPE RIALYNQIAV DCGAQFSAGK HLESKTWGIF TEKVFTVKPV 
       560        570        580        590        600
KMKVRVRSEP SLKGYVFSRS SAFSCRMGGK GITGIRAARL YTIGAMPRWS 
       610        620        630        640        650
RRIRDVYPGS LEHRTASQRY GEPVTVYRFG RWSSAIPLRW AVRAPTRTVG 
       660        670        680        690        700
NPVQSLPDWF TVGPAASSVA ADSNAFGAVS RVLRRMFPGL PRKLASAGIP 
       710        720        730        740        750
PYLPRVFGGG GLVKSTGLTT KIGAVASRRW MSRIGHDLYR SRERKSTLGR 
       760        770        780        790        800
VWTLSTSPAY AASLHEVEKF MDRPDIILTR KCRNPMLKHA RELGLFEEVF 
       810        820        830        840        850
ESRVGGGILW ASLNGKALVE SHSPSILQVS RNLRRSLACP SGGFLRPSAP 
       860        870        880        890        900
IGKLVQRHTL PRGTVWFLES SATDSARQGG MGLPPPPPPP LGGGGMAGPP 
       910        920        930        940 
PPPFMGLRPE SSVPTSVPFT PSMFSERLAA LESLFGRPPP S
Length:941
Mass (Da):104,297
Last modified:May 1, 1999 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7FB9CED5D4442D11
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U90136 Genomic RNA Translation: AAC98708.1

Protein sequence database of the Protein Information Resource

More...PIRi		A38149

NCBI Reference Sequences

More...RefSeqi		NP_660177.1, NC_004050.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		949220

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		vg:949220

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90136 Genomic RNA Translation: AAC98708.1
PIRiA38149
RefSeqiNP_660177.1, NC_004050.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

GeneIDi949220
KEGGivg:949220

Family and domain databases

InterProiView protein in InterPro
IPR043502, DNA/RNA_pol_sf
SUPFAMiSSF56672, SSF56672, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRDRP_SCV23
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q07048
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: May 1, 1999
Last modified: September 29, 2021
This is version 69 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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