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Entry version 198 (18 Sep 2019)
Sequence version 1 (01 Feb 1995)
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Protein

Complement component 1 Q subcomponent-binding protein, mitochondrial

Gene

C1QBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular "heads" of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK. Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-type or response. By acting as C1q receptor is involved in chemotaxis of immature dendritic cells and neutrophils and is proposed to signal through CD209/DC-SIGN on immature dendritic cells, through integrin alpha-4/beta-1 during trophoblast invasion of the decidua, and through integrin beta-1 during endothelial cell adhesion and spreading. Signaling involved in inhibition of innate immune response is implicating the PI3K-AKT/PKB pathway. Required for protein synthesis in mitochondria (PubMed:28942965). In mitochondrial translation may be involved in formation of functional 55S mitoribosomes; the function seems to involve its RNA-binding activity. May be involved in the nucleolar ribosome maturation process; the function may involve the exchange of FBL for RRP1 in the association with pre-ribosome particles. Involved in regulation of RNA splicing by inhibiting the RNA-binding capacity of SRSF1 and its phosphorylation. Is required for the nuclear translocation of splicing factor U2AF1L4. Involved in regulation of CDKN2A- and HRK-mediated apoptosis. Stabilizes mitochondrial CDKN2A isoform smARF. May be involved in regulation of FOXC1 transcriptional activity and NFY/CCAAT-binding factor complex-mediated transcription. May play a role in antibacterial defense as it can bind to cell surface hyaluronan and inhibit Streptococcus pneumoniae hyaluronate lyase. May be involved in modulation of the immune response; ligation by HCV core protein is resulting in suppression of interleukin-12 production in monocyte-derived dendritic cells. Involved in regulation of antiviral response by inhibiting DDX58- and IFIH1-mediated signaling pathways probably involving its association with MAVS after viral infection.20 Publications
(Microbial infection) Involved in HIV-1 replication, presumably by contributing to splicing of viral RNA.1 Publication
(Microbial infection) In infection processes acts as an attachment site for microbial proteins, including Listeria monocytogenes internalin B (InlB) and Staphylococcus aureus protein A.3 Publications
(Microbial infection) Involved in replication of Rubella virus.1 Publication

Caution

The subcellular location has been matter of debate. After being reported to be exclusively localized to mitochondria, demonstrations of promiscuous associations and locations were considered as artifactual due to the extremely acidic character and the use of different tagged versions of the protein (PubMed:9305894, PubMed:11493647). However, its location to multiple compartments linked to diverse functions is now accepted. The N-termini of the surface and secreted forms are identical to the reported processed mitochondrial form.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAdaptive immunity, Apoptosis, Complement pathway, Host-virus interaction, Immunity, Innate immunity, mRNA processing, mRNA splicing, Ribosome biogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q07021

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.B.103.1.1 the putative ca(2+) uniporter (gc1qr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Complement component 1 Q subcomponent-binding protein, mitochondrial
Alternative name(s):
ASF/SF2-associated protein p32
Glycoprotein gC1qBP
Short name:
C1qBP
Hyaluronan-binding protein 1
Mitochondrial matrix protein p32
gC1q-R protein
p33
Short name:
SF2AP321 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C1QBP
Synonyms:GC1QBP, HABP1, SF2P32
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1243 C1QBP

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601269 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q07021

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Mitochondrion, Nucleus, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Combined oxidative phosphorylation deficiency 33 (COXPD33)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder caused by multiple mitochondrial respiratory chain defects and impaired mitochondrial energy metabolism. Clinical manifestations are highly variable. Affected infants present with cardiomyopathy accompanied by multisystemic features involving liver, kidney, and brain. Death in infancy is observed in some patients. Children and adults present with myopathy and progressive external ophthalmoplegia.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_080391186C → S in COXPD33; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs748497469EnsemblClinVar.1
Natural variantiVAR_080392188Missing in COXPD33; unknown pathological significance. 1 Publication1
Natural variantiVAR_080393204F → L in COXPD33; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs767427194EnsemblClinVar.1
Natural variantiVAR_080394247G → W in COXPD33. 1 Publication1
Natural variantiVAR_080395275L → F in COXPD33; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1555532484EnsemblClinVar.1
Natural variantiVAR_080396275L → P in COXPD33. 1 PublicationCorresponds to variant dbSNP:rs1555532483EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi107G → D: Impairs HIV RNA splicing in mouse cells. 1 Publication1

Keywords - Diseasei

Disease mutation, Primary mitochondrial disease

Organism-specific databases

DisGeNET

More...
DisGeNETi
708

MalaCards human disease database

More...
MalaCardsi
C1QBP
MIMi617713 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000108561

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25624

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB09130 Copper
DB08818 Hyaluronic acid

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C1QBP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
730772

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 73MitochondrionCombined sources2 PublicationsAdd BLAST73
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001859074 – 282Complement component 1 Q subcomponent-binding protein, mitochondrialAdd BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei87PhosphoserineCombined sources1
Modified residuei91N6-acetyllysineCombined sources1
Modified residuei188PhosphotyrosineCombined sources1
Modified residuei201PhosphoserineCombined sources1
Modified residuei205PhosphoserineCombined sources1
Modified residuei214PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

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CPTACi
CPTAC-176

Encyclopedia of Proteome Dynamics

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EPDi
Q07021

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q07021

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q07021

MaxQB - The MaxQuant DataBase

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MaxQBi
Q07021

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q07021

PeptideAtlas

More...
PeptideAtlasi
Q07021

PRoteomics IDEntifications database

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PRIDEi
Q07021

ProteomicsDB human proteome resource

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ProteomicsDBi
58500

Consortium for Top Down Proteomics

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TopDownProteomicsi
Q07021

2D gel databases

DOSAC-COBS 2D-PAGE database

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DOSAC-COBS-2DPAGEi
Q07021

USC-OGP 2-DE database

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OGPi
Q07021

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q07021

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q07021

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q07021

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q07021

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed on cell surface of peripheral blood cells (at protein level); Surface expression is reported for macrophages and monocyte-derived dendritic cells.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Enhanced cell surface expression upon platelet and monocyte activation.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000108561 Expressed in 222 organ(s), highest expression level in frontal cortex

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q07021 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q07021 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA026483

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer; three monomers form a donut-shaped structure with an unusually asymmetric charge distribution on the surface.

Interacts with CDK13, HRK, VTN, NFYB, ADRA1B, FOXC1, DDX21, DDX50, NCL, SRSF1, SRSF9 and CDKN2A isoform smARF.

Interacts with CD93; the association may represent a cell surface C1q receptor.

Interacts with KRT1; the association represents a cell surface kininogen receptor.

Interacts with CD209; the interaction is indicative for a C1q:C1QBP:CD209 signaling complex.

Interacts with FBL and RRP1; the respective interactions with C1QBP are competetive. Probably associates with the mitoribosome.

Interacts with MAVS; the interaction occurs upon viral transfection.

Interacts with PPIF.

Interacts with U2AF1L4.

Interacts with PLEKHN1 (PubMed:18191643).

Interacts with VGF-derived peptide TLQP-21 (By similarity).

By similarity15 Publications

(Microbial infection)

Interacts with Rubella virus capsid protein; the interaction occurs in mitochondria (PubMed:10823864, PubMed:12034482).

Interacts with Rubella virus protease/methyltransferase p150 (PubMed:22238231).

3 Publications

(Microbial infection)

Interacts with Staphylococcus aureus protein A/spa.

1 Publication

(Microbial infection)

Interacts with Staphylococcus aureus protein A/spa, HIV-1 Tat and HCV core protein.

1 Publication

(Microbial infection)

Interacts with HIV-1 Tat and HCV core protein.

1 Publication

(Microbial infection)

Interacts with L.monocytogenes internalin B.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107169, 355 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q07021

Database of interacting proteins

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DIPi
DIP-31164N

Protein interaction database and analysis system

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IntActi
Q07021, 139 interactors

Molecular INTeraction database

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MINTi
Q07021

STRING: functional protein association networks

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STRINGi
9606.ENSP00000225698

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1282
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q07021

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q07021

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni76 – 93C1q bindingAdd BLAST18
Regioni168 – 213Interaction with MAVS1 PublicationAdd BLAST46

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MAM33 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4024 Eukaryota
ENOG4111G4Z LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000018406

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000046272

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q07021

KEGG Orthology (KO)

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KOi
K15414

Identification of Orthologs from Complete Genome Data

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OMAi
ATHYEHS

Database of Orthologous Groups

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OrthoDBi
888304at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q07021

TreeFam database of animal gene trees

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TreeFami
TF315160

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.10.280.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003428 MAM33
IPR036561 MAM33_sf

The PANTHER Classification System

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PANTHERi
PTHR10826 PTHR10826, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF02330 MAM33, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54529 SSF54529, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q07021-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPLLRCVPR VLGSSVAGLR AAAPASPFRQ LLQPAPRLCT RPFGLLSVRA
60 70 80 90 100
GSERRPGLLR PRGPCACGCG CGSLHTDGDK AFVDFLSDEI KEERKIQKHK
110 120 130 140 150
TLPKMSGGWE LELNGTEAKL VRKVAGEKIT VTFNINNSIP PTFDGEEEPS
160 170 180 190 200
QGQKVEEQEP ELTSTPNFVV EVIKNDDGKK ALVLDCHYPE DEVGQEDEAE
210 220 230 240 250
SDIFSIREVS FQSTGESEWK DTNYTLNTDS LDWALYDHLM DFLADRGVDN
260 270 280
TFADELVELS TALEHQEYIT FLEDLKSFVK SQ
Length:282
Mass (Da):31,362
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2F747FA73BB1314B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L3Q7I3L3Q7_HUMAN
Complement component 1 Q subcompone...
C1QBP
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3B0I3L3B0_HUMAN
Complement component 1 Q subcompone...
C1QBP hCG_2040042
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JLC0A0A0G2JLC0_HUMAN
Complement component 1 Q subcompone...
C1QBP
9Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_080391186C → S in COXPD33; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs748497469EnsemblClinVar.1
Natural variantiVAR_080392188Missing in COXPD33; unknown pathological significance. 1 Publication1
Natural variantiVAR_080393204F → L in COXPD33; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs767427194EnsemblClinVar.1
Natural variantiVAR_080394247G → W in COXPD33. 1 Publication1
Natural variantiVAR_080395275L → F in COXPD33; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1555532484EnsemblClinVar.1
Natural variantiVAR_080396275L → P in COXPD33. 1 PublicationCorresponds to variant dbSNP:rs1555532483EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
L04636 mRNA Translation: AAA16315.1
X75913 mRNA Translation: CAA53512.1
AF338439 Genomic DNA Translation: AAK26580.1
BT019898 mRNA Translation: AAV38701.1
BT019899 mRNA Translation: AAV38702.1
DQ372108 Genomic DNA Translation: ABC79624.1
BC000435 mRNA Translation: AAH00435.1
BC013731 mRNA Translation: AAH13731.1
M69039 mRNA Translation: AAA73055.1
AF275902 mRNA Translation: AAF78763.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11071.1

Protein sequence database of the Protein Information Resource

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PIRi
JT0762

NCBI Reference Sequences

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RefSeqi
NP_001203.1, NM_001212.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000225698; ENSP00000225698; ENSG00000108561

Database of genes from NCBI RefSeq genomes

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GeneIDi
708

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:708

UCSC genome browser

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UCSCi
uc002gby.2 human

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04636 mRNA Translation: AAA16315.1
X75913 mRNA Translation: CAA53512.1
AF338439 Genomic DNA Translation: AAK26580.1
BT019898 mRNA Translation: AAV38701.1
BT019899 mRNA Translation: AAV38702.1
DQ372108 Genomic DNA Translation: ABC79624.1
BC000435 mRNA Translation: AAH00435.1
BC013731 mRNA Translation: AAH13731.1
M69039 mRNA Translation: AAA73055.1
AF275902 mRNA Translation: AAF78763.1
CCDSiCCDS11071.1
PIRiJT0762
RefSeqiNP_001203.1, NM_001212.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1P32X-ray2.25A/B/C74-282[»]
3RPXX-ray2.65A/B/C96-282[»]
SMRiQ07021
ModBaseiSearch...

Protein-protein interaction databases

BioGridi107169, 355 interactors
CORUMiQ07021
DIPiDIP-31164N
IntActiQ07021, 139 interactors
MINTiQ07021
STRINGi9606.ENSP00000225698

Chemistry databases

DrugBankiDB09130 Copper
DB08818 Hyaluronic acid

Protein family/group databases

TCDBi9.B.103.1.1 the putative ca(2+) uniporter (gc1qr) family

PTM databases

iPTMnetiQ07021
PhosphoSitePlusiQ07021
SwissPalmiQ07021

Polymorphism and mutation databases

BioMutaiC1QBP
DMDMi730772

2D gel databases

DOSAC-COBS-2DPAGEiQ07021
OGPiQ07021

Proteomic databases

CPTACiCPTAC-176
EPDiQ07021
jPOSTiQ07021
MassIVEiQ07021
MaxQBiQ07021
PaxDbiQ07021
PeptideAtlasiQ07021
PRIDEiQ07021
ProteomicsDBi58500
TopDownProteomicsiQ07021

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
708
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225698; ENSP00000225698; ENSG00000108561
GeneIDi708
KEGGihsa:708
UCSCiuc002gby.2 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
708
DisGeNETi708

GeneCards: human genes, protein and diseases

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GeneCardsi
C1QBP
HGNCiHGNC:1243 C1QBP
HPAiHPA026483
MalaCardsiC1QBP
MIMi601269 gene
617713 phenotype
neXtProtiNX_Q07021
OpenTargetsiENSG00000108561
PharmGKBiPA25624

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4024 Eukaryota
ENOG4111G4Z LUCA
GeneTreeiENSGT00390000018406
HOGENOMiHOG000046272
InParanoidiQ07021
KOiK15414
OMAiATHYEHS
OrthoDBi888304at2759
PhylomeDBiQ07021
TreeFamiTF315160

Enzyme and pathway databases

ReactomeiR-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation
SIGNORiQ07021

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
C1QBP human
EvolutionaryTraceiQ07021

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
C1QBP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
708

Pharos

More...
Pharosi
Q07021
PMAP-CutDBiQ07021

Protein Ontology

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PROi
PR:Q07021

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000108561 Expressed in 222 organ(s), highest expression level in frontal cortex
ExpressionAtlasiQ07021 baseline and differential
GenevisibleiQ07021 HS

Family and domain databases

Gene3Di3.10.280.10, 1 hit
InterProiView protein in InterPro
IPR003428 MAM33
IPR036561 MAM33_sf
PANTHERiPTHR10826 PTHR10826, 1 hit
PfamiView protein in Pfam
PF02330 MAM33, 1 hit
SUPFAMiSSF54529 SSF54529, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC1QBP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q07021
Secondary accession number(s): Q2HXR8, Q9NNY8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 18, 2019
This is version 198 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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