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Protein

60S ribosomal protein L18

Gene

RPL18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the large ribosomal subunit.1 Publication3 Publications

GO - Molecular functioni

  • RNA binding Source: ProtInc
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L18
Alternative name(s):
Large ribosomal subunit protein eL181 Publication
Gene namesi
Name:RPL18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000063177.12
HGNCiHGNC:10310 RPL18
MIMi604179 gene
neXtProtiNX_Q07020

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi6141
MalaCardsiRPL18
OpenTargetsiENSG00000063177
PharmGKBiPA34679

Polymorphism and mutation databases

BioMutaiRPL18

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001327692 – 18860S ribosomal protein L18Add BLAST187

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki119Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei130PhosphoserineCombined sources1
Modified residuei158PhosphothreonineCombined sources1
Cross-linki164Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ07020
MaxQBiQ07020
PaxDbiQ07020
PeptideAtlasiQ07020
PRIDEiQ07020
ProteomicsDBi58499
TopDownProteomicsiQ07020-1 [Q07020-1]

2D gel databases

SWISS-2DPAGEiQ07020

PTM databases

iPTMnetiQ07020
PhosphoSitePlusiQ07020
SwissPalmiQ07020

Expressioni

Gene expression databases

BgeeiENSG00000063177
CleanExiHS_RPL18
ExpressionAtlasiQ07020 baseline and differential
GenevisibleiQ07020 HS

Organism-specific databases

HPAiHPA046572

Interactioni

Subunit structurei

Component of the large ribosomal subunit.1 Publication3 Publications

Protein-protein interaction databases

BioGridi112061, 276 interactors
CORUMiQ07020
IntActiQ07020, 34 interactors
MINTiQ07020
STRINGi9606.ENSP00000447001

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LQ1-188[»]
4V6Xelectron microscopy5.00CQ1-188[»]
5AJ0electron microscopy3.50AQ1-188[»]
5LKSelectron microscopy3.60LQ1-188[»]
5T2Celectron microscopy3.60K1-188[»]
6EK0electron microscopy2.90LQ1-188[»]
ProteinModelPortaliQ07020
SMRiQ07020
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1714 Eukaryota
COG1727 LUCA
GeneTreeiENSGT00390000012976
HOGENOMiHOG000213425
HOVERGENiHBG000875
InParanoidiQ07020
KOiK02883
PhylomeDBiQ07020
TreeFamiTF300202

Family and domain databases

InterProiView protein in InterPro
IPR036227 L18e/L15P_sf
IPR000039 Ribosomal_L18e
IPR021131 Ribosomal_L18e/L15P
IPR021132 Ribosomal_L18e_CS
PANTHERiPTHR10934 PTHR10934, 1 hit
PfamiView protein in Pfam
PF17135 Ribosomal_L18, 1 hit
SUPFAMiSSF52080 SSF52080, 1 hit
PROSITEiView protein in PROSITE
PS01106 RIBOSOMAL_L18E, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q07020-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGVDIRHNKD RKVRRKEPKS QDIYLRLLVK LYRFLARRTN STFNQVVLKR
60 70 80 90 100
LFMSRTNRPP LSLSRMIRKM KLPGRENKTA VVVGTITDDV RVQEVPKLKV
110 120 130 140 150
CALRVTSRAR SRILRAGGKI LTFDQLALDS PKGCGTVLLS GPRKGREVYR
160 170 180
HFGKAPGTPH SHTKPYVRSK GRKFERARGR RASRGYKN
Length:188
Mass (Da):21,634
Last modified:January 23, 2007 - v2
Checksum:iC4E416E7A5329B7C
GO
Isoform 2 (identifier: Q07020-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-30: MGVDIRHNKDRKVRRKEPKSQDIYLRLLVK → M

Note: No experimental confirmation available. Based on EST data.
Show »
Length:159
Mass (Da):18,091
Checksum:i1F622F3CD8BABC8E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62S → C in AAH21743 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0551701 – 30MGVDI…RLLVK → M in isoform 2. CuratedAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11566 mRNA Translation: AAA16329.1
AB061825 Genomic DNA Translation: BAB79463.1
AC022154 Genomic DNA No translation available.
BC000374 mRNA Translation: AAH00374.1
BC009708 mRNA Translation: AAH09708.1
BC021743 mRNA Translation: AAH21743.1
CCDSiCCDS12726.1 [Q07020-1]
CCDS58669.1 [Q07020-2]
PIRiS38352
RefSeqiNP_000970.1, NM_000979.3 [Q07020-1]
NP_001257419.1, NM_001270490.1 [Q07020-2]
UniGeneiHs.515517

Genome annotation databases

EnsembliENST00000549920; ENSP00000447001; ENSG00000063177 [Q07020-1]
ENST00000552588; ENSP00000449204; ENSG00000063177 [Q07020-2]
GeneIDi6141
KEGGihsa:6141
UCSCiuc002pjq.3 human [Q07020-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRL18_HUMAN
AccessioniPrimary (citable) accession number: Q07020
Secondary accession number(s): F8VWC5, Q8WTZ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 174 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

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