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UniProtKB - Q07017 (OL56_STRAT)
Protein
Oleandomycin polyketide synthase, modules 5 and 6
Gene
orfB
Organism
Streptomyces antibioticus
Status
Functioni
May be involved in the biosynthesis of the oleandomycin lactone ring.
Cofactori
pantetheine 4'-phosphateNote: Binds 2 phosphopantetheines covalently.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 210 | For beta-ketoacyl synthase 1 activity | 1 | |
Active sitei | 660 | Acyl-ester intermediate | 1 | |
Active sitei | 1859 | For beta-ketoacyl synthase 2 activity | 1 | |
Active sitei | 2311 | Acyl-ester intermediate | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 1203 – 1249 | NADPAdd BLAST | 47 | |
Nucleotide bindingi | 2859 – 2905 | NADPAdd BLAST | 47 |
GO - Molecular functioni
- 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: InterPro
- phosphopantetheine binding Source: InterPro
GO - Biological processi
- antibiotic biosynthetic process Source: UniProtKB-KW
- fatty acid biosynthetic process Source: InterPro
Keywordsi
Molecular function | Acyltransferase, Multifunctional enzyme, Transferase |
Biological process | Antibiotic biosynthesis |
Ligand | NADP |
Protein family/group databases
ESTHERi | strat-ol56, Thioesterase |
Names & Taxonomyi
Protein namesi | Recommended name: Oleandomycin polyketide synthase, modules 5 and 6 |
Gene namesi | Name:orfB |
Organismi | Streptomyces antibioticus |
Taxonomic identifieri | 1890 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Streptomycetales › Streptomycetaceae › Streptomyces |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000180297 | 1 – 3519 | Oleandomycin polyketide synthase, modules 5 and 6Add BLAST | 3519 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1524 | O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation | 1 | |
Modified residuei | 3178 | O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation | 1 |
Keywords - PTMi
Phosphopantetheine, PhosphoproteinProteomic databases
PRIDEi | Q07017 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1489 – 1564 | Carrier 1PROSITE-ProRule annotationAdd BLAST | 76 | |
Domaini | 3143 – 3218 | Carrier 2PROSITE-ProRule annotationAdd BLAST | 76 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | ? – 3519 | Module 6 | ||
Regioni | 1 – ? | Module 5 | ||
Regioni | 32 – 501 | Beta-ketoacyl synthase 1Add BLAST | 470 | |
Regioni | 569 – 890 | Acyltransferase (AT) 1Add BLAST | 322 | |
Regioni | 1200 – 1382 | Beta-ketoacyl reductase 1Add BLAST | 183 | |
Regioni | 1686 – 2156 | Beta-ketoacyl synthase 2Add BLAST | 471 | |
Regioni | 2220 – 2541 | Acyltransferase (AT) 2Add BLAST | 322 | |
Regioni | 2856 – 3038 | Beta-ketoacyl reductase 2Add BLAST | 183 | |
Regioni | 3224 – 3245 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 3270 – 3519 | ThioesteraseAdd BLAST | 250 |
Keywords - Domaini
RepeatFamily and domain databases
Gene3Di | 1.10.1200.10, 2 hits 3.40.366.10, 2 hits 3.40.47.10, 2 hits 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR001227, Ac_transferase_dom_sf IPR036736, ACP-like_sf IPR014043, Acyl_transferase IPR016035, Acyl_Trfase/lysoPLipase IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR016036, Malonyl_transacylase_ACP-bd IPR036291, NAD(P)-bd_dom_sf IPR032821, PKS_assoc IPR020841, PKS_Beta-ketoAc_synthase_dom IPR041618, PKS_DE IPR013968, PKS_KR IPR020806, PKS_PP-bd IPR020802, PKS_thioesterase IPR015083, Polyketide_synth_docking IPR036299, Polyketide_synth_docking_sf IPR009081, PP-bd_ACP IPR006162, Ppantetheine_attach_site IPR001031, Thioesterase IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF00698, Acyl_transf_1, 2 hits PF08990, Docking, 1 hit PF16197, KAsynt_C_assoc, 2 hits PF00109, ketoacyl-synt, 2 hits PF02801, Ketoacyl-synt_C, 2 hits PF08659, KR, 2 hits PF18369, PKS_DE, 2 hits PF00550, PP-binding, 2 hits PF00975, Thioesterase, 1 hit |
SMARTi | View protein in SMART SM00827, PKS_AT, 2 hits SM00825, PKS_KS, 2 hits SM00823, PKS_PP, 2 hits SM00824, PKS_TE, 1 hit |
SUPFAMi | SSF101173, SSF101173, 1 hit SSF47336, SSF47336, 1 hit SSF51735, SSF51735, 4 hits SSF52151, SSF52151, 2 hits SSF53474, SSF53474, 1 hit SSF53901, SSF53901, 2 hits SSF55048, SSF55048, 2 hits |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 2 hits PS50075, CARRIER, 2 hits PS00012, PHOSPHOPANTETHEINE, 2 hits |
i Sequence
Sequence statusi: Complete.
Q07017-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEAEKLREY LWRATTELKE VSDRLRETEE RAREPIAIVG MSCRFPGGGD
60 70 80 90 100
ATVNTPEQFW DLLNSGGDGI AGLPEDRGWD LGRLYDPDPD RAGTSYVREG
110 120 130 140 150
GFLYDSGEFD AAFFGISPRE ALAMDPQQRL LLETSWEAFE SAGIKRAALR
160 170 180 190 200
GSDTGVYIGA WSTGYAGSPY RLVEGLEGQL AIGTTLGAAS GRVAYTFGLE
210 220 230 240 250
GPAVTVDTAC SSSLVALHLA VQGLRRGECS LALVGGVTVM SSPVTLTTFS
260 270 280 290 300
RQRGLSVDGR CKAFPASADG FGAAEGVGVL LVERLSDARR LGHRVLAVVR
310 320 330 340 350
GSAVNQDGAS NGLTAPNGPS QQRVIRAALA DAGLAPADVD VVEAHGTGTR
360 370 380 390 400
LGDPIEAQAL LATYGQGRAG GRPVWLGSVK SNIGHTQAAA GVAGVMKMVL
410 420 430 440 450
ALGRGVVPKT LHVDEPSPHV DWSAGAVELL TEERPWEPEA ERLRRAGISA
460 470 480 490 500
FGVSGTNAHV IVEEAPAEPE PEPGTRVVAA GDLVVPWVVS GRDARALRAQ
510 520 530 540 550
AARLAAHVSG VSAVDVGWSL VATRSVFEHR AVAIGSELDS MAGSLAGFAA
560 570 580 590 600
GGVVPGVVSG VAPAEGRRVV FVFPGQGSQW VGMAAGLLDA CPVFAEAVAE
610 620 630 640 650
CAAVLDPVTG WSLVEVLQGR DATVLGRVDV VQPALWAVMV SLARTWRYYG
660 670 680 690 700
VEPAAVVGHS QGEIAAACVA GGLSLADGAR VVVLRSRAIA RIAGGGGMVS
710 720 730 740 750
VSLPAGRVRT MLEEFDGRLS VAAVNGPSST VVSGDVQALD ELLAGCEREG
760 770 780 790 800
VRARRVPVDY ASHSAQMDQL RDELLEALAD ITPQDSSVPF FSTVTADWLG
810 820 830 840 850
TTALGAGYWF TNLRETVRFQ EAVEGLVAQG MGAFVECSPH PVLVPGIEQT
860 870 880 890 900
LDALDQNAAV FGSLRRDEGG LDRFLTSLAE AFVQGVPVDW SRAFEGVTPR
910 920 930 940 950
TVDLPTYPFQ RQHYWLMAEE APVSQPPHSE NSFWSVVADA DAEAAAELLG
960 970 980 990 1000
VDVEAVEAVM PALSSWHRQS QLRAEVNQWR YDVAWKRLTT GALPEKPGNW
1010 1020 1030 1040 1050
LVVTPAGTDT TFAESLARTA AAELGVSVSF AQVDTAHPDR SQYAHALRQA
1060 1070 1080 1090 1100
LTGPENVDHL VSLLALDQAT DDLAAAPSCL AASLVLAQAL VDLGRVGEGP
1110 1120 1130 1140 1150
RLWLVTRGAV VAGPSDAGAV IDPVQAQVWG FGRVLGLEHP ELWGGLIDLP
1160 1170 1180 1190 1200
VGVDEEVCRR FVGVVASAGF EDQVAVRGSG VWVRRLVRAV VDGGGGGWRP
1210 1220 1230 1240 1250
RGTVLVTGGL GGLGAHTARW LVGGGADHVV LVSRRGGSAP GAGDLVRELE
1260 1270 1280 1290 1300
GLGGARVSVR ACDVADRVAL RALLSDLGEP VTAVFHAAGV PQSTPLAEIS
1310 1320 1330 1340 1350
VQEAADVMAA KVAGAVNLGE LVDPCGLEAF VLFSSNAGVW GSGGQAVYAA
1360 1370 1380 1390 1400
ANAFLDALAV RRRGVGLPAT SVAWGMWAGE GMASVGGAAR ELSRRGVRAM
1410 1420 1430 1440 1450
DPERAVAVMA DAVGRGEAFV AVADVDWERF VTGFASARPR PLISDLPEVR
1460 1470 1480 1490 1500
AVVEGQVQGR GQGLGLVGEE ESSGWLKRLS GLSRVRQEEE LVELVRAQAA
1510 1520 1530 1540 1550
VVLGHGSAQD VPAERAFKEL GFDSLTAVEL RNGLAAATGI RLPATMAFDH
1560 1570 1580 1590 1600
PNATAIARFL QSQLLPDAES ESAVPSSPED EVRQALASLS LDQLKGAGLL
1610 1620 1630 1640 1650
DPLLALTRLR EINSTVQNPE PTTESIDEMD GETCCAWRSA KSTAEPLTTG
1660 1670 1680 1690 1700
ADMPDPTAKY VEALRASLKE NERLRQQNHS LLAASREAIA ITAMSCRFGG
1710 1720 1730 1740 1750
GIDSPEDLWR FLAEGRDAVA GLPEDRGWDL DALYHPDPEN PGTTYVREGA
1760 1770 1780 1790 1800
FRYDAAQFDA GFFGISPREA LAMDPQQRLL LETSWELFER ADIDPYTVRG
1810 1820 1830 1840 1850
TATGIFIGAG HQGYGPDPKR APESVAGYLL TGTASAVLSG RISYTFGLEG
1860 1870 1880 1890 1900
PAVTVDTACS SSLVALHLAV QALRRGECSL AIAGGVAVMS TPDAFVEFSR
1910 1920 1930 1940 1950
QQGMARDGRC KAFAAAADGM GWGEGVSLLL LERLSDARRL GHRVLAVVRG
1960 1970 1980 1990 2000
SAVNQDGASN GLAAPNGPSQ QRVIRAALAD AGLAPADVDV VEAHGTGTRL
2010 2020 2030 2040 2050
GDPIEAQALL ATYGQGRAGG RPVWLGSVKS NIGHTQAAAG VAGVMKMVLA
2060 2070 2080 2090 2100
LGRGVVPKTL HVDEPSPHVD WSAGAVELLT EERPWEPEAE RLRRAGISAF
2110 2120 2130 2140 2150
GVSGTNAHVI VEEAPAEPEP EPGTRVVAAG DLVVPWVVSG RDVGALREQA
2160 2170 2180 2190 2200
ARLAAHVSST GAGVVDVGWS LVATRSVFEH RAVMVGTDLD SMAGSLAGFA
2210 2220 2230 2240 2250
AGGVVPGVVS GVAPAEGRRV VFVFPGQGSQ WVGMAAGLLD ACPVFAEAVA
2260 2270 2280 2290 2300
ECAAVLDPVT GWSLVEVLQG RDATVLGRVD VVQPALWAVM VSLARTWRYY
2310 2320 2330 2340 2350
GVEPAAVVGH SQGEIAAACV AGGLSLADGA RVVVLRSRAI ARIAGGGGMV
2360 2370 2380 2390 2400
SVSLPAGRVR TMLDTYGGRV SVAAVNGPSS TVVSGDVQAL DELLAGCERE
2410 2420 2430 2440 2450
GVRARRVPVD YASHSAQMDQ LRDELLEALA DITPQDSSVP FFSTVTADWL
2460 2470 2480 2490 2500
DTTALDAGYW FTNLRETVRF QEAVEGLVAQ GMGAFVECSP HPVLVPGIEQ
2510 2520 2530 2540 2550
TLDALDQNAA VLGSLRRDEG GLDRLLTSLA EAFVQGVPVD WTHAFEGVTP
2560 2570 2580 2590 2600
RTVDLPTYPF QRQRFWLDGS PASSANGVDG EADAMIWDAV EREDSVAVAE
2610 2620 2630 2640 2650
ELGIDAEALH TVLPALSSWR RRRVEHRRLQ DWRYRVEWKP FPAALDEVLG
2660 2670 2680 2690 2700
GGWLFVVPRG LADDGVVARV VAAVTARGGE VSVVELDPTR PDRRAYAEAV
2710 2720 2730 2740 2750
AGRGVSGVVS FLSWDDRRHS EHPVVPAGLA ASLVLAQALV DLGRVGEGPR
2760 2770 2780 2790 2800
LWLVTRDAVV AGPSDAGAVI DPVQAQVWGF GRVLGLEHPE LWGGLIDLPV
2810 2820 2830 2840 2850
EAPEPGSTCD HTYADLLATV VASAGFEDQV AVRGSGVWVR RLVRAVVDGG
2860 2870 2880 2890 2900
GGGWRPRGTV LVTGGLGGLG AHTARWLVGG GADHVVLVSR RGGSAPGAGD
2910 2920 2930 2940 2950
LVRELEGLGG ARVSVRACDV ADRVALRALL SDLGEPVTAV FHAAGVPQST
2960 2970 2980 2990 3000
PLAEISVQEA ADVMAAKVAG AVNLGELVDP CGLEAFVLFS SNAGVWGSGG
3010 3020 3030 3040 3050
QAVYAAANAF LDALAVRRRG VGLPATSVAW GMWAGEGMAS VGGAARELSR
3060 3070 3080 3090 3100
RGVRAMDPER AVAVMADAVG RGEAFVAVAD VDWERFVTGF ASARPRPLIS
3110 3120 3130 3140 3150
DLPEVRTALR NQEQEQLHAP VPEDRSAQLL RRLSMLSPAG REAELVKLVR
3160 3170 3180 3190 3200
TEAAAVLGHG SAQDVPAERA FKELGFDSLT AVQLRNRLAA ATGTRLPASA
3210 3220 3230 3240 3250
VFDHPHAAAL ARWLLAGMRH ADGGHGGGHA GGPGPDADEG RSAGAGHSGM
3260 3270 3280 3290 3300
LADLYRRSAE LGRSREFIGL LADTAAFRPV FHGPADLDAP LEAVPLADGV
3310 3320 3330 3340 3350
RKPQLICCSG TAPVGGPHEF ARLASFFRGT RAVSALPLPG YLPGEQLPAD
3360 3370 3380 3390 3400
LDAVLAAQAE AVEKQTGGAP FVLVGYSAGG LMAHALACHL AGRGTPPSGE
3410 3420 3430 3440 3450
VLVDVYPPGR QEPVFGWQKE LTEGMFAQDF VPMDDTRLTA LGTYDRLMGE
3460 3470 3480 3490 3500
WRPAPSGLPT LLIRATEPMA EWTGAIDWRA SWEYDHTAVD MPGNHFTIMR
3510
EHAEDAARHI DVWLKGLTP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L09654 Unassigned DNA Translation: AAA19695.1 |
PIRi | S43048 |
Genome annotation databases
KEGGi | ag:AAA19695 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L09654 Unassigned DNA Translation: AAA19695.1 |
PIRi | S43048 |
3D structure databases
SMRi | Q07017 |
ModBasei | Search... |
Protein family/group databases
ESTHERi | strat-ol56, Thioesterase |
Proteomic databases
PRIDEi | Q07017 |
Genome annotation databases
KEGGi | ag:AAA19695 |
Family and domain databases
Gene3Di | 1.10.1200.10, 2 hits 3.40.366.10, 2 hits 3.40.47.10, 2 hits 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR001227, Ac_transferase_dom_sf IPR036736, ACP-like_sf IPR014043, Acyl_transferase IPR016035, Acyl_Trfase/lysoPLipase IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR016036, Malonyl_transacylase_ACP-bd IPR036291, NAD(P)-bd_dom_sf IPR032821, PKS_assoc IPR020841, PKS_Beta-ketoAc_synthase_dom IPR041618, PKS_DE IPR013968, PKS_KR IPR020806, PKS_PP-bd IPR020802, PKS_thioesterase IPR015083, Polyketide_synth_docking IPR036299, Polyketide_synth_docking_sf IPR009081, PP-bd_ACP IPR006162, Ppantetheine_attach_site IPR001031, Thioesterase IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF00698, Acyl_transf_1, 2 hits PF08990, Docking, 1 hit PF16197, KAsynt_C_assoc, 2 hits PF00109, ketoacyl-synt, 2 hits PF02801, Ketoacyl-synt_C, 2 hits PF08659, KR, 2 hits PF18369, PKS_DE, 2 hits PF00550, PP-binding, 2 hits PF00975, Thioesterase, 1 hit |
SMARTi | View protein in SMART SM00827, PKS_AT, 2 hits SM00825, PKS_KS, 2 hits SM00823, PKS_PP, 2 hits SM00824, PKS_TE, 1 hit |
SUPFAMi | SSF101173, SSF101173, 1 hit SSF47336, SSF47336, 1 hit SSF51735, SSF51735, 4 hits SSF52151, SSF52151, 2 hits SSF53474, SSF53474, 1 hit SSF53901, SSF53901, 2 hits SSF55048, SSF55048, 2 hits |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 2 hits PS50075, CARRIER, 2 hits PS00012, PHOSPHOPANTETHEINE, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | OL56_STRAT | |
Accessioni | Q07017Primary (citable) accession number: Q07017 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 112 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |