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Protein

Tumor necrosis factor receptor superfamily member 9

Gene

TNFRSF9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • signaling receptor activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5669034 TNFs bind their physiological receptors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 9
Alternative name(s):
4-1BB ligand receptor
CDw137
T-cell antigen 4-1BB homolog
T-cell antigen ILA
CD_antigen: CD137
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNFRSF9
Synonyms:CD137, ILA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000049249.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11924 TNFRSF9

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602250 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q07011

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 186ExtracellularSequence analysisAdd BLAST163
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei187 – 213HelicalSequence analysisAdd BLAST27
Topological domaini214 – 255CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3604

Open Targets

More...
OpenTargetsi
ENSG00000049249

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36617

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3712857

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1878

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TNFRSF9

Domain mapping of disease mutations (DMDM)

More...
DMDMi
728738

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 231 PublicationAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003457724 – 255Tumor necrosis factor receptor superfamily member 9Add BLAST232

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi28 ↔ 37PROSITE-ProRule annotation
Disulfide bondi31 ↔ 45PROSITE-ProRule annotation
Disulfide bondi48 ↔ 62PROSITE-ProRule annotation
Disulfide bondi65 ↔ 78PROSITE-ProRule annotation
Disulfide bondi68 ↔ 86PROSITE-ProRule annotation
Disulfide bondi88 ↔ 94PROSITE-ProRule annotation
Disulfide bondi99 ↔ 106PROSITE-ProRule annotation
Disulfide bondi102 ↔ 117PROSITE-ProRule annotation
Disulfide bondi121 ↔ 133PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi138N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi139 ↔ 158PROSITE-ProRule annotation
Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q07011

PeptideAtlas

More...
PeptideAtlasi
Q07011

PRoteomics IDEntifications database

More...
PRIDEi
Q07011

ProteomicsDB human proteome resource

More...
ProteomicsDBi
58498

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q07011

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q07011

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed on the surface of activated T-cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000049249 Expressed in 82 organ(s), highest expression level in buccal mucosa cell

CleanEx database of gene expression profiles

More...
CleanExi
HS_TNFRSF9

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q07011 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q07011 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA071425

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TRAF1, TRAF2 and TRAF3. Interacts with LRR-repeat protein 1/LRR-1.3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109817, 13 interactors

Database of interacting proteins

More...
DIPi
DIP-3021N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q07011

Protein interaction database and analysis system

More...
IntActi
Q07011, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000366729

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1255
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q07011

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q07011

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati24 – 45TNFR-Cys 1Add BLAST22
Repeati47 – 86TNFR-Cys 2Add BLAST40
Repeati87 – 118TNFR-Cys 3Add BLAST32
Repeati119 – 159TNFR-Cys 4Add BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni214 – 255Interaction with LRR-1Add BLAST42

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IW3N Eukaryota
ENOG41129F9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111279

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000033708

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000021

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q07011

KEGG Orthology (KO)

More...
KOi
K05146

Identification of Orthologs from Complete Genome Data

More...
OMAi
FKQPFMR

Database of Orthologous Groups

More...
OrthoDBi
EOG091G03XW

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q07011

TreeFam database of animal gene trees

More...
TreeFami
TF336151

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13410 TNFRSF9, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR020413 TNFR_9
IPR034020 TNFRSF9_N

The PANTHER Classification System

More...
PANTHERi
PTHR23097:SF136 PTHR23097:SF136, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00020 TNFR_c6, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01924 TNFACTORR9

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00208 TNFR, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184 SSF57184, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00652 TNFR_NGFR_1, 1 hit
PS50050 TNFR_NGFR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q07011-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNSCYNIVA TLLLVLNFER TRSLQDPCSN CPAGTFCDNN RNQICSPCPP
60 70 80 90 100
NSFSSAGGQR TCDICRQCKG VFRTRKECSS TSNAECDCTP GFHCLGAGCS
110 120 130 140 150
MCEQDCKQGQ ELTKKGCKDC CFGTFNDQKR GICRPWTNCS LDGKSVLVNG
160 170 180 190 200
TKERDVVCGP SPADLSPGAS SVTPPAPARE PGHSPQIISF FLALTSTALL
210 220 230 240 250
FLLFFLTLRF SVVKRGRKKL LYIFKQPFMR PVQTTQEEDG CSCRFPEEEE

GGCEL
Length:255
Mass (Da):27,899
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF3A563FE5EF00460
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EJQ2K7EJQ2_HUMAN
Tumor necrosis factor receptor supe...
TNFRSF9
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJ11K7EJ11_HUMAN
Tumor necrosis factor receptor supe...
TNFRSF9
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01892056A → T1 PublicationCorresponds to variant dbSNP:rs9657963EnsemblClinVar.1
Natural variantiVAR_018921115K → N1 PublicationCorresponds to variant dbSNP:rs9657965Ensembl.1
Natural variantiVAR_018922176A → D1 PublicationCorresponds to variant dbSNP:rs9657979Ensembl.1
Natural variantiVAR_035478250E → G in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs776878260Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U03397 mRNA Translation: AAA53133.1
L12964 mRNA Translation: AAA62478.2
AY438976 Genomic DNA Translation: AAR05440.1
AL009183 Genomic DNA No translation available.
BC006196 mRNA Translation: AAH06196.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS92.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I38426

NCBI Reference Sequences

More...
RefSeqi
NP_001552.2, NM_001561.5
XP_011539688.1, XM_011541386.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.738942
Hs.86447

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000377507; ENSP00000366729; ENSG00000049249
ENST00000615230; ENSP00000478699; ENSG00000049249

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3604

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3604

UCSC genome browser

More...
UCSCi
uc001aot.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03397 mRNA Translation: AAA53133.1
L12964 mRNA Translation: AAA62478.2
AY438976 Genomic DNA Translation: AAR05440.1
AL009183 Genomic DNA No translation available.
BC006196 mRNA Translation: AAH06196.1
CCDSiCCDS92.1
PIRiI38426
RefSeqiNP_001552.2, NM_001561.5
XP_011539688.1, XM_011541386.2
UniGeneiHs.738942
Hs.86447

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6A3VX-ray3.39B/D/F/H/J/L/N/P/R/T/V/X24-180[»]
6A3WX-ray2.00C/F/I/L24-180[»]
6BWVX-ray2.40D/E24-160[»]
6CPRX-ray2.70D/E/F23-160[»]
6CU0X-ray3.20G/H/I/J/K/L23-160[»]
ProteinModelPortaliQ07011
SMRiQ07011
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109817, 13 interactors
DIPiDIP-3021N
ELMiQ07011
IntActiQ07011, 1 interactor
STRINGi9606.ENSP00000366729

Chemistry databases

ChEMBLiCHEMBL3712857
GuidetoPHARMACOLOGYi1878

PTM databases

iPTMnetiQ07011
PhosphoSitePlusiQ07011

Polymorphism and mutation databases

BioMutaiTNFRSF9
DMDMi728738

Proteomic databases

PaxDbiQ07011
PeptideAtlasiQ07011
PRIDEiQ07011
ProteomicsDBi58498

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3604
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377507; ENSP00000366729; ENSG00000049249
ENST00000615230; ENSP00000478699; ENSG00000049249
GeneIDi3604
KEGGihsa:3604
UCSCiuc001aot.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3604
DisGeNETi3604
EuPathDBiHostDB:ENSG00000049249.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TNFRSF9
HGNCiHGNC:11924 TNFRSF9
HPAiHPA071425
MIMi602250 gene
neXtProtiNX_Q07011
OpenTargetsiENSG00000049249
PharmGKBiPA36617

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IW3N Eukaryota
ENOG41129F9 LUCA
GeneTreeiENSGT00730000111279
HOGENOMiHOG000033708
HOVERGENiHBG000021
InParanoidiQ07011
KOiK05146
OMAiFKQPFMR
OrthoDBiEOG091G03XW
PhylomeDBiQ07011
TreeFamiTF336151

Enzyme and pathway databases

ReactomeiR-HSA-5669034 TNFs bind their physiological receptors

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CD137

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3604

Protein Ontology

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PROi
PR:Q07011

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000049249 Expressed in 82 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_TNFRSF9
ExpressionAtlasiQ07011 baseline and differential
GenevisibleiQ07011 HS

Family and domain databases

CDDicd13410 TNFRSF9, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR020413 TNFR_9
IPR034020 TNFRSF9_N
PANTHERiPTHR23097:SF136 PTHR23097:SF136, 1 hit
PfamiView protein in Pfam
PF00020 TNFR_c6, 1 hit
PRINTSiPR01924 TNFACTORR9
SMARTiView protein in SMART
SM00208 TNFR, 2 hits
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 1 hit
PS50050 TNFR_NGFR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNR9_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q07011
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: December 5, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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