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Protein

Tumor necrosis factor receptor superfamily member 9

Gene

TNFRSF9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.

GO - Molecular functioni

  • signaling receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-5669034 TNFs bind their physiological receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 9
Alternative name(s):
4-1BB ligand receptor
CDw137
T-cell antigen 4-1BB homolog
T-cell antigen ILA
CD_antigen: CD137
Gene namesi
Name:TNFRSF9
Synonyms:CD137, ILA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000049249.8
HGNCiHGNC:11924 TNFRSF9
MIMi602250 gene
neXtProtiNX_Q07011

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 186ExtracellularSequence analysisAdd BLAST163
Transmembranei187 – 213HelicalSequence analysisAdd BLAST27
Topological domaini214 – 255CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3604
OpenTargetsiENSG00000049249
PharmGKBiPA36617

Chemistry databases

ChEMBLiCHEMBL3712857
GuidetoPHARMACOLOGYi1878

Polymorphism and mutation databases

BioMutaiTNFRSF9
DMDMi728738

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000003457724 – 255Tumor necrosis factor receptor superfamily member 9Add BLAST232

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 37PROSITE-ProRule annotation
Disulfide bondi31 ↔ 45PROSITE-ProRule annotation
Disulfide bondi48 ↔ 62PROSITE-ProRule annotation
Disulfide bondi65 ↔ 78PROSITE-ProRule annotation
Disulfide bondi68 ↔ 86PROSITE-ProRule annotation
Disulfide bondi88 ↔ 94PROSITE-ProRule annotation
Disulfide bondi99 ↔ 106PROSITE-ProRule annotation
Disulfide bondi102 ↔ 117PROSITE-ProRule annotation
Disulfide bondi121 ↔ 133PROSITE-ProRule annotation
Glycosylationi138N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi139 ↔ 158PROSITE-ProRule annotation
Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ07011
PeptideAtlasiQ07011
PRIDEiQ07011
ProteomicsDBi58498

PTM databases

iPTMnetiQ07011
PhosphoSitePlusiQ07011

Expressioni

Tissue specificityi

Expressed on the surface of activated T-cells.

Gene expression databases

BgeeiENSG00000049249 Expressed in 82 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_TNFRSF9
ExpressionAtlasiQ07011 baseline and differential
GenevisibleiQ07011 HS

Organism-specific databases

HPAiHPA071425

Interactioni

Subunit structurei

Interacts with TRAF1, TRAF2 and TRAF3. Interacts with LRR-repeat protein 1/LRR-1.3 Publications

Protein-protein interaction databases

BioGridi109817, 13 interactors
DIPiDIP-3021N
ELMiQ07011
IntActiQ07011, 1 interactor
STRINGi9606.ENSP00000366729

Structurei

Secondary structure

1255
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ07011
SMRiQ07011
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati24 – 45TNFR-Cys 1Add BLAST22
Repeati47 – 86TNFR-Cys 2Add BLAST40
Repeati87 – 118TNFR-Cys 3Add BLAST32
Repeati119 – 159TNFR-Cys 4Add BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni214 – 255Interaction with LRR-1Add BLAST42

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW3N Eukaryota
ENOG41129F9 LUCA
GeneTreeiENSGT00730000111279
HOGENOMiHOG000033708
HOVERGENiHBG000021
InParanoidiQ07011
KOiK05146
OMAiFKQPFMR
OrthoDBiEOG091G03XW
PhylomeDBiQ07011
TreeFamiTF336151

Family and domain databases

CDDicd13410 TNFRSF9, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR020413 TNFR_9
IPR034020 TNFRSF9_N
PANTHERiPTHR23097:SF136 PTHR23097:SF136, 1 hit
PfamiView protein in Pfam
PF00020 TNFR_c6, 1 hit
PRINTSiPR01924 TNFACTORR9
SMARTiView protein in SMART
SM00208 TNFR, 2 hits
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 1 hit
PS50050 TNFR_NGFR_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q07011-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNSCYNIVA TLLLVLNFER TRSLQDPCSN CPAGTFCDNN RNQICSPCPP
60 70 80 90 100
NSFSSAGGQR TCDICRQCKG VFRTRKECSS TSNAECDCTP GFHCLGAGCS
110 120 130 140 150
MCEQDCKQGQ ELTKKGCKDC CFGTFNDQKR GICRPWTNCS LDGKSVLVNG
160 170 180 190 200
TKERDVVCGP SPADLSPGAS SVTPPAPARE PGHSPQIISF FLALTSTALL
210 220 230 240 250
FLLFFLTLRF SVVKRGRKKL LYIFKQPFMR PVQTTQEEDG CSCRFPEEEE

GGCEL
Length:255
Mass (Da):27,899
Last modified:February 1, 1995 - v1
Checksum:iF3A563FE5EF00460
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EJQ2K7EJQ2_HUMAN
Tumor necrosis factor receptor supe...
TNFRSF9
87Annotation score:
K7EJ11K7EJ11_HUMAN
Tumor necrosis factor receptor supe...
TNFRSF9
75Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01892056A → T1 PublicationCorresponds to variant dbSNP:rs9657963EnsemblClinVar.1
Natural variantiVAR_018921115K → N1 PublicationCorresponds to variant dbSNP:rs9657965Ensembl.1
Natural variantiVAR_018922176A → D1 PublicationCorresponds to variant dbSNP:rs9657979Ensembl.1
Natural variantiVAR_035478250E → G in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs776878260Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03397 mRNA Translation: AAA53133.1
L12964 mRNA Translation: AAA62478.2
AY438976 Genomic DNA Translation: AAR05440.1
AL009183 Genomic DNA No translation available.
BC006196 mRNA Translation: AAH06196.1
CCDSiCCDS92.1
PIRiI38426
RefSeqiNP_001552.2, NM_001561.5
XP_011539688.1, XM_011541386.2
UniGeneiHs.738942
Hs.86447

Genome annotation databases

EnsembliENST00000377507; ENSP00000366729; ENSG00000049249
ENST00000615230; ENSP00000478699; ENSG00000049249
GeneIDi3604
KEGGihsa:3604
UCSCiuc001aot.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03397 mRNA Translation: AAA53133.1
L12964 mRNA Translation: AAA62478.2
AY438976 Genomic DNA Translation: AAR05440.1
AL009183 Genomic DNA No translation available.
BC006196 mRNA Translation: AAH06196.1
CCDSiCCDS92.1
PIRiI38426
RefSeqiNP_001552.2, NM_001561.5
XP_011539688.1, XM_011541386.2
UniGeneiHs.738942
Hs.86447

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6BWVX-ray2.40D/E24-160[»]
6CPRX-ray2.70D/E/F23-160[»]
6CU0X-ray3.20G/H/I/J/K/L23-160[»]
ProteinModelPortaliQ07011
SMRiQ07011
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109817, 13 interactors
DIPiDIP-3021N
ELMiQ07011
IntActiQ07011, 1 interactor
STRINGi9606.ENSP00000366729

Chemistry databases

ChEMBLiCHEMBL3712857
GuidetoPHARMACOLOGYi1878

PTM databases

iPTMnetiQ07011
PhosphoSitePlusiQ07011

Polymorphism and mutation databases

BioMutaiTNFRSF9
DMDMi728738

Proteomic databases

PaxDbiQ07011
PeptideAtlasiQ07011
PRIDEiQ07011
ProteomicsDBi58498

Protocols and materials databases

DNASUi3604
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377507; ENSP00000366729; ENSG00000049249
ENST00000615230; ENSP00000478699; ENSG00000049249
GeneIDi3604
KEGGihsa:3604
UCSCiuc001aot.4 human

Organism-specific databases

CTDi3604
DisGeNETi3604
EuPathDBiHostDB:ENSG00000049249.8
GeneCardsiTNFRSF9
HGNCiHGNC:11924 TNFRSF9
HPAiHPA071425
MIMi602250 gene
neXtProtiNX_Q07011
OpenTargetsiENSG00000049249
PharmGKBiPA36617
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IW3N Eukaryota
ENOG41129F9 LUCA
GeneTreeiENSGT00730000111279
HOGENOMiHOG000033708
HOVERGENiHBG000021
InParanoidiQ07011
KOiK05146
OMAiFKQPFMR
OrthoDBiEOG091G03XW
PhylomeDBiQ07011
TreeFamiTF336151

Enzyme and pathway databases

ReactomeiR-HSA-5669034 TNFs bind their physiological receptors

Miscellaneous databases

GeneWikiiCD137
GenomeRNAii3604
PROiPR:Q07011
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000049249 Expressed in 82 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_TNFRSF9
ExpressionAtlasiQ07011 baseline and differential
GenevisibleiQ07011 HS

Family and domain databases

CDDicd13410 TNFRSF9, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR020413 TNFR_9
IPR034020 TNFRSF9_N
PANTHERiPTHR23097:SF136 PTHR23097:SF136, 1 hit
PfamiView protein in Pfam
PF00020 TNFR_c6, 1 hit
PRINTSiPR01924 TNFACTORR9
SMARTiView protein in SMART
SM00208 TNFR, 2 hits
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 1 hit
PS50050 TNFR_NGFR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTNR9_HUMAN
AccessioniPrimary (citable) accession number: Q07011
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 7, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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