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Entry version 101 (26 Feb 2020)
Sequence version 1 (31 Oct 2006)
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Protein

Chromodomain-helicase-DNA-binding protein 7

Gene

CHD7

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi994 – 1001ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding, Helicase, Hydrolase
Biological processrRNA processing, Transcription, Transcription regulation
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chromodomain-helicase-DNA-binding protein 7 (EC:3.6.4.12)
Short name:
CHD-7
Alternative name(s):
ATP-dependent helicase CHD7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHD7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002899651 – 3011Chromodomain-helicase-DNA-binding protein 7Add BLAST3011

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2561PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q06A37

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the neural epithelium, otic placodes, optic placodes, branchial arches, and the olfactory placodes,.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression is pan-neuronal at stages 8-20. Expressed throughout the rostral neural ectoderm and along the rostrocaudal axis but is absent from the more lateral, non-neuronal ectoderm. Adjacent to the neural tube, detected at the optic and otic placodes. At stage 20, expression is observed in the branchial arches and olfactory placodes in addition to brain and optic and otic placodes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSGALG00000015472 Expressed in cerebellum and 9 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000024904

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q06A37

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini801 – 868Chromo 1PROSITE-ProRule annotationAdd BLAST68
Domaini883 – 948Chromo 2PROSITE-ProRule annotationAdd BLAST66
Domaini981 – 1155Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST175
Domaini1295 – 1465Helicase C-terminalPROSITE-ProRule annotationAdd BLAST171

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2403 – 2433Sequence analysisAdd BLAST31

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1106 – 1109DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi151 – 225Gln-richAdd BLAST75
Compositional biasi492 – 560Gln-richAdd BLAST69
Compositional biasi602 – 720Lys-richAdd BLAST119
Compositional biasi1939 – 1945Poly-Arg7
Compositional biasi2248 – 2251Poly-Asp4
Compositional biasi2728 – 2738Poly-AlaAdd BLAST11
Compositional biasi2782 – 2787Poly-Ala6
Compositional biasi2863 – 2899Thr-richAdd BLAST37

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0383 Eukaryota
COG0553 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000315_5_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q06A37

KEGG Orthology (KO)

More...
KOi
K14437

Database of Orthologous Groups

More...
OrthoDBi
7181at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q06A37

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.28.130, 2 hits
3.40.50.10810, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006576 BRK_domain
IPR037259 BRK_sf
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR023780 Chromo_domain
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07533 BRK, 2 hits
PF00385 Chromo, 2 hits
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00592 BRK, 2 hits
SM00298 CHROMO, 2 hits
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF160481 SSF160481, 2 hits
SSF52540 SSF52540, 2 hits
SSF54160 SSF54160, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50013 CHROMO_2, 2 hits
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q06A37-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADPGMMSLF GEDGNIFSEG LEGLGECGYP ENTVNPMGQQ MPMDQGFPSL
60 70 80 90 100
QSSLHHPPAN QNQAKLTHFD HYNQYEQQKM HLMDQPNRMI SNAPGNGIAS
110 120 130 140 150
PHSQYHNPPV PQVPHGSGAS GQMGVYPSMQ NERHGQPFVD SGSMWGPRAV
160 170 180 190 200
QVPDQIRAPY QQQQQQPQPT QPPQAPSGPP GQGHPQHMQQ MGNYMARGDF
210 220 230 240 250
SMQQHGQPQQ QRMNQFSQGQ EGLNQGNPFI ATSGPGHLSH VPQQNPSMAP
260 270 280 290 300
SLRHSVQQFH HHPPTALHGE SVAHSPRFSP NPPQQGAVRP QTLNFSSRSQ
310 320 330 340 350
TVPSPTINNS GQYSRYPYSN LNQGLVNNTG MNQNLGLTNN TPMNQSVPRY
360 370 380 390 400
PNAVGFPSNS GQGLMHQQPI HPSGSLNQMN TQTMHPSQPQ GTYASPPPMS
410 420 430 440 450
PMKAMSNPAG TPPPQVRPGS AGIPMEVGSY PNIPHPQPSH QPPGAMGIGQ
460 470 480 490 500
RNMGPRNMQQ NRPFMGMSST PREMGGHMRP NGCPGVGLAD PQAIQERLIS
510 520 530 540 550
GQQLPSQQQS FQQQMPTCPP MQPHPGIHHQ SSPPPHPHHQ PWAQLHQSPQ
560 570 580 590 600
NTPQKVPVLQ HSPSEPFLEK PVPDMTQVSG PNTQLVKSDD YLPSVEPQPQ
610 620 630 640 650
QKKKKKKNNH IAAEGPSKSF GKEDFPGGLD SQNLSRNSVD CSQEDKKKKK
660 670 680 690 700
KPKAKKEPKD PKEPKEKKEP KTPKVPKTPK EPKEKKAKNT TPKPKTSKKT
710 720 730 740 750
SNKKTDSESS AAKKKVNKGK EGSENSDLDK TPPPSPHPED EDDPGVQKRR
760 770 780 790 800
SSRQVKRKRY TEDLEFKISD EEADDADAAG RDSPSNTSQS EQQESADAEG
810 820 830 840 850
PVVEKIMSSR SVKKKMENGE EVEIEEFYVK YKNFSYLHCQ WASVEELDKD
860 870 880 890 900
KRIQQKIKRF KAKQGQNKFL SEIDDELFNP DYVEIDRILD FSRSTDDNGE
910 920 930 940 950
PVTHYLVKWC SLPYEDSTWE LKQDIDQAKI EEFEKLMSRE PEMERVERPP
960 970 980 990 1000
ADDWKKSESS REYKNNNKLR EYQLEGVNWL LFNWYNTRNC ILADEMGLGK
1010 1020 1030 1040 1050
TIQSITFLYE IYLKGIHGPF LVIAPLSTIP NWEREFRTWT ELNVVVYHGS
1060 1070 1080 1090 1100
QASRRTIQLY EMYFKDPQGR VIKGSYKFHA IITTFEMILT DCPELRNIPW
1110 1120 1130 1140 1150
RCVVIDEAHR LKNRNCKLLE GLKMMDLEHK VLLTGTPLQN TVEELFSLLH
1160 1170 1180 1190 1200
FLEPGRFPSE TTFMQEFGDL KTEEQVQKLQ AILKPMMLRR LKEDVEKNLA
1210 1220 1230 1240 1250
PKEETIIEVE LTNIQKKYYR AILEKNFAFL SKGGGQANVP NLLNTMMELR
1260 1270 1280 1290 1300
KCCNHPYLIN GAEEKILEEF KETHNADSPD FQLQAMIQAA GKLVLIDKLL
1310 1320 1330 1340 1350
PKLKAGGHRV LIFSQMVRCL DILEDYLIQR RYPYERIDGR VRGNLRQAAI
1360 1370 1380 1390 1400
DRFSRPDSDR FVFLLCTRAG GLGINLTAAD TCIIFDSDWN PQNDLQAQAR
1410 1420 1430 1440 1450
CHRIGQSKSV KIYRLITRNS YEREMFDKAS LKLGLDKAVL QSMSGRENAT
1460 1470 1480 1490 1500
NGVQQLSKKE IEDLLRKGAY GALMDEEDEG SKFCEEDIDQ ILLRRTHTIT
1510 1520 1530 1540 1550
IESEGKGSTF AKASFVASGN RTDISLDDPN FWQKWAKKAE LDIDALNGRN
1560 1570 1580 1590 1600
NLVIDTPRVR KQTRLYSAVK EDELMEFSDL ESDSEEKPST KPRRPQDKSQ
1610 1620 1630 1640 1650
GYARSECFRV EKNLLVYGWG RWTDILSHGR YKRQLTEQDV ETICRTILVY
1660 1670 1680 1690 1700
CLNHYKGDEN IKSFIWDLIT PTADGQTRAL VNHSGLSAPV PRGRKGKKVK
1710 1720 1730 1740 1750
AQSSQPMLQD ADWLTTCNPD VLFQEDSYRK HLKHHCNKVL LRVRMLYYLR
1760 1770 1780 1790 1800
QEVIGDQADR ILEGADSSEV DVWIPEPFHA EVPADWWDKE ADKSLLIGVF
1810 1820 1830 1840 1850
KHGYEKYNSM RADSTLCFLE RVGMPDAKAI AAEQRGTDML ADGGDGGEFD
1860 1870 1880 1890 1900
REDEDPEYKP TRTPFKDEID EFANSPPEDK EESIEIHPNK HSESNSELGQ
1910 1920 1930 1940 1950
LYWPNTSTLT TRLRRLITAY QRSYKRQQMR QEALMKTDRR RRRPREEVRA
1960 1970 1980 1990 2000
LEAEREAIIT EKRQKWTRRE EADFYRVVST FGIIFDPIKH QFDWNQFRAF
2010 2020 2030 2040 2050
ARLDKKSDES LEKYFNGFVN MCRRVCRMPV KPDDEPPDLS TMIEPITEER
2060 2070 2080 2090 2100
ASRTLYRIEL LRKIREQVLH HPQLGERLKL CQPSLDLPEW WECGKHDKDL
2110 2120 2130 2140 2150
LIGAAKHGVS RTDYHILNDP ELSFLEAHKN FAQNRGTGNA NTVSSLHPVG
2160 2170 2180 2190 2200
AGCSQTPPIV PSTPVQEEKS TEQTESKVEG SENPAAKEKS DIKEETDIAD
2210 2220 2230 2240 2250
KDTKQDCDAE AETGSVKCEL KDIEMSTDVD PKSISEKGSE EDEEEKLDDD
2260 2270 2280 2290 2300
DKSEESSQPE AGAVSQGKNF DEESNASMST ARDETRDGFY MEDGDPSVVQ
2310 2320 2330 2340 2350
LLHERTFAFS FWPKDRVMIN RLDNICEAVL KGKWPVNRRQ MFDFQGLIPG
2360 2370 2380 2390 2400
YTPTAVDSPL QKRSFAELSM IGQASISGSE DITASPQLSK EDALNLSVPR
2410 2420 2430 2440 2450
QRRRRRRKIE IEAERAAKRR NLMEMVAQLR ESQVVSENGQ EKVVDLSKAS
2460 2470 2480 2490 2500
REATSSTSNF SSVTSKFILP NVSTPVSDAF KTQMELLQAG LSRTPTRHLL
2510 2520 2530 2540 2550
NGSLIDGEPP MKRRRGRRKN VEGLDLLFMS NKRTSLTVED AEVTKAFEED
2560 2570 2580 2590 2600
MEALPARNIP SPGQLDPDTR IPVINLEDGT RLVGEDAPKN KDLVEWLKLH
2610 2620 2630 2640 2650
PTYTVDMPSY VPKSADVLFS SFQKPKQKRH RCRNPNKLDI NTLTGEERVP
2660 2670 2680 2690 2700
VVNKRNGKKM GGAMAPPMKD LPRWLEENPE FAVAPDWTDI VKQSGFVPES
2710 2720 2730 2740 2750
MFDRLLTGPV VREEGASRRG RRPKSEIAKA AAAAAAVAST SGINPLLMNS
2760 2770 2780 2790 2800
LFAGMDLTSL QNLQNLQSLQ LAGLMGFPPG LATAAAAGGD AKNPAAMLPL
2810 2820 2830 2840 2850
MLPGMAGLPN MFGLSGLLNN PITATTGNAT TASGQGETED GASKAEEKKN
2860 2870 2880 2890 2900
ENEEENKDSE KSTDTVSATD SANGSVSAAT AATTATATTT TTTNTGLPTN
2910 2920 2930 2940 2950
PLAFNPFLLS TMAPGLFYPS MFLPPGLGGL TLPGFPALAG LQNAVGSNEE
2960 2970 2980 2990 3000
KATDKTEGTA FKDEENLEGS DAEESLDKTA DSSILEDEIA QGEELDSLDG
3010
GEEIENNEND E
Length:3,011
Mass (Da):338,213
Last modified:October 31, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE544AB2C80E7C6D7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ978381 mRNA Translation: ABI96999.1

NCBI Reference Sequences

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RefSeqi
NP_001071054.1, NM_001077586.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
421140

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:421140

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ978381 mRNA Translation: ABI96999.1
RefSeqiNP_001071054.1, NM_001077586.2

3D structure databases

SMRiQ06A37
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000024904

Proteomic databases

PaxDbiQ06A37

Genome annotation databases

GeneIDi421140
KEGGigga:421140

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55636

Phylogenomic databases

eggNOGiKOG0383 Eukaryota
COG0553 LUCA
HOGENOMiCLU_000315_5_0_1
InParanoidiQ06A37
KOiK14437
OrthoDBi7181at2759
PhylomeDBiQ06A37

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q06A37

Gene expression databases

BgeeiENSGALG00000015472 Expressed in cerebellum and 9 other tissues

Family and domain databases

Gene3Di2.20.28.130, 2 hits
3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR006576 BRK_domain
IPR037259 BRK_sf
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR023780 Chromo_domain
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PfamiView protein in Pfam
PF07533 BRK, 2 hits
PF00385 Chromo, 2 hits
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00592 BRK, 2 hits
SM00298 CHROMO, 2 hits
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF160481 SSF160481, 2 hits
SSF52540 SSF52540, 2 hits
SSF54160 SSF54160, 2 hits
PROSITEiView protein in PROSITE
PS50013 CHROMO_2, 2 hits
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHD7_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q06A37
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 31, 2006
Last modified: February 26, 2020
This is version 101 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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