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UniProtKB - Q06A28 (RIR1_MUHVS)

Entry version 55 (07 Apr 2021)
Sequence version 1 (31 Oct 2006)
Previous versions | rss
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Protein

Ribonucleoside-diphosphate reductase large subunit-like protein

Gene

RIR1

Organism
Murid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Provides optimal viral replication conditions by promoting host cell survival and avoiding the host inflammatory response linked to NF-kappa-B activation. Blocks RIPK1 ubiquitination, thereby preventing NF-kappa-B activation and virally induced inflammatory response. Prevents host necroptosis by targeting RIPK3 thereby preventing the formation of necroptotic RIPK1-RIPK3 complexes. Also inhibits ZBP1-induced necroptosis. Does not have ribonucleotide reductase activity. Betaherpesviruses probably use another strategy to expand the dNTP pool in a quiescent host cell.7 Publications

Caution

Lacks the conserved sequence Asn-x-Cys-x-Glu essential for ribonucleotide reductase activity.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interaction, Inhibition of host NF-kappa-B by virus

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase large subunit-like proteinUniRule annotation
Alternative name(s):
Viral inhibitor of RIP activation
Cleaved into the following 2 chains:
N-terminal peptide
116 kDa peptide
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RIR1UniRule annotation
Synonyms:M45, m45.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMurid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10367 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Duplodnaviria › Heunggongvirae › Peploviricota › Herviviricetes › Herpesvirales › Herpesviridae › Betaherpesvirinae › Muromegalovirus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiMus musculus (Mouse) [TaxID: 10090]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008774 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome
  • UP000180711 Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Host cytoplasm, Virion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi61 – 64IQIG → AAAA in M45mut(RHIM); abolished ability to prevent necroptosis in infected cells. 2 Publications4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004121111 – 1174Ribonucleoside-diphosphate reductase large subunit-like proteinAdd BLAST1174
ChainiPRO_00004121121 – 277N-terminal peptideAdd BLAST277
ChainiPRO_0000412113278 – 1174116 kDa peptideAdd BLAST897

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Undergoes proteolytic cleavage, generating two peptides, a N-terminal and a 116 kDa. The N-terminal peptide retains RIPK1- and RIPK3-binding activity as well as cell death suppression activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei277 – 278Cleavage2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Keywords - Developmental stagei

Late protein

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Self-assembles into homo-oligomeric amyloid fibrils.

Interacts with host RIPK1 (via RIP homotypic interaction motif); this interaction inhibits RIPK1 ubiquitination thereby preventing effective activation of host NF-kappa-B.

Interacts with host RIPK3 (via RIP homotypic interaction motif); this interaction disrupts RIPK3-RIPK1 interactions characteristic of TNF-alpha induced necroptosis, thereby suppressing this death pathway.

Interacts (via RIP homotypic interaction motif) with host ZBP1 (via RIP homotypic interaction motif); this interaction inhibits recruitment of RIPK1 and RIPK3 to ZBP1 and prevents ZBP1-induced NF-kappa-B activation.

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

Database of interacting proteins

More...DIPi		DIP-29743N

Protein interaction database and analysis system

More...IntActi		Q06A28, 4 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi50 – 72RIP homotypic interaction motif (RHIM)2 PublicationsAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi82 – 85Poly-Arg4
Compositional biasi91 – 315Ala-richAdd BLAST225
Compositional biasi257 – 263Poly-Gln7

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal region drives rapid self-assembly into homo-oligomeric amyloid fibrils and interacts with the RHIMs of host kinases RIPK1 and RIPK3, and ZBP1 to form heteromeric amyloid fibrils.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ribonucleoside diphosphate reductase large chain family.UniRule annotation

Family and domain databases

HAMAP database of protein families

More...HAMAPi		MF_04027, HSV_RIR1_betahv, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR034716, HSV_RIR1_betahv
IPR025735, RHIM_dom
IPR000788, RNR_lg_C
IPR039718, Rrm1

The PANTHER Classification System

More...PANTHERi		PTHR11573, PTHR11573, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12721, RHIM, 1 hit
PF02867, Ribonuc_red_lgC, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01183, RIBORDTASEM1

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q06A28-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRQPKVYSD PDNGFFFLDV PMPDDGQGGQ QTATTAAGGA FGVGGGHSVP 
        60         70         80         90        100
YVRIMNGVSG IQIGNHNAMS IASCWSPSYT DRRRRSYPKT ATNAAADRVA 
       110        120        130        140        150
AAVSAANAAV NAAAAAAAAG GGGGANLLAA AVTCANQRGC CGGNGGHSLP 
       160        170        180        190        200
PTRMPKTNAT AAAAPAVAGA SNAKSDNNHA NATSGAGSAA ATPAATTPAA 
       210        220        230        240        250
TAVENRRPSP SPSTASTAPC DEGSSPRHHR PSHVSVGTQA TPSTPIPIPA 
       260        270        280        290        300
PRCSTGQQQQ QPQAKKLKPA KADPLLYAAT MPPPASVTTA AAAAVAPESE 
       310        320        330        340        350
SSPAASAPPA AAAMATGGDD EDQSSFSFVS DDVLGEFEDL RIAGLPVRDE 
       360        370        380        390        400
MRPPTPTMTV IPVSRPFRAG RDSGRDALFD DAVESVRCYC HGILGNSRFC 
       410        420        430        440        450
ALVNEKCSEP AKERMARIRR YAADVTRCGP LALYTAIVSS ANRLIQTDPS 
       460        470        480        490        500
CDLDLAECYV ETASKRNAVP LSAFYRDCDR LRDAVAAFFK TYGMVVDAMA 
       510        520        530        540        550
QRITERVGPA LGRGLYSTVV MMDRCGNSFQ GREETPISVF ARVAAALAVE 
       560        570        580        590        600
CEVDGGVSYK ILSSKPVDAA QAFDAFLSAL CSFAIIPSPR VLAYAGFGGS 
       610        620        630        640        650
NPIFDAVSYR AQFYSAESTI NGTLHDICDM VTNGLSVSVS AADLGGDIVA 
       660        670        680        690        700
SLHILGQQCK ALRPYARFKT VLRIYFDIWS VDALKIFSFI LDVGREYEGL 
       710        720        730        740        750
MAFAVNTPRI FWDRYLDSSG DKMWLMFARR EAAALCGLDL KSFRNVYEKM 
       760        770        780        790        800
ERDGRSAITV SPWWAVCQLD ACVARGNTAV VFPHNVKSMI PENIGRPAVC 
       810        820        830        840        850
GPGVSVVSGG FVGCTPIHEL CINLENCVLE GAAVESSVDV VLGLGCRFSF 
       860        870        880        890        900
KALESLVRDA VVLGNLLIDM TVRTNAYGAG KLLTLYRDLH IGVVGFHAVM 
       910        920        930        940        950
NRLGQKFADM ESYDLNQRIA EFIYYTAVRA SVDLCMAGAD PFPKFPKSLY 
       960        970        980        990       1000
AAGRFYPDLF DDDERGPRRM TKEFLEKLRE DVVKHGIRNA SFITGCSADE 
      1010       1020       1030       1040       1050
AANLAGTTPG FWPRRDNVFL EQTPLMMTPT KDQMLDECVR SVKIEPHRLH 
      1060       1070       1080       1090       1100
EEDLSCLGEN RPVELPVLNS RLRQISKESA TVAVRRGRSA PFYDDSDDED 
      1110       1120       1130       1140       1150
EVACSETGWT VSTDAVIKMC VDRQPFVDHA QSLPVAIGFG GSSVELARHL 
      1160       1170 
RRGNALGLSV GVYKCSMPPS VNYR
Length:1,174
Mass (Da):125,215
Last modified:October 31, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBDDC93B8E71E40C7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U68299 Genomic DNA No translation available.
DQ978788 Genomic DNA Translation: ABI94733.1
GU305914 Genomic DNA Translation: ADD10427.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68299 Genomic DNA No translation available.
DQ978788 Genomic DNA Translation: ABI94733.1
GU305914 Genomic DNA Translation: ADD10427.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

DIPiDIP-29743N
IntActiQ06A28, 4 interactors

Family and domain databases

HAMAPiMF_04027, HSV_RIR1_betahv, 1 hit
InterProiView protein in InterPro
IPR034716, HSV_RIR1_betahv
IPR025735, RHIM_dom
IPR000788, RNR_lg_C
IPR039718, Rrm1
PANTHERiPTHR11573, PTHR11573, 1 hit
PfamiView protein in Pfam
PF12721, RHIM, 1 hit
PF02867, Ribonuc_red_lgC, 1 hit
PRINTSiPR01183, RIBORDTASEM1

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRIR1_MUHVS
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q06A28
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: October 31, 2006
Last modified: April 7, 2021
This is version 55 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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