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UniProtKB - Q06953 (GDPPS_VIBCL)
Protein
GDP-perosamine synthase
Gene
rfbE
Organism
Vibrio cholerae
Status
Functioni
Catalyzes the synthesis of GDP-perosamine from GDP-4-keto-6-deoxy-D-mannose and L-glutamate. Shows also weak activity with L-glutamine.
1 PublicationCatalytic activityi
- EC:2.6.1.1021 Publication
Cofactori
pyridoxal 5'-phosphate1 Publication
Kineticsi
- KM=0.06 mM for GDP-4-keto-6-deoxy-D-mannose1 Publication
- KM=0.1 mM for L-glutamate1 Publication
pH dependencei
Optimum pH is 8.0.1 Publication
: LPS O-antigen biosynthesis Pathwayi
This protein is involved in the pathway LPS O-antigen biosynthesis, which is part of Bacterial outer membrane biogenesis.1 PublicationView all proteins of this organism that are known to be involved in the pathway LPS O-antigen biosynthesis and in Bacterial outer membrane biogenesis.
GO - Molecular functioni
- GDP-4-dehydro-6-deoxy-D-mannose-4-aminotransferase activity Source: UniProtKB-EC
GO - Biological processi
- O antigen biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Aminotransferase, Transferase |
Biological process | Lipopolysaccharide biosynthesis |
Ligand | Pyridoxal phosphate |
Enzyme and pathway databases
UniPathwayi | UPA00281 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:rfbE1 Publication |
Organismi | Vibrio cholerae |
Taxonomic identifieri | 666 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000430721 | 1 – 367 | GDP-perosamine synthaseAdd BLAST | 367 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 181 | N6-(pyridoxal phosphate)lysineBy similarity | 1 |
Interactioni
Subunit structurei
Homotetramer.
1 PublicationFamily & Domainsi
Sequence similaritiesi
Belongs to the DegT/DnrJ/EryC1 family.Curated
Family and domain databases
CDDi | cd00616, AHBA_syn, 1 hit |
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR000653, DegT/StrS_aminotransferase IPR015424, PyrdxlP-dep_Trfase IPR015421, PyrdxlP-dep_Trfase_major IPR015422, PyrdxlP-dep_Trfase_small |
PANTHERi | PTHR30244, PTHR30244, 1 hit |
Pfami | View protein in Pfam PF01041, DegT_DnrJ_EryC1, 1 hit |
PIRSFi | PIRSF000390, PLP_StrS, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
i Sequence
Sequence statusi: Complete.
Q06953-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIPVYEPSLD GNERKYLNDC IDSGWVSSRG KYIDRFETEF AEFLKVKHAT
60 70 80 90 100
TVSNGTVALH LAMSALGITQ GDEVIVPTFT YVASVNTIVQ CGALPVFAEI
110 120 130 140 150
EGESLQVSVE DVKRKINKKT KAVMAVHIYG QACDIQSLRD LCDEHGLYLI
160 170 180 190 200
EDCAEAIGTA VNGKKVGTFG DVSTFSFFGN KTITSGEGGM VVSNSDIIID
210 220 230 240 250
KCLRLKNQGV VAGKRYWHDL VAYNYRMTNL CAAIGVAQLE RVDKIIKAKR
260 270 280 290 300
DIAEIYRSEL AGLPMQVHKE SNGTFHSYWL TSIILDQEFE VHRDGLMTFL
310 320 330 340 350
ENNDIESRPF FYPAHTLPMY EHLAEKTAFP LSNSYSHRGI NLPSWPGLCD
360
DQVKEICNCI KNYFNCI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59554 Genomic DNA Translation: CAA42137.1 |
PIRi | S28471 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59554 Genomic DNA Translation: CAA42137.1 |
PIRi | S28471 |
3D structure databases
SMRi | Q06953 |
ModBasei | Search... |
Enzyme and pathway databases
UniPathwayi | UPA00281 |
Family and domain databases
CDDi | cd00616, AHBA_syn, 1 hit |
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR000653, DegT/StrS_aminotransferase IPR015424, PyrdxlP-dep_Trfase IPR015421, PyrdxlP-dep_Trfase_major IPR015422, PyrdxlP-dep_Trfase_small |
PANTHERi | PTHR30244, PTHR30244, 1 hit |
Pfami | View protein in Pfam PF01041, DegT_DnrJ_EryC1, 1 hit |
PIRSFi | PIRSF000390, PLP_StrS, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GDPPS_VIBCL | |
Accessioni | Q06953Primary (citable) accession number: Q06953 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 29, 2014 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 71 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families