Transcription factor SOX-4

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription activator activity, RNA polymerase II-specific Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Genome-wide promoter analysis of the SOX4 transcriptional network in prostate cancer cells."
    Scharer C.D., McCabe C.D., Ali-Seyed M., Berger M.F., Bulyk M.L., Moreno C.S.
    Cancer Res 69:709-717(2009) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: BHF-UCLInferred from direct assayⁱ
  • Ref.5

    "Ubc9 interacts with SOX4 and represses its transcriptional activity."
    Pan X., Li H., Zhang P., Jin B., Man J., Tian L., Su G., Zhao J., Li W., Liu H., Gong W., Zhou T., Zhang X.
    Biochem. Biophys. Res. Commun. 344:727-734(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH UBE2I, SUBCELLULAR LOCATION.
  • "The high mobility group transcription factor, SOX4, transactivates the human CD2 enhancer."
    Wotton D., Lake R.A., Farr C.J., Owen M.J.
    J Biol Chem 270:7515-7522(1995) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
• miRNA binding Source: Ensembl
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: UniProtKBInferred from direct assayⁱ
  • "CD56 expression in human myeloma cells derived from the neurogenic gene expression: possible role of the SRY-HMG box gene, SOX4."
    Iqbal M.S., Otsuyama K., Shamsasenjan K., Asaoku H., Kawano M.M.
    Int J Hematol 91:267-275(2010) [PubMed] [Europe PMC] [Abstract]
• sequence-specific double-stranded DNA binding Source: ARUK-UCLInferred from direct assayⁱ
  • "Impact of cytosine methylation on DNA binding specificities of human transcription factors."
    Yin Y., Morgunova E., Jolma A., Kaasinen E., Sahu B., Khund-Sayeed S., Das P.K., Kivioja T., Dave K., Zhong F., Nitta K.R., Taipale M., Popov A., Ginno P.A., Domcke S., Yan J., Schubeler D., Vinson C., Taipale J.
    Science 356:0-0(2017) [PubMed] [Europe PMC] [Abstract]
• transcription cis-regulatory region binding Source: UniProtKB

GO - Biological processⁱ

• anatomical structure morphogenesis Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• ascending aorta morphogenesis Source: BHF-UCL
• atrial septum primum morphogenesis Source: BHF-UCL
• cardiac right ventricle morphogenesis Source: BHF-UCL
• cardiac ventricle formation Source: UniProtKB
• cell differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to glucose stimulus Source: UniProtKB
• endocrine pancreas development Source: Ensembl
• glial cell development Source: UniProtKB
• glial cell proliferation Source: UniProtKB
• glucose homeostasis Source: UniProtKB
• heart development Source: BHF-UCL
• hematopoietic stem cell homeostasis Source: Ensembl
• kidney morphogenesis Source: BHF-UCL
• limb bud formation Source: UniProtKB
• mitral valve morphogenesis Source: BHF-UCL
• negative regulation of cell death Source: UniProtKB
• negative regulation of cell population proliferation Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Induction of SOX4 by DNA damage is critical for p53 stabilization and function."
    Pan X., Zhao J., Zhang W.N., Li H.Y., Mu R., Zhou T., Zhang H.Y., Gong W.L., Yu M., Man J.H., Zhang P.J., Li A.L., Zhang X.M.
    Proc Natl Acad Sci U S A 106:3788-3793(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of protein ubiquitination Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Induction of SOX4 by DNA damage is critical for p53 stabilization and function."
    Pan X., Zhao J., Zhang W.N., Li H.Y., Mu R., Zhou T., Zhang H.Y., Gong W.L., Yu M., Man J.H., Zhang P.J., Li A.L., Zhang X.M.
    Proc Natl Acad Sci U S A 106:3788-3793(2009) [PubMed] [Europe PMC] [Abstract]
• neural tube formation Source: UniProtKB
• neuroepithelial cell differentiation Source: UniProtKB
• noradrenergic neuron differentiation Source: UniProtKB
• positive regulation of apoptotic process Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Functional identification of the pro-apoptotic effector domain in human Sox4."
    Hur E.H., Hur W., Choi J.Y., Kim I.K., Kim H.Y., Yoon S.K., Rhim H.
    Biochem Biophys Res Commun 325:59-67(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of canonical Wnt signaling pathway Source: UniProtKB
• positive regulation of cell population proliferation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells."
    Sinner D., Kordich J.J., Spence J.R., Opoka R., Rankin S., Lin S.C., Jonatan D., Zorn A.M., Wells J.M.
    Mol Cell Biol 27:7802-7815(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gamma-delta T cell differentiation Source: UniProtKB
• positive regulation of insulin secretion Source: UniProtKB
• positive regulation of myoblast differentiation Source: UniProtKBInferred from direct assayⁱ
  • Ref.6

    "KAT5-mediated SOX4 acetylation orchestrates chromatin remodeling during myoblast differentiation."
    Jang S.M., Kim J.W., Kim C.H., An J.H., Johnson A., Song P.I., Rhee S., Choi K.H.
    Cell Death Dis. 6:e1857-e1857(2015) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH HDAC1, ACETYLATION AT LYS-95, MUTAGENESIS OF LYS-45 AND LYS-95.
• positive regulation of N-terminal peptidyl-lysine acetylation Source: UniProtKBInferred from direct assayⁱ
  • "Induction of SOX4 by DNA damage is critical for p53 stabilization and function."
    Pan X., Zhao J., Zhang W.N., Li H.Y., Mu R., Zhou T., Zhang H.Y., Gong W.L., Yu M., Man J.H., Zhang P.J., Li A.L., Zhang X.M.
    Proc Natl Acad Sci U S A 106:3788-3793(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • "Genome-wide promoter analysis of the SOX4 transcriptional network in prostate cancer cells."
    Scharer C.D., McCabe C.D., Ali-Seyed M., Berger M.F., Bulyk M.L., Moreno C.S.
    Cancer Res 69:709-717(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: UniProtKBInferred from direct assayⁱ
  • "Genome-wide promoter analysis of the SOX4 transcriptional network in prostate cancer cells."
    Scharer C.D., McCabe C.D., Ali-Seyed M., Berger M.F., Bulyk M.L., Moreno C.S.
    Cancer Res 69:709-717(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of translation Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Induction of SOX4 by DNA damage is critical for p53 stabilization and function."
    Pan X., Zhao J., Zhang W.N., Li H.Y., Mu R., Zhou T., Zhang H.Y., Gong W.L., Yu M., Man J.H., Zhang P.J., Li A.L., Zhang X.M.
    Proc Natl Acad Sci U S A 106:3788-3793(2009) [PubMed] [Europe PMC] [Abstract]
• pro-B cell differentiation Source: BHF-UCL
• protein stabilization Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells."
    Sinner D., Kordich J.J., Spence J.R., Opoka R., Rankin S., Lin S.C., Jonatan D., Zorn A.M., Wells J.M.
    Mol Cell Biol 27:7802-7815(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of DNA damage response, signal transduction by p53 class mediator Source: GO_CentralInferred from mutant phenotypeⁱ
  • "Induction of SOX4 by DNA damage is critical for p53 stabilization and function."
    Pan X., Zhao J., Zhang W.N., Li H.Y., Mu R., Zhou T., Zhang H.Y., Gong W.L., Yu M., Man J.H., Zhang P.J., Li A.L., Zhang X.M.
    Proc Natl Acad Sci U S A 106:3788-3793(2009) [PubMed] [Europe PMC] [Abstract]
• regulation of protein stability Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Induction of SOX4 by DNA damage is critical for p53 stabilization and function."
    Pan X., Zhao J., Zhang W.N., Li H.Y., Mu R., Zhou T., Zhang H.Y., Gong W.L., Yu M., Man J.H., Zhang P.J., Li A.L., Zhang X.M.
    Proc Natl Acad Sci U S A 106:3788-3793(2009) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription, DNA-templated Source: BHF-UCLInferred from direct assayⁱ
  • Ref.5

    "Ubc9 interacts with SOX4 and represses its transcriptional activity."
    Pan X., Li H., Zhang P., Jin B., Man J., Tian L., Su G., Zhao J., Li W., Liu H., Gong W., Zhou T., Zhang X.
    Biochem. Biophys. Res. Commun. 344:727-734(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH UBE2I, SUBCELLULAR LOCATION.
  • "The high mobility group transcription factor, SOX4, transactivates the human CD2 enhancer."
    Wotton D., Lake R.A., Farr C.J., Owen M.J.
    J Biol Chem 270:7515-7522(1995) [PubMed] [Europe PMC] [Abstract]
• skeletal system development Source: UniProtKB
• somatic stem cell population maintenance Source: Ensembl
• spinal cord development Source: UniProtKB
• spinal cord motor neuron differentiation Source: UniProtKB
• sympathetic nervous system development Source: UniProtKB
• T cell differentiation Source: BHF-UCL
• ventricular septum morphogenesis Source: BHF-UCL

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

Mutagenesis

Keywords - Diseaseⁱ

Organism-specific databases

Miscellaneous databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Motif

Compositional bias

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MVQQTNNAEN TEALLAGESS DSGAGLELGI ASSPTPGSTA STGGKADDPS 
        60         70         80         90        100
WCKTPSGHIK RPMNAFMVWS QIERRKIMEQ SPDMHNAEIS KRLGKRWKLL 
       110        120        130        140        150
KDSDKIPFIR EAERLRLKHM ADYPDYKYRP RKKVKSGNAN SSSSAAASSK 
       160        170        180        190        200
PGEKGDKVGG SGGGGHGGGG GGGSSNAGGG GGGASGGGAN SKPAQKKSCG 
       210        220        230        240        250
SKVAGGAGGG VSKPHAKLIL AGGGGGGKAA AAAAASFAAE QAGAAALLPL 
       260        270        280        290        300
GAAADHHSLY KARTPSASAS ASSAASASAA LAAPGKHLAE KKVKRVYLFG 
       310        320        330        340        350
GLGTSSSPVG GVGAGADPSD PLGLYEEEGA GCSPDAPSLS GRSSAASSPA 
       360        370        380        390        400
AGRSPADHRG YASLRAASPA PSSAPSHASS SASSHSSSSS SSGSSSSDDE 
       410        420        430        440        450
FEDDLLDLNP SSNFESMSLG SFSSSSALDR DLDFNFEPGS GSHFEFPDYC 
       460        470 
TPEVSEMISG DWLESSISNL VFTY                             

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 6
   Human chromosome 6: entries, gene names and cross-references to MIM
2. Human entries with genetic variants
   List of human entries with genetic variants
3. Human variants curated from literature reports
   Index of human variants curated from literature reports
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot