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Protein

Transcription factor SOX-4

Gene

SOX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi59 – 127HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-3769402 Deactivation of the beta-catenin transactivating complex
SIGNORiQ06945

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-4
Gene namesi
Name:SOX4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000124766.5
HGNCiHGNC:11200 SOX4
MIMi184430 gene
neXtProtiNX_Q06945

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6659
OpenTargetsiENSG00000124766
PharmGKBiPA36037

Polymorphism and mutation databases

BioMutaiSOX4
DMDMi548952

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000487241 – 474Transcription factor SOX-4Add BLAST474

Proteomic databases

EPDiQ06945
MaxQBiQ06945
PaxDbiQ06945
PeptideAtlasiQ06945
PRIDEiQ06945
ProteomicsDBi58488

PTM databases

iPTMnetiQ06945
PhosphoSitePlusiQ06945

Expressioni

Tissue specificityi

Testis, brain, and heart.

Gene expression databases

BgeeiENSG00000124766 Expressed in 235 organ(s), highest expression level in cerebral cortex
CleanExiHS_SOX4
GenevisibleiQ06945 HS

Organism-specific databases

HPAiHPA029901

Interactioni

Subunit structurei

Interacts with UBE2I.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TP53P046374EBI-6672525,EBI-366083

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112542, 33 interactors
CORUMiQ06945
DIPiDIP-58650N
IntActiQ06945, 4 interactors
STRINGi9606.ENSP00000244745

Structurei

3D structure databases

ProteinModelPortaliQ06945
SMRiQ06945
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi386 – 397Poly-SerAdd BLAST12

Phylogenomic databases

eggNOGiENOG410IPZ6 Eukaryota
ENOG4111U1K LUCA
GeneTreeiENSGT00760000118988
HOGENOMiHOG000231874
HOVERGENiHBG005040
InParanoidiQ06945
KOiK09268
OMAiGENPAWC
OrthoDBiEOG091G0F15
PhylomeDBiQ06945

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR017386 SOX-11/4
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PIRSFiPIRSF038098 SOX-12/11/4a, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q06945-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVQQTNNAEN TEALLAGESS DSGAGLELGI ASSPTPGSTA STGGKADDPS
60 70 80 90 100
WCKTPSGHIK RPMNAFMVWS QIERRKIMEQ SPDMHNAEIS KRLGKRWKLL
110 120 130 140 150
KDSDKIPFIR EAERLRLKHM ADYPDYKYRP RKKVKSGNAN SSSSAAASSK
160 170 180 190 200
PGEKGDKVGG SGGGGHGGGG GGGSSNAGGG GGGASGGGAN SKPAQKKSCG
210 220 230 240 250
SKVAGGAGGG VSKPHAKLIL AGGGGGGKAA AAAAASFAAE QAGAAALLPL
260 270 280 290 300
GAAADHHSLY KARTPSASAS ASSAASASAA LAAPGKHLAE KKVKRVYLFG
310 320 330 340 350
GLGTSSSPVG GVGAGADPSD PLGLYEEEGA GCSPDAPSLS GRSSAASSPA
360 370 380 390 400
AGRSPADHRG YASLRAASPA PSSAPSHASS SASSHSSSSS SSGSSSSDDE
410 420 430 440 450
FEDDLLDLNP SSNFESMSLG SFSSSSALDR DLDFNFEPGS GSHFEFPDYC
460 470
TPEVSEMISG DWLESSISNL VFTY
Length:474
Mass (Da):47,263
Last modified:June 1, 1994 - v1
Checksum:iCB75B76ABF507A07
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71Q → P in CAA46612 (PubMed:1614875).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70683 mRNA Translation: CAA50018.1
AL136179 Genomic DNA No translation available.
BC072668 mRNA Translation: AAH72668.1
X65661 mRNA Translation: CAA46612.1
CCDSiCCDS4547.1
PIRiI38240
RefSeqiNP_003098.1, NM_003107.2
UniGeneiHs.643910

Genome annotation databases

EnsembliENST00000244745; ENSP00000244745; ENSG00000124766
GeneIDi6659
KEGGihsa:6659
UCSCiuc003ndi.4 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70683 mRNA Translation: CAA50018.1
AL136179 Genomic DNA No translation available.
BC072668 mRNA Translation: AAH72668.1
X65661 mRNA Translation: CAA46612.1
CCDSiCCDS4547.1
PIRiI38240
RefSeqiNP_003098.1, NM_003107.2
UniGeneiHs.643910

3D structure databases

ProteinModelPortaliQ06945
SMRiQ06945
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112542, 33 interactors
CORUMiQ06945
DIPiDIP-58650N
IntActiQ06945, 4 interactors
STRINGi9606.ENSP00000244745

PTM databases

iPTMnetiQ06945
PhosphoSitePlusiQ06945

Polymorphism and mutation databases

BioMutaiSOX4
DMDMi548952

Proteomic databases

EPDiQ06945
MaxQBiQ06945
PaxDbiQ06945
PeptideAtlasiQ06945
PRIDEiQ06945
ProteomicsDBi58488

Protocols and materials databases

DNASUi6659
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244745; ENSP00000244745; ENSG00000124766
GeneIDi6659
KEGGihsa:6659
UCSCiuc003ndi.4 human

Organism-specific databases

CTDi6659
DisGeNETi6659
EuPathDBiHostDB:ENSG00000124766.5
GeneCardsiSOX4
HGNCiHGNC:11200 SOX4
HPAiHPA029901
MIMi184430 gene
neXtProtiNX_Q06945
OpenTargetsiENSG00000124766
PharmGKBiPA36037
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPZ6 Eukaryota
ENOG4111U1K LUCA
GeneTreeiENSGT00760000118988
HOGENOMiHOG000231874
HOVERGENiHBG005040
InParanoidiQ06945
KOiK09268
OMAiGENPAWC
OrthoDBiEOG091G0F15
PhylomeDBiQ06945

Enzyme and pathway databases

ReactomeiR-HSA-3769402 Deactivation of the beta-catenin transactivating complex
SIGNORiQ06945

Miscellaneous databases

ChiTaRSiSOX4 human
GeneWikiiSOX4
GenomeRNAii6659
PROiPR:Q06945
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124766 Expressed in 235 organ(s), highest expression level in cerebral cortex
CleanExiHS_SOX4
GenevisibleiQ06945 HS

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR017386 SOX-11/4
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PIRSFiPIRSF038098 SOX-12/11/4a, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSOX4_HUMAN
AccessioniPrimary (citable) accession number: Q06945
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 7, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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