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Entry version 140 (07 Oct 2020)
Sequence version 2 (21 Sep 2011)
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Protein

PX domain-containing protein YPR097W

Gene

YPR097W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Present with 3080 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • phosphatidylinositol binding Source: SGD

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PX domain-containing protein YPR097W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:YPR097W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XVI

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YPR097W

Saccharomyces Genome Database

More...
SGDi
S000006301, YPR097W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, Mitochondrion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002578261 – 1073PX domain-containing protein YPR097WAdd BLAST1073

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei310PhosphoserineCombined sources1
Modified residuei451PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q06839

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q06839

PRoteomics IDEntifications database

More...
PRIDEi
Q06839

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q06839

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q06839

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
36264, 52 interactors

Database of interacting proteins

More...
DIPi
DIP-49374N

Protein interaction database and analysis system

More...
IntActi
Q06839, 4 interactors

Molecular INTeraction database

More...
MINTi
Q06839

STRING: functional protein association networks

More...
STRINGi
4932.YPR097W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q06839, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini273 – 506PXPROSITE-ProRule annotationAdd BLAST234

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.1 Publication

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2273, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007739_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q06839

Identification of Orthologs from Complete Genome Data

More...
OMAi
YTRQRDK

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024554, DUF3818_PX-associated
IPR001683, Phox
IPR024555, PX-associated
IPR036871, PX_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12825, DUF3818, 1 hit
PF00787, PX, 1 hit
PF12828, PXB, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00312, PX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF64268, SSF64268, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50195, PX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q06839-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MITQDTPALN PTEEHYLKRE LLRCQLDYEI GKLNDQFALR KFGYPFSPND
60 70 80 90 100
PTAPQPISNN DSSPVLGGKG HFSVNYPMLS YVLQEFISTF PLLSTNLLVD
110 120 130 140 150
EKFWQSKVQV FFEHFMSLGF SESYDREEAS KRKKVSKKLS KVILLLFNSG
160 170 180 190 200
VGSFQEQAYY NEDKFVLQSG QARKRSNIEK FAMPTRENLE NLLTNESVFI
210 220 230 240 250
NGWDVNIISV FNKNSRKCTE SVDNDKSSKS TPTSSPKSHA IKSFASTSKW
260 270 280 290 300
MKNAFNNTIN STINSMPESS ASLFSKLSLG VPSTKSKQSR KHHYFLIKIK
310 320 330 340 350
KQDDDDQDNS NEENSNLDHH AGYFYVTRTY SDFKKLSHDL KSEFPGKKCP
360 370 380 390 400
RLPHRNKKVT SMITKTEVLH NGQTKSAARE KIVNTFDTDL QSASESDNSS
410 420 430 440 450
FLQTTNELSA TETVLTEKET ETLRKNILNE IKEEDNIDED EYEEEGEGEE
460 470 480 490 500
SDFDEYKDAS DSKINTLVGE KMRTSLRQYL RTLCKDAEVS QSSSIRRFFL
510 520 530 540 550
SGPNLDIKDI NPKIADDIRN RALIDVSNLE NQIRFQQMAL EKSLKLQDSM
560 570 580 590 600
KDFKTSLLKD EKYLMSLLVE IKDNTKVEDL SPLLQDFVEW CKIYISSMIY
610 620 630 640 650
QMFLGNDNSY ELYTQIRRLH KLMPYTVMGQ IMKFTNPIAI MRGMIELFMA
660 670 680 690 700
QPFGGHSLLQ TMFSTILTDD LKTQKVAIKE LERKIAEMDP GASVVTKCLK
710 720 730 740 750
DFVFNNDTKD EHDTKLFTMD AVNAESESMN MPVPLIVLMK SAAANLIPDE
760 770 780 790 800
VVAGLIESYS SWKLQKEDTD ALNVTSEDQS GIYFTHVKDL WQLYIKEHDK
810 820 830 840 850
QLMRQLWQDP ELTQMLKAIV TMIYEPMVKI FKVARMDVAL KNFEKFMSDL
860 870 880 890 900
IRLVDDVING QLGVSTQFDV VEEIHNLVTK HQDAFFEFIH DVYLNDSEGI
910 920 930 940 950
FEGFITWITT IVKFLQKSKF GGPSERIDFN KLICRDDIDI DVKLLKVQVN
960 970 980 990 1000
NVLNKKIGAR KIYKKLLDLK VKQGTKQNNK HAAGILQKNW SDINSLVMPS
1010 1020 1030 1040 1050
SSGSFGLGDG DLVDLDLDTG DYDFLHKENE VELEKQYKDL LNLVVDESEI
1060 1070
DKLRSQVFAQ ELKNYLEAQI AKK
Length:1,073
Mass (Da):123,084
Last modified:September 21, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3D5B831A7E9B3334
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti848S → G in AAB68142 (PubMed:9169875).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U51033 Genomic DNA Translation: AAB68142.1
BK006949 Genomic DNA Translation: DAA11512.2

Protein sequence database of the Protein Information Resource

More...
PIRi
S69079

NCBI Reference Sequences

More...
RefSeqi
NP_015422.2, NM_001184194.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YPR097W_mRNA; YPR097W; YPR097W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
856212

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YPR097W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51033 Genomic DNA Translation: AAB68142.1
BK006949 Genomic DNA Translation: DAA11512.2
PIRiS69079
RefSeqiNP_015422.2, NM_001184194.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi36264, 52 interactors
DIPiDIP-49374N
IntActiQ06839, 4 interactors
MINTiQ06839
STRINGi4932.YPR097W

PTM databases

CarbonylDBiQ06839
iPTMnetiQ06839

Proteomic databases

MaxQBiQ06839
PaxDbiQ06839
PRIDEiQ06839

Genome annotation databases

EnsemblFungiiYPR097W_mRNA; YPR097W; YPR097W
GeneIDi856212
KEGGisce:YPR097W

Organism-specific databases

EuPathDBiFungiDB:YPR097W
SGDiS000006301, YPR097W

Phylogenomic databases

eggNOGiKOG2273, Eukaryota
HOGENOMiCLU_007739_1_0_1
InParanoidiQ06839
OMAiYTRQRDK

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q06839
RNActiQ06839, protein

Family and domain databases

InterProiView protein in InterPro
IPR024554, DUF3818_PX-associated
IPR001683, Phox
IPR024555, PX-associated
IPR036871, PX_dom_sf
PfamiView protein in Pfam
PF12825, DUF3818, 1 hit
PF00787, PX, 1 hit
PF12828, PXB, 1 hit
SMARTiView protein in SMART
SM00312, PX, 1 hit
SUPFAMiSSF64268, SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195, PX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYP097_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q06839
Secondary accession number(s): D6W496
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: September 21, 2011
Last modified: October 7, 2020
This is version 140 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names
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