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Entry version 152 (02 Jun 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Arf guanine nucleotide exchange factor SYT1

Gene

SYT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide exchange factor for Arf GTPases, stimulating the nucleotide exchange from the GDP-bound to the GTP-bound form. Catalyzes both the GDP release by and the GTP binding to ARF2. Has no exchange activity on Rab GTPases. Involved in vesicular transport.

1 Publication

Miscellaneous

Present with 279 molecules/cell in log phase SD medium.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by brefeldin A.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-6811438, Intra-Golgi traffic

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Arf guanine nucleotide exchange factor SYT1
Short name:
Arf-GEF SYT1
Alternative name(s):
Suppressor of YPT3 protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYT1
Ordered Locus Names:YPR095C
ORF Names:P9513.17
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XVI

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000006299, SYT1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YPR095C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002706201 – 1226Arf guanine nucleotide exchange factor SYT1Add BLAST1226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei277PhosphothreonineCombined sources1
Modified residuei369PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q06836

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q06836

PRoteomics IDEntifications database

More...
PRIDEi
Q06836

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q06836

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
36263, 142 interactors

Protein interaction database and analysis system

More...
IntActi
Q06836, 2 interactors

Molecular INTeraction database

More...
MINTi
Q06836

STRING: functional protein association networks

More...
STRINGi
4932.YPR095C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q06836, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q06836

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini405 – 620SEC7PROSITE-ProRule annotationAdd BLAST216
Domaini844 – 1074PHAdd BLAST231

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni17 – 39DisorderedSequence analysisAdd BLAST23
Regioni113 – 158DisorderedSequence analysisAdd BLAST46
Regioni311 – 405DisorderedSequence analysisAdd BLAST95
Regioni954 – 1022DisorderedSequence analysisAdd BLAST69
Regioni1178 – 1198DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi17 – 37Polar residuesSequence analysisAdd BLAST21
Compositional biasi117 – 140Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi348 – 363Polar residuesSequence analysisAdd BLAST16
Compositional biasi386 – 405Polar residuesSequence analysisAdd BLAST20
Compositional biasi954 – 974Polar residuesSequence analysisAdd BLAST21
Compositional biasi981 – 1019Polar residuesSequence analysisAdd BLAST39

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SEC7 domain is sufficient for nucleotide exchange activity.

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0929, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008280_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q06836

Identification of Orthologs from Complete Genome Data

More...
OMAi
ANTICNK

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00171, Sec7, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1000.11, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001849, PH_domain
IPR023394, Sec7_C_sf
IPR000904, Sec7_dom
IPR035999, Sec7_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01369, Sec7, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233, PH, 1 hit
SM00222, Sec7, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48425, SSF48425, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50190, SEC7, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q06836-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNQSISSLIK LKFLQSHSND KNGNKKGGSN VSTGIDKLRE SESYRSPFLQ
60 70 80 90 100
LAEIQEHTNN DDDKLDVKEC EPTKKHSKLS RIRRKMGRLD LNFRSANEKG
110 120 130 140 150
SEDDEILVAQ HLRNGQDPEE MPFKSENNID SIEKVPKPDG ERVTLTSSGS
160 170 180 190 200
DNVKRNSKHA PFIPVKPALE KFPSSNRLSR DYRKSQEPTL FNGDRLVPTL
210 220 230 240 250
PTVSRISTSS SVGSSTAASR YFNPSKRAVV ASSSSSSSSI KFNSLHAIPL
260 270 280 290 300
DATPQIELAK QQDEISKRRF GRRRSRTVDV FDYINKNNTA KNKPPLSPSS
310 320 330 340 350
FIRTIDEKNT NSLMQDPMGS RGPLLPDDAN IISNDTDGAE ASHPDHQVLS
360 370 380 390 400
RSRSQSTSFV QGKGGKRKSI EDEGYHNKLG LPHGSGPTSV YNNKSNANST
410 420 430 440 450
ITGMSRRSSS IVNALSSFVN LRSSSLSSSR QQHLQQQQQL QQKLDVSLED
460 470 480 490 500
LPPVPAPEFS DSCKDFLIKL APYGKFIGII LTEKDDEFKK NCLNYLLTNC
510 520 530 540 550
FEFKNDPLDI ALRKLLMFLE LPKETQQIDR LIMAFSFAYY KAQKSYSKKK
560 570 580 590 600
GIECPWSNAD QVYFIAFSLL MLHTDYFNPN NKSKMTKHDF VDLVHNDKYS
610 620 630 640 650
GGNEIPMAVL TYFYENVTAK ESPKFNYFLM SPMALDDSIL DKDAFDTNFA
660 670 680 690 700
ITLSSNSMYS PIDMIKRGSI IPKEASLSPI FYPLTNSISA SGIAPSTAAS
710 720 730 740 750
CPPSTSGTIN GANLGTANSN SNRPASNSIS SYFSYNPSSS SSGNATLVQD
760 770 780 790 800
DINVYSHIIN DTLNEVNLFP EVSKYWNKNA LKANLLRNEE HKYEKYYSIM
810 820 830 840 850
NDTKGGYLRF HKSQLNKLNL PNFEILNDNS RSGCKNSDYK YCKILQMGAI
860 870 880 890 900
MNLGMPSRKF SIVNSAKIHW KKEFAILTSL GLLICDKMDW INPQMMKDPK
910 920 930 940 950
SGTTNYIIDF KSGFSFVPGS TIDVYNGLFA DRERDSLGKS HFASLVLAYT
960 970 980 990 1000
EHHSTGSHTS NTTAASSSAK HNEGVFEPSS DEEDSITNST DGTSSVSNGE
1010 1020 1030 1040 1050
SDNDSVSSSD NQLSSNDSNE DYHSIKDEYP IFEDENADCL LYLHTCHRNF
1060 1070 1080 1090 1100
IWKCANKYER DNWIDSINLF SAYDGCYVEI GSIANTICNK RKLTILQRME
1110 1120 1130 1140 1150
RLRSIKSAKW EKLKKFESTL MLMGKCVPIS TKTKTDMINR IRQLAVRMDW
1160 1170 1180 1190 1200
LIYEIKRSEL FVSIIKEVTR KQAEKNILEH GKGEEEGQGN NDDSDGIDDI
1210 1220
EESFLFNENS LQVCVSDSSY DEYSNE
Length:1,226
Mass (Da):137,583
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i562029624DDAB658
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U51033 Genomic DNA Translation: AAB68141.1
BK006949 Genomic DNA Translation: DAA11510.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S69078

NCBI Reference Sequences

More...
RefSeqi
NP_015420.1, NM_001184192.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YPR095C_mRNA; YPR095C; YPR095C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
856210

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YPR095C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51033 Genomic DNA Translation: AAB68141.1
BK006949 Genomic DNA Translation: DAA11510.1
PIRiS69078
RefSeqiNP_015420.1, NM_001184192.1

3D structure databases

SMRiQ06836
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi36263, 142 interactors
IntActiQ06836, 2 interactors
MINTiQ06836
STRINGi4932.YPR095C

PTM databases

iPTMnetiQ06836

Proteomic databases

MaxQBiQ06836
PaxDbiQ06836
PRIDEiQ06836

Genome annotation databases

EnsemblFungiiYPR095C_mRNA; YPR095C; YPR095C
GeneIDi856210
KEGGisce:YPR095C

Organism-specific databases

SGDiS000006299, SYT1
VEuPathDBiFungiDB:YPR095C

Phylogenomic databases

eggNOGiKOG0929, Eukaryota
HOGENOMiCLU_008280_0_0_1
InParanoidiQ06836
OMAiANTICNK

Enzyme and pathway databases

ReactomeiR-SCE-6811438, Intra-Golgi traffic

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q06836
RNActiQ06836, protein

Family and domain databases

CDDicd00171, Sec7, 1 hit
Gene3Di1.10.1000.11, 1 hit
InterProiView protein in InterPro
IPR001849, PH_domain
IPR023394, Sec7_C_sf
IPR000904, Sec7_dom
IPR035999, Sec7_dom_sf
PfamiView protein in Pfam
PF01369, Sec7, 1 hit
SMARTiView protein in SMART
SM00233, PH, 1 hit
SM00222, Sec7, 1 hit
SUPFAMiSSF48425, SSF48425, 1 hit
PROSITEiView protein in PROSITE
PS50190, SEC7, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYT1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q06836
Secondary accession number(s): D6W494
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 1, 1996
Last modified: June 2, 2021
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names
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