PRDX1

Functionⁱ

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H₂O₂ (PubMed:9497357). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity).By similarity1 Publication

Miscellaneous

The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.1 Publication

Catalytic activityⁱ

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	52	Cysteine sulfenic acid (-SOH) intermediate2 Publications		1

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
identical protein binding Source: Ensembl
peroxidase activity
Source: MGI
Inferred from direct assayⁱ
- 11986303
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889
thioredoxin peroxidase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 18606987

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 8089076
cell redox homeostasis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cellular response to oxidative stress Source: Reactome
erythrocyte homeostasis Source: Ensembl
hydrogen peroxide catabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 18606987
natural killer cell activation
Source: UniProtKB
Inferred from direct assayⁱ
- 8462106
natural killer cell mediated cytotoxicity Source: Ensembl
regulation of NIK/NF-kappaB signaling Source: Ensembl
regulation of stress-activated MAPK cascade Source: Ensembl
removal of superoxide radicals Source: Ensembl
response to oxidative stress
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
retina homeostasis
Source: UniProtKB
Inferred from high throughput expression patternⁱ
- 23580065
skeletal system development
Source: ProtInc
Traceable author statementⁱ
- 8089076

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Antioxidant, Oxidoreductase, Peroxidase

Molecular function

Antioxidant, Oxidoreductase, Peroxidase

Enzyme and pathway databases

BRENDAⁱ	1.11.1.15 2681
Reactomeⁱ	R-HSA-3299685 Detoxification of Reactive Oxygen Species R-HSA-5628897 TP53 Regulates Metabolic Genes R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
SIGNORⁱ	Q06830

Protein family/group databases

PeroxiBaseⁱ	4501 Hs2CysPrx01

PeroxiBaseⁱ

4501 Hs2CysPrx01

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Peroxiredoxin-1 (EC:1.11.1.152 Publications) Alternative name(s): Natural killer cell-enhancing factor A Short name: NKEF-A Proliferation-associated gene protein Short name: PAG Thioredoxin peroxidase 2 Thioredoxin-dependent peroxide reductase 2
Gene namesⁱ	Name:PRDX1 Synonyms:PAGA, PAGB, TDPX2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000117450.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9352 PRDX1
MIMⁱ	176763 gene
neXtProtⁱ	NX_Q06830

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	90	T → A: Abolishes phosphorylation by CDK1; 30% reduction in enzymatic activity. 1 Publication		1
Mutagenesisⁱ	90	T → D: 87% reduction in enzymatic activity. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5052
MalaCards human disease database More...MalaCardsⁱ	PRDX1
Open Targets More...OpenTargetsⁱ	ENSG00000117450
PharmGKBⁱ	PA33722

Chemistry databases

ChEMBLⁱ	CHEMBL5315

ChEMBLⁱ

CHEMBL5315

Polymorphism and mutation databases

BioMutaⁱ	PRDX1
DMDMⁱ	548453

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000135076	2 – 199	Peroxiredoxin-1Add BLAST		198

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineCombined sources	1
Modified residueⁱ	7	N6-acetyllysine; alternateCombined sources	1
Cross-linkⁱ	7	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	16	N6-acetyllysineCombined sources	1
Modified residueⁱ	27	N6-acetyllysineCombined sources	1
Modified residueⁱ	32	PhosphoserineCombined sources	1
Modified residueⁱ	35	N6-acetyllysine; alternateCombined sources	1
Modified residueⁱ	35	N6-succinyllysine; alternateBy similarity	1
Disulfide bondⁱ	52	Interchain (with C-173); in linked formCombined sources1 Publication
Modified residueⁱ	90	Phosphothreonine; by CDK11 Publication	1
Cross-linkⁱ	120	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	136	N6-acetyllysineBy similarity	1
Disulfide bondⁱ	173	Interchain (with C-52); in linked formCombined sources1 Publication
Cross-linkⁱ	185	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources

Post-translational modificationⁱ

Phosphorylated on Thr-90 during the M-phase, which leads to a more than 80% decrease in enzymatic activity.1 Publication

The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) instead of its condensation to a disulfide bond. It can be reactivated by forming a transient disulfide bond with sulfiredoxin SRXN1, which reduces the cysteine sulfinic acid in an ATP- and Mg-dependent manner.6 Publications

Keywords - PTMⁱ

Acetylation, Disulfide bond, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q06830
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q06830
PaxDbⁱ	Q06830
PeptideAtlas More...PeptideAtlasⁱ	Q06830
PRIDEⁱ	Q06830
ProteomicsDBⁱ	12697 58486
TopDownProteomicsⁱ	Q06830

2D gel databases

DOSAC-COBS 2D-PAGE database More...DOSAC-COBS-2DPAGEⁱ	Q06830
USC-OGP 2-DE database More...OGPⁱ	Q06830
SWISS-2DPAGEⁱ	Q06830
UCD-2DPAGEⁱ	Q06830

PTM databases

iPTMnetⁱ	Q06830
PhosphoSitePlusⁱ	Q06830
SwissPalmⁱ	Q06830

Expressionⁱ

Inductionⁱ

Constitutively expressed in most human cells; is induced to higher levels upon serum stimulation in untransformed and transformed cells.

Gene expression databases

Bgeeⁱ	ENSG00000117450 Expressed in 230 organ(s), highest expression level in thyroid gland
CleanExⁱ	HS_PRDX1
ExpressionAtlasⁱ	Q06830 baseline and differential
Genevisibleⁱ	Q06830 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB004682 HPA007730

HPAⁱ

CAB004682
HPA007730

Interactionⁱ

Subunit structureⁱ

Homodimer; disulfide-linked, upon oxidation. 5 homodimers assemble to form a ring-like decamer (PubMed:18172504). Interacts with GDPD5; forms a mixed-disulfide with GDPD5 (By similarity). Interacts with SESN1 and SESN2 (PubMed:15105503). Interacts with FAM107A (PubMed:21969592).By similarity3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
AR	P10275	3	EBI-353193,EBI-608057
PTEN	P60484	7	EBI-353193,EBI-696162
SRXN1	Q9BYN0	3	EBI-353193,EBI-15678820
STK4	Q13043	11	EBI-353193,EBI-367376
TERF1	P54274	2	EBI-353193,EBI-710997

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
identical protein binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111089, 140 interactors
CORUMⁱ	Q06830
Database of interacting proteins More...DIPⁱ	DIP-33152N
IntActⁱ	Q06830, 64 interactors
Molecular INTeraction database More...MINTⁱ	Q06830
STRINGⁱ	9606.ENSP00000262746

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	2 – 5	Combined sources	4
Beta strandⁱ	16 – 20	Combined sources	5
Beta strandⁱ	26 – 30	Combined sources	5
Helixⁱ	31 – 34	Combined sources	4
Beta strandⁱ	37 – 43	Combined sources	7
Helixⁱ	48 – 50	Combined sources	3
Helixⁱ	54 – 61	Combined sources	8
Helixⁱ	63 – 68	Combined sources	6
Beta strandⁱ	71 – 79	Combined sources	9
Helixⁱ	81 – 88	Combined sources	8
Helixⁱ	92 – 94	Combined sources	3
Beta strandⁱ	104 – 106	Combined sources	3
Helixⁱ	111 – 115	Combined sources	5
Turnⁱ	121 – 123	Combined sources	3
Beta strandⁱ	124 – 126	Combined sources	3
Beta strandⁱ	128 – 133	Combined sources	6
Beta strandⁱ	137 – 145	Combined sources	9
Helixⁱ	153 – 168	Combined sources	16
Beta strandⁱ	169 – 171	Combined sources	3
Helixⁱ	181 – 183	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q06830
SMRⁱ	Q06830
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q06830

EvolutionaryTraceⁱ

Q06830

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	6 – 165	ThioredoxinPROSITE-ProRule annotationAdd BLAST		160

Sequence similaritiesⁱ

Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.Curated

Keywords - Domainⁱ

Redox-active center

Phylogenomic databases

eggNOGⁱ	KOG0852 Eukaryota COG0450 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004653
HOVERGENⁱ	HBG000286
InParanoidⁱ	Q06830
KEGG Orthology (KO) More...KOⁱ	K13279
OMAⁱ	WYPKDFT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IE5
PhylomeDBⁱ	Q06830
TreeFamⁱ	TF105181

Family and domain databases

InterProⁱ	View protein in InterPro IPR000866 AhpC/TSA IPR024706 Peroxiredoxin_AhpC-typ IPR019479 Peroxiredoxin_C IPR036249 Thioredoxin-like_sf IPR013766 Thioredoxin_domain
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10417 1-cysPrx_C, 1 hit PF00578 AhpC-TSA, 1 hit
PIRSFⁱ	PIRSF000239 AHPC, 1 hit
SUPFAMⁱ	SSF52833 SSF52833, 1 hit
PROSITEⁱ	View protein in PROSITE PS51352 THIOREDOXIN_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q06830-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSGNAKIGH PAPNFKATAV MPDGQFKDIS LSDYKGKYVV FFFYPLDFTF 
        60         70         80         90        100
VCPTEIIAFS DRAEEFKKLN CQVIGASVDS HFCHLAWVNT PKKQGGLGPM 
       110        120        130        140        150
NIPLVSDPKR TIAQDYGVLK ADEGISFRGL FIIDDKGILR QITVNDLPVG 
       160        170        180        190 
RSVDETLRLV QAFQFTDKHG EVCPAGWKPG SDTIKPDVQK SKEYFSKQK

Length:199

Mass (Da):22,110

Last modified:June 1, 1994 - v1

Checksum:ⁱ8F68E56D75BF5304

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0A0MSI0	A0A0A0MSI0_HUMAN	Peroxiredoxin-1 Peroxiredoxin-1	PRDX1	171	Annotation score:
A0A0A0MRQ5	A0A0A0MRQ5_HUMAN	Peroxiredoxin-1 Peroxiredoxin-1	PRDX1	97	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	147	L → P (PubMed:8026862).Curated	1
Sequence conflictⁱ	149 – 150	VG → CC (PubMed:8026862).Curated	2
Sequence conflictⁱ	189	Q → P (PubMed:8026862).Curated	1
Sequence conflictⁱ	191	S → T (PubMed:8026862).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_025050	62	R → G1 PublicationCorresponds to variant dbSNP:rs34034070Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X67951 mRNA Translation: CAA48137.1 L19184 mRNA Translation: AAA50464.1 BT019740 mRNA Translation: AAV38545.1 CR407652 mRNA Translation: CAG28580.1 DQ297142 Genomic DNA Translation: ABB84465.1 AB451262 mRNA Translation: BAG70076.1 AB451388 mRNA Translation: BAG70202.1 AL451136 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06975.1 CH471059 Genomic DNA Translation: EAX06976.1 CH471059 Genomic DNA Translation: EAX06978.1 CH471059 Genomic DNA Translation: EAX06979.1 CH471059 Genomic DNA Translation: EAX06980.1 CH471059 Genomic DNA Translation: EAX06981.1 CH471059 Genomic DNA Translation: EAX06982.1 BC007063 mRNA Translation: AAH07063.1 BC021683 mRNA Translation: AAH21683.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS522.1
PIRⁱ	A46711
NCBI Reference Sequences More...RefSeqⁱ	NP_001189360.1, NM_001202431.1 NP_002565.1, NM_002574.3 NP_859047.1, NM_181696.2 NP_859048.1, NM_181697.2
UniGeneⁱ	Hs.180909 Hs.679832 Hs.731900

Genome annotation databases

Ensemblⁱ	ENST00000262746; ENSP00000262746; ENSG00000117450 ENST00000319248; ENSP00000361152; ENSG00000117450
GeneIDⁱ	5052
KEGGⁱ	hsa:5052
UCSC genome browser More...UCSCⁱ	uc001coa.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q06830	PRDX1 isoform 1		PANTR		199	UniRef100_Q06830
Uncharacterized protein		PANPA		199
Peroxiredoxin-1 (Fragment)		HUMAN		171
PRDX1 isoform 4 (Fragment)		PANTR		171

Protein	Similar proteins		Species	Score	Length	Source
Q06830	Peroxiredoxin-1		MYOLU		199	UniRef90_Q06830
Peroxiredoxin-1		CRIGR		199
Peroxiredoxin-1		MOUSE		199
Peroxiredoxin-1	)	RAT		199
PRDX1 isoform 1		PANTR		199
+104

Protein	Similar proteins		Species	Score	Length	Source
Q06830	Peroxiredoxin-1	)	RAT		199	UniRef50_Q06830
Peroxiredoxin-1		CRIGR		199
Peroxiredoxin-1		MOUSE		199
Peroxiredoxin-1		MYOLU		199
Peroxiredoxin-2	)	HUMAN		198
+527

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X67951 mRNA Translation: CAA48137.1 L19184 mRNA Translation: AAA50464.1 BT019740 mRNA Translation: AAV38545.1 CR407652 mRNA Translation: CAG28580.1 DQ297142 Genomic DNA Translation: ABB84465.1 AB451262 mRNA Translation: BAG70076.1 AB451388 mRNA Translation: BAG70202.1 AL451136 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06975.1 CH471059 Genomic DNA Translation: EAX06976.1 CH471059 Genomic DNA Translation: EAX06978.1 CH471059 Genomic DNA Translation: EAX06979.1 CH471059 Genomic DNA Translation: EAX06980.1 CH471059 Genomic DNA Translation: EAX06981.1 CH471059 Genomic DNA Translation: EAX06982.1 BC007063 mRNA Translation: AAH07063.1 BC021683 mRNA Translation: AAH21683.1
CCDSⁱ	CCDS522.1
PIRⁱ	A46711
RefSeqⁱ	NP_001189360.1, NM_001202431.1 NP_002565.1, NM_002574.3 NP_859047.1, NM_181696.2 NP_859048.1, NM_181697.2
UniGeneⁱ	Hs.180909 Hs.679832 Hs.731900

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2RII	X-ray	2.60	A/B	1-199	[»]
	3HY2	X-ray	2.10	A/B	1-199	[»]
	4XCS	X-ray	2.10	A/B/C/D/E/F	1-199	[»]
ProteinModelPortalⁱ	Q06830
SMRⁱ	Q06830
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111089, 140 interactors
CORUMⁱ	Q06830
DIPⁱ	DIP-33152N
IntActⁱ	Q06830, 64 interactors
MINTⁱ	Q06830
STRINGⁱ	9606.ENSP00000262746

Chemistry databases

ChEMBLⁱ	CHEMBL5315

ChEMBLⁱ

CHEMBL5315

Protein family/group databases

PeroxiBaseⁱ	4501 Hs2CysPrx01

PeroxiBaseⁱ

4501 Hs2CysPrx01

PTM databases

iPTMnetⁱ	Q06830
PhosphoSitePlusⁱ	Q06830
SwissPalmⁱ	Q06830

Polymorphism and mutation databases

BioMutaⁱ	PRDX1
DMDMⁱ	548453

2D gel databases

DOSAC-COBS-2DPAGEⁱ	Q06830
OGPⁱ	Q06830
SWISS-2DPAGEⁱ	Q06830
UCD-2DPAGEⁱ	Q06830

Proteomic databases

EPDⁱ	Q06830
MaxQBⁱ	Q06830
PaxDbⁱ	Q06830
PeptideAtlasⁱ	Q06830
PRIDEⁱ	Q06830
ProteomicsDBⁱ	12697 58486
TopDownProteomicsⁱ	Q06830

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5052
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000262746; ENSP00000262746; ENSG00000117450 ENST00000319248; ENSP00000361152; ENSG00000117450
GeneIDⁱ	5052
KEGGⁱ	hsa:5052
UCSCⁱ	uc001coa.4 human

Organism-specific databases

CTDⁱ	5052
DisGeNETⁱ	5052
EuPathDBⁱ	HostDB:ENSG00000117450.13
GeneCardsⁱ	PRDX1
HGNCⁱ	HGNC:9352 PRDX1
HPAⁱ	CAB004682 HPA007730
MalaCardsⁱ	PRDX1
MIMⁱ	176763 gene
neXtProtⁱ	NX_Q06830
OpenTargetsⁱ	ENSG00000117450
PharmGKBⁱ	PA33722
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0852 Eukaryota COG0450 LUCA
GeneTreeⁱ	ENSGT00390000004653
HOVERGENⁱ	HBG000286
InParanoidⁱ	Q06830
KOⁱ	K13279
OMAⁱ	WYPKDFT
OrthoDBⁱ	EOG091G0IE5
PhylomeDBⁱ	Q06830
TreeFamⁱ	TF105181

Enzyme and pathway databases

BRENDAⁱ	1.11.1.15 2681
Reactomeⁱ	R-HSA-3299685 Detoxification of Reactive Oxygen Species R-HSA-5628897 TP53 Regulates Metabolic Genes R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
SIGNORⁱ	Q06830

Miscellaneous databases

ChiTaRSⁱ	PRDX1 human
EvolutionaryTraceⁱ	Q06830
GeneWikiⁱ	Peroxiredoxin_1
GenomeRNAiⁱ	5052
Protein Ontology More...PROⁱ	PR:Q06830
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000117450 Expressed in 230 organ(s), highest expression level in thyroid gland
CleanExⁱ	HS_PRDX1
ExpressionAtlasⁱ	Q06830 baseline and differential
Genevisibleⁱ	Q06830 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000866 AhpC/TSA IPR024706 Peroxiredoxin_AhpC-typ IPR019479 Peroxiredoxin_C IPR036249 Thioredoxin-like_sf IPR013766 Thioredoxin_domain
Pfamⁱ	View protein in Pfam PF10417 1-cysPrx_C, 1 hit PF00578 AhpC-TSA, 1 hit
PIRSFⁱ	PIRSF000239 AHPC, 1 hit
SUPFAMⁱ	SSF52833 SSF52833, 1 hit
PROSITEⁱ	View protein in PROSITE PS51352 THIOREDOXIN_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PRDX1_HUMAN
Accessionⁱ	Q06830Primary (citable) accession number: Q06830 Secondary accession number(s): B5BU26 , D3DPZ8, P35703, Q2V576, Q5T154, Q5T155
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
	Last sequence update:	June 1, 1994
	Last modified:	November 7, 2018
	This is version 208 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q06830 (PRDX1_HUMAN)

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Peroxiredoxin-1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Extracellular region or secreted

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ