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UniProtKB - Q06819 (DIB1_YEAST)
Protein
Spliceosomal protein DIB1
Gene
DIB1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.
GO - Biological processi
- mRNA splicing, via spliceosome Source: SGD
Keywordsi
Biological process | mRNA processing, mRNA splicing |
Names & Taxonomyi
Protein namesi | Recommended name: Spliceosomal protein DIB1 |
Gene namesi | Name:DIB1 Synonyms:CDH1, SNU16 Ordered Locus Names:YPR082C ORF Names:P9513.12 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000006286, DIB1 |
VEuPathDBi | FungiDB:YPR082C |
Subcellular locationi
Nucleus
Nucleus
- spliceosomal complex Source: GO_Central
- U4/U6 x U5 tri-snRNP complex Source: SGD
- U5 snRNP Source: SGD
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000218286 | 2 – 143 | Spliceosomal protein DIB1Add BLAST | 142 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
MaxQBi | Q06819 |
PaxDbi | Q06819 |
PRIDEi | Q06819 |
PTM databases
iPTMneti | Q06819 |
Interactioni
Subunit structurei
Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1.
1 PublicationBinary interactionsi
Q06819
With | #Exp. | IntAct |
---|---|---|
PRP6 [P19735] | 3 | EBI-166,EBI-227 |
Protein-protein interaction databases
BioGRIDi | 36253, 153 interactors |
ComplexPortali | CPX-25, U4/U6.U5 tri-small nuclear ribonucleoprotein complex CPX-29, U5 small nuclear ribonucleoprotein complex |
DIPi | DIP-1289N |
IntActi | Q06819, 16 interactors |
MINTi | Q06819 |
STRINGi | 4932.YPR082C |
Miscellaneous databases
RNActi | Q06819, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the DIM1 family.Curated
Phylogenomic databases
eggNOGi | KOG3414, Eukaryota |
GeneTreei | ENSGT00390000010779 |
HOGENOMi | CLU_117348_0_0_1 |
InParanoidi | Q06819 |
OMAi | DFNEMYE |
Family and domain databases
CDDi | cd02954, DIM1, 1 hit |
InterProi | View protein in InterPro IPR004123, Dim1 IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR12052, PTHR12052, 1 hit |
Pfami | View protein in Pfam PF02966, DIM1, 1 hit |
PIRSFi | PIRSF017199, mRNA_splic_U5, 1 hit |
SMARTi | View protein in SMART SM01410, DIM1, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q06819-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASVLLPQLR TGWHVDQAIV TETKRLVVIR FGRKNDRQCM IMDELLSSIA
60 70 80 90 100
ERVRNFAVIY LCDIDEVSDF DEMYELTDPM TVMFFYHNKH MMCDFGTGNN
110 120 130 140
NKLNFIVDDK QEMIDILETI FRGARKNKGL VVSPYDYNHK RVS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U51033 Genomic DNA Translation: AAB68131.1 AY558054 Genomic DNA Translation: AAS56380.1 BK006949 Genomic DNA Translation: DAA11500.1 |
PIRi | S69068 |
RefSeqi | NP_015407.1, NM_001184179.1 |
Genome annotation databases
EnsemblFungii | YPR082C_mRNA; YPR082C; YPR082C |
GeneIDi | 856197 |
KEGGi | sce:YPR082C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U51033 Genomic DNA Translation: AAB68131.1 AY558054 Genomic DNA Translation: AAS56380.1 BK006949 Genomic DNA Translation: DAA11500.1 |
PIRi | S69068 |
RefSeqi | NP_015407.1, NM_001184179.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3JCM | electron microscopy | 3.80 | L | 1-143 | [»] | |
5GAN | electron microscopy | 3.60 | D | 1-143 | [»] | |
5GAP | electron microscopy | 3.60 | D | 1-143 | [»] | |
5NRL | electron microscopy | 7.20 | D | 1-143 | [»] | |
5ZWM | electron microscopy | 3.40 | E | 1-143 | [»] | |
5ZWO | electron microscopy | 3.90 | E | 1-143 | [»] | |
SMRi | Q06819 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 36253, 153 interactors |
ComplexPortali | CPX-25, U4/U6.U5 tri-small nuclear ribonucleoprotein complex CPX-29, U5 small nuclear ribonucleoprotein complex |
DIPi | DIP-1289N |
IntActi | Q06819, 16 interactors |
MINTi | Q06819 |
STRINGi | 4932.YPR082C |
PTM databases
iPTMneti | Q06819 |
Proteomic databases
MaxQBi | Q06819 |
PaxDbi | Q06819 |
PRIDEi | Q06819 |
Genome annotation databases
EnsemblFungii | YPR082C_mRNA; YPR082C; YPR082C |
GeneIDi | 856197 |
KEGGi | sce:YPR082C |
Organism-specific databases
SGDi | S000006286, DIB1 |
VEuPathDBi | FungiDB:YPR082C |
Phylogenomic databases
eggNOGi | KOG3414, Eukaryota |
GeneTreei | ENSGT00390000010779 |
HOGENOMi | CLU_117348_0_0_1 |
InParanoidi | Q06819 |
OMAi | DFNEMYE |
Miscellaneous databases
PROi | PR:Q06819 |
RNActi | Q06819, protein |
Family and domain databases
CDDi | cd02954, DIM1, 1 hit |
InterProi | View protein in InterPro IPR004123, Dim1 IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR12052, PTHR12052, 1 hit |
Pfami | View protein in Pfam PF02966, DIM1, 1 hit |
PIRSFi | PIRSF017199, mRNA_splic_U5, 1 hit |
SMARTi | View protein in SMART SM01410, DIM1, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DIB1_YEAST | |
Accessioni | Q06819Primary (citable) accession number: Q06819 Secondary accession number(s): D6W484 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 175 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XVI
Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families