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Protein

Polyprotein ABA-1

Gene

ABA-1

Organism
Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has high binding affinity for fatty acids and retinoids.

GO - Molecular functioni

Keywordsi

LigandLipid-binding, Retinol-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyprotein ABA-1
Alternative name(s):
Body fluid allergen 1
Nematode polyprotein allergen ABA-1
Short name:
NPA ABA-1
Allergen: Asc s 1
Cleaved into the following 6 chains:
Gene namesi
Name:ABA-1
OrganismiAscaris suum (Pig roundworm) (Ascaris lumbricoides)
Taxonomic identifieri6253 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaAscarididaAscaridoideaAscarididaeAscaris

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3541 Asc s 1.0101
61 Asc s 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000287126‹1 – 1365Polyprotein ABA-1Add BLAST›1365
PeptideiPRO_0000042221‹1 – 133ABA-1B1 repeat unitCuratedAdd BLAST›133
PeptideiPRO_0000042222134 – 266ABA-1A4 repeat unitCuratedAdd BLAST133
PeptideiPRO_0000042223267 – 399ABA-1A3 repeat unitCuratedAdd BLAST133
PeptideiPRO_0000042224400 – 533ABA-1A2 repeat unitCuratedAdd BLAST134
PeptideiPRO_0000042225534 – 666ABA-1A1 repeat unitCuratedAdd BLAST133
PeptideiPRO_0000042226667 – 799ABA-1A1 repeat unitCuratedAdd BLAST133
PeptideiPRO_0000042227800 – 932ABA-1A1 repeat unitCuratedAdd BLAST133
PeptideiPRO_0000042228933 – 1065ABA-1A1 repeat unitCuratedAdd BLAST133
PeptideiPRO_00000206061066 – 1198ABA-1A1 repeat unitCuratedAdd BLAST133
PeptideiPRO_00000206071199 – 1331ABA-1A1 repeat unitCuratedAdd BLAST133
PeptideiPRO_00000206081332 – 1365C-terminal extension peptideSequence analysisAdd BLAST34

Post-translational modificationi

Nematode polyprotein allergens (NPAs) are synthesized as large polypeptides that are subsequently proteolytically cleaved to active polypeptide units.

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PRIDEiQ06811

Expressioni

Tissue specificityi

Pseudocoelomic fluid.

Structurei

Secondary structure

11365
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1199 – 1201Combined sources3
Helixi1204 – 1206Combined sources3
Turni1207 – 1213Combined sources7
Helixi1216 – 1227Combined sources12
Helixi1232 – 1244Combined sources13
Helixi1248 – 1269Combined sources22
Helixi1271 – 1284Combined sources14
Helixi1288 – 1298Combined sources11
Helixi1305 – 1313Combined sources9
Helixi1315 – 1321Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XV9NMR-A534-662[»]
SMRiQ06811
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NPA family.Curated

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.10.533.30, 10 hits
InterProiView protein in InterPro
IPR032487 ABA-1_nematode
IPR038289 DVA-1_sf
PfamiView protein in Pfam
PF16469 NPA, 10 hits

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06811-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
TMEHYLKTYL SWLTEEQKEK LKEMKEAGKT KAEIQHEVMH YYDQLHGEEK
60 70 80 90 100
QQATEKLKVG CKMLLKGIIG EEKVVELRNM KEAGADIQEL QQKVEKMLSE
110 120 130 140 150
VTDEKQKEKV HEYGPACKKI FGATTLQHHR RRRHHFTLES SLDTHLKWLS
160 170 180 190 200
QEQKDELLKM KKDGKTKKEL EAKILHYYDE LEGDAKKEAT EHLKGGCGEI
210 220 230 240 250
LKHVVGEEKA AELKNLKDSG ASKEELKAKV EEALHAVTDE EKKQYIADFG
260 270 280 290 300
PACKKIYGVH TSRRRRHHFT LESSLDTHLK WLSQEQKDEL LKMKKDGKAK
310 320 330 340 350
KELEAKILHY YDELEGDAKK EATEHLKGGC AEILKHVVGE EKAAELKNLK
360 370 380 390 400
DSGASKEELK AKVEEALHAV TDEEKKQYIA DFGPACKKIY GVHTSRRRRH
410 420 430 440 450
HFTLESSLDT HLKWLSQEQK DELLKMKKDG KTKKDLQAKI LHYYDELEGD
460 470 480 490 500
AKKEATEHLK DGCREILKHV VGEEKEAELK KLKDSGASKE EVKAKVEEAL
510 520 530 540 550
HAVTDEEKKQ YIADFGPACK KIFGAAHTSR RRRHHFTLES SLDTHLKWLS
560 570 580 590 600
QEQKDELLKM KKDGKAKKEL EAKILHYYDE LEGDAKKEAT EHLKGGCREI
610 620 630 640 650
LKHVVGEEKA AELKNLKDSG ASKEELKAKV EEALHAVTDE EKKQYIADFG
660 670 680 690 700
PACKKIYGVH TSRRRRHHFT LESSLDTHLK WLSQEQKDEL LKMKKDGKAK
710 720 730 740 750
KELEAKILHY YDELEGDAKK EATEHLKGGC REILKHVVGE EKAAELKNLK
760 770 780 790 800
DSGASKEELK AKVEEALHAV TDEEKKQYIA DFGPACKKIY GVHTSRRRRH
810 820 830 840 850
HFTLESSLDT HLKWLSQEQK DELLKMKKDG KAKKELEAKI LHYYDELEGD
860 870 880 890 900
AKKEATEHLK GGCREILKHV VGEEKAAELK NLKDSGASKE ELKAKVEEAL
910 920 930 940 950
HAVTDEEKKQ YIADFGPACK KIYGVHTSRR RRHHFTLESS LDTHLKWLSQ
960 970 980 990 1000
EQKDELLKMK KDGKAKKELE AKILHYYDEL EGDAKKEATE HLKGGCREIL
1010 1020 1030 1040 1050
KHVVGEEKAA ELKNLKDSGA SKEELKAKVE EALHAVTDEE KKQYIADFGP
1060 1070 1080 1090 1100
ACKKIYGVHT SRRRRHHFTL ESSLDTHLKW LSQEQKDELL KMKKDGKAKK
1110 1120 1130 1140 1150
ELEAKILHYY DELEGDAKKE ATEHLKGGCR EILKHVVGEE KAAELKNLKD
1160 1170 1180 1190 1200
SGASKEELKA KVEEALHAVT DEEKKQYIAD FGPACKKIYG VHTSRRRRHH
1210 1220 1230 1240 1250
FTLESSLDTH LKWLSQEQKD ELLKMKKDGK AKKELEAKIL HYYDELEGDA
1260 1270 1280 1290 1300
KKEATEHLKG GCREILKHVV GEEKAAELKN LKDSGASKEE LKAKVEEALH
1310 1320 1330 1340 1350
AVTDEEKKQY IADFGPACKK IYGVHTSRRR RYHAEDGTDD IDGLAQSRQR
1360
RSGFFEKLID VFAFF
Length:1,365
Mass (Da):156,880
Last modified:October 11, 2005 - v2
Checksum:iF7F43B78606863DD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051702 mRNA Translation: AAC06015.1
L03211 mRNA Translation: AAB41117.1
PIRiA48576
T31423

Similar proteinsi

Entry informationi

Entry nameiABA1_ASCSU
AccessioniPrimary (citable) accession number: Q06811
Secondary accession number(s): O61566, Q9TWU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 11, 2005
Last modified: May 23, 2018
This is version 65 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

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