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Entry version 68 (11 Dec 2019)
Sequence version 2 (11 Oct 2005)
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Protein

Polyprotein ABA-1

Gene

ABA-1

Organism
Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has high binding affinity for fatty acids and retinoids.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandLipid-binding, Retinol-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polyprotein ABA-1
Alternative name(s):
Body fluid allergen 1
Nematode polyprotein allergen ABA-1
Short name:
NPA ABA-1
Allergen: Asc s 1
Cleaved into the following 6 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABA-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAscaris suum (Pig roundworm) (Ascaris lumbricoides)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6253 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaSpirurinaAscaridomorphaAscaridoideaAscarididaeAscaris

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section is used for proteins that cause an allergic reaction in mammals. We usually specify in which species the protein is allergenic.<p><a href='/help/allergenic_properties' target='_top'>More...</a></p>Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergome; a platform for allergen knowledge

More...
Allergomei
3541 Asc s 1.0101
61 Asc s 1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000287126‹1 – 1365Polyprotein ABA-1Add BLAST›1365
<p>This subsection of the 'PTM / Processing' section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_0000042221‹1 – 133ABA-1B1 repeat unitCuratedAdd BLAST›133
PeptideiPRO_0000042222134 – 266ABA-1A4 repeat unitCuratedAdd BLAST133
PeptideiPRO_0000042223267 – 399ABA-1A3 repeat unitCuratedAdd BLAST133
PeptideiPRO_0000042224400 – 533ABA-1A2 repeat unitCuratedAdd BLAST134
PeptideiPRO_0000042225534 – 666ABA-1A1 repeat unitCuratedAdd BLAST133
PeptideiPRO_0000042226667 – 799ABA-1A1 repeat unitCuratedAdd BLAST133
PeptideiPRO_0000042227800 – 932ABA-1A1 repeat unitCuratedAdd BLAST133
PeptideiPRO_0000042228933 – 1065ABA-1A1 repeat unitCuratedAdd BLAST133
PeptideiPRO_00000206061066 – 1198ABA-1A1 repeat unitCuratedAdd BLAST133
PeptideiPRO_00000206071199 – 1331ABA-1A1 repeat unitCuratedAdd BLAST133
PeptideiPRO_00000206081332 – 1365C-terminal extension peptideSequence analysisAdd BLAST34

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Nematode polyprotein allergens (NPAs) are synthesized as large polypeptides that are subsequently proteolytically cleaved to active polypeptide units.

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q06811

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Pseudocoelomic fluid.

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11365
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q06811

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NPA family.Curated

Keywords - Domaini

Repeat

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.533.30, 10 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032487 ABA-1_nematode
IPR038289 DVA-1_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16469 NPA, 10 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q06811-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
TMEHYLKTYL SWLTEEQKEK LKEMKEAGKT KAEIQHEVMH YYDQLHGEEK
60 70 80 90 100
QQATEKLKVG CKMLLKGIIG EEKVVELRNM KEAGADIQEL QQKVEKMLSE
110 120 130 140 150
VTDEKQKEKV HEYGPACKKI FGATTLQHHR RRRHHFTLES SLDTHLKWLS
160 170 180 190 200
QEQKDELLKM KKDGKTKKEL EAKILHYYDE LEGDAKKEAT EHLKGGCGEI
210 220 230 240 250
LKHVVGEEKA AELKNLKDSG ASKEELKAKV EEALHAVTDE EKKQYIADFG
260 270 280 290 300
PACKKIYGVH TSRRRRHHFT LESSLDTHLK WLSQEQKDEL LKMKKDGKAK
310 320 330 340 350
KELEAKILHY YDELEGDAKK EATEHLKGGC AEILKHVVGE EKAAELKNLK
360 370 380 390 400
DSGASKEELK AKVEEALHAV TDEEKKQYIA DFGPACKKIY GVHTSRRRRH
410 420 430 440 450
HFTLESSLDT HLKWLSQEQK DELLKMKKDG KTKKDLQAKI LHYYDELEGD
460 470 480 490 500
AKKEATEHLK DGCREILKHV VGEEKEAELK KLKDSGASKE EVKAKVEEAL
510 520 530 540 550
HAVTDEEKKQ YIADFGPACK KIFGAAHTSR RRRHHFTLES SLDTHLKWLS
560 570 580 590 600
QEQKDELLKM KKDGKAKKEL EAKILHYYDE LEGDAKKEAT EHLKGGCREI
610 620 630 640 650
LKHVVGEEKA AELKNLKDSG ASKEELKAKV EEALHAVTDE EKKQYIADFG
660 670 680 690 700
PACKKIYGVH TSRRRRHHFT LESSLDTHLK WLSQEQKDEL LKMKKDGKAK
710 720 730 740 750
KELEAKILHY YDELEGDAKK EATEHLKGGC REILKHVVGE EKAAELKNLK
760 770 780 790 800
DSGASKEELK AKVEEALHAV TDEEKKQYIA DFGPACKKIY GVHTSRRRRH
810 820 830 840 850
HFTLESSLDT HLKWLSQEQK DELLKMKKDG KAKKELEAKI LHYYDELEGD
860 870 880 890 900
AKKEATEHLK GGCREILKHV VGEEKAAELK NLKDSGASKE ELKAKVEEAL
910 920 930 940 950
HAVTDEEKKQ YIADFGPACK KIYGVHTSRR RRHHFTLESS LDTHLKWLSQ
960 970 980 990 1000
EQKDELLKMK KDGKAKKELE AKILHYYDEL EGDAKKEATE HLKGGCREIL
1010 1020 1030 1040 1050
KHVVGEEKAA ELKNLKDSGA SKEELKAKVE EALHAVTDEE KKQYIADFGP
1060 1070 1080 1090 1100
ACKKIYGVHT SRRRRHHFTL ESSLDTHLKW LSQEQKDELL KMKKDGKAKK
1110 1120 1130 1140 1150
ELEAKILHYY DELEGDAKKE ATEHLKGGCR EILKHVVGEE KAAELKNLKD
1160 1170 1180 1190 1200
SGASKEELKA KVEEALHAVT DEEKKQYIAD FGPACKKIYG VHTSRRRRHH
1210 1220 1230 1240 1250
FTLESSLDTH LKWLSQEQKD ELLKMKKDGK AKKELEAKIL HYYDELEGDA
1260 1270 1280 1290 1300
KKEATEHLKG GCREILKHVV GEEKAAELKN LKDSGASKEE LKAKVEEALH
1310 1320 1330 1340 1350
AVTDEEKKQY IADFGPACKK IYGVHTSRRR RYHAEDGTDD IDGLAQSRQR
1360
RSGFFEKLID VFAFF
Length:1,365
Mass (Da):156,880
Last modified:October 11, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF7F43B78606863DD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF051702 mRNA Translation: AAC06015.1
L03211 mRNA Translation: AAB41117.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A48576
T31423

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051702 mRNA Translation: AAC06015.1
L03211 mRNA Translation: AAB41117.1
PIRiA48576
T31423

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XV9NMR-A534-662[»]
SMRiQ06811
ModBaseiSearch...
PDBe-KBiSearch...

Protein family/group databases

Allergomei3541 Asc s 1.0101
61 Asc s 1

Proteomic databases

PRIDEiQ06811

Family and domain databases

Gene3Di1.10.533.30, 10 hits
InterProiView protein in InterPro
IPR032487 ABA-1_nematode
IPR038289 DVA-1_sf
PfamiView protein in Pfam
PF16469 NPA, 10 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABA1_ASCSU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q06811
Secondary accession number(s): O61566, Q9TWU7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 11, 2005
Last modified: December 11, 2019
This is version 68 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Allergens
    Nomenclature of allergens and list of entries
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