Tie1

Functionⁱ

Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.By similarity

Catalytic activityⁱ

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	866	ATPPROSITE-ProRule annotation		1
Active siteⁱ	975	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	841 – 849	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
transmembrane receptor protein tyrosine kinase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

angiogenesis Source: UniProtKB-KW
blood vessel development
Source: MGI
Inferred from mutant phenotypeⁱ
- 23918385
in utero embryonic development
Source: MGI
Inferred from genetic interactionⁱ
- 11172728
negative regulation of angiogenesis
Source: MGI
Inferred from mutant phenotypeⁱ
- 9683559
negative regulation of cell migration
Source: MGI
Inferred from mutant phenotypeⁱ
- 9683559
plasma membrane fusion
Source: MGI
Inferred from mutant phenotypeⁱ
- 9683559
response to retinoic acid
Source: BHF-UCL
Inferred from direct assayⁱ
- 18439490
vasculogenesis Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Receptor, Transferase, Tyrosine-protein kinase
Biological process	Angiogenesis
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.10.1 3474

BRENDAⁱ

2.7.10.1 3474

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tyrosine-protein kinase receptor Tie-1 (EC:2.7.10.1)
Gene namesⁱ	Name:Tie1 Synonyms:Tie, Tie-1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 4

Organism-specific databases

MGIⁱ	MGI:99906 Tie1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	23 – 755	ExtracellularSequence analysisAdd BLAST	733
Transmembraneⁱ	756 – 780	HelicalSequence analysisAdd BLAST	25
Topological domainⁱ	781 – 1134	CytoplasmicSequence analysisAdd BLAST	354

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL2034800

ChEMBLⁱ

CHEMBL2034800

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 22	Add BLAST		22
ChainⁱPRO_0000024472	23 – 1134	Tyrosine-protein kinase receptor Tie-1Add BLAST		1112

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	81	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	159	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	226 ↔ 235	By similarity
Disulfide bondⁱ	229 ↔ 242	By similarity
Disulfide bondⁱ	244 ↔ 253	By similarity
Disulfide bondⁱ	266 ↔ 276	By similarity
Disulfide bondⁱ	270 ↔ 289	By similarity
Disulfide bondⁱ	291 ↔ 300	By similarity
Disulfide bondⁱ	313 ↔ 325	By similarity
Disulfide bondⁱ	319 ↔ 331	By similarity
Disulfide bondⁱ	333 ↔ 342	By similarity
Glycosylationⁱ	501	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	592	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	705	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	1003	Phosphotyrosine; by autocatalysisBy similarity	1

Post-translational modificationⁱ

Phosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2.By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q06806
PaxDbⁱ	Q06806
PeptideAtlas More...PeptideAtlasⁱ	Q06806
PRIDEⁱ	Q06806

PTM databases

iPTMnetⁱ	Q06806
PhosphoSitePlusⁱ	Q06806

Expressionⁱ

Tissue specificityⁱ

Specifically expressed in developing vascular endothelial cells. Abundantly expressed in lung and heart, moderately in brain, liver and kidney, and weakly in thymus, spleen and testis.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000033191 Expressed in 203 organ(s), highest expression level in cardiac muscle of left ventricle
CleanExⁱ	MM_TIE1
ExpressionAtlasⁱ	Q06806 baseline and differential
Genevisibleⁱ	Q06806 MM

Interactionⁱ

Subunit structureⁱ

Heterodimer with TEK/TIE2.By similarity

Protein-protein interaction databases

IntActⁱ	Q06806, 1 interactor
Molecular INTeraction database More...MINTⁱ	Q06806
STRINGⁱ	10090.ENSMUSP00000037129

Chemistry databases

BindingDBⁱ

Q06806

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q06806
SMRⁱ	Q06806
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	43 – 123	Ig-like C2-type 1Add BLAST	81
Domainⁱ	212 – 254	EGF-like 1PROSITE-ProRule annotationAdd BLAST	43
Domainⁱ	256 – 301	EGF-like 2PROSITE-ProRule annotationAdd BLAST	46
Domainⁱ	303 – 343	EGF-like 3PROSITE-ProRule annotationAdd BLAST	41
Domainⁱ	349 – 440	Ig-like C2-type 2Add BLAST	92
Domainⁱ	444 – 543	Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST	100
Domainⁱ	546 – 638	Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST	93
Domainⁱ	642 – 736	Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST	95
Domainⁱ	835 – 1114	Protein kinasePROSITE-ProRule annotationAdd BLAST	280

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

EGF-like domain, Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0200 Eukaryota COG0515 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00810000125384
HOGENOMⁱ	HOG000049232
HOVERGENⁱ	HBG007316
InParanoidⁱ	Q06806
KEGG Orthology (KO) More...KOⁱ	K05120
OMAⁱ	FENFTYA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00RL
TreeFamⁱ	TF317568

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00063 FN3, 3 hits
Gene3Dⁱ	2.60.40.10, 5 hits
InterProⁱ	View protein in InterPro IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR003961 FN3_dom IPR036116 FN3_sf IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR013151 Immunoglobulin IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR008266 Tyr_kinase_AS IPR020635 Tyr_kinase_cat_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00041 fn3, 3 hits PF00047 ig, 2 hits PF07714 Pkinase_Tyr, 1 hit
PRINTSⁱ	PR00109 TYRKINASE
SMARTⁱ	View protein in SMART SM00181 EGF, 3 hits SM00060 FN3, 3 hits SM00409 IG, 2 hits SM00219 TyrKc, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 2 hits SSF49265 SSF49265, 2 hits SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00022 EGF_1, 3 hits PS01186 EGF_2, 3 hits PS50026 EGF_3, 3 hits PS50853 FN3, 3 hits PS50835 IG_LIKE, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.ⁱShow all

Q06806-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVWWGSSLLL PTLFLASHVG ASVDLTLLAN LRITDPQRFF LTCVSGEAGA 
        60         70         80         90        100
GRSSDPPLLL EKDDRIVRTF PPGQPLYLAR NGSHQVTLRG FSKPSDLVGV 
       110        120        130        140        150
FSCVGGAGAR RTRVLYVHNS PGAHLFPDKV THTVNKGDTA VLSAHVHKEK 
       160        170        180        190        200
QTDVIWKNNG SYFNTLDWQE ADDGRFQLQL QNVQPPSSGI YSATYLEASP 
       210        220        230        240        250
LGSAFFRLIV RGCGAGRWGP GCVKDCPGCL HGGVCHDHDG ECVCPPGFTG 
       260        270        280        290        300
TRCEQACREG RFGQSCQEQC PGTAGCRGLT FCLPDPYGCS CGSGWRGSQC 
       310        320        330        340        350
QEACAPGHFG ADCRLQCQCQ NGGTCDRFSG CVCPSGWHGV HCEKSDRIPQ 
       360        370        380        390        400
ILSMATEVEF NIGTMPRINC AAAGNPFPVR GSMKLRKPDG TMLLSTKVIV 
       410        420        430        440        450
EPDRTTAEFE VPSLTLGDSG FWECRVSTSG GQDSRRFKVN VKVPPVPLTA 
       460        470        480        490        500
PRLLAKQSRQ LVVSPLVSFS GDGPISSVRL HYRPQDSTIA WSAIVVDPSE 
       510        520        530        540        550
NVTLMNLKPK TGYNVRVQLS RPGEGGEGGW GPSALMTTDC PEPLLQPWLE 
       560        570        580        590        600
SWHVEGPDRL RVSWSLPSVP LSGDGFLLRL WDGARGQERR ENISFPQART 
       610        620        630        640        650
ALLTGLTPGT HYQLDVRLYH CTLLGPASPP AHVHLPPSGP PAPRHLHAQA 
       660        670        680        690        700
LSDSEIQLMW QHPEAPSGPI SKYIVEIQVA GGSGDPQWMD VDRPEETSII 
       710        720        730        740        750
VRGLNASTRY LFRVRASVQG LGDWSNTVEE ATLGNGLQSE GPVRESRAAE 
       760        770        780        790        800
EGLDQQLVLA VVGSVSATCL TILAALLALV CIRRSCLHRR RTFTYQSGSG 
       810        820        830        840        850
EETILQFSSG TLTLTRRPKP QPEPLSYPVL EWEDITFEDL IGEGNFGQVI 
       860        870        880        890        900
RAMIKKDGLK MNAAIKMLKE YASENDHRDF AGELEVLCKL GHHPNIINLL 
       910        920        930        940        950
GACENRGYLY IAIEYAPYGN LLDFLRKSRV LETDPAFARE HGTASTLSSR 
       960        970        980        990       1000
QLLRFASDAA NGMQYLSEKQ FIHRDLAARN VLVGENLASK IADFGLSRGE 
      1010       1020       1030       1040       1050
EVYVKKTMGR LPVRWMAIES LNYSVYTTKS DVWSFGVLLW EIVSLGGTPY 
      1060       1070       1080       1090       1100
CGMTCAELYE KLPQGYRMEQ PRNCDDEVYE LMRQCWRDRP YERPPFAQIA 
      1110       1120       1130 
LQLGRMLEAR KAYVNMSLFE NFTYAGIDAT AEEA

Length:1,134

Mass (Da):124,583

Last modified:July 27, 2011 - v3

Checksum:ⁱ9669098A843B36F2

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	Q6PAP2	Q6PAP2_MOUSE		Tie1 protein Tie1 protein (Tyrosine-protein kinase receptor Tie-1)	Tie1	647	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	307	G → D in CAA50556 (PubMed:8415706).Curated	1
Sequence conflictⁱ	307	G → D in CAA56739 (PubMed:8415706).Curated	1
Sequence conflictⁱ	307	G → D in CAA52148 (PubMed:8395828).Curated	1
Sequence conflictⁱ	307	G → D in AAH46452 (PubMed:15489334).Curated	1
Sequence conflictⁱ	599	R → L in CAA50556 (PubMed:8415706).Curated	1
Sequence conflictⁱ	741	G → D in CAA50556 (PubMed:8415706).Curated	1
Sequence conflictⁱ	741	G → D in CAA56739 (PubMed:8415706).Curated	1
Sequence conflictⁱ	741	G → D in CAA52148 (PubMed:8395828).Curated	1
Sequence conflictⁱ	741	G → D in AAH46452 (PubMed:15489334).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X71425 mRNA Translation: CAA50556.1 X80764 mRNA Translation: CAA56739.1 X73960 mRNA Translation: CAA52148.1 AK052192 mRNA Translation: BAC34876.1 AK052413 mRNA Translation: BAC34979.1 AL627212 Genomic DNA Translation: CAM15213.1 BC046452 mRNA Translation: AAH46452.2 S79346 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS18553.1
PIRⁱ	JN0711
NCBI Reference Sequences More...RefSeqⁱ	NP_035717.2, NM_011587.2
UniGeneⁱ	Mm.4345

Genome annotation databases

Ensemblⁱ	ENSMUST00000047421; ENSMUSP00000037129; ENSMUSG00000033191
GeneIDⁱ	21846
KEGGⁱ	mmu:21846
UCSC genome browser More...UCSCⁱ	uc008ukh.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q06806	Receptor tyrosine kinase (Fragment)		Mus sp.		19	UniRef100_Q06806

Protein	Similar proteins		Species	Score	Length	Source
Q06806	Tyrosine-protein kinase receptor Tie-1	)	HUMAN		1138	UniRef90_P35590
Tyrosine-protein kinase receptor Tie-1		BOVIN		1136
TIE1		CEREH		1152
Tyrosine-protein kinase receptor Tie-1 isoform 1		HETGA		1147
tyrosine-protein kinase receptor Tie-1 isoform X1		ERIEU		1145
+115

Protein	Similar proteins		Species	Score	Length	Source
Q06806	Tyrosine-protein kinase receptor Tie-1	)	HUMAN		1138	UniRef50_P35590
Tyrosine-protein kinase receptor Tie-1		BOVIN		1136
TIE1		CEREH		1152
Tyrosine-protein kinase receptor Tie-1 isoform 1		HETGA		1147
tyrosine-protein kinase receptor Tie-1 isoform X1		ERIEU		1145
+190

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X71425 mRNA Translation: CAA50556.1 X80764 mRNA Translation: CAA56739.1 X73960 mRNA Translation: CAA52148.1 AK052192 mRNA Translation: BAC34876.1 AK052413 mRNA Translation: BAC34979.1 AL627212 Genomic DNA Translation: CAM15213.1 BC046452 mRNA Translation: AAH46452.2 S79346 Genomic DNA No translation available.
CCDSⁱ	CCDS18553.1
PIRⁱ	JN0711
RefSeqⁱ	NP_035717.2, NM_011587.2
UniGeneⁱ	Mm.4345

3D structure databases

ProteinModelPortalⁱ	Q06806
SMRⁱ	Q06806
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q06806, 1 interactor
MINTⁱ	Q06806
STRINGⁱ	10090.ENSMUSP00000037129

Chemistry databases

BindingDBⁱ	Q06806
ChEMBLⁱ	CHEMBL2034800

PTM databases

iPTMnetⁱ	Q06806
PhosphoSitePlusⁱ	Q06806

Proteomic databases

MaxQBⁱ	Q06806
PaxDbⁱ	Q06806
PeptideAtlasⁱ	Q06806
PRIDEⁱ	Q06806

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000047421; ENSMUSP00000037129; ENSMUSG00000033191
GeneIDⁱ	21846
KEGGⁱ	mmu:21846
UCSCⁱ	uc008ukh.1 mouse

Organism-specific databases

CTDⁱ	7075
MGIⁱ	MGI:99906 Tie1

Phylogenomic databases

eggNOGⁱ	KOG0200 Eukaryota COG0515 LUCA
GeneTreeⁱ	ENSGT00810000125384
HOGENOMⁱ	HOG000049232
HOVERGENⁱ	HBG007316
InParanoidⁱ	Q06806
KOⁱ	K05120
OMAⁱ	FENFTYA
OrthoDBⁱ	EOG091G00RL
TreeFamⁱ	TF317568

Enzyme and pathway databases

BRENDAⁱ	2.7.10.1 3474

BRENDAⁱ

2.7.10.1 3474

Miscellaneous databases

ChiTaRSⁱ	Tie1 mouse
Protein Ontology More...PROⁱ	PR:Q06806
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000033191 Expressed in 203 organ(s), highest expression level in cardiac muscle of left ventricle
CleanExⁱ	MM_TIE1
ExpressionAtlasⁱ	Q06806 baseline and differential
Genevisibleⁱ	Q06806 MM

Family and domain databases

CDDⁱ	cd00063 FN3, 3 hits
Gene3Dⁱ	2.60.40.10, 5 hits
InterProⁱ	View protein in InterPro IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR003961 FN3_dom IPR036116 FN3_sf IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR013151 Immunoglobulin IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR008266 Tyr_kinase_AS IPR020635 Tyr_kinase_cat_dom
Pfamⁱ	View protein in Pfam PF00041 fn3, 3 hits PF00047 ig, 2 hits PF07714 Pkinase_Tyr, 1 hit
PRINTSⁱ	PR00109 TYRKINASE
SMARTⁱ	View protein in SMART SM00181 EGF, 3 hits SM00060 FN3, 3 hits SM00409 IG, 2 hits SM00219 TyrKc, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 2 hits SSF49265 SSF49265, 2 hits SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00022 EGF_1, 3 hits PS01186 EGF_2, 3 hits PS50026 EGF_3, 3 hits PS50853 FN3, 3 hits PS50835 IG_LIKE, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00109 PROTEIN_KINASE_TYR, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TIE1_MOUSE
Accessionⁱ	Q06806Primary (citable) accession number: Q06806 Secondary accession number(s): Q811F4, Q8BGI2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
	Last sequence update:	July 27, 2011
	Last modified:	September 12, 2018
	This is version 173 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q06806 (TIE1_MOUSE)

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Tyrosine-protein kinase receptor Tie-1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ