UniProtKB - Q06806 (TIE1_MOUSE)
Protein
Tyrosine-protein kinase receptor Tie-1
Gene
Tie1
Organism
Mus musculus (Mouse)
Status
Functioni
Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.By similarity
Catalytic activityi
- EC:2.7.10.1PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 866 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 975 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 841 – 849 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- transmembrane receptor protein tyrosine kinase activity Source: GO_Central
GO - Biological processi
- angiogenesis Source: GO_Central
- blood vessel development Source: MGI
- in utero embryonic development Source: MGI
- multicellular organism development Source: GO_Central
- negative regulation of angiogenesis Source: MGI
- negative regulation of cell migration Source: MGI
- plasma membrane fusion Source: MGI
- positive regulation of angiogenesis Source: GO_Central
- positive regulation of kinase activity Source: GO_Central
- response to retinoic acid Source: BHF-UCL
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
- vasculogenesis Source: MGI
Keywordsi
Molecular function | Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Biological process | Angiogenesis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.1, 3474 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Tie1 Synonyms:Tie, Tie-1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:99906, Tie1 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: MGI
Other locations
- integral component of membrane Source: MGI
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 23 – 755 | ExtracellularSequence analysisAdd BLAST | 733 | |
Transmembranei | 756 – 780 | HelicalSequence analysisAdd BLAST | 25 | |
Topological domaini | 781 – 1134 | CytoplasmicSequence analysisAdd BLAST | 354 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Add BLAST | 22 | |
ChainiPRO_0000024472 | 23 – 1134 | Tyrosine-protein kinase receptor Tie-1Add BLAST | 1112 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 81 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 159 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 226 ↔ 235 | By similarity | ||
Disulfide bondi | 229 ↔ 242 | By similarity | ||
Disulfide bondi | 244 ↔ 253 | By similarity | ||
Disulfide bondi | 266 ↔ 276 | By similarity | ||
Disulfide bondi | 270 ↔ 289 | By similarity | ||
Disulfide bondi | 291 ↔ 300 | By similarity | ||
Disulfide bondi | 313 ↔ 325 | By similarity | ||
Disulfide bondi | 319 ↔ 331 | By similarity | ||
Disulfide bondi | 333 ↔ 342 | By similarity | ||
Glycosylationi | 501 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 592 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 705 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 1003 | Phosphotyrosine; by autocatalysisBy similarity | 1 |
Post-translational modificationi
Phosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2.By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
CPTACi | non-CPTAC-3623 |
MaxQBi | Q06806 |
PaxDbi | Q06806 |
PeptideAtlasi | Q06806 |
PRIDEi | Q06806 |
PTM databases
GlyGeni | Q06806, 5 sites |
iPTMneti | Q06806 |
PhosphoSitePlusi | Q06806 |
Expressioni
Tissue specificityi
Specifically expressed in developing vascular endothelial cells. Abundantly expressed in lung and heart, moderately in brain, liver and kidney, and weakly in thymus, spleen and testis.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000033191, Expressed in cardiac muscle of left ventricle and 224 other tissues |
ExpressionAtlasi | Q06806, baseline and differential |
Genevisiblei | Q06806, MM |
Interactioni
Subunit structurei
Heterodimer with TEK/TIE2.
By similarityProtein-protein interaction databases
IntActi | Q06806, 1 interactor |
MINTi | Q06806 |
STRINGi | 10090.ENSMUSP00000037129 |
Chemistry databases
BindingDBi | Q06806 |
Miscellaneous databases
RNActi | Q06806, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 43 – 123 | Ig-like C2-type 1Add BLAST | 81 | |
Domaini | 212 – 254 | EGF-like 1PROSITE-ProRule annotationAdd BLAST | 43 | |
Domaini | 256 – 301 | EGF-like 2PROSITE-ProRule annotationAdd BLAST | 46 | |
Domaini | 303 – 343 | EGF-like 3PROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 349 – 440 | Ig-like C2-type 2Add BLAST | 92 | |
Domaini | 444 – 543 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 100 | |
Domaini | 546 – 638 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 642 – 736 | Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 835 – 1114 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 280 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.PROSITE-ProRule annotation
Keywords - Domaini
EGF-like domain, Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0200, Eukaryota |
GeneTreei | ENSGT00940000157693 |
HOGENOMi | CLU_008888_0_0_1 |
InParanoidi | Q06806 |
OMAi | NASTCYL |
OrthoDBi | 707342at2759 |
TreeFami | TF317568 |
Family and domain databases
CDDi | cd00063, FN3, 3 hits |
Gene3Di | 2.60.40.10, 5 hits |
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013151, Immunoglobulin IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF00041, fn3, 3 hits PF00047, ig, 2 hits PF07714, PK_Tyr_Ser-Thr, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00181, EGF, 3 hits SM00060, FN3, 3 hits SM00409, IG, 2 hits SM00219, TyrKc, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits SSF49265, SSF49265, 2 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 3 hits PS01186, EGF_2, 3 hits PS50026, EGF_3, 3 hits PS50853, FN3, 3 hits PS50835, IG_LIKE, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q06806-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVWWGSSLLL PTLFLASHVG ASVDLTLLAN LRITDPQRFF LTCVSGEAGA
60 70 80 90 100
GRSSDPPLLL EKDDRIVRTF PPGQPLYLAR NGSHQVTLRG FSKPSDLVGV
110 120 130 140 150
FSCVGGAGAR RTRVLYVHNS PGAHLFPDKV THTVNKGDTA VLSAHVHKEK
160 170 180 190 200
QTDVIWKNNG SYFNTLDWQE ADDGRFQLQL QNVQPPSSGI YSATYLEASP
210 220 230 240 250
LGSAFFRLIV RGCGAGRWGP GCVKDCPGCL HGGVCHDHDG ECVCPPGFTG
260 270 280 290 300
TRCEQACREG RFGQSCQEQC PGTAGCRGLT FCLPDPYGCS CGSGWRGSQC
310 320 330 340 350
QEACAPGHFG ADCRLQCQCQ NGGTCDRFSG CVCPSGWHGV HCEKSDRIPQ
360 370 380 390 400
ILSMATEVEF NIGTMPRINC AAAGNPFPVR GSMKLRKPDG TMLLSTKVIV
410 420 430 440 450
EPDRTTAEFE VPSLTLGDSG FWECRVSTSG GQDSRRFKVN VKVPPVPLTA
460 470 480 490 500
PRLLAKQSRQ LVVSPLVSFS GDGPISSVRL HYRPQDSTIA WSAIVVDPSE
510 520 530 540 550
NVTLMNLKPK TGYNVRVQLS RPGEGGEGGW GPSALMTTDC PEPLLQPWLE
560 570 580 590 600
SWHVEGPDRL RVSWSLPSVP LSGDGFLLRL WDGARGQERR ENISFPQART
610 620 630 640 650
ALLTGLTPGT HYQLDVRLYH CTLLGPASPP AHVHLPPSGP PAPRHLHAQA
660 670 680 690 700
LSDSEIQLMW QHPEAPSGPI SKYIVEIQVA GGSGDPQWMD VDRPEETSII
710 720 730 740 750
VRGLNASTRY LFRVRASVQG LGDWSNTVEE ATLGNGLQSE GPVRESRAAE
760 770 780 790 800
EGLDQQLVLA VVGSVSATCL TILAALLALV CIRRSCLHRR RTFTYQSGSG
810 820 830 840 850
EETILQFSSG TLTLTRRPKP QPEPLSYPVL EWEDITFEDL IGEGNFGQVI
860 870 880 890 900
RAMIKKDGLK MNAAIKMLKE YASENDHRDF AGELEVLCKL GHHPNIINLL
910 920 930 940 950
GACENRGYLY IAIEYAPYGN LLDFLRKSRV LETDPAFARE HGTASTLSSR
960 970 980 990 1000
QLLRFASDAA NGMQYLSEKQ FIHRDLAARN VLVGENLASK IADFGLSRGE
1010 1020 1030 1040 1050
EVYVKKTMGR LPVRWMAIES LNYSVYTTKS DVWSFGVLLW EIVSLGGTPY
1060 1070 1080 1090 1100
CGMTCAELYE KLPQGYRMEQ PRNCDDEVYE LMRQCWRDRP YERPPFAQIA
1110 1120 1130
LQLGRMLEAR KAYVNMSLFE NFTYAGIDAT AEEA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ6PAP2 | Q6PAP2_MOUSE | Tie1 protein | Tie1 | 647 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 307 | G → D in CAA50556 (PubMed:8415706).Curated | 1 | |
Sequence conflicti | 307 | G → D in CAA56739 (PubMed:8415706).Curated | 1 | |
Sequence conflicti | 307 | G → D in CAA52148 (PubMed:8395828).Curated | 1 | |
Sequence conflicti | 307 | G → D in AAH46452 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 599 | R → L in CAA50556 (PubMed:8415706).Curated | 1 | |
Sequence conflicti | 741 | G → D in CAA50556 (PubMed:8415706).Curated | 1 | |
Sequence conflicti | 741 | G → D in CAA56739 (PubMed:8415706).Curated | 1 | |
Sequence conflicti | 741 | G → D in CAA52148 (PubMed:8395828).Curated | 1 | |
Sequence conflicti | 741 | G → D in AAH46452 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X71425 mRNA Translation: CAA50556.1 X80764 mRNA Translation: CAA56739.1 X73960 mRNA Translation: CAA52148.1 AK052192 mRNA Translation: BAC34876.1 AK052413 mRNA Translation: BAC34979.1 AL627212 Genomic DNA No translation available. BC046452 mRNA Translation: AAH46452.2 S79346 Genomic DNA No translation available. |
CCDSi | CCDS18553.1 |
PIRi | JN0711 |
RefSeqi | NP_035717.2, NM_011587.2 |
Genome annotation databases
Ensembli | ENSMUST00000047421; ENSMUSP00000037129; ENSMUSG00000033191 |
GeneIDi | 21846 |
KEGGi | mmu:21846 |
UCSCi | uc008ukh.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X71425 mRNA Translation: CAA50556.1 X80764 mRNA Translation: CAA56739.1 X73960 mRNA Translation: CAA52148.1 AK052192 mRNA Translation: BAC34876.1 AK052413 mRNA Translation: BAC34979.1 AL627212 Genomic DNA No translation available. BC046452 mRNA Translation: AAH46452.2 S79346 Genomic DNA No translation available. |
CCDSi | CCDS18553.1 |
PIRi | JN0711 |
RefSeqi | NP_035717.2, NM_011587.2 |
3D structure databases
SMRi | Q06806 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q06806, 1 interactor |
MINTi | Q06806 |
STRINGi | 10090.ENSMUSP00000037129 |
Chemistry databases
BindingDBi | Q06806 |
ChEMBLi | CHEMBL2034800 |
PTM databases
GlyGeni | Q06806, 5 sites |
iPTMneti | Q06806 |
PhosphoSitePlusi | Q06806 |
Proteomic databases
CPTACi | non-CPTAC-3623 |
MaxQBi | Q06806 |
PaxDbi | Q06806 |
PeptideAtlasi | Q06806 |
PRIDEi | Q06806 |
Protocols and materials databases
Antibodypediai | 32289, 711 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000047421; ENSMUSP00000037129; ENSMUSG00000033191 |
GeneIDi | 21846 |
KEGGi | mmu:21846 |
UCSCi | uc008ukh.1, mouse |
Organism-specific databases
CTDi | 7075 |
MGIi | MGI:99906, Tie1 |
Phylogenomic databases
eggNOGi | KOG0200, Eukaryota |
GeneTreei | ENSGT00940000157693 |
HOGENOMi | CLU_008888_0_0_1 |
InParanoidi | Q06806 |
OMAi | NASTCYL |
OrthoDBi | 707342at2759 |
TreeFami | TF317568 |
Enzyme and pathway databases
BRENDAi | 2.7.10.1, 3474 |
Miscellaneous databases
BioGRID-ORCSi | 21846, 2 hits in 19 CRISPR screens |
ChiTaRSi | Tie1, mouse |
PROi | PR:Q06806 |
RNActi | Q06806, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000033191, Expressed in cardiac muscle of left ventricle and 224 other tissues |
ExpressionAtlasi | Q06806, baseline and differential |
Genevisiblei | Q06806, MM |
Family and domain databases
CDDi | cd00063, FN3, 3 hits |
Gene3Di | 2.60.40.10, 5 hits |
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013151, Immunoglobulin IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF00041, fn3, 3 hits PF00047, ig, 2 hits PF07714, PK_Tyr_Ser-Thr, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00181, EGF, 3 hits SM00060, FN3, 3 hits SM00409, IG, 2 hits SM00219, TyrKc, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits SSF49265, SSF49265, 2 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 3 hits PS01186, EGF_2, 3 hits PS50026, EGF_3, 3 hits PS50853, FN3, 3 hits PS50835, IG_LIKE, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TIE1_MOUSE | |
Accessioni | Q06806Primary (citable) accession number: Q06806 Secondary accession number(s): Q811F4, Q8BGI2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 187 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human and mouse protein kinases
Human and mouse protein kinases: classification and index