UniProtKB - Q06805 (TIE1_BOVIN)
Protein
Tyrosine-protein kinase receptor Tie-1
Gene
TIE1
Organism
Bos taurus (Bovine)
Status
Functioni
Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.By similarity
Catalytic activityi
- EC:2.7.10.1PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 868 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 977 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 843 – 851 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- transmembrane receptor protein tyrosine kinase activity Source: GO_Central
GO - Biological processi
- angiogenesis Source: GO_Central
- multicellular organism development Source: GO_Central
- positive regulation of angiogenesis Source: GO_Central
- positive regulation of kinase activity Source: GO_Central
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Keywordsi
Molecular function | Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Biological process | Angiogenesis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.1, 908 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:TIE1 Synonyms:TIE, TIE-1 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 24 – 757 | ExtracellularSequence analysisAdd BLAST | 734 | |
Transmembranei | 758 – 782 | HelicalSequence analysisAdd BLAST | 25 | |
Topological domaini | 783 – 1136 | CytoplasmicSequence analysisAdd BLAST | 354 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Add BLAST | 23 | |
ChainiPRO_0000024470 | 24 – 1136 | Tyrosine-protein kinase receptor Tie-1Add BLAST | 1113 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 84 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 159 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 226 ↔ 235 | PROSITE-ProRule annotation | ||
Disulfide bondi | 229 ↔ 242 | PROSITE-ProRule annotation | ||
Disulfide bondi | 244 ↔ 253 | PROSITE-ProRule annotation | ||
Disulfide bondi | 317 ↔ 325 | PROSITE-ProRule annotation | ||
Disulfide bondi | 319 ↔ 331 | PROSITE-ProRule annotation | ||
Disulfide bondi | 333 ↔ 342 | PROSITE-ProRule annotation | ||
Glycosylationi | 501 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 594 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 707 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 1005 | Phosphotyrosine; by autocatalysisBy similarity | 1 |
Post-translational modificationi
Phosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2.By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q06805 |
PRIDEi | Q06805 |
Expressioni
Tissue specificityi
Specifically expressed in developing vascular endothelial cells.1 Publication
Interactioni
Subunit structurei
Heterodimer with TEK/TIE2.
By similarityProtein-protein interaction databases
STRINGi | 9913.ENSBTAP00000004917 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 43 – 106 | Ig-like C2-type 1Add BLAST | 64 | |
Domaini | 212 – 254 | EGF-like 1PROSITE-ProRule annotationAdd BLAST | 43 | |
Domaini | 256 – 301 | EGF-like 2PROSITE-ProRule annotationAdd BLAST | 46 | |
Domaini | 303 – 343 | EGF-like 3PROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 370 – 424 | Ig-like C2-type 2Add BLAST | 55 | |
Domaini | 444 – 543 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 100 | |
Domaini | 546 – 640 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 644 – 737 | Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 837 – 1116 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 280 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.PROSITE-ProRule annotation
Keywords - Domaini
EGF-like domain, Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0200, Eukaryota |
InParanoidi | Q06805 |
OrthoDBi | 707342at2759 |
Family and domain databases
CDDi | cd00063, FN3, 3 hits |
Gene3Di | 2.60.40.10, 5 hits |
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR003961, FN3_dom IPR036116, FN3_sf IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013151, Immunoglobulin IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF00041, fn3, 3 hits PF00047, ig, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00181, EGF, 3 hits SM00060, FN3, 3 hits SM00409, IG, 2 hits SM00219, TyrKc, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits SSF49265, SSF49265, 2 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 3 hits PS01186, EGF_2, 3 hits PS50026, EGF_3, 2 hits PS50853, FN3, 3 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q06805-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVWLEPPLLL PIFFLASHVG AAVDLTLLAD LRLTEPQRFF LTCVSGEAGA
60 70 80 90 100
GRGSDAWGPP LLLEKDDRIV RTPRPWQPPH IARNGSSRVT VRGFSQPSDL
110 120 130 140 150
VGVFSCVGGG GTRVLYVHNS PGAHLLPDKV THTVNKGDTA VLSARVRKEK
160 170 180 190 200
QTDVIWKSNG SYFYTLDRHE AQDGQFLLQL PNVQPSSSGI YSATYLEASP
210 220 230 240 250
LGSAFFRLIV RGCEAGRWGQ DCTKECPGCL HGGVCHDQDG ECVCPPGFTG
260 270 280 290 300
TRCEQACREG RFGQSCQEQC PGTSGCRGLT FCLPDPYGCS CGSGWRGSQC
310 320 330 340 350
QEACAPGRFG ADCHLQCQCQ NGGTCDRFSG CVCPSGWHGM HCEKSDRIPQ
360 370 380 390 400
ILDMVSELEF NLDTMPRINC AAAGNPFPVR GSMELRKPDG TVLLSTKAIV
410 420 430 440 450
EPDRTTAEFE VPRLALGDSG LWECRVSTSG GQDSRRFRIN VKVPPVPLTA
460 470 480 490 500
PRLLAKQSRQ LVVSPLVSFS GDGPIASVRL HYRPQDSTMA WSTIVVDPSE
510 520 530 540 550
NVTLMNLRPK TGYSVRVQLS RPGEGGEGAW GPPTLMTTDC PEPLLKPWLE
560 570 580 590 600
GWHVEGPDRL RVSWSLPPVP GPLVGDGFLL RLWDGARGQE RRENVSSPQA
610 620 630 640 650
RTALLTGLTP GTYYQLDVRL YHCTLLGPAS PAARVLLPPS GPPAPRHLHA
660 670 680 690 700
QALSDSEIQL MWQRPEAAAG PISKYIVEVQ VAGGSGDPLW MDVDRPEETS
710 720 730 740 750
TIVRGLNAST RYLFRVRASV QGPGDWSNVV EQSTLGNGLQ IEGPVQEIHA
760 770 780 790 800
AEEGLDQQLV LAVVGSVSAT CLTILAALLT LACIRKSCLH RRRTFTYQSG
810 820 830 840 850
SGEETILQFS SGTLTLTRRP KPQPEPLNYP VLEWEDITFE DLIGEGNFGQ
860 870 880 890 900
VIRAMIKKDG LKMNAAIKML KEYASENDHR DFAGELEVLC KLGHHPNIIN
910 920 930 940 950
LLGACENRGY LYIAIEYAPY GNLLDFLRKS RVLETDPAFA REHGTASTLS
960 970 980 990 1000
SRQLLRFASD AANGMQYLSE KQFIHRDLAA RNVLVGENLA SKIADFGLSR
1010 1020 1030 1040 1050
GEEVYVKKTM GRLPVRWMAI ESLNYSVYTT KSDVWSFGVL LWEIVSLGGT
1060 1070 1080 1090 1100
PYCGMTCAEL YEKLPQAYRM EQPRNCDDEV YELMRQCWRD RPYERPPFAQ
1110 1120 1130
IALQLGRMLE ARKAYVNMSL FENFTYAGID ATAEEA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X71423 mRNA Translation: CAA50554.1 |
PIRi | S57845 |
RefSeqi | NP_776390.1, NM_173965.2 |
Genome annotation databases
GeneIDi | 280941 |
KEGGi | bta:280941 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X71423 mRNA Translation: CAA50554.1 |
PIRi | S57845 |
RefSeqi | NP_776390.1, NM_173965.2 |
3D structure databases
SMRi | Q06805 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000004917 |
Proteomic databases
PaxDbi | Q06805 |
PRIDEi | Q06805 |
Genome annotation databases
GeneIDi | 280941 |
KEGGi | bta:280941 |
Organism-specific databases
CTDi | 7075 |
Phylogenomic databases
eggNOGi | KOG0200, Eukaryota |
InParanoidi | Q06805 |
OrthoDBi | 707342at2759 |
Enzyme and pathway databases
BRENDAi | 2.7.10.1, 908 |
Family and domain databases
CDDi | cd00063, FN3, 3 hits |
Gene3Di | 2.60.40.10, 5 hits |
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR003961, FN3_dom IPR036116, FN3_sf IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013151, Immunoglobulin IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF00041, fn3, 3 hits PF00047, ig, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00181, EGF, 3 hits SM00060, FN3, 3 hits SM00409, IG, 2 hits SM00219, TyrKc, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits SSF49265, SSF49265, 2 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 3 hits PS01186, EGF_2, 3 hits PS50026, EGF_3, 2 hits PS50853, FN3, 3 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TIE1_BOVIN | |
Accessioni | Q06805Primary (citable) accession number: Q06805 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | December 2, 2020 | |
This is version 148 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families